Konrad Reinhart

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. doi request reprint Consensus statement of the ESICM task force on colloid volume therapy in critically ill patients
    Konrad Reinhart
    Department for Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
    Intensive Care Med 38:368-83. 2012
  2. pmc New approaches to sepsis: molecular diagnostics and biomarkers
    Konrad Reinhart
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Jena, Germany
    Clin Microbiol Rev 25:609-34. 2012
  3. pmc Randomized trial evaluating serial protein C levels in severe sepsis patients treated with variable doses of drotrecogin alfa (activated)
    Andrew F Shorr
    Washington Hospital Center, 110 Irving Street NW, Washington DC 20010, USA
    Crit Care 14:R229. 2010
  4. pmc Diagnosis of ventilator-associated pneumonia: a systematic review of the literature
    Alvaro Rea-Neto
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University Hospital, 07743 Jena, Germany
    Crit Care 12:R56. 2008
  5. pmc Protein C: a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated)
    Andrew F Shorr
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Washington Hospital Center, Irving Street, Washington, District of Columbia 20010, USA
    Crit Care 12:R45. 2008
  6. pmc The international PROGRESS registry of patients with severe sepsis: drotrecogin alfa (activated) use and patient outcomes
    Greg Martin
    Division of Pulmonary, Allergy, and Critical Care, Emory University, Atlanta, Georgia 30322, USA
    Crit Care 13:R103. 2009
  7. pmc Global utilization of low-dose corticosteroids in severe sepsis and septic shock: a report from the PROGRESS registry
    Richard Beale
    Division of Asthma, King s College London, Guy s, Campus, Great Maze Pond, London SE1 9RT, UK
    Crit Care 14:R102. 2010
  8. pmc Is albumin administration in the acutely ill associated with increased mortality? Results of the SOAP study
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 9:R745-54. 2005
  9. pmc Anemia and blood transfusion in a surgical intensive care unit
    Yasser Sakr
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University Hospital, Erlanger Allee 103, Jena 07743, Germany
    Crit Care 14:R92. 2010
  10. pmc A positive fluid balance is associated with a worse outcome in patients with acute renal failure
    Didier Payen
    Department of Anesthesiology and Intensive Care, CHU Lariboisière, 2, rue Ambroise Pare, F 75475 Paris Cedex 10, France
    Crit Care 12:R74. 2008

Collaborators

Detail Information

Publications150 found, 100 shown here

  1. doi request reprint Consensus statement of the ESICM task force on colloid volume therapy in critically ill patients
    Konrad Reinhart
    Department for Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
    Intensive Care Med 38:368-83. 2012
    ....
  2. pmc New approaches to sepsis: molecular diagnostics and biomarkers
    Konrad Reinhart
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Jena, Germany
    Clin Microbiol Rev 25:609-34. 2012
    ..Novel approaches to sepsis promise to transform sepsis from a physiologic syndrome into a group of distinct biochemical disorders and help in the development of better diagnostic tools and effective adjunctive sepsis therapies...
  3. pmc Randomized trial evaluating serial protein C levels in severe sepsis patients treated with variable doses of drotrecogin alfa (activated)
    Andrew F Shorr
    Washington Hospital Center, 110 Irving Street NW, Washington DC 20010, USA
    Crit Care 14:R229. 2010
    ..The purpose of this study was to evaluate the dose and duration of drotrecogin alfa (activated) treatment using serial measurements of protein C compared to standard therapy in patients with severe sepsis...
  4. pmc Diagnosis of ventilator-associated pneumonia: a systematic review of the literature
    Alvaro Rea-Neto
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University Hospital, 07743 Jena, Germany
    Crit Care 12:R56. 2008
    ....
  5. pmc Protein C: a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated)
    Andrew F Shorr
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Washington Hospital Center, Irving Street, Washington, District of Columbia 20010, USA
    Crit Care 12:R45. 2008
    ..The goal of this study was to identify a dependable, sensitive measure with which to monitor disease progression and response in patients during DrotAA treatment...
  6. pmc The international PROGRESS registry of patients with severe sepsis: drotrecogin alfa (activated) use and patient outcomes
    Greg Martin
    Division of Pulmonary, Allergy, and Critical Care, Emory University, Atlanta, Georgia 30322, USA
    Crit Care 13:R103. 2009
    ....
  7. pmc Global utilization of low-dose corticosteroids in severe sepsis and septic shock: a report from the PROGRESS registry
    Richard Beale
    Division of Asthma, King s College London, Guy s, Campus, Great Maze Pond, London SE1 9RT, UK
    Crit Care 14:R102. 2010
    ....
  8. pmc Is albumin administration in the acutely ill associated with increased mortality? Results of the SOAP study
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, 1070 Brussels, Belgium
    Crit Care 9:R745-54. 2005
    ..Albumin administration in the critically ill has been the subject of some controversy. We investigated the use of albumin solutions in European intensive care units (ICUs) and its relationship to outcome...
  9. pmc Anemia and blood transfusion in a surgical intensive care unit
    Yasser Sakr
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University Hospital, Erlanger Allee 103, Jena 07743, Germany
    Crit Care 14:R92. 2010
    ..Studies in intensive care unit (ICU) patients have suggested that anemia and blood transfusions can influence outcomes, but these effects have not been widely investigated specifically in surgical ICU patients...
  10. pmc A positive fluid balance is associated with a worse outcome in patients with acute renal failure
    Didier Payen
    Department of Anesthesiology and Intensive Care, CHU Lariboisière, 2, rue Ambroise Pare, F 75475 Paris Cedex 10, France
    Crit Care 12:R74. 2008
    ..The aim of the present observational study was to analyze the influence of patient characteristics and fluid balance on the outcome of ARF in intensive care unit (ICU) patients...
  11. ncbi request reprint Anti-tumor necrosis factor therapy in sepsis: update on clinical trials and lessons learned
    K Reinhart
    Department of Anesthesiology and Intensive Care Medicine, University Hospital, Jena, Germany
    Crit Care Med 29:S121-5. 2001
    ..Tumor necrosis factor (TNF) is an important mediator involved in the pathogenesis of sepsis. We review clinical studies investigating the efficacy of anti-TNF therapy in decreasing mortality rates in septic patients...
  12. ncbi request reprint Continuous central venous and pulmonary artery oxygen saturation monitoring in the critically ill
    Konrad Reinhart
    Department of Anesthesia and Intensive Care Medicine, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
    Intensive Care Med 30:1572-8. 2004
    ..To compare the course of continuously measured mixed and central venous O(2) saturations in high-risk patients and to evaluate the impact of various factors that might interfere with reflection spectrophotometry...
  13. doi request reprint Biomarkers as a guide for antimicrobial therapy
    Konrad Reinhart
    Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University, Jena, Germany
    Int J Antimicrob Agents 36:S17-21. 2010
    ..However, the utility of these novel diagnostic tools in the clinical setting remains to be proven...
  14. ncbi request reprint Markers for sepsis diagnosis: what is useful?
    Konrad Reinhart
    Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University, Erlanger Allee 101, D 07743 Jena, Germany
    Crit Care Clin 22:503-19, ix-x. 2006
    ..It is important to identify markers for an early diagnosis of sepsis and organ dysfunction. This article presents currently interesting sepsis biomarkers. Other novel markers and their potential role are discussed...
  15. ncbi request reprint Effects of fluid resuscitation with synthetic colloids or crystalloids alone on shock reversal, fluid balance, and patient outcomes in patients with severe sepsis: a prospective sequential analysis
    Ole Bayer
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University Jena, Jena, Germany
    Crit Care Med 40:2543-51. 2012
    ..To assess shock reversal and required fluid volumes in patients with septic shock...
  16. doi request reprint Antiplatelet drugs and outcome in mixed admissions to an intensive care unit
    Johannes Winning
    Medical Doctor and Senior Officer, Clinic of Anesthesiology and Intensive Care Medicine, University Hospital Jena, Jena, Germany
    Crit Care Med 38:32-7. 2010
    ..Platelet activation has been implicated in microvascular thrombosis and organ failure. We tested the hypothesis that antiplatelet drugs favorably affect outcome in patients nonelectively admitted to an intensive care unit...
  17. ncbi request reprint Variations in the ratio between von Willebrand factor and its cleaving protease during systemic inflammation and association with severity and prognosis of organ failure
    Ralf A Claus
    Dept of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University, Erlanger Allee 101, D 07747 Jena, Germany
    Thromb Haemost 101:239-47. 2009
    ..These findings suggest that ADAMTS13, VWF and related parameters, even in a combined approach, might be useful for the diagnosis and the therapeutic monitoring of patients with sepsis associated thrombotic microangiopathy...
  18. doi request reprint Renal effects of synthetic colloids and crystalloids in patients with severe sepsis: a prospective sequential comparison
    Ole Bayer
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany
    Crit Care Med 39:1335-42. 2011
    ..4 and gelatin are considered to be less harmful. We hypothesized that fluid therapy with only crystalloids would decrease the incidence of acute kidney injury...
  19. ncbi request reprint Antithrombin levels, morbidity, and mortality in a surgical intensive care unit
    Yasser Sakr
    Department of Anesthesiology and Intensive Care, and Institute of Clinical Chemistry and Laboratory Medicine, Friedrich Schiller University Hospital, Jena, Germany
    Anesth Analg 105:715-23. 2007
    ..We investigated the time course of AT levels in a surgical ICU and tested the hypothesis that AT levels may be associated with morbidity and increased mortality rates in a cohort of surgical ICU patients...
  20. doi request reprint Perioperative fluid therapy with tetrastarch and gelatin in cardiac surgery--a prospective sequential analysis*
    Ole Bayer
    1Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Jena, Germany 2Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany 3Department of Cardiothoracic Surgery, Jena University Hospital, Friedrich Schiller University, Jena, Germany 4Department of Medicine, McMaster University, Hamilton, ON, Canada 5Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada 6Department of Mechanical and Process Engineering, Furtwangen University, Villingen Schwenningen, Germany
    Crit Care Med 41:2532-42. 2013
    ..To determine clinical outcomes of synthetic colloids, tetrastarch, and gelatin, used before and after cardiac surgery...
  21. doi request reprint Lipopolysaccharide binding protein in a surgical intensive care unit: a marker of sepsis?
    Yasser Sakr
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University Hospital, Jena, Germany
    Crit Care Med 36:2014-22. 2008
    ....
  22. doi request reprint Epidemiology of and factors associated with end-of-life decisions in a surgical intensive care unit
    Anne Meissner
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University Hospital, Jena, Germany
    Crit Care Med 38:1060-8. 2010
    ..To investigate the epidemiology of and possible factors associated with end-of-life decisions in a surgical intensive care unit...
  23. doi request reprint Is the SAPS II score valid in surgical intensive care unit patients?
    Yasser Sakr
    Department of Anaesthesiology and Intensive Care, Friedrich Schiller University Hospital, Jena, Germany
    J Eval Clin Pract 18:231-7. 2012
    ....
  24. ncbi request reprint Neutrophil stimulation with granulocyte colony-stimulating factor worsens ventilator-induced lung injury and mortality in rats
    Waheedullah Karzai
    Department of Anesthesiology and Critical Care Medicine, Friedrich Schiller University Hospital, Jena, Germany
    Anesthesiology 103:996-1005. 2005
    ....
  25. doi request reprint Heparin-induced thrombocytopenia type II in a surgical intensive care unit
    Yasser Sakr
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University Hospital, Jena, Germany
    J Crit Care 27:232-41. 2012
    ..The aim of this study was to investigate the epidemiology of and outcome from heparin-induced thrombocytopenia type II (HIT) in surgical intensive care unit (ICU) patients...
  26. pmc The late phase of sepsis is characterized by an increased microbiological burden and death rate
    Gordon P Otto
    Clinic for Anesthesiology and Intensive Care, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany
    Crit Care 15:R183. 2011
    ..The aim of this study was to determine the clinical significance of the 'late phase' of sepsis with respect to overall survival and occurrence of microbiological findings...
  27. pmc HES 130/0.4 impairs haemostasis and stimulates pro-inflammatory blood platelet function
    Maik Sossdorf
    Department of Anaesthesiology and Intensive Care Therapy, Jena University Hospital, D 07740 Jena, Germany
    Crit Care 13:R208. 2009
    ..4 has fewer adverse effects than HES 200/0.5 and exerts anti-inflammatory properties, we compared the effects of HES 130/0.4, HES 200/0.5 and saline on in vitro haemostasis and pro-inflammatory platelet function...
  28. doi request reprint The impact of age on outcome after major surgical procedures
    Cristina Elia
    Department of Anaesthesiology and Intensive Care, Friedrich Schiller University Hospital, Jena, Germany
    J Crit Care 28:413-20. 2013
    ..The aim of this study was to investigate the effects of age on outcome in a large cohort of surgical intensive care unit (ICU) patients...
  29. pmc Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study
    Frank Bloos
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany
    Crit Care 15:R88. 2011
    ..The intent of this study was to determine whether serum procalcitonin (PCT) levels are associated with prognosis, measured as organ dysfunctions and 28-day mortality, in patients with severe pneumonia...
  30. doi request reprint Obesity is associated with increased morbidity but not mortality in critically ill patients
    Yasser Sakr
    Department of Anaesthesiology and Intensive Care, Friedrich Schiller University Jena, Jena, Germany
    Intensive Care Med 34:1999-2009. 2008
    ..To investigate the possible impact of obesity on morbidity and mortality in intensive care unit (ICU) patients included in the European observational sepsis occurrence in acutely ill patients (SOAP) study...
  31. doi request reprint Potential effect of physiotherapeutic treatment on mortality rate in patients with severe sepsis and septic shock: a retrospective cohort analysis
    Maik Sossdorf
    Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany Electronic address
    J Crit Care 28:954-8. 2013
    ..The aim of the study was to examine the onset and frequency of physiotherapeutic interventions (PTI) and their potential effects on the intensive care unit (ICU) mortality rate in patients with severe sepsis or septic shock...
  32. doi request reprint Gene polymorphisms in the heme degradation pathway and outcome of severe human sepsis
    Christoph Sponholz
    Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany
    Shock 38:459-65. 2012
    ....
  33. doi request reprint Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial
    Frank M Brunkhorst
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University, Jena, Germany
    JAMA 307:2390-9. 2012
    ..Early appropriate antimicrobial therapy leads to lower mortality rates associated with severe sepsis. The role of empirical combination therapy comprising at least 2 antibiotics of different mechanisms remains controversial...
  34. doi request reprint Current practice in nutritional support and its association with mortality in septic patients--results from a national, prospective, multicenter study
    Gunnar Elke
    Department of Anesthesiology and Intensive Care Medicine, University Medical Center Schleswig Holstein, Campus Kiel, Germany
    Crit Care Med 36:1762-7. 2008
    ..To identify current clinical practice regarding nutrition and its association with morbidity and mortality in patients with severe sepsis or septic shock in Germany...
  35. ncbi request reprint Protein C concentrations correlate with organ dysfunction and predict outcome independent of the presence of sepsis
    Frank Brunkhorst
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University, Jena, Germany
    Anesthesiology 107:15-23. 2007
    ..The authors investigated the time courses of protein C concentrations and their relation to the presence of sepsis, organ dysfunction/failure, and outcome...
  36. doi request reprint Are renal adverse effects of hydroxyethyl starches merely a consequence of their incorrect use?
    Christiane S Hartog
    Klinik für Anästhesiologie und Intensivmedizin, Friedrich Schiller Universitat Jena, Jena, Germany
    Wien Klin Wochenschr 123:145-55. 2011
    ..These comments imply that renal adverse events in clinical studies are the consequence of an inappropriate use of HES. We therefore searched for evidence whether these suggested measures are beneficial...
  37. doi request reprint Inflammation-associated ADAMTS13 deficiency promotes formation of ultra-large von Willebrand factor
    Clemens L Bockmeyer
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital, Friedrich Schiller University, Erlanger Allee 101, D 07747 Jena, Germany
    Haematologica 93:137-40. 2008
    ..Our data support the view that systemic inflammation results in an ADAMTS13 deficiency which activates hemostasis...
  38. doi request reprint Attributable costs of patients with candidemia and potential implications of polymerase chain reaction-based pathogen detection on antifungal therapy in patients with sepsis
    Frank Bloos
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany
    J Crit Care 28:2-8. 2013
    ....
  39. pmc Evaluation of a polymerase chain reaction assay for pathogen detection in septic patients under routine condition: an observational study
    Frank Bloos
    Deptartment of Anesthesiology and Intensive Care Therapy, Jena University Hospital, Germany
    PLoS ONE 7:e46003. 2012
    ..This study was undertaken to compare PCR with blood culture results under routine conditions regarding 1. impact on antimicrobial therapy, and 2. time to result, in patients with presumed sepsis...
  40. doi request reprint Intensive insulin therapy and pentastarch resuscitation in severe sepsis
    Frank M Brunkhorst
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University, Jena, Germany
    N Engl J Med 358:125-39. 2008
    ..The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking to support the choice of either crystalloids or colloids...
  41. doi request reprint The obesity paradox in surgical intensive care unit patients
    Robert Hutagalung
    Department of Anaesthesiology and Intensive Care, Friedrich Schiller University, Erlanger Allee 103, 07743, Jena, Germany
    Intensive Care Med 37:1793-9. 2011
    ..To investigate the possible impact of obesity, as assessed by body mass index (BMI), on outcome in surgical intensive care unit (ICU) patients...
  42. doi request reprint Low and "supranormal" central venous oxygen saturation and markers of tissue hypoxia in cardiac surgery patients: a prospective observational study
    Suzanne Perz
    Department of Anesthesiology and Critical Care Therapy, Jena University Hospital, 07740 Jena, Germany
    Intensive Care Med 37:52-9. 2011
    ..To characterize incidence of low, normal and "supranormal" central venous oxygen saturation (ScvO(2)) and the relation to markers of tissue hypoxia, course and outcome in cardiac surgery patients...
  43. ncbi request reprint Venous oximetry
    Gernot Marx
    Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller Universität, Jena, Germany
    Curr Opin Crit Care 12:263-8. 2006
    ..This review discusses recent data on the impact of using venous oximetry by obtaining mixed venous oxygen saturation or central venous oxygen saturation as useful monitoring parameters in critically ill patients...
  44. doi request reprint Prospective assessment of hepatic function and mechanisms of dysfunction in the critically ill
    Andreas Kortgen
    Department of Anaesthesiology and Critical Care Therapy, Friedrich Schiller University, Jena, Germany
    Shock 32:358-65. 2009
    ..The observed differential susceptibility of the polar surfaces of human hepatocytes has potential implications for monitoring liver function and drug-induced liver injury...
  45. pmc Systematic analysis of hydroxyethyl starch (HES) reviews: proliferation of low-quality reviews overwhelms the results of well-performed meta-analyses
    Christiane S Hartog
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
    Intensive Care Med 38:1258-71. 2012
    ..We have therefore examined the relationship between the methodological quality of published HES reviews, authors' potential conflicts of interest (pCOI) and the recommendations made...
  46. ncbi request reprint Isotonic and hypertonic crystalloid solutions in the critically ill
    Michael Bauer
    Department of Anesthesiology and Intensive Care Therapy, Friedrich Schiller University, Erlanger Allee, 101, D 07747 Jena, Germany
    Best Pract Res Clin Anaesthesiol 23:173-81. 2009
    ....
  47. ncbi request reprint Open randomized phase II trial of an extracorporeal endotoxin adsorber in suspected Gram-negative sepsis
    Konrad Reinhart
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Bachstrasse 18, 07743 Jena, Germany
    Crit Care Med 32:1662-8. 2004
    ..An initial phase II trial to investigate the safety and therapeutic effect of the endotoxin adsorber system EN 500 in septic patients suffering from presumed Gram-negative infection...
  48. pmc Distinct different contributions of the alternative and classical complement activation pathway for the innate host response during sepsis
    Katja Dahlke
    Department of Anesthesiology and Intensive Care Therapy, Jena University Hospital, Friedrich Schiller University Jena, 07747 Jena, Germany
    J Immunol 186:3066-75. 2011
    ..Our results provide evidence for the new concept that the alternative complement activation pathway exerts a distinctly different contribution to the innate host response during sepsis when compared with the classical pathway...
  49. doi request reprint Biomarkers in the critically ill patient: procalcitonin
    Konrad Reinhart
    Clinic of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University Jena, Erlanger Allee 101, 07740 Jena, Germany
    Crit Care Clin 27:253-63. 2011
    ..In this review the present use of PCT on the ICU and in critically ill patients is summarized, included it's role for diagnosis of severe sepsis and septic shock and antibiotic stewardship with PCT...
  50. doi request reprint Moderate-dose vasopressin therapy may impair gastric mucosal perfusion in severe sepsis: a pilot study
    Stefan Klinzing
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University, Jena, Germany
    Anesthesiology 114:1396-402. 2011
    ..The effects of moderate-dose vasopressin on gastric mucosal perfusion and its relation to global and hepatosplanchnic hemodynamic and oxygen transport variables were investigated in patients with severe sepsis...
  51. doi request reprint A systematic review of third-generation hydroxyethyl starch (HES 130/0.4) in resuscitation: safety not adequately addressed
    Christiane S Hartog
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Erlanger Allee 101, D 07747 Jena, Germany
    Anesth Analg 112:635-45. 2011
    ..4 resuscitation are sufficiently well designed to draw conclusions about the safety of this compound. In addition, we wanted to assess crystalloid-to-colloid fluid ratios in studies with goal-directed fluid regimen...
  52. ncbi request reprint Prognostic value of extravascular lung water in critically ill patients
    Samir G Sakka
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Bachstrasse 18, D 07740 Jena, Germany
    Chest 122:2080-6. 2002
    ..In this study, we analyzed the prognostic value of EVLW in critically ill patients...
  53. doi request reprint Characterization of buccal microvascular response in patients with septic shock
    Yasser Sakr
    Department of Anaesthesiology and Intensive Care, Friedrich Schiller University Hospital, Jena, Germany
    Eur J Anaesthesiol 27:388-94. 2010
    ..The aim of the present study was to characterize the buccal microvascular response in patients with septic shock using combined laser Doppler flowmetry/visual light spectroscopy measurements...
  54. doi request reprint The efficacy and safety of colloid resuscitation in the critically ill
    Christiane S Hartog
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University, Jena, Germany
    Anesth Analg 112:156-64. 2011
    ..4 are still lacking despite its widespread and increasing use. Because there are safer and equally effective alternatives in the form of crystalloids, use of synthetic colloids should be avoided except in the context of clinical studies...
  55. doi request reprint Fluctuations in serum sodium level are associated with an increased risk of death in surgical ICU patients
    Yasser Sakr
    Departments of Anesthesiology and Intensive Care, Friedrich Schiller University Hospital, Jena, Germany
    Crit Care Med 41:133-42. 2013
    ....
  56. ncbi request reprint Platelet-derived microvesicles induce differential gene expression in monocytic cells: a DNA microarray study
    Florian Setzer
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Jena, Jena, Germany
    Platelets 17:571-6. 2006
    ..The data indicate that PMV signal differential expression of inflammation-relevant genes in monocytic cells and may represent a novel link between hemostasis and inflammation...
  57. doi request reprint Influence of hydroxyethyl starch (HES) 130/0.4 on hemostasis as measured by viscoelastic device analysis: a systematic review
    Christiane S Hartog
    Department for Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University, Jena, Germany
    Intensive Care Med 37:1725-37. 2011
    ..Hydroxyethyl starch solutions (HES) are plasma volume expanders which affect hemostasis. Newer HES 130/0.4 is said to be safer. Reevaluation of published evidence is necessary after the recent retraction of studies...
  58. ncbi request reprint The value of venous oximetry
    Konrad Reinhart
    Klinik f Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller Universität, Jena, Germany
    Curr Opin Crit Care 11:259-63. 2005
    ..This review discusses the physiology and clinical application of these parameters...
  59. pmc Hydroxyethylstarch impairs renal function and induces interstitial proliferation, macrophage infiltration and tubular damage in an isolated renal perfusion model
    Lars Hüter
    Department of Anaesthesiology and Intensive Care Medicine, University of Jena, Erlanger Allee, Jena, Germany
    Crit Care 13:R23. 2009
    ..The aim of the study was to evaluate some of the underlying pathomechanisms of hydroxyethylstarch (HES) induced adverse effects on renal function using 24 porcine kidneys in an isolated perfusion model over six hours...
  60. doi request reprint A multicenter trial to compare blood culture with polymerase chain reaction in severe human sepsis
    Frank Bloos
    Department of Anesthesiology and Intensive Care Therapy, University Hospital Jena, Erlanger Allee 101, 07747 Jena, Germany
    Intensive Care Med 36:241-7. 2010
    ..To assess the presence of microbial DNA in the blood by polymerase chain reaction (PCR) and its association with disease severity and markers of inflammation in severe sepsis and to compare the performance of PCR with blood culture (BC)...
  61. ncbi request reprint Platelet and leukocyte activation correlate with the severity of septic organ dysfunction
    Stefan Russwurm
    Department of Anesthesiology and Intensive Care Medicine, Jena, Germany
    Shock 17:263-8. 2002
    ....
  62. doi request reprint CONTRA: Hydroxyethyl starch solutions are unsafe in critically ill patients
    Christiane Hartog
    Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University, Erlanger Allee 101, 07747 Jena, Germany
    Intensive Care Med 35:1337-42. 2009
    ..To describe the risk-benefit profile of hydroxyethyl starch (HES)...
  63. doi request reprint Family satisfaction in the intensive care unit: a quantitative and qualitative analysis
    Daniel Schwarzkopf
    Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany
    Intensive Care Med 39:1071-9. 2013
    ..To assess family satisfaction in the intensive care unit (ICU) and areas for improvement using quantitative and qualitative analyses...
  64. ncbi request reprint Early- versus late-onset shock in European intensive care units
    Yasser Sakr
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University, Jena, Germany
    Shock 28:636-643. 2007
    ..6; 95% confidence interval, 1.6-4.3, P < 0.001). These observations have important implications in establishing individual prognosis as well as in the design and interpretation of clinical trials...
  65. pmc Readmission to a surgical intensive care unit: incidence, outcome and risk factors
    Axel Kaben
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University Hospital, Erlanger Allee 101, Jena, 07743, Germany
    Crit Care 12:R123. 2008
    ..We investigated the incidence of, outcome from and possible risk factors for readmission to the surgical intensive care unit (ICU) at Friedrich Schiller University Hospital, Jena, Germany...
  66. pmc Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature
    Christoph Sponholz
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University, Erlanger Allee 103, 07743 Jena, Germany
    Crit Care 10:R145. 2006
    ....
  67. doi request reprint Molecular diagnostics of sepsis--where are we today?
    Michael Bauer
    Klinik für Anästhesiologie und Intensivtherapie, Universitatsklinikum Jena, Erlanger Allee 101, 07743 Jena, Germany
    Int J Med Microbiol 300:411-3. 2010
    ..Clinical utility of both, molecular tests to identify the pathogen and the ensuing host response, has still to be evaluated in prospective trials...
  68. ncbi request reprint Protection with antibody to tumor necrosis factor differs with similarly lethal Escherichia coli versus Staphylococcus aureus pneumonia in rats
    Waheedullah Karzai
    Department of Anesthesiology and Intensive Care Medicine, University Hospital, Jena, Germany
    Anesthesiology 99:81-9. 2003
    ..Differing factors may alter the effects of antibody to tumor necrosis factor (TNF) in infection and sepsis. The authors tested whether bacteria type or treatment route alters antibody to TNF in a rat model of bacterial pneumonia...
  69. ncbi request reprint Venous oximetry
    Frank Bloos
    Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller Universität, Erlanger Allee 101, 07747, Jena, Germany
    Intensive Care Med 31:911-3. 2005
  70. ncbi request reprint High-dose vasopressin is not superior to norepinephrine in septic shock
    Stefan Klinzing
    Department of Anesthesiology and Intensive Care Medicine, Freidrich Schiller University, Jena, Germany
    Crit Care Med 31:2646-50. 2003
    ..We examined the effects of arginine vasopressin, when substituted for norepinephrine as a vasopressor in septic shock, on global and hepatosplanchnic hemodynamic and oxygen transport variables...
  71. ncbi request reprint Thyroid hormone response to moderate hypothermia in severe brain injury
    Winfried Meissner
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University Jena, Bachstrasse 18, 07740 Jena, Germany
    Intensive Care Med 29:44-8. 2003
    ..To examine the effect of controlled moderate hypothermia on thyroid response in head-injured patients...
  72. ncbi request reprint Both gram-negative and gram-positive experimental pneumonia induce profound lymphocyte but not respiratory epithelial cell apoptosis
    Torsten Schreiber
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA
    Shock 26:271-6. 2006
    ..Increased lymphocyte but not bronchial cell apoptosis occurs in both gram-positive and gram-negative pneumonia and probably involves both the extrinsic and intrinsic pathway...
  73. ncbi request reprint Transcription in response to physical stress--clues to the molecular mechanisms of exercise-induced asthma
    Thomas Hilberg
    Department of Sports Medicine Friedrich Schiller University Jena, Germany
    FASEB J 19:1492-4. 2005
    ....
  74. ncbi request reprint Comparison of cardiac output and circulatory blood volumes by transpulmonary thermo-dye dilution and transcutaneous indocyanine green measurement in critically ill patients
    Samir G Sakka
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Jena, Germany
    Chest 121:559-65. 2002
    ..We prospectively studied the agreement between transpulmonary aortic fiberoptic-based and pulse dye densitometry (PDD) measurements of cardiac output and circulatory blood volumes...
  75. ncbi request reprint Catecholamines and splanchnic perfusion
    A Meier-Hellmann
    Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University, Bachstrasse 18, D 07743, Jena
    Schweiz Med Wochenschr 130:1942-7. 2000
    ..Until the various catecholamine regimes are more fully examined, recommendations for catecholamine support in sepsis must be considered "conditional"...
  76. ncbi request reprint Therapeutic options for the treatment of impaired gut function
    A Meier-Hellmann
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Jena, Germany
    J Am Soc Nephrol 12:S65-9. 2001
    ..It has been suggested that dopexamine can improve splanchnic perfusion, but because these effects remain somewhat controversial, a general recommendation for dopexamine to improve gut perfusion is not justified...
  77. ncbi request reprint Late cardiac arrhythmias after blunt chest trauma
    S G Sakka
    Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Germany
    Intensive Care Med 26:792-5. 2000
    ..Case reports of two patients who developed fatal cardiac arrhythmias several days after blunt chest trauma...
  78. ncbi request reprint Lipopolysaccharide induces distinct alterations in the microtubule cytoskeleton of monocytes
    S Russwurm
    University of Jena, Department of Anaesthesiology and Critical Care Medicine, Germany
    Cell Biol Toxicol 16:339-46. 2000
    ..Therefore, we conclude, that the microtubule cytoskeleton is an essential intracellular target for sepsis-relevant bacterial components such as lipopolysaccharides...
  79. ncbi request reprint [Left ventricular aneurysm after myocardial contusion caused by blunt chest trauma]
    S G Sakka
    Klinik für Anästhesiologie und Intensivmedizin, Friedrich Schiller Universitat Jena
    Anasthesiol Intensivmed Notfallmed Schmerzther 35:412-6. 2000
    ..Finally, septic shock complicated the case and the patient died 30 days of intensive care from therapy-refractory multiple organ system failure...
  80. doi request reprint [Diagnosis and causal treatment of sepsis]
    F M Brunkhorst
    Paul Martini Forschergruppe für klinische Sepsisforschung, Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller Universitat Jena, Erlanger Allee 101, 07743, Jena, Deutschland
    Internist (Berl) 50:810-6. 2009
    ..A closer cooperation between microbiologists, infection control specialists and clinical infectious disease consultants may be a key factor to overcome the raising problems in the future...
  81. doi request reprint [Supportive and adjunctive sepsis therapy]
    F M Brunkhorst
    Paul Martini FG Klinische Sepsisforschung, Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller Universitat Jena, Erlanger Allee 101, 07743, Jena, Deutschland
    Internist (Berl) 50:817-24, 826-7. 2009
    ..The German Competence Network Sepsis (SepNet) is currently studying further relevant questions...
  82. ncbi request reprint Effect of plasma and LPS on respiratory burst of neutrophils in septic patients
    C Pascual
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University, Jena, Germany
    Intensive Care Med 24:1181-6. 1998
    ..To compare the respiratory burst of neutrophils in sepsis and control patients using lipopolysaccharide (LPS), autologous plasma, and a combination of the two...
  83. ncbi request reprint Glycosylphosphatidylinositol-specific phospholipase D in blood serum: is the liver the only source of the enzyme?
    H Rhode
    Institute of Biochemistry, Medical Faculty, Friedrich Schiller University, Jena, Germany
    Clin Chim Acta 281:127-45. 1999
    ..To find possible other sources of plasma GPI-PLD besides the liver, the GPI-degrading activity was measured in different organs of the rat. Product formation was analysed using [125I]TID-labeled GPI-AP...
  84. ncbi request reprint A piglet model for evaluation of cerebral blood flow and brain oxidative metabolism during gradual cerebral perfusion pressure decrease
    R Bauer
    Institute for Pathophysiology, Friedrich Schiller University, Jena, Germany
    Pediatr Neurosurg 30:62-9. 1999
    ..We conclude that the model simulates the effects of an acute intracranial focal mass expansion and is well suited for the evaluation of different therapeutical strategies for increased ICP in newborns and infants...
  85. ncbi request reprint Effect of antioxidants on induction time of luminol luminescence elicited by 3-morpholinosydnonimine (SIN-1)
    C Pascual
    Institute of Biochemistry Friedrich Schiller University, Jena, Germany
    Luminescence 14:83-9. 1999
    ..SIN-1 could be useful as a source of oxidant for the characterization of antioxidant behaviour in a system where superoxide and nitric oxide are simultaneously generated...
  86. ncbi request reprint Oral naloxone reverses opioid-associated constipation
    W Meissner
    Clinic of Anaesthesiology and Intensive Care, Friedrich Schiller University Jena, D 07740, Jena, Germany
    Pain 84:105-9. 2000
    ..To prevent systemic withdrawal signs, therapy should be started with low doses and patients carefully monitored during titration...
  87. ncbi request reprint Atropine test and circulatory arrest in the fossa posterior assessed by transcranial Doppler
    E Huttemann
    Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University Jena, Germany
    Intensive Care Med 26:422-5. 2000
    ..e., increase in heart rate of less than 3% after intravenous administration of 3 mg atropine) correctly predicts circulatory arrest in the fossa posterior during craniocaudal herniation in patients with primary supratentorial lesions...
  88. doi request reprint [Prevention and follow-up care of sepsis. 1st revision of S2k guidelines of the German Sepsis Society (Deutsche Sepsis-Gesellschaft e.V., DSG) and the German Interdisciplinary Association of Intensive Care and Emergency Medicine (Deutsche Interdisziplinär
    F M Brunkhorst
    Klinik für Anästhesiologie und Intensivtherapie, Universitätsklinikum Jena der Friedrich Schiller Universität Jena, Erlanger Allee 101, Jena, Germany
    Internist (Berl) 51:925-32. 2010
    ....
  89. ncbi request reprint Dysfunction of vasomotor reactivity in severe sepsis and septic shock
    C Terborg
    Department of Neurology, Friedrich Schiller University of Jena, Germany
    Intensive Care Med 27:1231-4. 2001
    ..We investigated whether carbon dioxide (CO2)-induced vasomotor reactivity (VMR) is impaired in septic patients, compared with values obtained outside sepsis...
  90. ncbi request reprint [New approaches to intensive care for sepsis]
    G Marx
    Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller Universitat Jena
    Chirurg 76:845-55. 2005
    ....
  91. ncbi request reprint [Diagnosis and therapy of sepsis: guidelines of the German Sepsis Society Inc. and the German Interdisciplinary Society for Intensive and Emergency Medicine]
    K Reinhart
    Deutsche Sepsis Gesellschaft e V c o Universitatsklinikum Jena, Erlanger Allee 101, 07747 Jena
    Anaesthesist 55:43-56. 2006
    ..The guidelines development process was carefully planned and strictly adhered to the requirements of the Working Group of Scientific Medical Societies (AWMF)...
  92. ncbi request reprint Left ventricular regional wall motion abnormalities during pneumoperitoneum in children
    E Huettemann
    Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University Jena, Bachstrasse 18, D 07740 Jena, Germany
    Br J Anaesth 90:733-6. 2003
    ..Since any increase in intra-abdominal pressure (IAP) exerted by a pneumoperitoneum is transmitted to the intrathoracic cavity, similar effects on LV regional wall motion cannot be ruled out...
  93. ncbi request reprint [Intensive insulin therapy in critically ill patients--contra]
    Gernot Marx
    Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller Universitat Jena
    Dtsch Med Wochenschr 131:2481. 2006
  94. ncbi request reprint Left ventricular dysfunction in lethal severe brain injury: impact of transesophageal echocardiography on patient management
    E Huttemann
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University, Bachstrasse 18, 07740 Jena, Germany
    Intensive Care Med 28:1084-8. 2002
    ..To evaluate the impact of transesophageal echocardiographic (TEE) studies on further patient management and incidence and degree of left ventricular (LV) dysfunction in patients with lethal severe brain injury...
  95. ncbi request reprint Urosepsis: from the intensive care viewpoint
    G Marx
    Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller Universität, Erlanger Allee 101, Jena, Germany
    Int J Antimicrob Agents 31:S79-84. 2008
    ..Time to initiation of therapy is crucial for surviving sepsis. Implementing new medical evidence in this context into daily clinical intensive care remains a major hurdle...
  96. ncbi request reprint [Transesophageal echocardiography and intraoperative management of patients with renal cell carcinoma and rena cava extension]
    E Huttemann
    Klinik für Anästhesiologie und Intensivtherapie, Universitatskliniken, Friedrich Schiller Universitat Jena
    Anaesthesist 51:116-9. 2002
    ..To evaluate the role of intraoperative real-time transesophageal echocardiography (TEE) for the anesthetic and surgical management of patients with renal cell carcinoma and vena cava extension...
  97. ncbi request reprint The use and safety of transoesophageal echocardiography in the general ICU -- a minireview
    E Huttemann
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital, Friedrich Schiller University Jena, Jena, Germany
    Acta Anaesthesiol Scand 48:827-36. 2004
    ..The efficacy of transoesophageal echocardiography (TEE) has been evaluated predominantly in medical and cardiac surgical ICUs. This article reviews the pertinent literature and evaluates the impact of TEE in a general surgical ICU...
  98. doi request reprint [Sepsis therapy: present guidelines and their application]
    F M Brunkhorst
    Klinik für Anästhesiologie und Intensivtherapie, Universitätsklinikum Jena der Friedrich Schiller Universität, Jena, Germany
    Chirurg 79:306-14. 2008
    ..Recombinant activated protein C is one choice for certain patients. The German Sepsis Competence Network (SepNet) is currently investigating other open questions...
  99. ncbi request reprint [Quality management in postoperative pain therapy]
    W Meissner
    Klinik für Anästhesiologie und Intensivtherapie, Friedrich Schiller Universitat Jena, Bachstrasse 18, 07743 Jena
    Anaesthesist 50:661-70. 2001
    ..This study reports the implementation of a quality management program to improve postoperative pain management at a university hospital...
  100. ncbi request reprint [Sepsis. Update on pathophysiology, diagnostics and therapy]
    M Bauer
    Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller Universität, Erlanger Allee 101, 07740 Jena
    Anaesthesist 55:835-45. 2006
    ..e. a reduction of mortality by 25% within the next 5 years...
  101. doi request reprint Mass spectometry-based protein patterns in the diagnosis of sepsis/systemic inflammatory response syndrome
    Michael Kiehntopf
    Institute of Clinical Chemistry and Laboratory Medicine, Jena University Hospital, Friedrich Schiller University Jena, Germany
    Shock 36:560-9. 2011
    ..Identification of discriminatory proteins suggests a direct link between infectious-related protease activity and a sepsis-specific diagnostic pattern for discrimination of patients with SIRS...