Ralf Schlosser

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. doi request reprint Dopaminergic modulation of brain systems subserving decision making under uncertainty: a study with fMRI and methylphenidate challenge
    R G M Schlösser
    Department of Psychiatry and Psychotherapy, University of Jena, Jena, Germany
    Synapse 63:429-42. 2009
  2. ncbi request reprint Altered benzodiazepine receptor sensitivity in alcoholism: a study with fMRI and acute lorazepam challenge
    Ralf G M Schlösser
    Department of Psychiatry, University of Jena, Philosophenweg 3, 07740 Jena, Germany
    Psychiatry Res 154:241-51. 2007
  3. ncbi request reprint White matter abnormalities and brain activation in schizophrenia: a combined DTI and fMRI study
    Ralf G M Schlösser
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University, 07743 Jena, Germany
    Schizophr Res 89:1-11. 2007
  4. doi request reprint Fronto-cingulate effective connectivity in major depression: a study with fMRI and dynamic causal modeling
    R G M Schlösser
    Department of Psychiatry, University of Jena, Germany
    Neuroimage 43:645-55. 2008
  5. ncbi request reprint Assessing the working memory network: studies with functional magnetic resonance imaging and structural equation modeling
    R G M Schlösser
    Department of Psychiatry, University of Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuroscience 139:91-103. 2006
  6. ncbi request reprint [Schizophrenia as a disconnection syndrome. Studies with functional magnetic resonance imaging and structural equation modeling]
    R Schlosser
    Psychiatrische Klinik, Universitat Jena
    Radiologe 45:137-40, 142-3. 2005
  7. ncbi request reprint Altered effective connectivity in drug free schizophrenic patients
    Ralf Schlosser
    Department of Psychiatry, University of Mainz, Germany
    Neuroreport 14:2233-7. 2003
  8. ncbi request reprint Altered effective connectivity during working memory performance in schizophrenia: a study with fMRI and structural equation modeling
    Ralf Schlosser
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Neuroimage 19:751-63. 2003
  9. doi request reprint Intensive practice of a cognitive task is associated with enhanced functional integration in schizophrenia
    R Schlosser
    Department of Psychiatry and Psychotherapy, University of Jena, Jena, Germany
    Psychol Med 39:1809-19. 2009
  10. ncbi request reprint Long-term effects of the substituted benzamide derivative amisulpride on baseline and stimulated prolactin levels
    R Schlosser
    Department of Psychiatry, University of Mainz, Germany
    Neuropsychobiology 46:33-40. 2002

Detail Information

Publications30

  1. doi request reprint Dopaminergic modulation of brain systems subserving decision making under uncertainty: a study with fMRI and methylphenidate challenge
    R G M Schlösser
    Department of Psychiatry and Psychotherapy, University of Jena, Jena, Germany
    Synapse 63:429-42. 2009
    ..The findings suggest a role of dopamine in uncertainty processing and shed light on the pharmacological mechanisms of methylphenidate...
  2. ncbi request reprint Altered benzodiazepine receptor sensitivity in alcoholism: a study with fMRI and acute lorazepam challenge
    Ralf G M Schlösser
    Department of Psychiatry, University of Jena, Philosophenweg 3, 07740 Jena, Germany
    Psychiatry Res 154:241-51. 2007
    ..Moreover, the results suggest enhanced responsivity to an acute GABAergic challenge in the right cerebellum with disease-related disruption of cerebellar functional integrity...
  3. ncbi request reprint White matter abnormalities and brain activation in schizophrenia: a combined DTI and fMRI study
    Ralf G M Schlösser
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University, 07743 Jena, Germany
    Schizophr Res 89:1-11. 2007
    ..It highlights a potential relationship between anatomical changes in a frontal-temporal anatomical circuit and functional alterations in the prefrontal cortex...
  4. doi request reprint Fronto-cingulate effective connectivity in major depression: a study with fMRI and dynamic causal modeling
    R G M Schlösser
    Department of Psychiatry, University of Jena, Germany
    Neuroimage 43:645-55. 2008
    ..The findings are consistent with current models of a differential involvement of the fronto-cingulate system in the pathophysiology of major depression...
  5. ncbi request reprint Assessing the working memory network: studies with functional magnetic resonance imaging and structural equation modeling
    R G M Schlösser
    Department of Psychiatry, University of Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuroscience 139:91-103. 2006
    ..Aside from a discussion of previous studies and their essential findings, advanced methodological issues and caveats as well as future perspectives of the method will be addressed...
  6. ncbi request reprint [Schizophrenia as a disconnection syndrome. Studies with functional magnetic resonance imaging and structural equation modeling]
    R Schlosser
    Psychiatrische Klinik, Universitat Jena
    Radiologe 45:137-40, 142-3. 2005
    ..The present findings are consistent with the model of schizophrenia as a disconnection syndrome and earlier concepts of "cognitive dysmetria" in schizophrenia...
  7. ncbi request reprint Altered effective connectivity in drug free schizophrenic patients
    Ralf Schlosser
    Department of Psychiatry, University of Mainz, Germany
    Neuroreport 14:2233-7. 2003
    ..The study demonstrated the feasibility to model information processing within cognitive networks and provided additional evidence for the concept of cognitive dysmetria in schizophrenia...
  8. ncbi request reprint Altered effective connectivity during working memory performance in schizophrenia: a study with fMRI and structural equation modeling
    Ralf Schlosser
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Neuroimage 19:751-63. 2003
    ....
  9. doi request reprint Intensive practice of a cognitive task is associated with enhanced functional integration in schizophrenia
    R Schlosser
    Department of Psychiatry and Psychotherapy, University of Jena, Jena, Germany
    Psychol Med 39:1809-19. 2009
    ..The question arises whether these differential temporal patterns of activation in schizophrenia patients and controls are going along with changes in task-related functional connectivity...
  10. ncbi request reprint Long-term effects of the substituted benzamide derivative amisulpride on baseline and stimulated prolactin levels
    R Schlosser
    Department of Psychiatry, University of Mainz, Germany
    Neuropsychobiology 46:33-40. 2002
    ..However, the findings indicate also that treatment with amisulpride at clinically effective doses can be achieved at significantly lower prolactin levels during the long-term maintenance phase than during the prior acute phase...
  11. ncbi request reprint Fronto-cingulate effective connectivity in obsessive compulsive disorder: a study with fMRI and dynamic causal modeling
    Ralf G M Schlösser
    Department of Psychiatry, University of Jena, Germany
    Hum Brain Mapp 31:1834-50. 2010
    ..These findings are consistent with an overactive error control system in OCD subserving suppression of prepotent responses during decision-making...
  12. ncbi request reprint Inefficient executive cognitive control in schizophrenia is preceded by altered functional activation during information encoding: an fMRI study
    Ralf G M Schlösser
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuropsychologia 46:336-47. 2008
    ..These results could be explained by increased top-down control processing from prefrontal cortex as a compensation for functional deficits occurring during encoding...
  13. ncbi request reprint Temporal changes in neural activation during practice of information retrieval from short-term memory: an fMRI study
    Kathrin Koch
    Department of Psychiatry, University of Jena, Philosophenweg 3, 07740 Jena, Germany
    Brain Res 1107:140-50. 2006
    ..The temporal changes in brain activation patterns could be attributed to enhanced efficiency of information processing as a result of cognitive practice...
  14. doi request reprint Predictors of response and remission in the acute treatment of first-episode schizophrenia patients--is it all about early response?
    Rebecca Schennach-Wolff
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Eur Neuropsychopharmacol 21:370-8. 2011
    ..To evaluate the predictive validity of early response compared to other well-known predictor variables in acutely ill first-episode patients...
  15. doi request reprint Short-term treatment with risperidone or haloperidol in first-episode schizophrenia: 8-week results of a randomized controlled trial within the German Research Network on Schizophrenia
    Hans Jurgen Moller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Int J Neuropsychopharmacol 11:985-97. 2008
    ..Risperidone has better extrapyramidal tolerability and treatment retention rate than the equivalent dose of haloperidol in these patients...
  16. ncbi request reprint Reduced heat pain thresholds after sad-mood induction are associated with changes in thalamic activity
    Gerd Wagner
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07743 Jena, Germany
    Neuropsychologia 47:980-7. 2009
    ..We present evidence that induced sad affect leads to reduced heat pain thresholds in healthy subjects. This is probably due to altered lateral thalamic activity, which is potentially associated with changed attentional processes...
  17. ncbi request reprint Akathisia and suicidal ideation in first-episode schizophrenia
    Florian Seemüller
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    J Clin Psychopharmacol 32:694-8. 2012
    ..The allocated treatment, anxiety, and nervousness had no influence. The present findings suggest a promoting effect of akathisia on suicidal ideation can not be ruled out in patients with FES...
  18. pmc Internal capsule size associated with outcome in first-episode schizophrenia
    Thomas Wobrock
    Department of Psychiatry and Psychotherapy, Georg August University Gottingen, Gottingen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:278-83. 2009
    ..In conclusion, reduced maximal area of ALIC, which can be interpreted as a disturbance of fronto-thalamic connectivity, is associated with poor outcome during the 1 year course of first-episode schizophrenia...
  19. ncbi request reprint Neural correlates of working memory dysfunction in first-episode schizophrenia patients: an fMRI multi-center study
    Frank Schneider
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Schizophr Res 89:198-210. 2007
    ....
  20. doi request reprint Neuropsychological impairments predict the clinical course in schizophrenia
    Wolfgang Wolwer
    Department of Psychiatry and Psychotherapy, Heinrich Heine University Düsseldorf Rhineland State Clinics Düsseldorf, Bergische Landstrasse 2, Dusseldorf, Germany
    Eur Arch Psychiatry Clin Neurosci 258:28-34. 2008
    ....
  21. doi request reprint The neural correlates of reward-related trial-and-error learning: an fMRI study with a probabilistic learning task
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
    Learn Mem 15:728-32. 2008
    ..In contrast, learning on the basis of predictable stimulus-outcome associations enables the brain to reduce resources in association with the processes of prediction...
  22. ncbi request reprint Characterization of BOLD-fMRI signal during a verbal fluency paradigm in patients with intracerebral tumors affecting the frontal lobe
    Ralf Schlosser
    Department of Psychiatry, Universit of Mainz, Germany
    Magn Reson Imaging 20:7-16. 2002
    ..Additional studies investigating alterations of the hemodynamic response depending on tumor location and histology are required in order to further elucidate the association between pathophysiology and BOLD fMRI signal...
  23. ncbi request reprint Increased prefrontal activation during pain perception in major depression
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University, Philosophenweg 3, Jena, Germany
    Biol Psychiatry 62:1281-7. 2007
    ....
  24. ncbi request reprint Maintenance treatment with risperidone or low-dose haloperidol in first-episode schizophrenia: 1-year results of a randomized controlled trial within the German Research Network on Schizophrenia
    Wolfgang Gaebel
    Department of Psychiatry and Psychotherapy, Heinrich Heine University of Dusseldorf, Rhineland State Clinics Düsseldorf, Dusseldorf, Germany
    J Clin Psychiatry 68:1763-74. 2007
    ..Accordingly, the hypothesis of whether 1-year relapse rate in first-episode schizophrenia under maintenance treatment with risperidone is lower compared to haloperidol in low dose was tested...
  25. ncbi request reprint Altered emotional and BOLD responses to negative, positive and ambiguous performance feedback in OCD
    Michael P I Becker
    Department of Biological and Clinical Psychology, Friedrich Schiller University, D 07743 Jena, Germany, Institute of Medical Psychology and Systems Neuroscience, University Hospital Muenster, D 48149 Muenster, Germany, and Department of Psychiatry and Psychotherapy, Jena University Hospital, D 07743 Jena, GermanyDepartment of Biological and Clinical Psychology, Friedrich Schiller University, D 07743 Jena, Germany, Institute of Medical Psychology and Systems Neuroscience, University Hospital Muenster, D 48149 Muenster, Germany, and Department of Psychiatry and Psychotherapy, Jena University Hospital, D 07743 Jena, Germany
    Soc Cogn Affect Neurosci 9:1127-33. 2014
    ..This suggests a parallel pattern of increased and decreased neural sensitivity to different kinds of feedback information and a general emotional hyperresponsivity to negative and ambiguous performance feedback in OCD. ..
  26. ncbi request reprint Association of an interleukin-1beta gene polymorphism at position -511 with Alzheimer's disease
    Christian Ehl
    Department of Psychiatry, University of Bonn, D 53105 Bonn, Germany
    Int J Mol Med 11:235-8. 2003
    ..Even though IL-1beta -511 polymorphism did not influence the risk of AD it might have a pathophysiological influence on the disease process...
  27. ncbi request reprint The Calgary Depression Rating Scale for Schizophrenia: development and interrater reliability of a German version (CDSS-G)
    M J Muller
    Department of Psychiatry, University of Mainz, Germany
    J Psychiatr Res 33:433-43. 1999
    ..The results demonstrate adequate to excellent interrater reliability of the CDSS-G corroborating the results of the original version in different settings...
  28. ncbi request reprint Occupancy of striatal D(2)-like dopamine receptors after treatment with the sigma ligand EMD 57445, a putative atypical antipsychotic
    G Grunder
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D 55131 Mainz, Germany
    Psychopharmacology (Berl) 146:81-6. 1999
    ..It has been reported recently to have antipsychotic activity in schizophrenia. However, its metabolite, EMD 59983, binds also to D(2) and D(3) dopamine (DA) receptors...
  29. ncbi request reprint Functional magnetic resonance imaging research in psychiatry
    E M Meisenzahl
    Department of Psychiatry, Ludwig Maxmilians University of Munich Medical School, Munich, Germany
    Neuroimaging Clin N Am 11:365-74, x. 2001
    ..Study designs involving fMRI capitalize on the technique's enhanced spatial and temporal resolution, noninvasive nature, and absence of radiation exposure...
  30. ncbi request reprint Effects of subchronic paroxetine administration on night-time endocrinological profiles in healthy male volunteers
    R Schlosser
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, D 55131, Mainz, Germany
    Psychoneuroendocrinology 25:377-88. 2000
    ....