Research Topics
| Beatrice L Pool-ZobelSummaryAffiliation: Friedrich Schiller University Country: Germany Publications
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Detail Information
Publications
Mechanisms by which vegetable consumption reduces genetic damage in humansB L Pool-Zobel
Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Karlsruhe, Germany
Cancer Epidemiol Biomarkers Prev 7:891-9. 1998..Enhancement of cytosolic proteins may be indicative of increased gene expression by vegetable juices, some of which may be associated with protective activities...- Genetic damage and repair in human rectal cells for biomonitoring: sex differences, effects of alcohol exposure, and susceptibilities in comparison to peripheral blood lymphocytesB L Pool-Zobel
Department of Nutritional Toxicology, Director of the Institute for Nutrition, Friedrich Schiller University of Jena, Dornburger Str 25, 07743 Jena, Germany
Mutat Res 551:127-34. 2004..Peripheral blood lymphocytes were additionally monitored to assess systemic exposure loads... - Butyrate may enhance toxicological defence in primary, adenoma and tumor human colon cells by favourably modulating expression of glutathione S-transferases genes, an approach in nutrigenomicsBeatrice Louise Pool-Zobel
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Dornburger Strasse 25, D 07743 Jena, Germany
Carcinogenesis 26:1064-76. 2005..An induction of the toxicological defence system possibly contributes to reported chemopreventive properties of butyrate, a product of dietary fibre fermentation in the gut... - Inulin-type fructans and reduction in colon cancer risk: review of experimental and human dataBeatrice L Pool-Zobel
Department of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich Schiller University Jena, Germany
Br J Nutr 93:S73-90. 2005..Thus, this specific type of dietary fibre exerted both blocking agent and suppressing agent types of chemopreventive activities... - Modulation of xenobiotic metabolising enzymes by anticarcinogens -- focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesisBeatrice Pool-Zobel
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University Jena, 07743 Jena, Germany
Mutat Res 591:74-92. 2005..In the future, it will be useful to determine GSTs during dietary intervention studies to enhance our understanding of this protective mechanism... - Overview of experimental data on reduction of colorectal cancer risk by inulin-type fructansBeatrice L Pool-Zobel
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Jena, Germany
J Nutr 137:2580S-2584S. 2007..The involved mechanisms possibly include reduction of exposure to risk factors and suppression of tumor cell survival... - Experimental evidences on the potential of prebiotic fructans to reduce the risk of colon cancerB Pool-Zobel
Institute for Nutrition, Department of Nutritional Toxicology, Friedrich Schiller University Jena, Germany
Br J Nutr 87:S273-81. 2002..In order to obtain more insight into this possibility, human dietary intervention studies relating biomarkers of reduced risk to inulin consumption are needed... - Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cellsB L Pool-Zobel
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Dornburger Strabetae 25, 07743 Jena, Germany
Carcinogenesis 21:1247-52. 2000..The genotoxic effects of genistein deserve further investigation... - Anthocyanins are potent antioxidants in model systems but do not reduce endogenous oxidative DNA damage in human colon cellsB L Pool-Zobel
Friedrich Schiller University of Jena, Department of Nutritional Toxicology, Germany
Eur J Nutr 38:227-34. 1999..This points to their potential for providing systemic protection in vivo, e.g., by scavenging oxidants in the blood stream and in the colon. Notably, both aglycons and glycosides have equally strong antioxidant activity... - Analysis of DNA strand breaks, oxidized bases, and glutathione S-transferase P1 in human colon cells from biopsiesB L Pool-Zobel
Institute of Nutritional Physiology, Federal Center for Nutrition Research, Karlsruhe, Germany
Cancer Epidemiol Biomarkers Prev 8:609-14. 1999..Lipid peroxidation is a possible risk factor. Together with GST as a potential biomarker of chemoprevention, the technique may serve as a valuable biomarker to assess exposure to risk factors... - Comet fluorescence in situ hybridization analysis for oxidative stress-induced DNA damage in colon cancer relevant genesMichael Glei
Institute for Nutrition, Dornburger Strasse 25, Friedrich Schiller University Jena, 07743 Jena, Germany
Toxicol Sci 96:279-84. 2007..This new experimental approach facilitates studies on effects of nutrition-related carcinogens in relevant target genes... - Bread enriched with green coffee extract has chemoprotective and antigenotoxic activities in human cellsMichael Glei
Friedrich Schiller University Jena Department of Nutritional Toxicology, Institute for Nutrition, Jena, Germany
Nutr Cancer 56:182-92. 2006..Supplementation also increases ChA content and antioxidative capacity. The treatment of the cells with supplemented bread increases resistance of colon and liver cells against H(2)O(2), a source of oxidative stress... - Influence of prebiotics and antioxidants in bread on the immune system, antioxidative status and antioxidative capacity in male smokers and non-smokersChristiane Seidel
Friedrich Schiller University, Institute of Nutrition, Dornburger Strasse 24 29, D 07743 Jena, Germany
Br J Nutr 97:349-56. 2007.... - Fruit juice consumption modulates antioxidative status, immune status and DNA damageAchim Bub
Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Haid und Neu Str 9, 76131 Karlsruhe, Germany
J Nutr Biochem 14:90-8. 2003..Further studies should focus on the time-delay between juice intake and changes in measured physiological functions, as well as on active polyphenolic metabolites mediating the observed effects... - 2-Dodecylcyclobutanone, a radiolytic product of palmitic acid, is genotoxic in primary human colon cells and in cells from preneoplastic lesionsNadine Knoll
Department of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich Schiller University, Dornburger Strasse 25, D-07743 Jena, Germany
Mutat Res 594:10-9. 2006..These findings provide additional evidence that this compound may be regarded as a possible risk factor for processes in colon carcinogenesis related to initiation and progression... - Fecal water genotoxicity is predictive of tumor-preventive activities by inulin-like oligofructoses, probiotics (Lactobacillus rhamnosus and Bifidobacterium lactis), and their synbiotic combinationAnnett Klinder
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Jena, Germany
Nutr Cancer 49:144-55. 2004.... - Hemoglobin and hemin induce DNA damage in human colon tumor cells HT29 clone 19A and in primary human colonocytesMichael Glei
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Dornburger Str 25, D 07743 Jena, Germany
Mutat Res 594:162-71. 2006..Thus, hemoglobin/hemin, whether available from red meat or from bowel bleeding, may pose genotoxic and cytotoxic risks to human colon cells, both of which contribute to initiation and progression of colorectal carcinogenesis... - Butyrate is only one of several growth inhibitors produced during gut flora-mediated fermentation of dietary fibre sourcesGabriele Beyer-Sehlmeyer
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Dornburger Str. 25, D-07743 Jena, Germany
Br J Nutr 90:1057-70. 2003.... - Genistein protects human mammary epithelial cells from benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide and 4-hydroxy-2-nonenal genotoxicity by modulating the glutathione/glutathione S-transferase systemClaudia Steiner
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University Jena, Dornburger Strasse 25, 07743 Jena, Germany
Carcinogenesis 28:738-48. 2007.... - Fecal water as a non-invasive biomarker in nutritional intervention: comparison of preparation methods and refinement of different endpointsAnnett Klinder
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Jena, Germany
Nutr Cancer 57:158-67. 2007..The higher volumes of FW obtained by preparation method B greatly enhance the perspectives of measuring different types of biological parameters and using these to disclose activities related to cancer development... - Both wheat (Triticum aestivum) bran arabinoxylans and gut flora-mediated fermentation products protect human colon cells from genotoxic activities of 4-hydroxynonenal and hydrogen peroxideMichael Glei
Department of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Strasse 25, 07743 Jena, Germany
J Agric Food Chem 54:2088-95. 2006..Thus, increases in SCFAs were not reflected by enhanced functional effects. The conclusion is that fermentation mixtures contain modulatory compounds that arise from the feces and might add to the effectiveness of SCFAs... - Reduced isoflavone metabolites formed by the human gut microflora suppress growth but do not affect DNA integrity of human prostate cancer cellsMarian Raschke
Institute for Nutritional Sciences, Department of Nutritional Toxicology, Friedrich-Schiller-University, Dornburger Strasse 25, 07743 Jena, Germany
Br J Nutr 96:426-34. 2006..Taken together, these data suggest a contribution of gut-formed isoflavone metabolites to the beneficial effects of dietary isoflavones on prostate cancer risk... - Genotoxicity of 4-hydroxy-2-nonenal in human colon tumor cells is associated with cellular levels of glutathione and the modulation of glutathione S-transferase A4 expression by butyrateNadine Knoll
Department of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich Schiller University, Dornburger Strasse 25, D-07743 Jena, Germany
Toxicol Sci 86:27-35. 2005..Since HNE contributes to colon carcinogenesis, the favorable modulation of the GSH/GST system by butyrate may contribute to chemoprevention and reduction of the risks... 
Use of Comet-FISH in the study of DNA damage and repair: reviewMichael Glei
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University Jena, Dornburger Street 24, 07743 Jena, Germany
Mutat Res 681:33-43. 2009....- Dietary intervention with the probiotics Lactobacillus acidophilus 145 and Bifidobacterium longum 913 modulates the potential of human faecal water to induce damage in HT29clone19A cellsDaniela L Oberreuther-Moschner
Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Haid-und-Neu-Strabetae 9, 76131 Karlsruhe, Germany
Br J Nutr 91:925-32. 2004..This protection reflected results from previous studies in carcinogen-exposed animals where probiotics reduced DNA damage in colon cells... - Does an extract of carob (Ceratonia siliqua L.) have chemopreventive potential related to oxidative stress and drug metabolism in human colon cells?Stefanie Klenow
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University Jena, Dornburger Strasse 24, 07743 Jena, Germany
J Agric Food Chem 57:2999-3004. 2009..Upregulation of stress-response genes could not be related to functional consequences... - Effects of fatty acids on metabolism and cell growth of human colon cell lines of different transformation stateNina Habermann
Department for Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Strasse 24, D 07743 Jena, Germany
Biofactors 35:460-7. 2009..ALA or GLA were less growth inhibitory than EPA or DHA and ARA had intermediary activity. The data show that the tested FAs are incorporated into colon cells. Furthermore, adenoma cells are more susceptible than the adenocarcinoma cells... - Basal colon crypt cells are more sensitive than surface cells toward hydrogen peroxide, a factor of oxidative stressDaniela L Oberreuther-Moschner
Institute of Nutritional Physiology, Federal Research Centre for Nutrition, Haid-und-Neu-Strasse 9, Karlsruhe, Germany
Toxicol Lett 159:212-8. 2005..We conclude that cells from lower crypt sections are more sensitive towards H(2)O(2) than differentiated cells at the surface of the crypt... - The gut fermentation product butyrate, a chemopreventive agent, suppresses glutathione S-transferase theta (hGSTT1) and cell growth more in human colon adenoma (LT97) than tumor (HT29) cellsTanja Kautenburger
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich-Schiller-University, Jena, Germany
J Cancer Res Clin Oncol 131:692-700. 2005..These findings indicate that butyrate formation in the gut lumen of humans could be protective by reducing survival of transformed colon cells... - Influence of inorganic and organic iron compounds on parameters of cell growth and survival in human colon cellsStefanie Klenow
Friedrich Schiller University Jena, Department of Nutritional Toxicology, Institute for Nutritional Sciences, Dornburger Str 24, 07743 Jena, Germany
Toxicol In Vitro 23:400-7. 2009..Since promotion of proliferation was only detectable under deficiency, cytotoxic properties of organic iron may be of more importance in colon carcinogenesis... - Genistein protects prostate cells against hydrogen peroxide-induced DNA damage and induces expression of genes involved in the defence against oxidative stressMarian Raschke
Department of Nutritional Toxicology, Friedrich-Schiller-University of Jena, Dornburger Strasse 25, 07743 Jena Germany
Carcinogenesis 27:2322-30. 2006..Genistein, therefore, might counteract the age-related decline of important antioxidative defence systems which in turn maintain DNA integrity... - Mixtures of SCFA, composed according to physiologically available concentrations in the gut lumen, modulate histone acetylation in human HT29 colon cancer cellsJeannette Kiefer
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich-Schiller-University, Dornburger Str. 25, D-07743 Jena, Germany
Br J Nutr 96:803-10. 2006..Together, these SCFA could possibly mediate important processes related to an altered transcriptional gene activation and thus contribute to biological effects possibly related to cancer progression or prevention... - Iron-overload induces oxidative DNA damage in the human colon carcinoma cell line HT29 clone 19AMichael Glei
Department of Nutritional Toxicology, Institute of Nutrition, Friedrich-Schiller-University, Dornburger Street 25, 07743 Jena, Germany
Mutat Res 519:151-61. 2002..g. from red meat) relative to the concentrations of antioxidants (from plant foods) in the gut are now needed to determine the optimal balance of food intake that will reduce exposure to this type of colon cancer risk factor... - Colon cancer risk factors from nutritionJens Berlau
Dept of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich Schiller University of Jena, Dornburger Strasse 25, 07743 Jena, Germany
Anal Bioanal Chem 378:737-43. 2004..Knowledge of individual susceptibility will also make it possible to recognise risks and design more specific nutritional recommendations... - New revival of an old biomarker: characterisation of buccal cells and determination of genetic damage in the isolated fraction of viable leucocytesKerstin Osswald
Department of Nutritional Toxicology, Institute of Nutrition, Friedrich-Schiller-University Jena, Domburger Street, 25, 07743 Jena, Germany
Mutat Res 544:321-9. 2003..The cells are useful targets of non-invasive biomarkers, which could be incorporated as tools in many types of intervention studies... 
Modulation of gene expression in eicosapentaenoic acid and docosahexaenoic acid treated human colon adenoma cellsNina Habermann
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University Jena, Dornburger Strasse 24, 07743, Jena, Germany
Genes Nutr 4:73-6. 2009..In our approach, we used preneoplastic adenoma cells which are a relevant model for target cells of chemoprevention. If verified with real time PCR, these results identify genes and targets for chemoprevention of colon cancer...- Precise breakpoint characterization of the colon adenocarcinoma cell line HT-29 clone 19A by means of 24-color fluorescence in situ hybridization and multicolor bandingAlma Kuechler
Genes Chromosomes Cancer 36:207-10. 2003 - Antioxidant effectiveness of phenolic apple juice extracts and their gut fermentation products in the human colon carcinoma cell line caco-2Phillip Bellion
Division of Food Chemistry and Toxicology, Department of Chemistry, University of Kaiserslautern, Erwin Schroedinger Str 52, D 67663 Kaiserslautern, Germany
J Agric Food Chem 56:6310-7. 2008..In conclusion, F-AEs/degradation products exhibit antioxidant activity in colon cells but to a lesser extent than the respective unfermented AEs/constituents... - Emerging diet-related surrogate end points for colorectal cancer: UK Food Standards Agency diet and colonic health workshop reportPeter Sanderson
Nutrition Division, Food Standards Agency, London, UK
Br J Nutr 91:315-23. 2004.... - Equol: a comparison of the effects of the racemic compound with that of the purified S-enantiomer on the growth, invasion, and DNA integrity of breast and prostate cells in vitroPamela J Magee
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland
Nutr Cancer 54:232-42. 2006.... - Ursodeoxycholic acid intervention in patients with familial adenomatous polyposis: a pilot studyMarloes Berkhout
Transl Res 150:147-9. 2007 - Effects of carrot and tomato juice consumption on faecal markers relevant to colon carcinogenesis in humansKerstin Schnäbele
Chair of the Biofunctionality of Food, Department of Food and Nutrition, Technical University of Munich, Hochfeldweg 1, 85350 Freising, Germany
Br J Nutr 99:606-13. 2008..In summary, in the present study, 2-week interventions with carotenoid-rich juices led only to minor changes in investigated luminal biomarkers relevant to colon carcinogenesis... - Blood mononucleocytes are sensitive to the DNA damaging effects of iron overload--in vitro and ex vivo results with human and rat cellsEunju Park
Department of Food and Nutrition, Kyungnam University, 449 Wolyoung dong, Masan 631 701, South Korea
Mutat Res 619:59-67. 2007..The measurement of DNA damage in human leucocytes could be used as a sensitive biomarker to study iron overload in vivo in humans and thus to determine whether supplementation results in genotoxic risk...