Achim Schneider

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. ncbi Screening for high-grade cervical intra-epithelial neoplasia and cancer by testing for high-risk HPV, routine cytology or colposcopy
    A Schneider
    Department of Gynecology, Friedrich Schiller University, Jena, Germany
    Int J Cancer 89:529-34. 2000
  2. ncbi Laparoscopy versus laparotomy in endometrial cancer: first analysis of survival of a randomized prospective study
    Roberto Tozzi
    Department of Gynaecologic Oncology, The Royal Marsden Hospital, London, United Kingdom
    J Minim Invasive Gynecol 12:130-6. 2005
  3. pmc Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome
    Gopeshwar Narayan
    Department of Pathology, Columbia University, New York, New York 10032, USA
    Mol Cancer 2:24. 2003
  4. pmc Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression
    Gopeshwar Narayan
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Mol Cancer 5:16. 2006
  5. pmc Chromosomal amplifications, 3q gain and deletions of 2q33-q37 are the frequent genetic changes in cervical carcinoma
    Pulivarthi H Rao
    Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX, USA
    BMC Cancer 4:5. 2004
  6. ncbi Surgical and radiographic staging in patients with cervical cancer
    Achim Schneider
    Department of Obstetrics and Gynecology, Friedrich Schiller University, Jena, Germany
    Curr Opin Obstet Gynecol 16:11-8. 2004
  7. ncbi [New concepts for staging and therapy of cervix cancer by endoscopic surgery]
    A Schneider
    Klinik fur Frauenheilkunde und Geburtshilfe, Abteilung Frauenheilkunde, Klinikum der Friedrich Schiller Universitat Jena
    Zentralbl Gynakol 123:250-4. 2001
  8. ncbi Dendritic cell-based tumor vaccine for cervical cancer I: in vitro stimulation with recombinant protein-pulsed dendritic cells induces specific T cells to HPV16 E7 or HPV18 E7
    Marion Nonn
    Gynäkologische Molekularbiologie, Universitatsfrauenklinik, Friedrich Schiller Universitat Jena, Bachstrasse 18, 07743, Jena, Germany
    J Cancer Res Clin Oncol 129:511-20. 2003
  9. doi Radical vaginal trachelectomy (RVT) combined with laparoscopic lymphadenectomy: prospective study of 225 patients with early-stage cervical cancer
    Malgorzata Lanowska
    Department of Gynecology, Charite University Medicine, Berlin, Germany
    Int J Gynecol Cancer 21:1458-64. 2011
  10. pmc Vaginal-assisted laparoscopic radical hysterectomy: rationale, technique, results
    Elisabeth Gottschalk
    Department of Gynecology, Charite Universitatsmedizin Berlin, Berlin, Germany
    JSLS 15:451-9. 2011

Detail Information

Publications93

  1. ncbi Screening for high-grade cervical intra-epithelial neoplasia and cancer by testing for high-risk HPV, routine cytology or colposcopy
    A Schneider
    Department of Gynecology, Friedrich Schiller University, Jena, Germany
    Int J Cancer 89:529-34. 2000
    ..In middle-aged women, testing for high-risk HPV types, particularly when negative, may be used to increase the screening interval in programs for secondary prevention of cervical cancer...
  2. ncbi Laparoscopy versus laparotomy in endometrial cancer: first analysis of survival of a randomized prospective study
    Roberto Tozzi
    Department of Gynaecologic Oncology, The Royal Marsden Hospital, London, United Kingdom
    J Minim Invasive Gynecol 12:130-6. 2005
    ..Laparoscopy has been proved to be safe and reliable in staging of patients with endometrial cancer. It has definite advantages over laparotomy, but a comparable survival outcome is still to be verified in prospective randomized trials...
  3. pmc Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome
    Gopeshwar Narayan
    Department of Pathology, Columbia University, New York, New York 10032, USA
    Mol Cancer 2:24. 2003
    ..Although a host of genetic alterations have been identified, molecular basis of CC development is still poorly understood...
  4. pmc Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression
    Gopeshwar Narayan
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY, USA
    Mol Cancer 5:16. 2006
    ..Slit genes mediate their effect by binding to its receptor Roundabout (Robo). These genes have shown to be inactivated by promoter hypermethylation in a number of human cancers...
  5. pmc Chromosomal amplifications, 3q gain and deletions of 2q33-q37 are the frequent genetic changes in cervical carcinoma
    Pulivarthi H Rao
    Texas Children s Cancer Center, Baylor College of Medicine, Houston, TX, USA
    BMC Cancer 4:5. 2004
    ..Therefore, genetic characterization is essential for understanding the biology and clinical heterogeneity in cervical cancer (CC)...
  6. ncbi Surgical and radiographic staging in patients with cervical cancer
    Achim Schneider
    Department of Obstetrics and Gynecology, Friedrich Schiller University, Jena, Germany
    Curr Opin Obstet Gynecol 16:11-8. 2004
    ..The most recent data on surgical and radiographic staging in patients with cervical cancer are analysed...
  7. ncbi [New concepts for staging and therapy of cervix cancer by endoscopic surgery]
    A Schneider
    Klinik fur Frauenheilkunde und Geburtshilfe, Abteilung Frauenheilkunde, Klinikum der Friedrich Schiller Universitat Jena
    Zentralbl Gynakol 123:250-4. 2001
    ..Following radical trachelectomy a pregnancy rate of 40% is achieved, the recurrence rate following conventional radical hysterectomy is identical...
  8. ncbi Dendritic cell-based tumor vaccine for cervical cancer I: in vitro stimulation with recombinant protein-pulsed dendritic cells induces specific T cells to HPV16 E7 or HPV18 E7
    Marion Nonn
    Gynäkologische Molekularbiologie, Universitatsfrauenklinik, Friedrich Schiller Universitat Jena, Bachstrasse 18, 07743, Jena, Germany
    J Cancer Res Clin Oncol 129:511-20. 2003
    ..The viral oncoproteins E6 and E7 are considered to be tumor-specific targets for immunotherapy. HPV E7 antigen-loaded dendritic cells (DC) were evaluated as cellular tumor vaccine...
  9. doi Radical vaginal trachelectomy (RVT) combined with laparoscopic lymphadenectomy: prospective study of 225 patients with early-stage cervical cancer
    Malgorzata Lanowska
    Department of Gynecology, Charite University Medicine, Berlin, Germany
    Int J Gynecol Cancer 21:1458-64. 2011
    ..The aim of the study was to prove the surgical and oncological safety of radical vaginal trachelectomy (RVT) and laparoscopic lymphadenectomy for patients with early-stage cervical cancer who are seeking parenthood...
  10. pmc Vaginal-assisted laparoscopic radical hysterectomy: rationale, technique, results
    Elisabeth Gottschalk
    Department of Gynecology, Charite Universitatsmedizin Berlin, Berlin, Germany
    JSLS 15:451-9. 2011
    ..Laparoscopic-assisted radical vaginal hysterectomy (LARVH) is associated with higher risk for urologic complications...
  11. doi Pregnancy after lymphadenectomy and neoadjuvant chemotherapy followed by radical vaginal trachelectomy in FIGO stage IB1 cervical cancer
    Elisabeth Gottschalk
    Department of Gynecology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Fertil Steril 95:2431.e5-7. 2011
    ..To report a case of full-term delivery after laparoscopic lymphadenectomy and neoadjuvant chemotherapy followed by radical vaginal trachelectomy in bulky stage IB1 cervical cancer...
  12. doi Invasive cervical cancer during pregnancy: laparoscopic nodal evaluation before oncologic treatment delay
    Giovanni Favero
    Department of Gynecology, Charite Universitatsmedizin, Berlin, Germany
    Gynecol Oncol 118:123-7. 2010
    ..We describe the results of 18 pregnant patients with cervical cancer who had their nodal status proved by means of laparoscopy...
  13. doi Laparoscopic pelvic lymphadenectomy in a patient with cervical cancer stage Ib1 complicated by a twin pregnancy
    Giovanni Favero
    Department of Gynecology, Charite Universitatsmedizin, Berlin, Germany
    J Minim Invasive Gynecol 17:118-20. 2010
    ..This case demonstrates the safety of operative nodal staging during gestation, even in a twin pregnancy. Exclusion of nodal metastasis may improve oncologic outcomes, and neoadjuvant chemotherapy should be administered when indicated...
  14. ncbi Dendritic cell-based tumor vaccine for cervical cancer II: results of a clinical pilot study in 15 individual patients
    Alfonso Ferrara
    Gynäkologische Molekularbiologie, Universitatsfrauenklinik, Friedrich Schiller Universitat Jena, Bachstrasse 18, 07743, Jena, Germany
    J Cancer Res Clin Oncol 129:521-30. 2003
    ..The viral oncoproteins E6 and E7 are considered to be tumor-specific targets for immunotherapy. HPV E7 antigen-loaded autologous dendritic cells (DC) were evaluated as cellular tumor vaccine in a case series of cervical cancer patients...
  15. ncbi Laparoscopic-assisted radical vaginal hysterectomy (LARVH): prospective evaluation of 200 patients with cervical cancer
    Hermann Hertel
    Department of Gynecology, Friedrich Schiller University of Jena, Bachstrasse 18, D 07740 Jena, Germany
    Gynecol Oncol 90:505-11. 2003
    ..The purpose of this study was to determine the survival of cervical cancer patients treated with laparoscopically assisted radical vaginal hysterectomy (LARVH). We quantify morbidity and correlate survival with known risk factors...
  16. doi Addressing concerns about cisplatin application during pregnancy
    Malgorzata Lanowska
    Department of Gynecology, Charite Universitatsmedizin, Berlin, Germany
    J Perinat Med 39:279-85. 2011
    ..Cisplatin is recommended to prevent cancer progression. This is a series correlating in vivo cisplatin concentration in the fetomaternal compartment and in breast milk with child development...
  17. doi Implication of the examining pathologist to meet the oncologic standard of lymph node count after laparoscopic lymphadenectomy
    Malgorzata Lanowska
    Department of Gynecology, Charite Universitatsmedizin, Berlin, Germany
    Oncology 79:161-7. 2010
    ..The lymph node number as benchmark in oncologic operations depends on the patient's anatomy, surgeon's skill and pathologist's accuracy. The influence of the pathologist is barely evaluated...
  18. ncbi Does radical trachelectomy influence uterine blood supply?
    Petra Klemm
    Department of Gynecology, Friedrich Schiller University, Bachstrasse 18, 07740 Jena, Germany
    Gynecol Oncol 96:283-6. 2005
    ..If pregnancy occurs, premature delivery is a known problem in these patients. We evaluated if uterine blood supply is decreased after radical trachelectomy as one of various possible causes of preterm birth...
  19. ncbi "Schauta sine utero": technique and results of laparoscopic-vaginal radical parametrectomy
    Christhardt Köhler
    Department of Obstetrics and Gynecology, Friedrich Schiller University, Bachstrasse 18, 07740, Jena, Germany
    Gynecol Oncol 91:359-68. 2003
    ..We evaluated whether radical parametrectomy without or with cervical stump exstirpation can be performed by a combined laparoscopic-vaginal approach...
  20. ncbi Introduction of transperitoneal lymphadenectomy in a gynecologic oncology center: analysis of 650 laparoscopic pelvic and/or paraaortic transperitoneal lymphadenectomies
    Christhardt Köhler
    Department of Obstetrics and Gynecology, Friedrich Schiller University of Jena, Jena, Germany
    Gynecol Oncol 95:52-61. 2004
    ..We evaluated the feasibility and oncologic value of laparoscopic transperitoneal pelvic and paraaortic lymphadenectomy in correlation to complication rate and body mass index...
  21. doi Uncommon synchronous association between ovarian carcinoma and gastrointestinal stromal tumor: a case study and literature review
    Giovanni Favero
    Department of Gynecology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Tumori 99:e70-2. 2013
    ..Usually, the diagnosis is accidentally established. We describe a patient with GIST and concurrent ovarian cancer and discuss the clinical implications of this finding...
  22. ncbi Cumulative 5-year diagnoses of CIN2, CIN3 or cervical cancer after concurrent high-risk HPV and cytology testing in a primary screening setting
    Heike Hoyer
    Institute of Medical Statistics, Information Sciences and Documentation, Friedrich Schiller University, Jena, Germany
    Int J Cancer 116:136-43. 2005
    ..Moreover, 2 women with prevalent cancer were missed by both tests. The prognostic relevance of concurrent high-risk HPV/cytology screening needs to be verified further by randomized trials...
  23. doi The colposcopic feature ridge sign is associated with the presence of cervical intraepithelial neoplasia 2/3 and human papillomavirus 16 in young women
    Cornelia Scheungraber
    Department of Gynecology, Friedrich Schiller University Jena, Jena, Germany
    J Low Genit Tract Dis 13:13-6. 2009
    ....
  24. ncbi Clinical implication of laparoscopic pelvic lymphadenectomy in patients with vulvar cancer and positive groin nodes
    Petra Klemm
    Department of Gynecology, Friedrich Schiller University, Jena, Germany
    Gynecol Oncol 99:101-5. 2005
    ..The aim of this case series was to demonstrate that histologic result of laparoscopic removed pelvic lymph nodes can be used to select patients who should not undergo pelvic irradiation...
  25. doi Combining T-cell vaccination and application of agonistic anti-GITR mAb (DTA-1) induces complete eradication of HPV oncogene expressing tumors in mice
    Corinna Hoffmann
    Department of Obstetrics and Gynecology, Charite Campus Benjamin Franklin, Hindenburgdamm, 12200 Berlin, Germany
    J Immunother 33:136-45. 2010
    ..Ad-p14 has clinical potential for treating HPV-induced lesions, and the added effect of immune response modifiers stresses the importance of combined protocols for immunotherapy of malignant tumors...
  26. doi Histopathology-based combined surgical approach to rectovaginal endometriosis
    Mandy Mangler
    Department of Gynecology, Charite Campus Mitte, Berlin, Germany
    Int J Gynaecol Obstet 103:59-64. 2008
    ..Only infiltrative disease should be treated by intestinal resection. However, infiltration of endometriosis cannot be confirmed by preoperative imaging techniques...
  27. ncbi Radical vaginal trachelectomy (RVT) combined with laparoscopic pelvic lymphadenectomy: prospective multicenter study of 100 patients with early cervical cancer
    Hermann Hertel
    Department of Gynecology, Medical School Hanover, Germany
    Gynecol Oncol 103:506-11. 2006
    ..We also wanted to prove the surgical safety of RVT...
  28. ncbi HPV16-E6 mRNA is superior to cytokeratin 19 mRNA as a molecular marker for the detection of disseminated tumour cells in sentinel lymph nodes of patients with cervical cancer by quantitative reverse-transcription PCR
    Norman Häfner
    Frauenklinik der Friedrich Schiller Universität Jena, Jena, Germany
    Int J Cancer 120:1842-6. 2007
    ..It is concluded that HPV16 E6 mRNA is more specific and more sensitive for the detection of tumour cells in SLN than CK19 mRNA. The specificity of CK19 is limited because of low level expression in uninvolved pelvic lymph nodes...
  29. doi Prevalence of lymph nodes in the parametrium of radical vaginal trachelectomy (RVT) specimen
    Malgorzata Lanowska
    Department of Gynecology, Charite Universitatsmedizin, Berlin, Germany
    Gynecol Oncol 121:298-302. 2011
    ..We tried to identify morphologic factors associated with the presence of parametrial lymph nodes...
  30. doi Laparoscopic temporary clipping of uterine artery during laparoscopic myomectomy
    Giuseppe Vercellino
    Department of Gynecology, Charite Universitatsmedizin, Berlin, Germany
    Arch Gynecol Obstet 286:1181-6. 2012
    ..Our aim is to study the feasibility and effect of bilateral laparoscopic temporary occlusion of uterine arteries by special vascular clamps on blood loss during laparoscopic myomectomy...
  31. ncbi Laparoscopic paraaortic left-sided transperitoneal infrarenal lymphadenectomy in patients with gynecologic malignancies: technique and results
    Christhardt Köhler
    Department of Obstetrics and Gynecology, Friedrich Schiller University, Bachstrasse 18, 07740, Jena, Germany
    Gynecol Oncol 91:139-48. 2003
    ..We evaluated whether left-sided paraaortic inframesenteric lymphadenectomy can be extended up to the left renal vein by laparoscopy...
  32. ncbi Vascular anomalies in the paraaortic region diagnosed by laparoscopy in patients with gynaecologic malignancies
    Petra Klemm
    Department of Gynecology, Friedrich Schiller University, Bachstrasse 18, 07740 Jena, Germany
    Gynecol Oncol 96:278-82. 2005
    ..In this study, we have documented the frequency and pattern of the vascular anomalies in paraaortic region intraoperatively and on cadavers in an attempt to increase surgical safety...
  33. ncbi Laparoscopic treatment of early ovarian cancer: surgical and survival outcomes
    Roberto Tozzi
    Department of Gynecology, Friedrich Schiller University, Jena, Germany
    Gynecol Oncol 93:199-203. 2004
    ..To investigate the feasibility and safety of laparoscopic surgery in patients with early ovarian cancer...
  34. doi Laparoscopic approach for correction of chylous fistula after pelvic and paraaortic lymphadenectomy
    Giovanni Favero
    Department of Gynecology, Charite Universitatsmedizin Berlin, Campus Mitte and Benjamin Franklin, Berlin, Germany
    J Minim Invasive Gynecol 17:262-4. 2010
    ..There was no evidence of recurrence after 2-month follow-up. This case demonstrates successful laparoscopic management of chylous ascites after para-aortic lymphadenectomy and chemoradiation, using suturing...
  35. ncbi Laparoscopic staging compared with imaging techniques in the staging of advanced cervical cancer
    Hermann Hertel
    Department of Gynecology, Friedrich Schiller University of Jena, Bachstrasse 18, D 07740 Jena, Germany
    Gynecol Oncol 87:46-51. 2002
    ..We evaluated the evidence of laparoscopy for decision regarding treatment options in advanced cervical cancer patients...
  36. ncbi Neonatal outcome in infants of patients with radical vaginal trachelectomy
    Mandy Mangler
    Department of Gynecology, Charite University Medicine Berlin, Berlin, Germany
    J Perinat Med 40:503-9. 2012
    ..After RVT, pregnancy rates vary between 40 % and 80 %. Outcome of infants is complicated by a preterm delivery rate of 30 – 50 %. We investigated pregnancy and neonatal outcome after RVT...
  37. doi Validity of the colposcopic criteria inner border sign, ridge sign, and rag sign for detection of high-grade cervical intraepithelial neoplasia
    Giuseppe F Vercellino
    Department of Gynecology, Charité Campus Benjamin Franklin and Charité Campus Charité Mitte, Berlin, Germany
    Obstet Gynecol 121:624-31. 2013
    ..To evaluate the association of three pathognomonic criteria, inner border, ridge sign, and rag sign with high-grade cervical intraepithelial neoplasia (CIN) using video exoscopy...
  38. doi Laparoscopy for differential diagnosis of a pelvic mass in a patient with Mayer-Rokitanski-Küster-Hauser (MRKH) syndrome
    Malgorzata Lanowska
    Department of Gynecology, Charite Universitatsmedizin, Berlin, Germany
    Fertil Steril 91:931.e17-8. 2009
    ..The rudimentary uterus may develop fibroids, and this event can lead to problems in differential diagnosis, especially if no vaginal reconstruction has been carried out...
  39. ncbi Vaccination trial with HPV16 L1E7 chimeric virus-like particles in women suffering from high grade cervical intraepithelial neoplasia (CIN 2/3)
    Andreas M Kaufmann
    Klinik fur Frauenheilkunde und Geburtshilfe, Friedrich Schiller Universitat, Bachstrasse 18, 07740 Jena, Germany
    Int J Cancer 121:2794-800. 2007
    ..Fifty-six percent of the responders were also HPV16 DNA-negative by the end of the study. Therefore, we demonstrated evidence for safety and a nonsignificant trend for the clinical efficacy of the HPV16 L1E7 CVLP vaccine...
  40. doi Pattern of cancer recurrence in 320 patients after radical vaginal trachelectomy
    Mandy Mangler
    Department of Gynecology, Charite University Medicine Berlin, Berlin, Germany
    Int J Gynecol Cancer 24:130-4. 2014
    ..We aim to analyze predictive and risk factors and death in patients with cervical cancer undergoing fertility preservation by laparoscopic lymphadenectomy and RVT...
  41. doi Value of diagnostic procedures in rectovaginal endometriosis
    Mandy Mangler
    Department of Gynecology, Charite Campus Mitte, Berlin, Germany
    Aust N Z J Obstet Gynaecol 53:389-94. 2013
    ..This study compares different imaging procedures in rectovaginal endometriosis cases in an everyday clinical setting...
  42. doi Immunohistochemical characterization of endometriosis-associated smooth muscle cells in human peritoneal endometriotic lesions
    Maria L Barcena de Arellano
    Endometriosis Research Center Berlin, Department of Gynecology, Charite, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Hum Reprod 26:2721-30. 2011
    ..The aim of this retrospective study was to investigate the extent of differentiation in endometriosis-associated SMC (EMaSMC) in peritoneal endometriotic lesions...
  43. doi Immunohistochemical evaluation of endometriotic lesions and disseminated endometriosis-like cells in incidental lymph nodes of patients with endometriosis
    Sylvia Mechsner
    Endometriosis Research Center Charité, Department of Gynecology, Charite, Campus Benjamin Franklin, Berlin, Germany
    Fertil Steril 94:457-63. 2010
    ..To investigate the frequency of endometriotic lesions and disseminated endometriotic-like cells in a series of incidentally removed lymph nodes (LNs) in patients with endometriosis...
  44. ncbi A region on human chromosome 4 (q35.1-->qter) induces senescence in cell hybrids and is involved in cervical carcinogenesis
    Claudia Backsch
    Gynäkologische Molekularbiologie, Abteilung Frauenheilkunde, Frauenklinik der Friedrich Schiller Universität Jena, Germany
    Genes Chromosomes Cancer 43:260-72. 2005
    ....
  45. ncbi Detection of cancer-related gene expression profiles in severe cervical neoplasia
    Igor Sopov
    Klinik fur Frauenheilkunde und Geburtshilfe, Friedrich Schiller Universitat, Jena, Germany
    Int J Cancer 112:33-43. 2004
    ..This approach also provides a basis for the identification of putative prognostic markers and for targeted molecular therapy...
  46. doi Inner border--a specific and significant colposcopic sign for moderate or severe dysplasia (cervical intraepithelial neoplasia 2 or 3)
    Cornelia Scheungraber
    Department of Gynecology, Friedrich Schiller University Jena, Jena, Germany
    J Low Genit Tract Dis 13:1-4. 2009
    ..Investigation of the correlation between the colposcopic sign inner border and cervical intraepithelial neoplasia (CIN) 2 or 3 and its association with specific human papillomavirus (HPV) types and the age of the patient...
  47. doi Neuroimmunomodulatory alterations in non-lesional peritoneum close to peritoneal endometriosis
    Julia Arnold
    Department of Gynecology, Endometriosis Research Centre, Charite, Berlin, Germany
    Neuroimmunomodulation 20:9-18. 2013
    ..Therefore, the density of sensory and sympathetic NFs was determined in distal unaffected peritoneum of endometriosis patients to be able to detect possible alterations in unaffected peritoneum...
  48. ncbi Enhancement of immunogenicity of Jeg3 cells by ectopic expression of HLA-A*0201 and CD80
    Serpil Koc
    Abteilung für Frauenheilkunde, Gynäkologische Molekularbiologie, Frauenklinik, FSU Jena, Jena, Germany
    Am J Reprod Immunol 50:243-53. 2003
    ..We investigated whether Jeg3 cells are capable of immune stimulation after complementation with classical HLA and T cell costimulatory signal CD80...
  49. ncbi Combined vaginal-laparoscopic-abdominal approach for the surgical treatment of rectovaginal endometriosis with bowel resection: a comparison of this new technique with various established approaches by laparoscopy and laparotomy
    Rosanna Zanetti-Dällenbach
    Department of Gynecology, Universitatsmedizin Berlin, Berlin, Germany
    Surg Endosc 22:995-1001. 2008
    ..This technique was compared to various established approaches where bowel resection was indicated by clinical symptoms and imaging results only...
  50. doi Lymph edema of the lower extremities after lymphadenectomy and radiotherapy for cervical cancer
    Jürgen Füller
    Department of Radiooncology, University Hospital, Friedrich Schiller University of Jena, Germany
    Strahlenther Onkol 184:206-11. 2008
    ..To assess the incidence of clinical lymph edema after lymphadenectomy and postoperative radiotherapy (RT)...
  51. ncbi Safety and immunogenicity of TA-HPV, a recombinant vaccinia virus expressing modified human papillomavirus (HPV)-16 and HPV-18 E6 and E7 genes, in women with progressive cervical cancer
    Andreas M Kaufmann
    Frauenklinik, Friedrich Schiller University of Jena, 07743 Jena, Germany
    Clin Cancer Res 8:3676-85. 2002
    ....
  52. ncbi [Interventional MR-mammography: manipulator-assisted large core biopsy and interstitial laser therapy of tumors of the female breast]]
    Stefan O Pfleiderer
    Institut für Diagnostische und Interventionelle Radiologie, Friedrich Schiller Universitat Jena
    Z Med Phys 13:198-202. 2003
    ..GRE information is suitable for therapy monitoring during ILT within the tumor. Further studies are necessary to evaluate the accuracy of the manipulator system and the efficacy of ILT in the treatment of breast lesions...
  53. ncbi A manipulator system for 14-gauge large core breast biopsies inside a high-field whole-body MR scanner
    Stefan O R Pfleiderer
    Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Jena, Germany
    J Magn Reson Imaging 17:493-8. 2003
    ..To investigate a robotic manipulator system for MR-guided breast biopsies inside a 1.5 T whole-body magnet...
  54. ncbi Cryotherapy of breast cancer under ultrasound guidance: initial results and limitations
    Stefan O R Pfleiderer
    Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Bachstrasse 18, 07740 Jena, Germany
    Eur Radiol 12:3009-14. 2002
    ..Remnant DCIS components which may not be detected preinterventionally represent a challenging problem for complete ablation. In tumours larger than 15 mm two or more cryo probes should be used to achieve larger iceballs...
  55. ncbi Differentiation of phyllodes breast tumors from fibroadenomas on MRI
    Susanne Wurdinger
    Department of Mammography, Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University, Bachstrasse 18, Jena D 07740, Germany
    AJR Am J Roentgenol 185:1317-21. 2005
    ..The purpose of our study was to evaluate the MRI appearance of phyllodes breast tumors and to differentiate them from fibroadenomas...
  56. ncbi Identification of a new proliferation-associated protein NET-1/C4.8 characteristic for a subset of high-grade cervical intraepithelial neoplasia and cervical carcinomas
    Volker Wollscheid
    Gynäkologische Molekularbiologie, Abteilung Frauenheilkunde, Klinik für Frauenheilkunde und Geburtshilfe der Friedrich Schiller Universität Jena, Jena, Germany
    Int J Cancer 99:771-5. 2002
    ..The potential importance for this gene in cervical carcinogenesis is underlined by an invariably strong expression in all undifferentiated squamous cell cancers examined. This indicates that this gene may be of prognostic value...
  57. doi Seroprevalence of anti-N-methyl-D-aspartate receptor antibodies in women with ovarian teratoma
    Mandy Mangler
    Department of Gynecology, Chariteplatz 1, Charite Campus Mitte, 10117, Berlin, Germany
    J Neurol 260:2831-5. 2013
    ..Our data support the current clinical practice that a systematic screening for anti-NMDA-R antibodies in teratoma patients is not indicated...
  58. ncbi Volatile organic compounds (VOCs) in exhaled breath of patients with breast cancer in a clinical setting
    Mandy Mangler
    Department of Gynecology, Charite Campus Mitte, Berlin, Germany
    Ginekol Pol 83:730-6. 2012
    ..This study aims to verify the existence of specific volatile organic compounds (VOCs) in the breath of breast cancer patients...
  59. ncbi Identification of a naturally processed HLA-A*0201 HPV18 E7 T cell epitope by tumor cell mediated in vitro vaccination
    Angela Kather
    Gynäkologische Molekularbiologie, Frauenklinik FSU Jena, Jena, Germany
    Int J Cancer 104:345-53. 2003
    ..We suggest that our approach is advantageous over conventional methods, because it yields candidate peptides that are relevant CTL epitopes that are expressed, processed and presented by tumor cells...
  60. ncbi Repair of prolapse with vaginal sacrocolporectopexy: technique and results
    Andreas Kavallaris
    Department of Gynecology, Friedrich Schiller University, Jena, Germany
    Eur J Obstet Gynecol Reprod Biol 122:237-42. 2005
    ..We developed a new technique of transvaginal sacrocolporectopexy for patients with prolapse of uterus and vagina or prolapse of the vaginal vault...
  61. ncbi Explorative laparoscopy prior to exenterative surgery
    Christhardt Köhler
    Department of Gynecology, Friedrich Schiller University, Bachstrasse 18, 07740 Jena, Germany
    Gynecol Oncol 86:311-5. 2002
    ..The objective of this study was to identify the advantages and limits of laparoscopy for assessment of eligibility for exenterative procedures in patients with gynecologic malignancies...
  62. ncbi A new approach to preserve fertility by using a coated nitinol stent in a patient with recurrent cervical stenosis
    Dorothee Grund
    Department of Gynecology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Fertil Steril 87:1212.e13-6. 2007
    ..The incidence of hematometra caused by cervical stenosis after conization is <1%. Nevertheless, if dilatation was unsuccessful, further therapy often remains unclear, and the clinical consequences can be severe, including hysterectomy...
  63. ncbi New paradigm for prevention of cervical cancer
    Andreas M Kaufmann
    Department of Gynecology, Charité Campus Benjamin Franklin and Campus Mitte, Hindenburgdamm 30, 12200 Berlin, Germany
    Eur J Obstet Gynecol Reprod Biol 130:25-9. 2007
    ..However, it represents the first vaccine that has the potential to eradicate 70% of cervical cancer world wide...
  64. ncbi Laparoscopic and vaginal repair of uterine scar dehiscence following cesarean section as detected by ultrasound
    Petra Klemm
    Department of Gynecology, Friedrich Schiller University Jena, Germany
    J Perinat Med 33:324-31. 2005
    ..In this case series we have described sonographic detection of scar dehiscence after CS and feasibility of vaginal or combined laparoscopic and vaginal scar excision and uterine repair...
  65. ncbi Detection of disseminated tumor cells in patients with cervical cancer
    Cornelia Scheungraber
    Klinik für Frauenheilkunde und Geburtshilfe der Friedrich Schiller Universität Jena, Abteilung Frauenheilkunde, Germany
    J Cancer Res Clin Oncol 128:329-35. 2002
    ..Detection of disseminated tumor cells in a cohort of patients presenting the entire spectrum of invasive cervical cancer...
  66. ncbi Endothelial progenitor cells in breast cancer patients
    Christiane Richter-Ehrenstein
    Department of Gynecology, Breast Unit, Charite, Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117, Berlin, Germany
    Breast Cancer Res Treat 106:343-9. 2007
    ..Therefore the aim of this study was a) to quantitate EPCs in breast cancer patients and b) to evaluate if the release of EPCs into the circulation is mainly regulated by the tumor himself...
  67. ncbi Folate, vitamin B12, and homocysteine status. findings of no relation between human papillomavirus persistence and cervical dysplasia
    Rebecca L Sedjo
    Arizona Cancer Center, 1515 N Campbell Avenue, Room 4977 C, Phoenix, AZ 85724 5024, USA
    Nutrition 19:497-502. 2003
    ..HPV infection alone appears to be insufficient to produce disease, suggesting that other cofactors may be needed. Folate, vitamin B12, and homocysteine, through their role in DNA methylation, may be involved in cervical neoplasia...
  68. ncbi Topographic distribution of sentinel lymph nodes in patients with cervical cancer
    Simone Marnitz
    Department of Radiooncology, Charite Universitatsmedizin Berlin, Germany
    Gynecol Oncol 103:35-44. 2006
    ..There are only limited data regarding the mapping of the removed SLN. A correlation between the localization of SLN and the tumor stage, histology or marker substance has never been investigated...
  69. ncbi Laparoscopic treatment of early ovarian cancer
    Roberto Tozzi
    Department of Gynaecologic Oncology, Royal Marsden Hospital, London, UK
    Curr Opin Obstet Gynecol 17:354-8. 2005
    ..Recently some studies have reinforced the arguments supporting the laparoscopic management of early ovarian cancer. These studies and reports questioning the use of laparoscopy in patients with early ovarian cancer will be reviewed...
  70. ncbi Indications for primary and secondary exenterations in patients with cervical cancer
    Simone Marnitz
    Department of Radiooncology, Charite Universitatsmedizin, Berlin, Germany
    Gynecol Oncol 103:1023-30. 2006
    ..In addition, the term "palliative exenteration" is not precisely defined. We evaluate the role of primary exenteration in patients with stage IVA cervical cancer and the role of secondary palliative exenteration...
  71. ncbi Is there a benefit of pretreatment laparoscopic transperitoneal surgical staging in patients with advanced cervical cancer?
    Simone Marnitz
    Department of Radiooncology, Charite Universitaetsmedizin, Berlin, Germany
    Gynecol Oncol 99:536-44. 2005
    ..The aim of this study is to describe the laparoscopic transperitoneal staging procedure in patients with cervical cancer and their oncologic outcome after primary chemoradiation...
  72. ncbi Differentiation of breast masses using 3-D sonographic and echo-enhancer-based evaluation of the vascular pattern: initial experiences
    Albrecht Hochmuth
    Sektion Neuroradiologie, Neurozentrum, Albert Ludwigs Universitat, Freiburg, Germany
    Ultrasound Med Biol 28:845-51. 2002
    ..The 3-D ultrasound (US) technique was of no additional value in differentiating breast masses. The calculation of time-intensity curves after administration of a contrast agent may be helpful in differentiating FA and DIC...
  73. ncbi An improved rearranged Human Papillomavirus Type 16 E7 DNA vaccine candidate (HPV-16 E7SH) induces an E7 wildtype-specific T cell response
    Peter Öhlschläger
    Frauenklinik der FSU Jena, Abteilung Gynäkologische Molekularbiologie, D 07743 Jena, Germany
    Vaccine 24:2880-93. 2006
    ..Importantly, the artificial HPV-gene has completely lost its transforming properties as measured in soft agar transformation assays. These results may be of importance for the development of vaccines based on oncogenes or oncoproteins...
  74. ncbi [Role of Laparoscopy in the Treatment of Endometrial Carcinoma]
    Dorothee Grund
    Klinik fur Gynakologie, Charite Universitatsmedizin Berlin, Berlin, Deutschland
    Gynakol Geburtshilfliche Rundsch 46:13-24. 2006
    ..The removal of metastatic lymph nodes seems to improve survival significantly...
  75. ncbi Interindividual variability of lymph drainages in patients with cervical cancer. Implication on irradiation planning
    Simone Marnitz
    Department of Radiooncology, Charite Universitatsmedizin, Campus Benjamin Franklin, 12200 Berlin, Germany
    Strahlenther Onkol 182:80-5. 2006
    ..Usually, standard fields are used with the upper field border on the fourth/fifth lumbar vertebra. The authors evaluated whether standard fields are sufficient for encompassing the common iliac lymph nodes...
  76. ncbi Uterus necrosis after radiochemotherapy in two patients with advanced cervical cancer
    Simone Marnitz
    Department of Radiooncology, Charite Universitatsmedizin, Berlin, Germany
    Strahlenther Onkol 182:45-51. 2006
    ..A large body of literature concerning therapy-related acute and late morbidity is available. Chemoradiation-associated necrosis of the uterus has not been described so far...
  77. ncbi Stage-adjusted chemoradiation in cervical cancer after transperitoneal laparoscopic staging
    Simone Marnitz
    Department of Radiooncology, Charite Berlin, Germany
    Strahlenther Onkol 183:473-8. 2007
    ..To evaluate the impact of transperitoneal laparoscopic staging on choice of subsequent therapy including oncologic outcome and toxicity of chemoradiation after surgical staging...
  78. ncbi The sentinel concept in patients with cervical cancer
    Achim Schneider
    Department of Gynecology and Gynecologic Oncology, Charite, Berlin, Germany
    J Surg Oncol 96:337-41. 2007
    ..Detection of circulating tumor cells in the sentinel node using HPVmRNA as marker may have a good prognostic value. Currently the sentinel concept should only be used in clinical studies before its validity has been proved...
  79. doi Sentinel node dissection is safe in the treatment of early-stage vulvar cancer
    Ate G J van der Zee
    Department of Obstetrics and Gynecology, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Oncol 26:884-9. 2008
    ..To investigate the safety and clinical utility of the sentinel node procedure in early-stage vulvar cancer patients...
  80. ncbi Vaginal cuff recurrence of endometrial cancer treated by laparoscopic-assisted vaginal hysterectomy
    Achim Schneider
    Gynecol Oncol 94:861; author reply 861. 2004
  81. ncbi HPV testing in the follow-up after treatment of women with CIN
    Helmut von Keyserling
    Department of Gynecologic Oncology, Charite Universitatsmedizin Berlin, Campus Mitte und Benjamin Franklin, Germany Hindenburgdamm 30, 12200 Berlin
    Gynecol Oncol 107:S5-7. 2007
  82. ncbi Complete remission after neoadjuvant chemoradiation in a stage IV vulvar cancer patient
    Annett Bischoff
    Department of Radiooncology, Charite University Hospital, Berlin, Germany
    Strahlenther Onkol 184:421-5. 2008
    ..The authors report on a modified neoadjuvant radiochemotherapy schedule which is isoeffective to the GOG (Gynecologic Oncology Group) protocol, but associated with less therapy-related toxicity...
  83. ncbi Sonographic monitoring of systemic and local methotrexate (MTX) therapy in patients with intact interstitial pregnancies
    Petra Klemm
    Friedrich Schiller University Jena, Germany
    J Perinat Med 34:149-57. 2006
    ..In this case series we describe sonographic monitoring under methotrexate (MTX) application and the residual sonographic findings after completing therapy...
  84. doi The majority of viral-cellular fusion transcripts in cervical carcinomas cotranscribe cellular sequences of known or predicted genes
    Irene Kraus
    Institute of Pathology, Rikshospitalet University Hospital, Oslo, Norway
    Cancer Res 68:2514-22. 2008
    ..These data suggest that the influence of HPV integration on host gene expression may not be a rare effect and should encourage more detailed analyses...
  85. ncbi Should all women be vaccinated against HPV?
    Heinz J Schmitt
    Pol Arch Med Wewn 117:448-51. 2007
  86. doi Multicenter validation study of the sentinel lymph node concept in cervical cancer: AGO Study Group
    Christopher Altgassen
    Department of Gynecology and Gynecologic Oncology, Universitatsmedizin Berlin, Charite, Hindenburgdamm 30, D 12203 Berlin, Germany
    J Clin Oncol 26:2943-51. 2008
    ..However, the diagnostic accuracy remains to be validated. We evaluated detection rate and diagnostic accuracy to predict the histopathologic pelvic nodal status in patients with cervical cancer of all stages...
  87. pmc Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha
    Luigi Scotto
    Department of Pathology, Columbia University Medical Center, New York, New York, USA
    Mol Cancer 7:58. 2008
    ..These changes may possess oncogenic properties by deregulating tumor-related genes. Gain of short arm of chromosome 5 (5p) is the most frequent karyotypic change in CC...
  88. ncbi Promoter hypermethylation of FANCF: disruption of Fanconi Anemia-BRCA pathway in cervical cancer
    Gopeshwar Narayan
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Cancer Res 64:2994-7. 2004
    ..Thus, these results have important implications in understanding the molecular basis of CC tumorigenesis and clinical management in designing targeted experimental therapeutic protocols...
  89. ncbi Disease-based therapy of patients with cervical cancer
    Achim Schneider
    Department of Gynecologic Oncology Charité, Berlin
    Gynecol Oncol 107:S16-7. 2007
  90. ncbi Analysis of morbidity in patients with endometrial cancer: is there a commitment to offer laparoscopy?
    Roberto Tozzi
    Department of Gynaecologic Oncology, The Royal Marsden Hospital, London, UK
    Gynecol Oncol 97:4-9. 2005
    ..The goal was to identify patients carrying specific risk factors for complications, who would most benefit of laparoscopy and be the ideal candidates for this surgical approach...
  91. ncbi Systematic identification and molecular characterization of genes differentially expressed in breast and ovarian cancer
    Edgar Dahl
    Institute of Pathology, RWTH Aachen, Germany
    J Pathol 205:21-8. 2005
    ..The majority of these differentially expressed genes have not been described previously in the context of breast and ovarian cancer, and may constitute novel diagnostic markers for these tumour entities...
  92. doi Type-dependent integration frequency of human papillomavirus genomes in cervical lesions
    Svetlana Vinokurova
    Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Cancer Res 68:307-13. 2008
    ....
  93. ncbi [Impact of vaccination against oncogenic human papillomavirus on the incidence and mortality of cervical cancer in Germany]
    Achim Schneider
    Klinik für Gynäkologie und gynäkologische Onkologie, Charite, Berlin
    Med Klin (Munich) 102:515-23. 2007
    ..The study aims to evaluate the achievable long-term impact of HPV vaccination on invasive cervical cancer (ICC) incidence and mortality in Germany, a country with an opportunistic Pap screening program and suboptimal participation...