Beatrice L Pool-Zobel

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. ncbi request reprint Mechanisms by which vegetable consumption reduces genetic damage in humans
    B L Pool-Zobel
    Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Karlsruhe, Germany
    Cancer Epidemiol Biomarkers Prev 7:891-9. 1998
  2. ncbi request reprint Genetic damage and repair in human rectal cells for biomonitoring: sex differences, effects of alcohol exposure, and susceptibilities in comparison to peripheral blood lymphocytes
    B L Pool-Zobel
    Department of Nutritional Toxicology, Director of the Institute for Nutrition, Friedrich Schiller University of Jena, Dornburger Str 25, 07743 Jena, Germany
    Mutat Res 551:127-34. 2004
  3. ncbi request reprint Butyrate may enhance toxicological defence in primary, adenoma and tumor human colon cells by favourably modulating expression of glutathione S-transferases genes, an approach in nutrigenomics
    Beatrice Louise Pool-Zobel
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Dornburger Strasse 25, D 07743 Jena, Germany
    Carcinogenesis 26:1064-76. 2005
  4. ncbi request reprint Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data
    Beatrice L Pool-Zobel
    Department of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich Schiller University Jena, Germany
    Br J Nutr 93:S73-90. 2005
  5. ncbi request reprint Modulation of xenobiotic metabolising enzymes by anticarcinogens -- focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis
    Beatrice Pool-Zobel
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University Jena, 07743 Jena, Germany
    Mutat Res 591:74-92. 2005
  6. ncbi request reprint Overview of experimental data on reduction of colorectal cancer risk by inulin-type fructans
    Beatrice L Pool-Zobel
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Jena, Germany
    J Nutr 137:2580S-2584S. 2007
  7. ncbi request reprint Experimental evidences on the potential of prebiotic fructans to reduce the risk of colon cancer
    B Pool-Zobel
    Institute for Nutrition, Department of Nutritional Toxicology, Friedrich Schiller University Jena, Germany
    Br J Nutr 87:S273-81. 2002
  8. ncbi request reprint Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cells
    B L Pool-Zobel
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Dornburger Strabetae 25, 07743 Jena, Germany
    Carcinogenesis 21:1247-52. 2000
  9. ncbi request reprint Anthocyanins are potent antioxidants in model systems but do not reduce endogenous oxidative DNA damage in human colon cells
    B L Pool-Zobel
    Friedrich Schiller University of Jena, Department of Nutritional Toxicology, Germany
    Eur J Nutr 38:227-34. 1999
  10. ncbi request reprint Analysis of DNA strand breaks, oxidized bases, and glutathione S-transferase P1 in human colon cells from biopsies
    B L Pool-Zobel
    Institute of Nutritional Physiology, Federal Center for Nutrition Research, Karlsruhe, Germany
    Cancer Epidemiol Biomarkers Prev 8:609-14. 1999

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Mechanisms by which vegetable consumption reduces genetic damage in humans
    B L Pool-Zobel
    Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Karlsruhe, Germany
    Cancer Epidemiol Biomarkers Prev 7:891-9. 1998
    ..Enhancement of cytosolic proteins may be indicative of increased gene expression by vegetable juices, some of which may be associated with protective activities...
  2. ncbi request reprint Genetic damage and repair in human rectal cells for biomonitoring: sex differences, effects of alcohol exposure, and susceptibilities in comparison to peripheral blood lymphocytes
    B L Pool-Zobel
    Department of Nutritional Toxicology, Director of the Institute for Nutrition, Friedrich Schiller University of Jena, Dornburger Str 25, 07743 Jena, Germany
    Mutat Res 551:127-34. 2004
    ..Peripheral blood lymphocytes were additionally monitored to assess systemic exposure loads...
  3. ncbi request reprint Butyrate may enhance toxicological defence in primary, adenoma and tumor human colon cells by favourably modulating expression of glutathione S-transferases genes, an approach in nutrigenomics
    Beatrice Louise Pool-Zobel
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Dornburger Strasse 25, D 07743 Jena, Germany
    Carcinogenesis 26:1064-76. 2005
    ..An induction of the toxicological defence system possibly contributes to reported chemopreventive properties of butyrate, a product of dietary fibre fermentation in the gut...
  4. ncbi request reprint Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data
    Beatrice L Pool-Zobel
    Department of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich Schiller University Jena, Germany
    Br J Nutr 93:S73-90. 2005
    ..Thus, this specific type of dietary fibre exerted both blocking agent and suppressing agent types of chemopreventive activities...
  5. ncbi request reprint Modulation of xenobiotic metabolising enzymes by anticarcinogens -- focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis
    Beatrice Pool-Zobel
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University Jena, 07743 Jena, Germany
    Mutat Res 591:74-92. 2005
    ..In the future, it will be useful to determine GSTs during dietary intervention studies to enhance our understanding of this protective mechanism...
  6. ncbi request reprint Overview of experimental data on reduction of colorectal cancer risk by inulin-type fructans
    Beatrice L Pool-Zobel
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Jena, Germany
    J Nutr 137:2580S-2584S. 2007
    ..The involved mechanisms possibly include reduction of exposure to risk factors and suppression of tumor cell survival...
  7. ncbi request reprint Experimental evidences on the potential of prebiotic fructans to reduce the risk of colon cancer
    B Pool-Zobel
    Institute for Nutrition, Department of Nutritional Toxicology, Friedrich Schiller University Jena, Germany
    Br J Nutr 87:S273-81. 2002
    ..In order to obtain more insight into this possibility, human dietary intervention studies relating biomarkers of reduced risk to inulin consumption are needed...
  8. ncbi request reprint Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cells
    B L Pool-Zobel
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Dornburger Strabetae 25, 07743 Jena, Germany
    Carcinogenesis 21:1247-52. 2000
    ..The genotoxic effects of genistein deserve further investigation...
  9. ncbi request reprint Anthocyanins are potent antioxidants in model systems but do not reduce endogenous oxidative DNA damage in human colon cells
    B L Pool-Zobel
    Friedrich Schiller University of Jena, Department of Nutritional Toxicology, Germany
    Eur J Nutr 38:227-34. 1999
    ..This points to their potential for providing systemic protection in vivo, e.g., by scavenging oxidants in the blood stream and in the colon. Notably, both aglycons and glycosides have equally strong antioxidant activity...
  10. ncbi request reprint Analysis of DNA strand breaks, oxidized bases, and glutathione S-transferase P1 in human colon cells from biopsies
    B L Pool-Zobel
    Institute of Nutritional Physiology, Federal Center for Nutrition Research, Karlsruhe, Germany
    Cancer Epidemiol Biomarkers Prev 8:609-14. 1999
    ..Lipid peroxidation is a possible risk factor. Together with GST as a potential biomarker of chemoprevention, the technique may serve as a valuable biomarker to assess exposure to risk factors...
  11. ncbi request reprint Comet fluorescence in situ hybridization analysis for oxidative stress-induced DNA damage in colon cancer relevant genes
    Michael Glei
    Institute for Nutrition, Dornburger Strasse 25, Friedrich Schiller University Jena, 07743 Jena, Germany
    Toxicol Sci 96:279-84. 2007
    ..This new experimental approach facilitates studies on effects of nutrition-related carcinogens in relevant target genes...
  12. ncbi request reprint Bread enriched with green coffee extract has chemoprotective and antigenotoxic activities in human cells
    Michael Glei
    Friedrich Schiller University Jena Department of Nutritional Toxicology, Institute for Nutrition, Jena, Germany
    Nutr Cancer 56:182-92. 2006
    ..Supplementation also increases ChA content and antioxidative capacity. The treatment of the cells with supplemented bread increases resistance of colon and liver cells against H(2)O(2), a source of oxidative stress...
  13. ncbi request reprint Hemoglobin and hemin induce DNA damage in human colon tumor cells HT29 clone 19A and in primary human colonocytes
    Michael Glei
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Dornburger Str 25, D 07743 Jena, Germany
    Mutat Res 594:162-71. 2006
    ..Thus, hemoglobin/hemin, whether available from red meat or from bowel bleeding, may pose genotoxic and cytotoxic risks to human colon cells, both of which contribute to initiation and progression of colorectal carcinogenesis...
  14. ncbi request reprint Fruit juice consumption modulates antioxidative status, immune status and DNA damage
    Achim Bub
    Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Haid und Neu Str 9, 76131 Karlsruhe, Germany
    J Nutr Biochem 14:90-8. 2003
    ..Further studies should focus on the time-delay between juice intake and changes in measured physiological functions, as well as on active polyphenolic metabolites mediating the observed effects...
  15. ncbi request reprint Fecal water genotoxicity is predictive of tumor-preventive activities by inulin-like oligofructoses, probiotics (Lactobacillus rhamnosus and Bifidobacterium lactis), and their synbiotic combination
    Annett Klinder
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Jena, Germany
    Nutr Cancer 49:144-55. 2004
    ....
  16. ncbi request reprint 2-Dodecylcyclobutanone, a radiolytic product of palmitic acid, is genotoxic in primary human colon cells and in cells from preneoplastic lesions
    Nadine Knoll
    Department of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich Schiller University, Dornburger Strasse 25, D 07743 Jena, Germany
    Mutat Res 594:10-9. 2006
    ..These findings provide additional evidence that this compound may be regarded as a possible risk factor for processes in colon carcinogenesis related to initiation and progression...
  17. ncbi request reprint Influence of prebiotics and antioxidants in bread on the immune system, antioxidative status and antioxidative capacity in male smokers and non-smokers
    Christiane Seidel
    Friedrich Schiller University, Institute of Nutrition, Dornburger Strasse 24 29, D 07743 Jena, Germany
    Br J Nutr 97:349-56. 2007
    ....
  18. ncbi request reprint Butyrate is only one of several growth inhibitors produced during gut flora-mediated fermentation of dietary fibre sources
    Gabriele Beyer-Sehlmeyer
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Dornburger Str 25, D 07743 Jena, Germany
    Br J Nutr 90:1057-70. 2003
    ....
  19. ncbi request reprint Genistein protects human mammary epithelial cells from benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide and 4-hydroxy-2-nonenal genotoxicity by modulating the glutathione/glutathione S-transferase system
    Claudia Steiner
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University Jena, Dornburger Strasse 25, 07743 Jena, Germany
    Carcinogenesis 28:738-48. 2007
    ....
  20. ncbi request reprint Both wheat (Triticum aestivum) bran arabinoxylans and gut flora-mediated fermentation products protect human colon cells from genotoxic activities of 4-hydroxynonenal and hydrogen peroxide
    Michael Glei
    Department of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Strasse 25, 07743 Jena, Germany
    J Agric Food Chem 54:2088-95. 2006
    ..Thus, increases in SCFAs were not reflected by enhanced functional effects. The conclusion is that fermentation mixtures contain modulatory compounds that arise from the feces and might add to the effectiveness of SCFAs...
  21. ncbi request reprint Fecal water as a non-invasive biomarker in nutritional intervention: comparison of preparation methods and refinement of different endpoints
    Annett Klinder
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Jena, Germany
    Nutr Cancer 57:158-67. 2007
    ..The higher volumes of FW obtained by preparation method B greatly enhance the perspectives of measuring different types of biological parameters and using these to disclose activities related to cancer development...
  22. ncbi request reprint Reduced isoflavone metabolites formed by the human gut microflora suppress growth but do not affect DNA integrity of human prostate cancer cells
    Marian Raschke
    Institute for Nutritional Sciences, Department of Nutritional Toxicology, Friedrich Schiller University, Dornburger Strasse 25, 07743 Jena, Germany
    Br J Nutr 96:426-34. 2006
    ..Taken together, these data suggest a contribution of gut-formed isoflavone metabolites to the beneficial effects of dietary isoflavones on prostate cancer risk...
  23. ncbi request reprint Genotoxicity of 4-hydroxy-2-nonenal in human colon tumor cells is associated with cellular levels of glutathione and the modulation of glutathione S-transferase A4 expression by butyrate
    Nadine Knoll
    Department of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich Schiller University, Dornburger Strasse 25, D 07743 Jena, Germany
    Toxicol Sci 86:27-35. 2005
    ..Since HNE contributes to colon carcinogenesis, the favorable modulation of the GSH/GST system by butyrate may contribute to chemoprevention and reduction of the risks...
  24. doi request reprint Use of Comet-FISH in the study of DNA damage and repair: review
    Michael Glei
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University Jena, Dornburger Street 24, 07743 Jena, Germany
    Mutat Res 681:33-43. 2009
    ....
  25. ncbi request reprint Dietary intervention with the probiotics Lactobacillus acidophilus 145 and Bifidobacterium longum 913 modulates the potential of human faecal water to induce damage in HT29clone19A cells
    Daniela L Oberreuther-Moschner
    Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Haid und Neu Strabetae 9, 76131 Karlsruhe, Germany
    Br J Nutr 91:925-32. 2004
    ..This protection reflected results from previous studies in carcinogen-exposed animals where probiotics reduced DNA damage in colon cells...
  26. doi request reprint Does an extract of carob (Ceratonia siliqua L.) have chemopreventive potential related to oxidative stress and drug metabolism in human colon cells?
    Stefanie Klenow
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University Jena, Dornburger Strasse 24, 07743 Jena, Germany
    J Agric Food Chem 57:2999-3004. 2009
    ..Upregulation of stress-response genes could not be related to functional consequences...
  27. doi request reprint Effects of fatty acids on metabolism and cell growth of human colon cell lines of different transformation state
    Nina Habermann
    Department for Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Strasse 24, D 07743 Jena, Germany
    Biofactors 35:460-7. 2009
    ..ALA or GLA were less growth inhibitory than EPA or DHA and ARA had intermediary activity. The data show that the tested FAs are incorporated into colon cells. Furthermore, adenoma cells are more susceptible than the adenocarcinoma cells...
  28. ncbi request reprint Basal colon crypt cells are more sensitive than surface cells toward hydrogen peroxide, a factor of oxidative stress
    Daniela L Oberreuther-Moschner
    Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Haid und Neu Strasse 9, Karlsruhe, Germany
    Toxicol Lett 159:212-8. 2005
    ..We conclude that cells from lower crypt sections are more sensitive towards H(2)O(2) than differentiated cells at the surface of the crypt...
  29. ncbi request reprint The gut fermentation product butyrate, a chemopreventive agent, suppresses glutathione S-transferase theta (hGSTT1) and cell growth more in human colon adenoma (LT97) than tumor (HT29) cells
    Tanja Kautenburger
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Jena, Germany
    J Cancer Res Clin Oncol 131:692-700. 2005
    ..Here we investigated kinetics of effects in HT29 and compared sensitivities with preneoplastic LT97 colon adenoma cells, to assess mechanisms of colon cancer chemoprevention in two stages of cell transformation...
  30. ncbi request reprint Influence of inorganic and organic iron compounds on parameters of cell growth and survival in human colon cells
    Stefanie Klenow
    Friedrich Schiller University Jena, Department of Nutritional Toxicology, Institute for Nutritional Sciences, Dornburger Str 24, 07743 Jena, Germany
    Toxicol In Vitro 23:400-7. 2009
    ..Since promotion of proliferation was only detectable under deficiency, cytotoxic properties of organic iron may be of more importance in colon carcinogenesis...
  31. ncbi request reprint Genistein protects prostate cells against hydrogen peroxide-induced DNA damage and induces expression of genes involved in the defence against oxidative stress
    Marian Raschke
    Department of Nutritional Toxicology, Friedrich Schiller University of Jena, Dornburger Strasse 25, 07743 Jena Germany
    Carcinogenesis 27:2322-30. 2006
    ..Genistein, therefore, might counteract the age-related decline of important antioxidative defence systems which in turn maintain DNA integrity...
  32. ncbi request reprint Mixtures of SCFA, composed according to physiologically available concentrations in the gut lumen, modulate histone acetylation in human HT29 colon cancer cells
    Jeannette Kiefer
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Dornburger Str 25, D 07743 Jena, Germany
    Br J Nutr 96:803-10. 2006
    ..Together, these SCFA could possibly mediate important processes related to an altered transcriptional gene activation and thus contribute to biological effects possibly related to cancer progression or prevention...
  33. ncbi request reprint Iron-overload induces oxidative DNA damage in the human colon carcinoma cell line HT29 clone 19A
    Michael Glei
    Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University, Dornburger Street 25, 07743 Jena, Germany
    Mutat Res 519:151-61. 2002
    ..g. from red meat) relative to the concentrations of antioxidants (from plant foods) in the gut are now needed to determine the optimal balance of food intake that will reduce exposure to this type of colon cancer risk factor...
  34. ncbi request reprint Colon cancer risk factors from nutrition
    Jens Berlau
    Dept of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich Schiller University of Jena, Dornburger Strasse 25, 07743 Jena, Germany
    Anal Bioanal Chem 378:737-43. 2004
    ..Knowledge of individual susceptibility will also make it possible to recognise risks and design more specific nutritional recommendations...
  35. ncbi request reprint New revival of an old biomarker: characterisation of buccal cells and determination of genetic damage in the isolated fraction of viable leucocytes
    Kerstin Osswald
    Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, Domburger Street, 25, 07743 Jena, Germany
    Mutat Res 544:321-9. 2003
    ..The cells are useful targets of non-invasive biomarkers, which could be incorporated as tools in many types of intervention studies...
  36. pmc Modulation of gene expression in eicosapentaenoic acid and docosahexaenoic acid treated human colon adenoma cells
    Nina Habermann
    Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University Jena, Dornburger Strasse 24, 07743, Jena, Germany
    Genes Nutr 4:73-6. 2009
    ..In our approach, we used preneoplastic adenoma cells which are a relevant model for target cells of chemoprevention. If verified with real time PCR, these results identify genes and targets for chemoprevention of colon cancer...
  37. ncbi request reprint Precise breakpoint characterization of the colon adenocarcinoma cell line HT-29 clone 19A by means of 24-color fluorescence in situ hybridization and multicolor banding
    Alma Kuechler
    Genes Chromosomes Cancer 36:207-10. 2003
  38. doi request reprint Antioxidant effectiveness of phenolic apple juice extracts and their gut fermentation products in the human colon carcinoma cell line caco-2
    Phillip Bellion
    Division of Food Chemistry and Toxicology, Department of Chemistry, University of Kaiserslautern, Erwin Schroedinger Str 52, D 67663 Kaiserslautern, Germany
    J Agric Food Chem 56:6310-7. 2008
    ..In conclusion, F-AEs/degradation products exhibit antioxidant activity in colon cells but to a lesser extent than the respective unfermented AEs/constituents...
  39. ncbi request reprint Emerging diet-related surrogate end points for colorectal cancer: UK Food Standards Agency diet and colonic health workshop report
    Peter Sanderson
    Nutrition Division, Food Standards Agency, London, UK
    Br J Nutr 91:315-23. 2004
    ....
  40. ncbi request reprint Equol: a comparison of the effects of the racemic compound with that of the purified S-enantiomer on the growth, invasion, and DNA integrity of breast and prostate cells in vitro
    Pamela J Magee
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland
    Nutr Cancer 54:232-42. 2006
    ....
  41. ncbi request reprint Ursodeoxycholic acid intervention in patients with familial adenomatous polyposis: a pilot study
    Marloes Berkhout
    Transl Res 150:147-9. 2007
  42. doi request reprint Effects of carrot and tomato juice consumption on faecal markers relevant to colon carcinogenesis in humans
    Kerstin Schnäbele
    Chair of the Biofunctionality of Food, Department of Food and Nutrition, Technical University of Munich, Hochfeldweg 1, 85350 Freising, Germany
    Br J Nutr 99:606-13. 2008
    ..In summary, in the present study, 2-week interventions with carotenoid-rich juices led only to minor changes in investigated luminal biomarkers relevant to colon carcinogenesis...
  43. ncbi request reprint Blood mononucleocytes are sensitive to the DNA damaging effects of iron overload--in vitro and ex vivo results with human and rat cells
    Eunju Park
    Department of Food and Nutrition, Kyungnam University, 449 Wolyoung dong, Masan 631 701, South Korea
    Mutat Res 619:59-67. 2007
    ..The measurement of DNA damage in human leucocytes could be used as a sensitive biomarker to study iron overload in vivo in humans and thus to determine whether supplementation results in genotoxic risk...