Hans Georg Schaible

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. doi request reprint Mechanisms of chronic pain in osteoarthritis
    Hans Georg Schaible
    Institute of Physiology Neurophysiology 1, Jena University Hospital Friedrich Schiller University Jena, Teichgraben 8, 07740, Jena, Germany
    Curr Rheumatol Rep 14:549-56. 2012
  2. pmc Potent anti-inflammatory and antinociceptive activity of the endothelin receptor antagonist bosentan in monoarthritic mice
    Anne Katja Imhof
    Institute of Pharmacology and Toxicology, University Hospital, Friedrich Schiller University, Drackendorfer Str 1, 07747 Jena, Germany
    Arthritis Res Ther 13:R97. 2011
  3. doi request reprint The role of proinflammatory cytokines in the generation and maintenance of joint pain
    H G Schaible
    Institute of Physiology Neurophysiology, Universitatsklinikum Jena, Jena, Germany
    Ann N Y Acad Sci 1193:60-9. 2010
  4. doi request reprint [The role of TNF-alpha as pain mediator]
    H G Schaible
    Institut für Physiologie 1 Neurophysiologie, Universitatsklinikum Jena, Teichgraben 8, 07740 Jena, Deutschland
    Z Rheumatol 69:237-9. 2010
  5. pmc Update on peripheral mechanisms of pain: beyond prostaglandins and cytokines
    Hans Georg Schaible
    Institute of Physiology I Neurophysiology, Jena University Hospital Friedrich Schiller University, Teichgraben 8, D 07740 Jena, Germany
    Arthritis Res Ther 13:210. 2011
  6. ncbi request reprint Neurogenic aspects of inflammation
    Hans Georg Schaible
    Department of Physiology, University of Jena, Am Teichgraben 8, 07740 Jena, Germany
    Rheum Dis Clin North Am 31:77-101, ix. 2005
  7. ncbi request reprint [Pathophysiology of pain]
    H G Schaible
    Abteilung Neurophysiologie, Institut fur Physiologie, Klinikum der FSU Jena, Teichgraben 8, 07740, Jena
    Orthopade 36:8, 10-2, 14-6. 2007
  8. ncbi request reprint Pathophysiology of pain
    Hans Georg Schaible
    Institut fur Physiologie, Friedrich Schiller Universitat Jena, Teichgraben 8, 07740 Jena, Germany
    Langenbecks Arch Surg 389:237-43. 2004
  9. ncbi request reprint [Epidemiology and pathophysiology of pain--new targets for pain therapy]
    Hans Georg Schaible
    Institut für Physiologie 1 Neurophysiologie, Universitätskinikum Jena, Teichgraben 8, 07743 Jena
    Med Monatsschr Pharm 32:164-71; quiz 173-4. 2009
  10. doi request reprint Joint pain
    Hans Georg Schaible
    Institute of Physiology 1 Neurophysiology, University Hospital Jena, Teichgraben 8, 07740 Jena, Germany
    Exp Brain Res 196:153-62. 2009

Collaborators

Detail Information

Publications55

  1. doi request reprint Mechanisms of chronic pain in osteoarthritis
    Hans Georg Schaible
    Institute of Physiology Neurophysiology 1, Jena University Hospital Friedrich Schiller University Jena, Teichgraben 8, 07740, Jena, Germany
    Curr Rheumatol Rep 14:549-56. 2012
    ..Concerning molecular mechanisms of OA pain and potential options for pain therapy, studies on nerve growth factor, cytokines, sodium channel blockers, hyaluronic acid preparations, and others are addressed in this review...
  2. pmc Potent anti-inflammatory and antinociceptive activity of the endothelin receptor antagonist bosentan in monoarthritic mice
    Anne Katja Imhof
    Institute of Pharmacology and Toxicology, University Hospital, Friedrich Schiller University, Drackendorfer Str 1, 07747 Jena, Germany
    Arthritis Res Ther 13:R97. 2011
    ..We therefore examined the effects of endothelin receptor antagonists on the development of arthritis and inflammatory pain in monoarthritic mice...
  3. doi request reprint The role of proinflammatory cytokines in the generation and maintenance of joint pain
    H G Schaible
    Institute of Physiology Neurophysiology, Universitatsklinikum Jena, Jena, Germany
    Ann N Y Acad Sci 1193:60-9. 2010
    ..Finally, in cultured DRG neurons TNF-alpha increased the proportion of neurons that express the TRPV1 receptor and may thus contribute to the generation of inflammation-evoked thermal hyperalgesia...
  4. doi request reprint [The role of TNF-alpha as pain mediator]
    H G Schaible
    Institut für Physiologie 1 Neurophysiologie, Universitatsklinikum Jena, Teichgraben 8, 07740 Jena, Deutschland
    Z Rheumatol 69:237-9. 2010
    ..Numerous nociceptors express the TNF receptors 1 and 2. By a direct action at the nociceptor TNF-alpha is involved in the generation and maintenance of inflammation-related pain...
  5. pmc Update on peripheral mechanisms of pain: beyond prostaglandins and cytokines
    Hans Georg Schaible
    Institute of Physiology I Neurophysiology, Jena University Hospital Friedrich Schiller University, Teichgraben 8, D 07740 Jena, Germany
    Arthritis Res Ther 13:210. 2011
    ....
  6. ncbi request reprint Neurogenic aspects of inflammation
    Hans Georg Schaible
    Department of Physiology, University of Jena, Am Teichgraben 8, 07740 Jena, Germany
    Rheum Dis Clin North Am 31:77-101, ix. 2005
    ..This article first addresses the activation of the nociceptive system by inflammation; the second part describes the effects of the nervous system on inflamed tissue...
  7. ncbi request reprint [Pathophysiology of pain]
    H G Schaible
    Abteilung Neurophysiologie, Institut fur Physiologie, Klinikum der FSU Jena, Teichgraben 8, 07740, Jena
    Orthopade 36:8, 10-2, 14-6. 2007
    ..The conscious pain is generated by thalamocortical networks that produce both sensory discriminative and affective components of the pain response...
  8. ncbi request reprint Pathophysiology of pain
    Hans Georg Schaible
    Institut fur Physiologie, Friedrich Schiller Universitat Jena, Teichgraben 8, 07740 Jena, Germany
    Langenbecks Arch Surg 389:237-43. 2004
    ..This review will briefly describe the "pain system" and then address neuronal mechanisms that are involved in clinical pain states...
  9. ncbi request reprint [Epidemiology and pathophysiology of pain--new targets for pain therapy]
    Hans Georg Schaible
    Institut für Physiologie 1 Neurophysiologie, Universitätskinikum Jena, Teichgraben 8, 07743 Jena
    Med Monatsschr Pharm 32:164-71; quiz 173-4. 2009
    ..In addition, the better understanding of neuronal mechanisms of placebo effects may open new pathways...
  10. doi request reprint Joint pain
    Hans Georg Schaible
    Institute of Physiology 1 Neurophysiology, University Hospital Jena, Teichgraben 8, 07740 Jena, Germany
    Exp Brain Res 196:153-62. 2009
    ..The overview will also address long-term changes of pain-related behavior, response properties of neurons and receptor expression in chronic animal models of arthritis...
  11. ncbi request reprint Spinal tumor necrosis factor alpha neutralization reduces peripheral inflammation and hyperalgesia and suppresses autonomic responses in experimental arthritis: a role for spinal tumor necrosis factor alpha during induction and maintenance of peripheral i
    Michael Karl Boettger
    Institute of Physiology I, University Hospital Jena, Jena, Germany
    Arthritis Rheum 62:1308-18. 2010
    ..This study was undertaken to test the hypothesis that spinal actions of the proinflammatory cytokine tumor necrosis factor alpha (TNFalpha) add significantly to both hyperalgesia and maintenance of peripheral inflammation...
  12. ncbi request reprint Antinociceptive effects of tumor necrosis factor alpha neutralization in a rat model of antigen-induced arthritis: evidence of a neuronal target
    Michael K Boettger
    University Hospital of Jena, Jena, Germany
    Arthritis Rheum 58:2368-78. 2008
    ....
  13. doi request reprint Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids
    Alejandro Telleria-Diaz
    Department of Physiology, University Hospital of Jena, Teichgraben 8, D 07740 Jena, Germany
    Pain 148:26-35. 2010
    ....
  14. ncbi request reprint Mechanisms of pain in arthritis
    Hans Georg Schaible
    Department of Physiology, Friedrich Schiller University of Jena, Jena, Germany
    Ann N Y Acad Sci 966:343-54. 2002
    ....
  15. ncbi request reprint The proportion of TRPV1 protein-positive lumbar DRG neurones does not increase in the course of acute and chronic antigen-induced arthritis in the knee joint of the rat
    Karl Jürgen Bär
    Institute of Physiology, University of Jena, Teichgraben 8, D 07740 Jena, Germany
    Neurosci Lett 361:172-5. 2004
    ..Thus AIA in the knee joint is not associated with an up-regulation of the TRPV1 receptor in the lumbar DRG neurones...
  16. doi request reprint Interleukin-17 sensitizes joint nociceptors to mechanical stimuli and contributes to arthritic pain through neuronal interleukin-17 receptors in rodents
    Frank Richter
    Institute of Physiology I Neurophysiology, Jena University Hospital Friedrich Schiller University Jena, Jena, Germany
    Arthritis Rheum 64:4125-34. 2012
    ..This study was undertaken to explore whether IL-17A acts on neurons, whether it sensitizes joint nociceptors, and whether neutralization of IL-17 is antinociceptive...
  17. pmc Neuronal prostaglandin E2 receptor subtype EP3 mediates antinociception during inflammation
    Gabriel Natura
    Institute of Physiology I, Jena University Hospital, Friedrich Schiller University Jena, 07740 Jena, Germany
    Proc Natl Acad Sci U S A 110:13648-53. 2013
    ..Importantly, we identified the EP3 receptor in the joint nerves of patients with painful osteoarthritis. ..
  18. ncbi request reprint Changes in the effect of spinal prostaglandin E2 during inflammation: prostaglandin E (EP1-EP4) receptors in spinal nociceptive processing of input from the normal or inflamed knee joint
    Karl Jürgen Bär
    Department of Physiology I, University of Jena, D 07740 Jena, Germany
    J Neurosci 24:642-51. 2004
    ..The latter might be an interesting target for controlling spinal hyperexcitability in inflammatory pain states...
  19. ncbi request reprint The relationship between sudden severe hypoxia and ischemia-associated spreading depolarization in adult rat brainstem in vivo
    Frank Richter
    Institute of Physiology I Neurophysiology, University Hospital Jena, Teichgraben 8, D 07740 Jena, Germany
    Exp Neurol 224:146-54. 2010
    ..Thus, sudden severe hypoxia/ischemia evokes SDs in the brainstem, but the occurrence of the so-elicited SD does not influence the immediate cardiovascular response to SSH...
  20. ncbi request reprint Calcitonin gene-related peptide enhances TTX-resistant sodium currents in cultured dorsal root ganglion neurons from adult rats
    Gabriel Natura
    Institut fur Physiologie, University of Jena, Teichgraben 8, D 07740 Jena, Germany
    Pain 116:194-204. 2005
    ..Thus, in addition to prostaglandins, CGRP is another mediator that affects TTX-R Na(+) currents which are thought to occur mainly in nociceptive DRG neurons...
  21. doi request reprint The role of interleukin-1β in arthritic pain: main involvement in thermal, but not mechanical, hyperalgesia in rat antigen-induced arthritis
    Matthias Ebbinghaus
    Jena University Hospital Friedrich Schiller University of Jena, Jena, Germany
    Arthritis Rheum 64:3897-907. 2012
    ..The aim of this study was to investigate the role of IL-1β in arthritic pain and to explore the antinociceptive potential of the IL-1 receptor type I (IL-1RI) antagonist anakinra...
  22. doi request reprint Spinally applied ketamine or morphine attenuate peripheral inflammation and hyperalgesia in acute and chronic phases of experimental arthritis
    Michael Karl Boettger
    Institute of Physiology I, University Hospital, Jena, Germany
    Brain Behav Immun 24:474-85. 2010
    ..These data thus propose a role of spinal NMDA- and opioid-receptors in the neuronal control of immune-mediated inflammation...
  23. doi request reprint Involvement of peripheral and spinal tumor necrosis factor α in spinal cord hyperexcitability during knee joint inflammation in rats
    Christian König
    Jena University Hospital and Friedrich Schiller University of Jena, Jena, Germany
    Arthritis Rheumatol 66:599-609. 2014
    ..The purpose of this study was to address the potential of peripheral and spinal TNFα to induce and maintain spinal hyperexcitability, which is a hallmark of pain states in the joints during rheumatoid arthritis and osteoarthritis...
  24. pmc Enhanced neuronal excitability in adult rat brainstem causes widespread repetitive brainstem depolarizations with cardiovascular consequences
    Frank Richter
    Institute of Physiology I Neurophysiology, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany
    J Cereb Blood Flow Metab 32:1535-45. 2012
    ..Brainstem RDs did not propagate into the cerebral cortex. We propose to consider brainstem RPs as a pathophysiological mechanism whose significance for brainstem disease states should be further explored...
  25. pmc Fibroblast-like synovial cells from normal and inflamed knee joints differently affect the expression of pain-related receptors in sensory neurones: a co-culture study
    Gisela Segond von Banchet
    Institute of Physiology, University of Jena, Teichgraben 8, D 07740 Jena, Germany
    Arthritis Res Ther 9:R6. 2007
    ..Importantly, the influence of FLS cells on DRG neurones is dependent on their state of activity, and soluble factors as well as direct cellular contacts are crucial for their interaction with neurones...
  26. doi request reprint Spinal interleukin-6 is an amplifier of arthritic pain in the rat
    Enrique Vazquez
    Institute of Physiology, Jena University Hospital, and Friedrich Schiller University Jena, Jena, Germany
    Arthritis Rheum 64:2233-42. 2012
    ....
  27. doi request reprint Neuronal IL-17 receptor upregulates TRPV4 but not TRPV1 receptors in DRG neurons and mediates mechanical but not thermal hyperalgesia
    Gisela Segond von Banchet
    Institute of Physiology 1, Jena University Hospital, Friedrich Schiller University Jena, Teichgraben 8, 07743 Jena, Germany
    Mol Cell Neurosci 52:152-60. 2013
    ..These data show, therefore, a particular role of IL-17 in mechanical hyperalgesia, and they suggest that this effect is linked to an activation and upregulation of TRPV4...
  28. ncbi request reprint Acute and long-term effects of IL-6 on cultured dorsal root ganglion neurones from adult rat
    Gisela Segond von Banchet
    Institute of Physiology, University of Jena, Germany
    J Neurochem 94:238-48. 2005
    ..These data show that IL-6 has short- and long-term effects on a proportion of DRG neurones. These effects are likely to contribute to pro-nociceptive effects of IL-6...
  29. ncbi request reprint Blockade of voltage-gated calcium channels in rat inhibits repetitive cortical spreading depression
    Frank Richter
    Department of Physiology, Friedrich Schiller University of Jena, Teichgraben 8, D 07740 Jena, Germany
    Neurosci Lett 334:123-6. 2002
    ..The results suggest that cortical excitability resulting in repetitive CSD is markedly influenced by N- and P/Q-type VGCCs and less by L-type VGCCs...
  30. ncbi request reprint Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat: an inflammatory mechanism of joint pain
    Daniel Brenn
    Friedrich Schiller University of Jena, Jena, Germany
    Arthritis Rheum 56:351-9. 2007
    ..Because interleukin-6 (IL-6) is a major inflammatory mediator, we investigated whether this cytokine has the potential to sensitize joint afferents to mechanical stimuli...
  31. ncbi request reprint Experimental arthritis causes tumor necrosis factor-alpha-dependent infiltration of macrophages into rat dorsal root ganglia which correlates with pain-related behavior
    Gisela Segond von Banchet
    Institute of Physiology I, University Hospital Jena, Germany
    Pain 145:151-9. 2009
    ..Thus, bilateral segment-specific infiltration of macrophages into DRGs is part of an unilateral inflammatory process in peripheral tissue and it may be involved in the generation of hyperalgesia in particular on the non-inflamed side...
  32. ncbi request reprint Gait abnormalities differentially indicate pain or structural joint damage in monoarticular antigen-induced arthritis
    Michael K Boettger
    Institute of Physiology I, University Hospital, Jena, Germany
    Pain 145:142-50. 2009
    ..Thus, gait abnormalities may not unequivocally be suitable for objective pain assessment in all stages of experimental arthritis...
  33. doi request reprint Effects of prostaglandin D2 on tetrodotoxin-resistant Na+ currents in DRG neurons of adult rat
    Andrea Ebersberger
    Department of Physiology I, Neurophysiology, University Hospital of Jena, Jena, Germany
    Pain 152:1114-26. 2011
    ..Thus, the net effect of PGD(2) on DRG neurons is pronociceptive, although the magnitude of the TTX-R Na(+) currents depends on the balance of DP1 and DP2 receptor activation...
  34. ncbi request reprint The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation
    Susanne Hensellek
    Institute of Physiology I, Friedrich Schiller University of Jena, Teichgraben 8, D 07740 Jena, Germany
    Mol Cell Neurosci 36:381-91. 2007
    ..Furthermore, we found that activation of ERK but not of p38 kinase or cyclooxygenases is critically involved in the TNFalpha-induced increase of TRPV1 receptor expression...
  35. pmc Prostaglandin E2 increases the expression of the neurokinin1 receptor in adult sensory neurones in culture: a novel role of prostaglandins
    Gisela Segond von Banchet
    Institute of Physiology I, University of Jena, Teichgraben 8, D 07740 Jena, Germany
    Br J Pharmacol 139:672-80. 2003
    ..4) These data show that the expression of NK(1) receptor-like immunoreactivity in DRG neurones is regulated by the inflammatory mediator PGE(2). This upregulation depends on the intracellular adenylyl cyclase-protein kinase A pathway...
  36. ncbi request reprint Spinal mechanisms contributing to joint pain
    Hans Georg Schaible
    Department of Physiology, Friedrich Schiller University of Jena, Teichgraben 8, D 07740 Jena, Germany
    Novartis Found Symp 260:4-22; discussion 22-7, 100-4, 277-9. 2004
    ..The latter compounds show enhanced release and an altered release pattern during inflammation in the joint...
  37. pmc Videoradiographic analysis of the range of motion in unilateral experimental knee joint arthritis in rats
    Michael K Boettger
    Institute of Physiology I Neurophysiology, University Hospital, Teichgraben 8, D 07743 Jena, Germany
    Arthritis Res Ther 13:R79. 2011
    ..Clinically, the range of motion (ROM) of the affected joint plays a major role in diagnosis and the assessment of treatment benefits. This parameter, however, is only insufficiently detected by currently used analytic systems in animals...
  38. doi request reprint The anti-inflammatory effects of sympathectomy in murine antigen-induced arthritis are associated with a reduction of Th1 and Th17 responses
    Matthias Ebbinghaus
    Institute of Pathology, University Hospital, Friedrich Schiller University, Jena, Germany
    Ann Rheum Dis 71:253-61. 2012
    ..It is unknown whether such bidirectional effects are inherent to all experimental arthritis models and/or whether critical time windows exist for influences of the SNS on inflammation...
  39. doi request reprint Assessment of rat antigen-induced arthritis and its suppression during glucocorticoid therapy by use of hemicyanine dye probes with different molecular weight in near-infrared fluorescence optical imaging
    Frederic Dietzel
    Institute of Diagnostic and Interventional Radiology, University Hospital Jena, Jena, Germany
    Invest Radiol 48:729-37. 2013
    ..Here, we investigated the selective accumulation behavior of two differently sized hemicyanine optical probes in arthritic joints and its modification during glucocorticoid therapy in the course of inflammation...
  40. doi request reprint Tumor necrosis factor causes persistent sensitization of joint nociceptors to mechanical stimuli in rats
    Frank Richter
    Jena University Hospital, Friedrich Schiller University of Jena, Jena, Germany
    Arthritis Rheum 62:3806-14. 2010
    ....
  41. pmc Evaluation of long-term antinociceptive properties of stabilized hyaluronic acid preparation (NASHA) in an animal model of repetitive joint pain
    Michael Karl Boettger
    Institute of Physiology I Neurophysiology, Jena University Hospital Friedrich Schiller University, Teichgraben 8, D 07743 Jena, Germany
    Arthritis Res Ther 13:R110. 2011
    ..We established a dose-response relationship for NASHA and we compared NASHA to other hyaluronans with different formulations that are in clinical use...
  42. pmc Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis
    Michael K Boettger
    Friedrich Schiller University, Jena, Germany
    Arthritis Res Ther 12:R140. 2010
    ....
  43. ncbi request reprint Spreading depression can be elicited in brain stem of immature but not adult rats
    Frank Richter
    Institute of Physiology, Neurophysiology, Friedrich Schiller University Jena, D 07740 Jena, Germany
    J Neurophysiol 90:2163-70. 2003
    ..Thus we demonstrate that the immature brain stem has the capacity to generate negative DC shifts, which could be relevant as a risk factor in newborn brain stem function...
  44. ncbi request reprint The role of spinal nuclear factor-kappa B in spinal hyperexcitability
    Andrea Ebersberger
    Department of Physiology I, University of Jena, Jena, Frankfurt Main, Germany
    Neuroreport 17:1615-8. 2006
    ..5 h after spinal administration, thus suggesting that spinal hyperexcitability is not maintained by continuous nuclear factor-kappaB activation...
  45. ncbi request reprint Tumor necrosis factor reduces the amplitude of rat cortical spreading depression in vivo
    Frank Richter
    Institute of Physiology I Neurophysiology, Jena University Hospital Friedrich Schiller University Jena, Jena
    Ann Neurol 76:43-53. 2014
    ..This question is important because TNF not only furthers inflammatory reactions but might also be neuroprotective. Here we tested the hypothesis that TNF affects CSD, and we explored the direction in which CSD is modified by TNF...
  46. ncbi request reprint Noradrenergic agonists and antagonists influence migration of cortical spreading depression in rat-a possible mechanism of migraine prophylaxis and prevention of postischemic neuronal damage
    Frank Richter
    Institute of Physiology Neurophysiology, Friedrich Schiller University Jena, Jena, Germany
    J Cereb Blood Flow Metab 25:1225-35. 2005
    ..The effect of beta-receptor antagonists in human migraine needs further exploration, since these drugs also work in migraine without aura...
  47. ncbi request reprint Pathophysiology and treatment of pain in joint disease
    Hans Georg Schaible
    Institut fur Physiologie, Universitat Jena, Teichgraben 8, D 07740 Jena, Germany
    Adv Drug Deliv Rev 58:323-42. 2006
    ..Therapeutic targets are also found among the axonal channels that set membrane potential and modulate discharge frequency such as voltage sensitive sodium channels and various potassium channels...
  48. doi request reprint Blockade of TTX-resistant and TTX-sensitive Na+ currents in cultured dorsal root ganglion neurons by fomocaine and the fomocaine derivative Oe 9000
    Marcus Baumgart
    Institut fur Biochemie und Biophysik, Biologisch Pharmazeutische Fakultät, Friedrich Schiller Universitat Jena, Philosophenweg 12, D 07743 Jena, Germany
    Brain Res 1358:54-63. 2010
    ..These data establish for the first time the functional suppression of TTX-R and TTX-S Na(+) currents by fomocaine and Oe 9000 in neurons. They support the further research into the use of Oe 9000 as a novel local anesthetic...
  49. doi request reprint Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune-mediated arthritis
    Anne Katja Imhof
    University Hospital and Friedrich Schiller University Jena, Jena, Germany
    Arthritis Rheum 63:2352-62. 2011
    ..The purpose of this study was to assess the effects of the stable somatostatin analogs octreotide and pasireotide (SOM230) in a mouse model of antigen-induced arthritis (AIA)...
  50. doi request reprint Molecular effects of interleukin-1β on dorsal root ganglion neurons: prevention of ligand-induced internalization of the bradykinin 2 receptor and downregulation of G protein-coupled receptor kinase 2
    Gisela Segond von Banchet
    Jena University Hospital Friedrich Schiller University Jena, Institute of Physiology Ι, Teichgraben 8, D 07743 Jena, Germany
    Mol Cell Neurosci 46:262-71. 2011
    ....
  51. doi request reprint A de novo gain-of-function mutation in SCN11A causes loss of pain perception
    Enrico Leipold
    Center for Molecular Biomedicine, Department of Biophysics, Friedrich Schiller University Jena and Jena University Hospital, Jena, Germany
    Nat Genet 45:1399-404. 2013
    ..The gain-of-function mechanism that underlies this channelopathy suggests an alternative way to modulate pain perception...
  52. pmc Enhanced neurogenesis in the hippocampal dentate gyrus during antigen-induced arthritis in adult rat--a crucial role of immunization
    Johannes Leuchtweis
    Institute of Physiology 1 Neurophysiology, Jena University Hospital Friedrich Schiller University of Jena, Jena, Germany
    PLoS ONE 9:e89258. 2014
    ..It seems noteworthy to further explore the clinical importance of this neuroimmune interaction. ..
  53. ncbi request reprint Voltage-gated calcium channels are not involved in generation and propagation of spreading depression (SD) in the brainstem of immature rats
    Frank Richter
    Institute of Physiology I Neurophysiology, Friedrich Schiller University Jena, Teichgraben 8, D 07740 Jena, Germany
    Neurosci Lett 390:15-20. 2005
    ..In summary, it is likely that K(+) initiates and propagates brainstem SDs...
  54. ncbi request reprint Spreading depression in the brainstem of the adult rat: electrophysiological parameters and influences on regional brainstem blood flow
    Frank Richter
    Institute of Physiology I Neurophysiology, Friedrich Schiller University Jena, Jena, Germany
    J Cereb Blood Flow Metab 28:984-94. 2008
    ..These data show that proper conditioning renders the brainstem susceptible to spreading depression, and that spreading depression at this site elicits changes in local circulation and systemic blood pressure...
  55. ncbi request reprint Descending control of persistent pain: inhibitory or facilitatory?
    Horacio Vanegas
    Instituto Venezolano de Investigaciones Cientificas IVIC, Apartado 21827, Caracas 1020A, Venezuela
    Brain Res Brain Res Rev 46:295-309. 2004
    ..Therapies that enhance descending inhibition and/or attenuate descending facilitation are furthermore an important target for research in the future...