Research Topics
| Andreas SauerbreiSummaryAffiliation: Friedrich Schiller University Country: Germany Publications
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Publications
[Laboratory diagnosis of herpes zoster: virology or serology?]Andreas Sauerbrei
Institut für Antivirale Chemotherapie, Friedrich Schiller Universitat Jena
Med Klin (Munich) 97:123-7. 2002..The diagnosis of herpes zoster is mostly based on clinical findings. In atypical cases, rapid and reliable virological diagnostics is necessary because effective antiviral chemotherapy is available...
Screening of herpes simplex virus type 1 isolates for acyclovir resistance using DiviTum® assayAndreas Sauerbrei
Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Clinic, Friedrich Schiller University Jena, Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
J Virol Methods 188:70-2. 2013..However, single ACV-resistant HSV-1 isolates can have TK activity values >30 DU/L. These strains are most likely ACV-resistant TK-altered mutants, but no evidence was provided for an alteration of the TK...
Does limited virucidal activity of biocides include duck hepatitis B virucidal action?Andreas Sauerbrei
Institute of Virology and Antiviral Chemotherapy, Jena University Clinic, Friedrich Schiller University of Jena, Jena, Germany
BMC Infect Dis 12:276. 2012..The present study compares the activity of five different biocides against DHBV and the classical test virus for limited virucidal activity, the vaccinia virus strain Lister Elstree (VACV) or the modified vaccinia Ankara strain (MVA)...- Significance of amino acid substitutions in the thymidine kinase gene of herpes simplex virus type 1 for resistanceAndreas Sauerbrei
Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Clinic, Friedrich Schiller University of Jena, 07745 Jena, Germany
Antiviral Res 96:105-7. 2012..In conclusion, the combination of methods described here represents a useful tool to evaluate the significance of aa substitutions for resistance of clinical HSV-1 strains... - Evaluation of three commercial varicella-zoster virus IgG enzyme-linked immunosorbent assays in comparison to the fluorescent-antibody-to-membrane-antigen testAndreas Sauerbrei
Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany
Clin Vaccine Immunol 19:1261-8. 2012..The automated performance of the Enzygnost anti-VZV/IgG assay correlated best with the FAMA reference assay... - Prevalence of herpes simplex virus type 1 glycoprotein G (gG) and gI genotypes in patients with different herpetic diseases during the last four decadesAndreas Sauerbrei
Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany
J Med Virol 84:651-6. 2012..HSV-1 infections result in clinical manifestations which are independent of the gG/gI genotype and recombinants are not associated with special herpetic diseases... - Recommendation for post-exposure prophylaxis after potential exposure to herpes b virus in GermanyThomas Remé
Institution for Statutory Accident Insurance and Prevention in the Health and Welfare Services, Department for Basic Sciences, Hamburg, Germany
J Occup Med Toxicol 4:29. 2009..This necessitates internal risk assessment. An interdisciplinary group of experts has developed an action plan for Germany... - Variability of immediate-early gene 62 in german varicella-zoster virus wild-type strainsA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
J Clin Microbiol 47:3717-20. 2009..M1 strains in Germany display a uniform ORF 62 pattern, suggesting that these strains were introduced from Africa and/or Asia via few sources during the last years... - Herpes simplex and varicella-zoster virus infections during pregnancy: current concepts of prevention, diagnosis and therapy. Part 2: Varicella-zoster virus infectionsA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
Med Microbiol Immunol 196:95-102. 2007..On the basis of the clinical consequences of varicella-zoster virus infections during pregnancy, the present paper summarizes the currently available concepts of prevention, diagnosis and therapy... - Hexon denaturation of human adenoviruses by different groups of biocidesA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
J Hosp Infect 65:264-70. 2007..The different chemical sensitivities of adenoviruses cannot be explained by the sensitivity of this main structural compound, but the present findings provide new insights into the virucidal action of disinfectants... - Different genotype pattern of varicella-zoster virus obtained from patients with varicella and zoster in GermanyA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Jena, Germany
J Med Virol 79:1025-31. 2007..As reasons, the spread of viruses, which may be imported originally by persons immigrating from warmer climates, or the recombination between wild-and vaccine-type viruses have to be considered... - Herpes simplex and varicella-zoster virus infections during pregnancy: current concepts of prevention, diagnosis and therapy. Part 1: herpes simplex virus infectionsA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
Med Microbiol Immunol 196:89-94. 2007..However, this surgical intervention may be reduced by suppressive treatment of recurrent genital herpes with aciclovir or valaciclovir... - Analysis of repeat units in the R2 region among different Oka varicella-zoster virus vaccine strains and wild-type strains in GermanyA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Jena, Germany
Intervirology 50:40-4. 2007..The present study compared the number of R2 repeat units in six different Oka strains and in 54 varicella-zoster virus (VZV) wild-type strains isolated from patients with varicella or zoster in Germany... - Validation of biocides against duck hepatitis B virus as a surrogate virus for human hepatitis B virusA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
J Hosp Infect 64:358-65. 2006..Indirect immunofluorescent staining allows reliable detection of DHBV infectivity, whereas the hepadnavirucidal effect can be evaluated by quantitative PCR... - Serological detection of varicella-zoster virus-specific immunoglobulin G by an enzyme-linked immunosorbent assay using glycoprotein antigenA Sauerbrei
Institute of Virology and Antiviral Therapy, University Clinic of Jena, Postfach, Hans Knoell Strasse 2, D 07745 Jena, Germany
J Clin Microbiol 44:3094-7. 2006..The test can also be recommended for measuring antibody response after varicella vaccination, particularly after the cutoff value was optimized... - Genotyping of different varicella vaccine strainsA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
J Clin Virol 37:109-17. 2006..These findings need attention since mutations in the vaccine strain could result in changes of virulence and efficacy of the vaccine... - Inhibitory efficacy of cyclosal-nucleoside monophosphates of aciclovir and brivudin on DNA synthesis of orthopoxvi rusesAndreas Sauerbrei
Institute of Virology and Antiviral Therapy, University of Jena, Jena, Germany
Antivir Chem Chemother 17:25-31. 2006..The high inhibitory efficacy on both replication of viral DNA and infectious viral particles in cell cultures makes these compounds promising candidates for in vivo experiments... - In vitro activity of cycloSal-nucleoside monophosphates and polyhydroxycarboxylates against orthopoxvirusesA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knöll Strasse 2, D 07745 Jena, Germany
Antiviral Res 67:147-54. 2005..However, most of the cycloSal-monophosphate derivatives of BVDU had a higher cytotoxicity than their parent nucleosides... - Novel recombinant ELISA assays for determination of type-specific IgG antibodies against HSV-1 and HSV-2Andreas Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Hans Knoell Strasse 2, D 07745 Jena, Germany
J Virol Methods 144:138-42. 2007..In conclusion, the novel immunoassays for determination of HSV-1 or HSV-2 IgG can be recommended for the reliable type-specific diagnosis of HSV infections... - Genotyping of varicella-zoster virus strains after serial passages in cell cultureAndreas Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
J Virol Methods 145:80-3. 2007..For rapid diagnostic identification of vaccine versus wild-type strains, the RFLP profile that is stable within several cell culture passages can be determined using DNA prepared from clinical specimens... - Genotypes of varicella-zoster virus wild-type strains in GermanyA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Jena, Germany
J Med Virol 80:1123-30. 2008..The possible recombinant could not be classified definitely by the scattered SNP method used and, therefore, has to be confirmed by full-genome sequencing studies... - Novel resistance-associated mutations of thymidine kinase and DNA polymerase genes of herpes simplex virus type 1 and type 2Andreas Sauerbrei
Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Clinic, Jena, Germany
Antivir Ther 16:1297-308. 2011..Studies to verify correlations between phenotypes and genotypes of herpes simplex virus (HSV) are an important tool to establish a database of resistance-associated mutations... - Immune response of varicella vaccinees to different varicella-zoster virus genotypesA Sauerbrei
Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Clinic, Germany
Vaccine 29:3873-7. 2011..In conclusion, this study provides first experimental evidence that varicella vaccines based on the Japanese Oka strain induce antibody response directed to VZV strains circulating currently in Germany... - Testing of herpes simplex virus for resistance to antiviral drugsAndreas Sauerbrei
Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Hospital, Jena, Germany
Virulence 1:555-7. 2010..In conclusion, for reliable interpretation of genotypic resistance, a database of non-synonymous mutations has to be established... - Sequence analysis of the glycoprotein E gene of varicella-zoster virus strains of clades 1, 3 and 5Andreas Sauerbrei
Reference Laboratory for HSV and VZV, Institute of Virology and Antiviral Therapy, Jena University Hospital, Hans Knoell Strasse 2, 07745 Jena, Germany
Arch Virol 156:505-9. 2011..The profile of single-nucleotide polymorphisms was found to be significantly associated with the VZV clades 1, 3 and 5... - Monitoring prevalence of varicella-zoster virus clades in GermanyA Sauerbrei
Institute of Virology and Antiviral Therapy, Jena University Hospital, Hans Knoell Strasse 2, 07745, Jena, Germany
Med Microbiol Immunol 200:99-107. 2011..In primary VZV infection, nearly 20% of clade 1 has been replaced by clade 5 that might spread more effectively in the population than the European VZV clades... - Virucidal efficacy of povidone-iodine-containing disinfectantsA Sauerbrei
Institute of Virology and Antiviral Therapy, Jena University Hospital, Jena, Germany
Lett Appl Microbiol 51:158-63. 2010..The objective of this study was to evaluate virucidal efficacy of the commercially available povidone-iodine formulations Betaisodona solution and Betaseptic Mundipharma (Mundipharma)... - Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virusA Sauerbrei
Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
Antiviral Res 86:246-52. 2010..g. site-directed mutagenesis experiments are required to characterize mutations of the TK and DNA pol genes in ACV-resistant viral strains as part of viral gene polymorphism or as cause of drug resistance... - Serological detection of specific IgG to varicella-zoster virus by novel ELISA based on viral glycoprotein antigenAndreas Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
Clin Lab 55:1-7. 2009..For determination of immunity post vaccination, a different approach for the interpretation of borderline results should be considered... - Seroprevalence of influenza A and B in German infants and adolescentsAndreas Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
Med Microbiol Immunol 198:93-101. 2009..In conclusion, the annual influenza vaccination in children and adolescents may improve considerably the protection against influenza virus infection occurring during epidemics... - Testing thermal resistance of virusesAndreas Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Jena, Germany
Arch Virol 154:115-9. 2009..In conclusion, human viruses and their surrogates for testing biocides may have a considerable thermal resistance that makes them difficult to be inactivated only by dry heat... - Utilization of the embryonated egg for in vivo evaluation of the anti-influenza virus activity of neuraminidase inhibitorsA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
Med Microbiol Immunol 195:65-71. 2006..Therefore, this model can be a valuable alternative approach for in vivo pre-testing anti-influenza virus activity of NA inhibitors... - Alternative methods for validation of cell culture infection with duck hepatitis B virusA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
J Virol Methods 129:178-85. 2005..Infection of cell cultures was most efficient 4 days after plating. The best identification of infected cultures was possible 6 days after infection with immunofluorescence using an antiserum against DHBV surface antigen... - [Antibodies against vaccine-preventable diseases in pregnant women and their offspring. Measles, mumps, rubella, poliomyelitis, and varicella]A Sauerbrei
Institut für Virologie und Antivirale Therapie, Friedrich Schiller Universitat Jena, Jena
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47:10-5. 2004..Despite the high seroprevalence of rubella and chickenpox, there is considerable potential for infections during pregnancy and neonatal period... - Immunofluorescence test for sensitive detection of varicella-zoster virus-specific IgG: an alternative to fluorescent antibody to membrane antigen testA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Postfach, D 07740 Jena, Germany
J Virol Methods 119:25-30. 2004..This simple technique can replace the labor-intensive FAMA procedure for laboratory determination of immunity to VZV... - Intracerebral varicella-zoster virus reactivation in congenital varicella syndromeA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Germany
Dev Med Child Neurol 45:837-40. 2003..This antiviral treatment was aimed at preventing progression of the disease. We concluded from this case that infants with intrauterine VZV infection can suffer intracerebral VZV reactivations that require antiviral treatment... - Molecular diagnosis of zoster post varicella vaccinationAndreas Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Winzerlaer Strasse 10, D 07745, Jena, Germany
J Clin Virol 27:190-9. 2003..Herpes zoster can be caused by endogenous reactivation of both wild-type virus or vaccine varicella-zoster virus (VZV) becoming latent within sensory ganglia after natural primary infection or varicella vaccination... - Semi-quantitative detection of viral RNA in influenza A virus-infected mice for evaluation of antiviral compoundsA Sauerbrei
Institute for Antiviral Chemotherapy, Friedrich Schiller University of Jena, Winzerlaer Strasse 10, D 07745 Jena, Germany
Antiviral Res 58:81-7. 2003..Viral load measurement by semi-quantitative detection of viral RNA allows rapid and sensitive screening of potential compounds with in vitro anti-influenza A virus activity... - Placental boost to varicella-zoster antibodies in the newbornAndreas Sauerbrei
Institute for Antiviral Chemotherapy, Friedrich Schiller University, Jena, Germany
J Perinat Med 30:345-8. 2002..The investigations revealed protective antibody levels in 96.7% of both newborns and mothers. In the cord blood samples, significantly higher titers were detected being indicative of an active placental transfer of VZV-specific IgG... - Laboratory diagnosis of central nervous system infections caused by herpesvirusesA Sauerbrei
Institute for Antiviral Chemotherapy, Friedrich Schiller University Jena, Winzerlaer Stasse 10, D 07745 Jena, Germany
J Clin Virol 25:S45-51. 2002..Herpes simplex encephalitis (HSE) has to be considered one of the most severe diseases. As effective antiviral drugs are available, rapid and reliable diagnosis has become important... - Resistance testing of clinical varicella-zoster virus strainsAndreas Sauerbrei
Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Hospital, Jena, Germany
Antiviral Res 90:242-7. 2011..In a considerable number of patients with clinical ACV-resistant VZV infections, resistance cannot be verified by virological methods... - Sensitivity of human adenoviruses to different groups of chemical biocidesA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
J Hosp Infect 57:59-66. 2004..The main reason for the different chemical sensitivity of adenovirus serotypes may be the composition of the viral capsid proteins. Alternatively a different chemical inactivation of the viral genome could be involved... - [Varicella during pregnancy. 2. Diagnosis, prevention and therapy]A Sauerbrei
Institut für Virologie und Antivirale Therapie, Friedrich Schiller Universitat, Jena
Dtsch Med Wochenschr 129:2045-7. 2004..As part 2, the present paper reviews the current possibilities of diagnosis, prevention and therapy of varicella-zoster virus infections during pregnancy... - [Antibodies against vaccine-preventable diseases in pregnant women and their offspring. Diphtheria, pertussis, tetanus]A Sauerbrei
Friedrich Schiller Universitat Jena, Jena
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47:16-20. 2004..In conclusion, the prevalence of antibodies determined suggests they are insufficient for protecting the newborns efficiently against pertussis and diphtheria in spite of the evidence for an active placental antibody transfer... - Serological detection of type-specific IgG to herpes simplex virus by novel ELISAs based on recombinant and highly purified glycoprotein GAndreas Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
Clin Lab 50:425-9. 2004..3%. There was a very good correlation between the results of the reference procedures and the evaluated tests. The novel immunoassays can be recommended for the reliable type-specific diagnosis of latent herpes simplex virus infections... - Gene polymorphism of thymidine kinase and DNA polymerase in clinical strains of herpes simplex virusKathrin Bohn
Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Jena University Clinic, Jena, Germany
Antivir Ther 16:989-97. 2011..The knowledge of gene polymorphism is an absolute requirement for the correct interpretation of genotypic findings... - Influenza infection of the embryonated hen's egg/an alternative model for in vivo evaluation of antiviral compoundsAlbert Härtl
Hans Knöll Institute for Natural Products Research, Jena, Germany
Arzneimittelforschung 54:130-4. 2004..In conclusion, the use of influenza virus-infected chick embryos for evaluation of new antiviral substances can lead to a considerable reduction in the number of small laboratory rodents required... - Prevalence of influenza A and B antibodies in pregnant women and their offspringPeter Wutzler
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Jena, Germany
J Clin Virol 46:161-4. 2009..Influenza is associated with substantial morbidity and mortality in pregnant women and neonates, but few countries offer annual influenza vaccination with the inactivated vaccine to all women who are, or intend to become, pregnant... - Genetic profile of an Oka varicella vaccine virus variant isolated from an infant with zosterAndreas Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich-Schiller University, Jena, Germany
J Clin Microbiol 42:5604-8. 2004..Further studies will be needed to identify potential virulence factors in variant vaccine strains... - Serological response to influenza A H1N1 vaccine (Pandemrix®) and seasonal influenza vaccine 2009/2010 in renal transplant recipients and in hemodialysis patientsUndine Ott
KfH Nierenzentrum, Jena, Germany
Med Microbiol Immunol 201:297-302. 2012..However, more than a half of these patients did not develop seroprotective antibody levels. Thus, new vaccines and altered vaccination regimes are likely necessary to achieve relevant antibody levels in these patient groups... - Prevalence of BK virus subtype I in GermanyAndi Krumbholz
Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University Jena, Jena, Germany
J Med Virol 78:1588-98. 2006..For the genotyping region, a relationship of BKV subgroups to disease patterns like hemorrhagic cystitis or tubulointerstitial nephritis could not be demonstrated... - Antiviral activity of cyclosaligenyl prodrugs of the nucleoside analogue bromovinyldeoxyuridine against herpes virusesAstrid Meerbach
Institute of Virology and Antiviral Therapy, Friedrich Schiller University Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
Int J Antimicrob Agents 27:423-30. 2006..Most remarkably, several cycloSal-BVDUMP triesters yielded promising anti-EBV activity whereas the parent compound BVDU was entirely inactive... - [Varicella during pregnancy. 1: Epidemiology and clinical aspects]A Sauerbrei
Institut für Virologie und Antivirale Therapie, Friedrich Schiller Universitat, Jena
Dtsch Med Wochenschr 129:1983-6. 2004..In the first part, the present paper reviews the currently available knowledge about the epidemiology and clinical consequences of varicella-zoster virus infections during pregnancy... - Molecular characterisation of varicella-zoster virus strains in Germany and differentiation from the Oka vaccine strainA Sauerbrei
Institute of Virology and Therapy, Friedrich Schiller University of Jena, Jena, Germany
J Med Virol 71:313-9. 2003..VZV wild-type strains containing a BglI restriction site in ORF 54 as well as Oka vaccine strains can rarely be detected... - Antibodies against vaccine-preventable diseases in pregnant women and their offspring in the eastern part of GermanyA Sauerbrei
Institute for Antiviral Chemotherapy, Friedrich-Schiller University of Jena, Germany
Med Microbiol Immunol 190:167-72. 2002..In conclusion, the prevalence of antibodies to pertussis (61%), diphtheria (81 %), poliomyelitis (55-59%) and measles (85%) is suggested to be insufficient in newborn infants to protect them against these infectious diseases... - Sequencing of 21 varicella-zoster virus genomes reveals two novel genotypes and evidence of recombinationRoland Zell
Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany
J Virol 86:1608-22. 2012..The split of ancestral clades 2/4 and 1/3/5/VIII/IX shows the greatest node height... - Epstein-Barr virus-associated pneumonia and bronchiolitis obliterans syndrome in a lung transplant recipientAndi Krumbholz
Institute of Virology and Antiviral Therapy, Jena University Hospital Friedrich Schiller University Jena, Jena, Germany
Med Microbiol Immunol 199:317-22. 2010..The clinical situation improved soon after re-transplantation, and the EBV load detected in the lower respiratory tract decreased significantly... - Virucidal activity of the new disinfectant monopercitric acidP Wutzler
Institute of Virology and Antiviral Therapy, Friedrich-Schiller University, Jena, Germany
Lett Appl Microbiol 39:194-8. 2004..2%. SIGNIFICANCE AND IMPACT OF THE STUDY: The high virucidal activity, short exposure times, and nontoxic by-products seem to make MPCA suitable as disinfectant for medical use and should warrant further investigation... - Fatal outcome of herpes simplex virus type 1-induced necrotic hepatitis in a neonateAstrid Meerbach
Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knöll Street 2, 07745 Jena, Germany
Med Microbiol Immunol 195:101-5. 2006..The diagnosis was performed postmortem by demonstration of HSV-1 DNA in liver tissue as well as by retrospective detection of HSV-specific antibodies... - Virological diagnosis of herpes simplex encephalitisA Sauerbrei
Institute for Antiviral Chemotherapy, Friedrich Schiller University Jena, Nordhäuser Strasse 78, D 99089, Erfurt, Germany
J Clin Virol 17:31-6. 2000..The herpes simplex encephalitis (HSE) represents one of the most severe infectious diseases of the central nervous system. As effective antiviral drugs are available, rapid and reliable diagnosis has become important... - Virucidal and chlamydicidal activities of eye drops with povidone-iodine liposome complexP Wutzler
Institute for Antiviral Chemotherapy, Friedrich Schiller University, Jena, Germany
Ophthalmic Res 32:118-25. 2000..There is no evidence for a genotoxic activity of these agents... - Virucidal efficacy of a combination of 0.2% peracetic acid and 80% (v/v) ethanol (PAA-ethanol) as a potential hand disinfectantP Wutzler
Institute for Antiviral Chemotherapy, Friedrich Schiller University of Jena, Winzelaer Str 10, 07745 Jena, Germany
J Hosp Infect 46:304-8. 2000.... - Seroprevalence of herpes simplex virus type 1 and type 2 in selected German populations-relevance for the incidence of genital herpesP Wutzler
Institute for Antiviral Chemotherapy, Friedrich Schiller University of Jena, Jena, Germany
J Med Virol 61:201-7. 2000.... - Laboratory diagnosis of herpes zosterA Sauerbrei
Institute for Antiviral Chemotherapy, Friedrich Schiller University Jena, Erfurt, Germany
J Clin Virol 14:31-6. 1999..These findings suggest that PCR is the method of choice for rapid laboratory diagnosis of zoster... - Congenital skin lesions caused by intrauterine infection with coxsackievirus B3A Sauerbrei
Institute for Antiviral Chemotherapy, Friedrich Schiller University of Jena, Erfurt, Germany
Infection 28:326-8. 2000..Serious neonatal coxsackievirus infections transplacentally acquired in late pregnancy involve primarily the central nervous system, heart, liver and rarely the skin... - Virucidal activity and cytotoxicity of the liposomal formulation of povidone-iodineP Wutzler
Institute for Antiviral Chemotherapy, Friedrich Schiller University, Winzerlaer Strasse 10, 07745 Jena, Germany
Antiviral Res 54:89-97. 2002.... - Inactivation of human adenovirus genome by different groups of disinfectantsA Sauerbrei
Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
J Hosp Infect 57:67-72. 2004..However, there was no clear correlation between the differences in the effect of disinfectants on infectivity of the complete viral particle and destruction of the viral genome... - [Varicella during pregnancy and in neonates]Peter Wutzler
Friedrich Schiller Universitat, Jena, BRD
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 50:237-44. 2007..Using currently available diagnostics, immuno-prophylactic and therapeutic opportunities, these serious consequences of varicella during pregnancy can be prevented... - In vitro cultivation and cryopreservation of duck embryonic hepatocytesM Schacke
Institute of Virology and Antiviral Chemotherapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
J Virol Methods 157:25-31. 2009..The use of cryopreserved hepatocytes is possible when freshly isolated cells from the liver of duck embryos are not available... - Comparative testing of liposomal and aqueous formulations of povidone-iodine for their angioirritative potential at the chorioallantoic membrane of ex ovo cultivated chick embryosP Wutzler
Institute for Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
Dermatology 207:43-7. 2003..Previous studies have shown that liposomal PVP-I formulations are less cytotoxic and that a special liposomal PVP-I hydrogel provides wound healing efficacy... - Varicella-zoster virus infections in pregnancyA Sauerbrei
Institute for Antiviral Chemotherapy, Friedrich Schiller Universitat Jena, Germany
Intervirology 41:191-6. 1998..As a consequence of maternal chickenpox within 12 days before delivery, 6 newborn babies developed neonatal varicella. Measures for diagnosis, treatment and prophylaxis are discussed... - Neonatal varicellaA Sauerbrei
Institute for Antiviral Chemotherapy, Klinikum of the Friedrich-Schiller University Jena, Winzerlaer Strasse 10, D-07745 Jena, Germany
J Perinatol 21:545-9. 2001..To prevent severe neonatal chickenpox, passive immunization is indicated. If varicella occurs, acyclovir treatment has to be administered promptly... - Differences in varicella-zoster virus seroepidemiology between temperate and tropical regionsAndreas Sauerbrei
Indian J Med Sci 61:123-4. 2007 - Anti-BK virus activity of nucleoside analogsParmjeet Randhawa
Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh, Room Medical Center, Pittsburgh, PA 15213, USA
Antimicrob Agents Chemother 52:1519-21. 2008.... - Hints of intracerebral varicella-zoster virus reactivation in congenital varicella syndromeAndreas Sauerbrei
Eur J Pediatr 162:354-5. 2003 - Herpes zoster by reactivated vaccine varicella zoster virus in a healthy childBarbara Uebe
Department of Paediatrics, University Hospital, Martin Luther University Halle Wittenberg, 06097 Halle, Germany
Eur J Pediatr 161:442-4. 2002..CONCLUSION: vaccine varicella zoster virus can occasionally reactivate in healthy children and present as herpes zoster. Virus characterisation is necessary to identify the strain and provide information on the incidence of occurrence... - European seroepidemiology network 2: Standardisation of assays for seroepidemiology of varicella zoster virusFernando de Ory
Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
J Clin Virol 36:111-8. 2006..The aim of the European Sero-Epidemiology Network (ESEN2) is to harmonise the serological surveillance of vaccine-preventable diseases in Europe...