Andreas Sauerbrei

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. ncbi request reprint [Laboratory diagnosis of herpes zoster: virology or serology?]
    Andreas Sauerbrei
    Institut für Antivirale Chemotherapie, Friedrich Schiller Universitat Jena
    Med Klin (Munich) 97:123-7. 2002
  2. pmc Varicella Outbreak in an Indian Couple Living in Germany Caused by VZV Clade VI Acquired during a Trip to The Netherlands
    Malgorzata Kolesnik
    Clinic and Policlinic for Dermatology und Venereology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    Case Report Med 2012:838241. 2012
  3. ncbi request reprint Phenotypic and genotypic testing of HSV-1 resistance to antivirals
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, Jena University Clinic, Friedrich Schiller University of Jena, Hans Knoell Straße 2, 07745, Jena, Germany
    Methods Mol Biol 1144:149-65. 2014
  4. doi request reprint Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum® assay
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Clinic, Friedrich Schiller University Jena, Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
    J Virol Methods 188:70-2. 2013
  5. pmc Does limited virucidal activity of biocides include duck hepatitis B virucidal action?
    Andreas Sauerbrei
    Institute of Virology and Antiviral Chemotherapy, Jena University Clinic, Friedrich Schiller University of Jena, Jena, Germany
    BMC Infect Dis 12:276. 2012
  6. doi request reprint Significance of amino acid substitutions in the thymidine kinase gene of herpes simplex virus type 1 for resistance
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Clinic, Friedrich Schiller University of Jena, 07745 Jena, Germany
    Antiviral Res 96:105-7. 2012
  7. pmc Evaluation of three commercial varicella-zoster virus IgG enzyme-linked immunosorbent assays in comparison to the fluorescent-antibody-to-membrane-antigen test
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany
    Clin Vaccine Immunol 19:1261-8. 2012
  8. doi request reprint Prevalence of herpes simplex virus type 1 glycoprotein G (gG) and gI genotypes in patients with different herpetic diseases during the last four decades
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany
    J Med Virol 84:651-6. 2012
  9. pmc Recommendation for post-exposure prophylaxis after potential exposure to herpes b virus in Germany
    Thomas Remé
    Institution for Statutory Accident Insurance and Prevention in the Health and Welfare Services, Department for Basic Sciences, Hamburg, Germany
    J Occup Med Toxicol 4:29. 2009
  10. ncbi request reprint Novel recombinant ELISA assays for determination of type-specific IgG antibodies against HSV-1 and HSV-2
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Hans Knoell Strasse 2, D 07745 Jena, Germany
    J Virol Methods 144:138-42. 2007

Detail Information

Publications86

  1. ncbi request reprint [Laboratory diagnosis of herpes zoster: virology or serology?]
    Andreas Sauerbrei
    Institut für Antivirale Chemotherapie, Friedrich Schiller Universitat Jena
    Med Klin (Munich) 97:123-7. 2002
    ..The diagnosis of herpes zoster is mostly based on clinical findings. In atypical cases, rapid and reliable virological diagnostics is necessary because effective antiviral chemotherapy is available...
  2. pmc Varicella Outbreak in an Indian Couple Living in Germany Caused by VZV Clade VI Acquired during a Trip to The Netherlands
    Malgorzata Kolesnik
    Clinic and Policlinic for Dermatology und Venereology, Otto von Guericke University Magdeburg, 39120 Magdeburg, Germany
    Case Report Med 2012:838241. 2012
    ..To the best of our knowledge, this is the first case of varicella by the VZV clade VI described in Germany, but the disease was acquired in The Netherlands...
  3. ncbi request reprint Phenotypic and genotypic testing of HSV-1 resistance to antivirals
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, Jena University Clinic, Friedrich Schiller University of Jena, Hans Knoell Straße 2, 07745, Jena, Germany
    Methods Mol Biol 1144:149-65. 2014
    ..This approach has the advantage of being faster, but only frameshift mutations and stops of translation can be interpreted without doubt and numerous amino acid substitutions are diagnostically less conclusive. ..
  4. doi request reprint Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum® assay
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Clinic, Friedrich Schiller University Jena, Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
    J Virol Methods 188:70-2. 2013
    ..However, single ACV-resistant HSV-1 isolates can have TK activity values >30 DU/L. These strains are most likely ACV-resistant TK-altered mutants, but no evidence was provided for an alteration of the TK...
  5. pmc Does limited virucidal activity of biocides include duck hepatitis B virucidal action?
    Andreas Sauerbrei
    Institute of Virology and Antiviral Chemotherapy, Jena University Clinic, Friedrich Schiller University of Jena, Jena, Germany
    BMC Infect Dis 12:276. 2012
    ..The present study compares the activity of five different biocides against DHBV and the classical test virus for limited virucidal activity, the vaccinia virus strain Lister Elstree (VACV) or the modified vaccinia Ankara strain (MVA)...
  6. doi request reprint Significance of amino acid substitutions in the thymidine kinase gene of herpes simplex virus type 1 for resistance
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Clinic, Friedrich Schiller University of Jena, 07745 Jena, Germany
    Antiviral Res 96:105-7. 2012
    ..In conclusion, the combination of methods described here represents a useful tool to evaluate the significance of aa substitutions for resistance of clinical HSV-1 strains...
  7. pmc Evaluation of three commercial varicella-zoster virus IgG enzyme-linked immunosorbent assays in comparison to the fluorescent-antibody-to-membrane-antigen test
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany
    Clin Vaccine Immunol 19:1261-8. 2012
    ..The automated performance of the Enzygnost anti-VZV/IgG assay correlated best with the FAMA reference assay...
  8. doi request reprint Prevalence of herpes simplex virus type 1 glycoprotein G (gG) and gI genotypes in patients with different herpetic diseases during the last four decades
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany
    J Med Virol 84:651-6. 2012
    ..HSV-1 infections result in clinical manifestations which are independent of the gG/gI genotype and recombinants are not associated with special herpetic diseases...
  9. pmc Recommendation for post-exposure prophylaxis after potential exposure to herpes b virus in Germany
    Thomas Remé
    Institution for Statutory Accident Insurance and Prevention in the Health and Welfare Services, Department for Basic Sciences, Hamburg, Germany
    J Occup Med Toxicol 4:29. 2009
    ..This necessitates internal risk assessment. An interdisciplinary group of experts has developed an action plan for Germany...
  10. ncbi request reprint Novel recombinant ELISA assays for determination of type-specific IgG antibodies against HSV-1 and HSV-2
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Hans Knoell Strasse 2, D 07745 Jena, Germany
    J Virol Methods 144:138-42. 2007
    ..In conclusion, the novel immunoassays for determination of HSV-1 or HSV-2 IgG can be recommended for the reliable type-specific diagnosis of HSV infections...
  11. ncbi request reprint Different genotype pattern of varicella-zoster virus obtained from patients with varicella and zoster in Germany
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Jena, Germany
    J Med Virol 79:1025-31. 2007
    ..As reasons, the spread of viruses, which may be imported originally by persons immigrating from warmer climates, or the recombination between wild-and vaccine-type viruses have to be considered...
  12. ncbi request reprint Hexon denaturation of human adenoviruses by different groups of biocides
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
    J Hosp Infect 65:264-70. 2007
    ..The different chemical sensitivities of adenoviruses cannot be explained by the sensitivity of this main structural compound, but the present findings provide new insights into the virucidal action of disinfectants...
  13. ncbi request reprint Herpes simplex and varicella-zoster virus infections during pregnancy: current concepts of prevention, diagnosis and therapy. Part 2: Varicella-zoster virus infections
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
    Med Microbiol Immunol 196:95-102. 2007
    ..On the basis of the clinical consequences of varicella-zoster virus infections during pregnancy, the present paper summarizes the currently available concepts of prevention, diagnosis and therapy...
  14. ncbi request reprint Herpes simplex and varicella-zoster virus infections during pregnancy: current concepts of prevention, diagnosis and therapy. Part 1: herpes simplex virus infections
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
    Med Microbiol Immunol 196:89-94. 2007
    ..However, this surgical intervention may be reduced by suppressive treatment of recurrent genital herpes with aciclovir or valaciclovir...
  15. ncbi request reprint Analysis of repeat units in the R2 region among different Oka varicella-zoster virus vaccine strains and wild-type strains in Germany
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Jena, Germany
    Intervirology 50:40-4. 2007
    ..The present study compared the number of R2 repeat units in six different Oka strains and in 54 varicella-zoster virus (VZV) wild-type strains isolated from patients with varicella or zoster in Germany...
  16. ncbi request reprint Validation of biocides against duck hepatitis B virus as a surrogate virus for human hepatitis B virus
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
    J Hosp Infect 64:358-65. 2006
    ..Indirect immunofluorescent staining allows reliable detection of DHBV infectivity, whereas the hepadnavirucidal effect can be evaluated by quantitative PCR...
  17. pmc Serological detection of varicella-zoster virus-specific immunoglobulin G by an enzyme-linked immunosorbent assay using glycoprotein antigen
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, University Clinic of Jena, Postfach, Hans Knoell Strasse 2, D 07745 Jena, Germany
    J Clin Microbiol 44:3094-7. 2006
    ..The test can also be recommended for measuring antibody response after varicella vaccination, particularly after the cutoff value was optimized...
  18. ncbi request reprint Genotyping of different varicella vaccine strains
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
    J Clin Virol 37:109-17. 2006
    ..These findings need attention since mutations in the vaccine strain could result in changes of virulence and efficacy of the vaccine...
  19. ncbi request reprint Inhibitory efficacy of cyclosal-nucleoside monophosphates of aciclovir and brivudin on DNA synthesis of orthopoxvi ruses
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, University of Jena, Jena, Germany
    Antivir Chem Chemother 17:25-31. 2006
    ..The high inhibitory efficacy on both replication of viral DNA and infectious viral particles in cell cultures makes these compounds promising candidates for in vivo experiments...
  20. ncbi request reprint Genotyping of varicella-zoster virus strains after serial passages in cell culture
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
    J Virol Methods 145:80-3. 2007
    ..For rapid diagnostic identification of vaccine versus wild-type strains, the RFLP profile that is stable within several cell culture passages can be determined using DNA prepared from clinical specimens...
  21. doi request reprint Genotypes of varicella-zoster virus wild-type strains in Germany
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Jena, Germany
    J Med Virol 80:1123-30. 2008
    ..The possible recombinant could not be classified definitely by the scattered SNP method used and, therefore, has to be confirmed by full-genome sequencing studies...
  22. doi request reprint Testing thermal resistance of viruses
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Jena, Germany
    Arch Virol 154:115-9. 2009
    ..In conclusion, human viruses and their surrogates for testing biocides may have a considerable thermal resistance that makes them difficult to be inactivated only by dry heat...
  23. doi request reprint Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Clinic, Jena, Germany
    Antivir Ther 16:1297-308. 2011
    ..Studies to verify correlations between phenotypes and genotypes of herpes simplex virus (HSV) are an important tool to establish a database of resistance-associated mutations...
  24. doi request reprint Resistance testing of clinical varicella-zoster virus strains
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Hospital, Jena, Germany
    Antiviral Res 90:242-7. 2011
    ..In a considerable number of patients with clinical ACV-resistant VZV infections, resistance cannot be verified by virological methods...
  25. doi request reprint Immune response of varicella vaccinees to different varicella-zoster virus genotypes
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Clinic, Germany
    Vaccine 29:3873-7. 2011
    ..In conclusion, this study provides first experimental evidence that varicella vaccines based on the Japanese Oka strain induce antibody response directed to VZV strains circulating currently in Germany...
  26. doi request reprint Sequence analysis of the glycoprotein E gene of varicella-zoster virus strains of clades 1, 3 and 5
    Andreas Sauerbrei
    Reference Laboratory for HSV and VZV, Institute of Virology and Antiviral Therapy, Jena University Hospital, Hans Knoell Strasse 2, 07745 Jena, Germany
    Arch Virol 156:505-9. 2011
    ..The profile of single-nucleotide polymorphisms was found to be significantly associated with the VZV clades 1, 3 and 5...
  27. doi request reprint Monitoring prevalence of varicella-zoster virus clades in Germany
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Jena University Hospital, Hans Knoell Strasse 2, 07745, Jena, Germany
    Med Microbiol Immunol 200:99-107. 2011
    ..In primary VZV infection, nearly 20% of clade 1 has been replaced by clade 5 that might spread more effectively in the population than the European VZV clades...
  28. ncbi request reprint Virucidal efficacy of povidone-iodine-containing disinfectants
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Jena University Hospital, Jena, Germany
    Lett Appl Microbiol 51:158-63. 2010
    ..The objective of this study was to evaluate virucidal efficacy of the commercially available povidone-iodine formulations Betaisodona solution and Betaseptic Mundipharma (Mundipharma)...
  29. doi request reprint Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
    Antiviral Res 86:246-52. 2010
    ..g. site-directed mutagenesis experiments are required to characterize mutations of the TK and DNA pol genes in ACV-resistant viral strains as part of viral gene polymorphism or as cause of drug resistance...
  30. pmc Variability of immediate-early gene 62 in german varicella-zoster virus wild-type strains
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
    J Clin Microbiol 47:3717-20. 2009
    ..M1 strains in Germany display a uniform ORF 62 pattern, suggesting that these strains were introduced from Africa and/or Asia via few sources during the last years...
  31. ncbi request reprint Serological detection of specific IgG to varicella-zoster virus by novel ELISA based on viral glycoprotein antigen
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
    Clin Lab 55:1-7. 2009
    ..For determination of immunity post vaccination, a different approach for the interpretation of borderline results should be considered...
  32. doi request reprint Seroprevalence of influenza A and B in German infants and adolescents
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
    Med Microbiol Immunol 198:93-101. 2009
    ..In conclusion, the annual influenza vaccination in children and adolescents may improve considerably the protection against influenza virus infection occurring during epidemics...
  33. ncbi request reprint In vitro activity of cycloSal-nucleoside monophosphates and polyhydroxycarboxylates against orthopoxviruses
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knöll Strasse 2, D 07745 Jena, Germany
    Antiviral Res 67:147-54. 2005
    ..However, most of the cycloSal-monophosphate derivatives of BVDU had a higher cytotoxicity than their parent nucleosides...
  34. ncbi request reprint Utilization of the embryonated egg for in vivo evaluation of the anti-influenza virus activity of neuraminidase inhibitors
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
    Med Microbiol Immunol 195:65-71. 2006
    ..Therefore, this model can be a valuable alternative approach for in vivo pre-testing anti-influenza virus activity of NA inhibitors...
  35. ncbi request reprint Alternative methods for validation of cell culture infection with duck hepatitis B virus
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
    J Virol Methods 129:178-85. 2005
    ..Infection of cell cultures was most efficient 4 days after plating. The best identification of infected cultures was possible 6 days after infection with immunofluorescence using an antiserum against DHBV surface antigen...
  36. ncbi request reprint Sensitivity of human adenoviruses to different groups of chemical biocides
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
    J Hosp Infect 57:59-66. 2004
    ..The main reason for the different chemical sensitivity of adenovirus serotypes may be the composition of the viral capsid proteins. Alternatively a different chemical inactivation of the viral genome could be involved...
  37. ncbi request reprint [Antibodies against vaccine-preventable diseases in pregnant women and their offspring. Measles, mumps, rubella, poliomyelitis, and varicella]
    A Sauerbrei
    Institut für Virologie und Antivirale Therapie, Friedrich Schiller Universitat Jena, Jena
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47:10-5. 2004
    ..Despite the high seroprevalence of rubella and chickenpox, there is considerable potential for infections during pregnancy and neonatal period...
  38. ncbi request reprint [Antibodies against vaccine-preventable diseases in pregnant women and their offspring. Diphtheria, pertussis, tetanus]
    A Sauerbrei
    Friedrich Schiller Universitat Jena, Jena
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47:16-20. 2004
    ..In conclusion, the prevalence of antibodies determined suggests they are insufficient for protecting the newborns efficiently against pertussis and diphtheria in spite of the evidence for an active placental antibody transfer...
  39. ncbi request reprint Immunofluorescence test for sensitive detection of varicella-zoster virus-specific IgG: an alternative to fluorescent antibody to membrane antigen test
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Postfach, D 07740 Jena, Germany
    J Virol Methods 119:25-30. 2004
    ..This simple technique can replace the labor-intensive FAMA procedure for laboratory determination of immunity to VZV...
  40. ncbi request reprint Testing of herpes simplex virus for resistance to antiviral drugs
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Hospital, Jena, Germany
    Virulence 1:555-7. 2010
    ..In conclusion, for reliable interpretation of genotypic resistance, a database of non-synonymous mutations has to be established...
  41. ncbi request reprint Serological detection of type-specific IgG to herpes simplex virus by novel ELISAs based on recombinant and highly purified glycoprotein G
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
    Clin Lab 50:425-9. 2004
    ..3%. There was a very good correlation between the results of the reference procedures and the evaluated tests. The novel immunoassays can be recommended for the reliable type-specific diagnosis of latent herpes simplex virus infections...
  42. ncbi request reprint Laboratory diagnosis of central nervous system infections caused by herpesviruses
    A Sauerbrei
    Institute for Antiviral Chemotherapy, Friedrich Schiller University Jena, Winzerlaer Stasse 10, D 07745 Jena, Germany
    J Clin Virol 25:S45-51. 2002
    ..Herpes simplex encephalitis (HSE) has to be considered one of the most severe diseases. As effective antiviral drugs are available, rapid and reliable diagnosis has become important...
  43. ncbi request reprint [Varicella during pregnancy. 2. Diagnosis, prevention and therapy]
    A Sauerbrei
    Institut für Virologie und Antivirale Therapie, Friedrich Schiller Universitat, Jena
    Dtsch Med Wochenschr 129:2045-7. 2004
    ..As part 2, the present paper reviews the current possibilities of diagnosis, prevention and therapy of varicella-zoster virus infections during pregnancy...
  44. ncbi request reprint Intracerebral varicella-zoster virus reactivation in congenital varicella syndrome
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Germany
    Dev Med Child Neurol 45:837-40. 2003
    ..This antiviral treatment was aimed at preventing progression of the disease. We concluded from this case that infants with intrauterine VZV infection can suffer intracerebral VZV reactivations that require antiviral treatment...
  45. ncbi request reprint Placental boost to varicella-zoster antibodies in the newborn
    Andreas Sauerbrei
    Institute for Antiviral Chemotherapy, Friedrich Schiller University, Jena, Germany
    J Perinat Med 30:345-8. 2002
    ..The investigations revealed protective antibody levels in 96.7% of both newborns and mothers. In the cord blood samples, significantly higher titers were detected being indicative of an active placental transfer of VZV-specific IgG...
  46. ncbi request reprint Semi-quantitative detection of viral RNA in influenza A virus-infected mice for evaluation of antiviral compounds
    A Sauerbrei
    Institute for Antiviral Chemotherapy, Friedrich Schiller University of Jena, Winzerlaer Strasse 10, D 07745 Jena, Germany
    Antiviral Res 58:81-7. 2003
    ..Viral load measurement by semi-quantitative detection of viral RNA allows rapid and sensitive screening of potential compounds with in vitro anti-influenza A virus activity...
  47. ncbi request reprint Molecular diagnosis of zoster post varicella vaccination
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Winzerlaer Strasse 10, D 07745, Jena, Germany
    J Clin Virol 27:190-9. 2003
    ..Herpes zoster can be caused by endogenous reactivation of both wild-type virus or vaccine varicella-zoster virus (VZV) becoming latent within sensory ganglia after natural primary infection or varicella vaccination...
  48. doi request reprint Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virus
    Kathrin Bohn
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Clinic, Jena, Germany
    Antivir Ther 16:989-97. 2011
    ..The knowledge of gene polymorphism is an absolute requirement for the correct interpretation of genotypic findings...
  49. doi request reprint Prevalence of influenza A and B antibodies in pregnant women and their offspring
    Peter Wutzler
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Jena, Germany
    J Clin Virol 46:161-4. 2009
    ..Influenza is associated with substantial morbidity and mortality in pregnant women and neonates, but few countries offer annual influenza vaccination with the inactivated vaccine to all women who are, or intend to become, pregnant...
  50. ncbi request reprint Influenza infection of the embryonated hen's egg/an alternative model for in vivo evaluation of antiviral compounds
    Albert Härtl
    Hans Knöll Institute for Natural Products Research, Jena, Germany
    Arzneimittelforschung 54:130-4. 2004
    ..In conclusion, the use of influenza virus-infected chick embryos for evaluation of new antiviral substances can lead to a considerable reduction in the number of small laboratory rodents required...
  51. pmc Genetic profile of an Oka varicella vaccine virus variant isolated from an infant with zoster
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
    J Clin Microbiol 42:5604-8. 2004
    ..Further studies will be needed to identify potential virulence factors in variant vaccine strains...
  52. ncbi request reprint Age-related and regional differences in the prevalence of hepatitis E virus-specific antibodies in pigs in Germany
    Andi Krumbholz
    Institute for Infection Medicine, Christian Albrecht University of Kiel and University Medical Center Schleswig Holstein, Campus Kiel, 24105 Kiel, Germany Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University Jena, 07740 Jena, Germany Electronic address
    Vet Microbiol 167:394-402. 2013
    ..The presence of anti-HEV-free herds may indicate that it is feasible to establish and sustain HEV-free pig herds. HEV seroprevalence still depends on the assay used for testing. This demonstrates an urgent need for test validation. ..
  53. ncbi request reprint Circulation of classical swine influenza virus in Europe between the wars?
    Jeannette Lange
    Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University, Hans Knoell Str 2, 07745, Jena, Germany
    Arch Virol 159:1467-73. 2014
    ..The source of A/swine/London is unknown, but its relationship to early classical swine influenza viruses suggests that the emergence of these viruses in Europe has to be antedated by 15-20 years. ..
  54. doi request reprint Virus isolate from carp: genetic characterization reveals a novel picornavirus with two aphthovirus 2A-like sequences
    Jeannette Lange
    Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University, Hans Knoell Str 2, 07745 Jena, Germany
    J Gen Virol 95:80-90. 2014
    ..5 %), duck hepatitis A virus (32.7 %) and swine pasivirus (29.3 %). Both the unique genome organization and low sequence similarity support the assignment of CPV-1 to a novel picornavirus species within a novel genus. ..
  55. doi request reprint Serological response to influenza A H1N1 vaccine (Pandemrix®) and seasonal influenza vaccine 2009/2010 in renal transplant recipients and in hemodialysis patients
    Undine Ott
    KfH Nierenzentrum, Jena, Germany
    Med Microbiol Immunol 201:297-302. 2012
    ..However, more than a half of these patients did not develop seroprotective antibody levels. Thus, new vaccines and altered vaccination regimes are likely necessary to achieve relevant antibody levels in these patient groups...
  56. ncbi request reprint Prevalence of BK virus subtype I in Germany
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University Jena, Jena, Germany
    J Med Virol 78:1588-98. 2006
    ..For the genotyping region, a relationship of BKV subgroups to disease patterns like hemorrhagic cystitis or tubulointerstitial nephritis could not be demonstrated...
  57. ncbi request reprint Antiviral activity of cyclosaligenyl prodrugs of the nucleoside analogue bromovinyldeoxyuridine against herpes viruses
    Astrid Meerbach
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
    Int J Antimicrob Agents 27:423-30. 2006
    ..Most remarkably, several cycloSal-BVDUMP triesters yielded promising anti-EBV activity whereas the parent compound BVDU was entirely inactive...
  58. ncbi request reprint Antibodies against vaccine-preventable diseases in pregnant women and their offspring in the eastern part of Germany
    A Sauerbrei
    Institute for Antiviral Chemotherapy, Friedrich Schiller University of Jena, Germany
    Med Microbiol Immunol 190:167-72. 2002
    ..In conclusion, the prevalence of antibodies to pertussis (61%), diphtheria (81 %), poliomyelitis (55-59%) and measles (85%) is suggested to be insufficient in newborn infants to protect them against these infectious diseases...
  59. ncbi request reprint Molecular characterisation of varicella-zoster virus strains in Germany and differentiation from the Oka vaccine strain
    A Sauerbrei
    Institute of Virology and Therapy, Friedrich Schiller University of Jena, Jena, Germany
    J Med Virol 71:313-9. 2003
    ..VZV wild-type strains containing a BglI restriction site in ORF 54 as well as Oka vaccine strains can rarely be detected...
  60. ncbi request reprint [Varicella during pregnancy. 1: Epidemiology and clinical aspects]
    A Sauerbrei
    Institut für Virologie und Antivirale Therapie, Friedrich Schiller Universitat, Jena
    Dtsch Med Wochenschr 129:1983-6. 2004
    ..In the first part, the present paper reviews the currently available knowledge about the epidemiology and clinical consequences of varicella-zoster virus infections during pregnancy...
  61. pmc Sequencing of 21 varicella-zoster virus genomes reveals two novel genotypes and evidence of recombination
    Roland Zell
    Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany
    J Virol 86:1608-22. 2012
    ..The split of ancestral clades 2/4 and 1/3/5/VIII/IX shows the greatest node height...
  62. doi request reprint Epstein-Barr virus-associated pneumonia and bronchiolitis obliterans syndrome in a lung transplant recipient
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Jena University Hospital Friedrich Schiller University Jena, Jena, Germany
    Med Microbiol Immunol 199:317-22. 2010
    ..The clinical situation improved soon after re-transplantation, and the EBV load detected in the lower respiratory tract decreased significantly...
  63. ncbi request reprint Virucidal activity of the new disinfectant monopercitric acid
    P Wutzler
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
    Lett Appl Microbiol 39:194-8. 2004
    ..The results were compared with that obtained with peracetic acid (PAA)...
  64. ncbi request reprint The genome of an influenza virus from a pilot whale: relation to influenza viruses of gulls and marine mammals
    Marco Groth
    Genome Research, Fritz Lipmann Institute, Leibniz Institute of Age Research, Beutenbergstr 11, D 07745 Jena, Germany
    Infect Genet Evol 24:183-6. 2014
    ..We conclude that A/whale/Maine/328B/1984 is the first record of an infection of a marine mammal from a gull-origin influenza virus. ..
  65. ncbi request reprint Fatal outcome of herpes simplex virus type 1-induced necrotic hepatitis in a neonate
    Astrid Meerbach
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knöll Street 2, 07745 Jena, Germany
    Med Microbiol Immunol 195:101-5. 2006
    ..The diagnosis was performed postmortem by demonstration of HSV-1 DNA in liver tissue as well as by retrospective detection of HSV-specific antibodies...
  66. ncbi request reprint Reassortants of the pandemic (H1N1) 2009 virus and establishment of a novel porcine H1N2 influenza virus, lineage in Germany
    Jeannette Lange
    Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University Jena, Hans Knöll Str 2, 07745 Jena, Germany
    Vet Microbiol 167:345-56. 2013
    ..The most frequent genotype emerged at least three times independently, one of which (Papenburg lineage) established a stable infection chain and became more prevalent in pigs than pdmH1N1 in Germany. ..
  67. ncbi request reprint Laboratory diagnosis of herpes zoster
    A Sauerbrei
    Institute for Antiviral Chemotherapy, Friedrich Schiller University Jena, Erfurt, Germany
    J Clin Virol 14:31-6. 1999
    ..These findings suggest that PCR is the method of choice for rapid laboratory diagnosis of zoster...
  68. ncbi request reprint Virucidal and chlamydicidal activities of eye drops with povidone-iodine liposome complex
    P Wutzler
    Institute for Antiviral Chemotherapy, Friedrich Schiller University, Jena, Germany
    Ophthalmic Res 32:118-25. 2000
    ..There is no evidence for a genotoxic activity of these agents...
  69. ncbi request reprint Virucidal activity and cytotoxicity of the liposomal formulation of povidone-iodine
    P Wutzler
    Institute for Antiviral Chemotherapy, Friedrich Schiller University, Winzerlaer Strasse 10, 07745 Jena, Germany
    Antiviral Res 54:89-97. 2002
    ....
  70. ncbi request reprint Virological diagnosis of herpes simplex encephalitis
    A Sauerbrei
    Institute for Antiviral Chemotherapy, Friedrich Schiller University Jena, Nordhäuser Strasse 78, D 99089, Erfurt, Germany
    J Clin Virol 17:31-6. 2000
    ..The herpes simplex encephalitis (HSE) represents one of the most severe infectious diseases of the central nervous system. As effective antiviral drugs are available, rapid and reliable diagnosis has become important...
  71. ncbi request reprint Seroprevalence of herpes simplex virus type 1 and type 2 in selected German populations-relevance for the incidence of genital herpes
    P Wutzler
    Institute for Antiviral Chemotherapy, Friedrich Schiller University of Jena, Jena, Germany
    J Med Virol 61:201-7. 2000
    ....
  72. ncbi request reprint Comparative testing of liposomal and aqueous formulations of povidone-iodine for their angioirritative potential at the chorioallantoic membrane of ex ovo cultivated chick embryos
    P Wutzler
    Institute for Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
    Dermatology 207:43-7. 2003
    ..Previous studies have shown that liposomal PVP-I formulations are less cytotoxic and that a special liposomal PVP-I hydrogel provides wound healing efficacy...
  73. ncbi request reprint [Varicella during pregnancy and in neonates]
    Peter Wutzler
    Friedrich Schiller Universitat, Jena, BRD
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 50:237-44. 2007
    ..Using currently available diagnostics, immuno-prophylactic and therapeutic opportunities, these serious consequences of varicella during pregnancy can be prevented...
  74. ncbi request reprint Congenital skin lesions caused by intrauterine infection with coxsackievirus B3
    A Sauerbrei
    Institute for Antiviral Chemotherapy, Friedrich Schiller University of Jena, Erfurt, Germany
    Infection 28:326-8. 2000
    ..Serious neonatal coxsackievirus infections transplacentally acquired in late pregnancy involve primarily the central nervous system, heart, liver and rarely the skin...
  75. ncbi request reprint In vitro cultivation and cryopreservation of duck embryonic hepatocytes
    M Schacke
    Institute of Virology and Antiviral Chemotherapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
    J Virol Methods 157:25-31. 2009
    ..The use of cryopreserved hepatocytes is possible when freshly isolated cells from the liver of duck embryos are not available...
  76. ncbi request reprint Varicella-zoster virus infections in pregnancy
    A Sauerbrei
    Institute for Antiviral Chemotherapy, Friedrich Schiller Universitat Jena, Germany
    Intervirology 41:191-6. 1998
    ..As a consequence of maternal chickenpox within 12 days before delivery, 6 newborn babies developed neonatal varicella. Measures for diagnosis, treatment and prophylaxis are discussed...
  77. ncbi request reprint Virucidal efficacy of a combination of 0.2% peracetic acid and 80% (v/v) ethanol (PAA-ethanol) as a potential hand disinfectant
    P Wutzler
    Institute for Antiviral Chemotherapy, Friedrich Schiller University of Jena, Winzelaer Str 10, 07745 Jena, Germany
    J Hosp Infect 46:304-8. 2000
    ....
  78. ncbi request reprint Inactivation of human adenovirus genome by different groups of disinfectants
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
    J Hosp Infect 57:67-72. 2004
    ..However, there was no clear correlation between the differences in the effect of disinfectants on infectivity of the complete viral particle and destruction of the viral genome...
  79. ncbi request reprint Evaluation of commercial herpes simplex virus IgG and IgM enzyme immunoassays
    Kristin Liermann
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Hospital, Friedrich Schiller University, Jena, Germany
    J Virol Methods 199:29-34. 2014
    ..While HSV type-common IgM ELISAs can be useful to confirm acute newly acquired HSV infections, the use of single-type IgM ELISAs on the basis of whole-virus antigen is dispensable. ..
  80. ncbi request reprint Neonatal varicella
    A Sauerbrei
    Institute for Antiviral Chemotherapy, Klinikum of the Friedrich-Schiller University Jena, Winzerlaer Strasse 10, D-07745 Jena, Germany
    J Perinatol 21:545-9. 2001
    ..To prevent severe neonatal chickenpox, passive immunization is indicated. If varicella occurs, acyclovir treatment has to be administered promptly...
  81. doi request reprint Prevalence of hepatitis E virus antibodies in children in Germany
    Andi Krumbholz
    From the Institute of Virology and Antiviral Therapy, Jena University Clinic, Friedrich Schiller University of Jena, Jena Institute for Infection Medicine, Christian Albrecht University of Kiel, Kiel Clinic of Pediatrics and Adolescent Medicine, Vivantes Clinic in Friedrichshain, Berlin Children s Hospital, Bremen University Children s Hospital, Pediatric Infectious Diseases, Wuerzburg HELIOS Children s Hospital, Krefeld Department of Paediatrics and Adolescent Medicine, Clinic Dritter Orden, Munich HELIOS Children s Hospital, Erfurt University Children s Hospital Mannheim, Heidelberg University and HELIOS Children s Hospital, Witten Herdecke University, Wuppertal, Germany
    Pediatr Infect Dis J 33:258-62. 2014
    ..Since asymptomatic hepatitis E virus (HEV) infections particularly affect children, there is a need for studies to determine the HEV seroprevalence among infants, children and adolescents...
  82. pmc Anti-BK virus activity of nucleoside analogs
    Parmjeet Randhawa
    Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, Room Medical Center, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 52:1519-21. 2008
    ....
  83. ncbi request reprint European seroepidemiology network 2: Standardisation of assays for seroepidemiology of varicella zoster virus
    Fernando de Ory
    Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
    J Clin Virol 36:111-8. 2006
    ..The aim of the European Sero-Epidemiology Network (ESEN2) is to harmonise the serological surveillance of vaccine-preventable diseases in Europe...
  84. ncbi request reprint Hints of intracerebral varicella-zoster virus reactivation in congenital varicella syndrome
    Andreas Sauerbrei
    Eur J Pediatr 162:354-5. 2003
  85. ncbi request reprint Differences in varicella-zoster virus seroepidemiology between temperate and tropical regions
    Andreas Sauerbrei
    Indian J Med Sci 61:123-4. 2007
  86. ncbi request reprint Herpes zoster by reactivated vaccine varicella zoster virus in a healthy child
    Barbara Uebe
    Department of Paediatrics, University Hospital, Martin Luther University Halle Wittenberg, 06097 Halle, Germany
    Eur J Pediatr 161:442-4. 2002
    ..As causative virus, VZV vaccine strain was identified by polymerase chain reaction and analysis of restriction fragment length polymorphisms of the amplified products...