Igor Nenadic

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. doi request reprint Effects of olanzapine on 31P MRS metabolic markers in schizophrenia
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany
    Hum Psychopharmacol 28:91-3. 2013
  2. doi request reprint Glutamate receptor δ 1 (GRID1) genetic variation and brain structure in schizophrenia
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743 Jena, Germany
    J Psychiatr Res 46:1531-9. 2012
  3. doi request reprint Heterogeneity of brain structural variation and the structural imaging endophenotypes in schizophrenia
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany
    Neuropsychobiology 66:44-9. 2012
  4. pmc Aging effects on regional brain structural changes in schizophrenia
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University of Jena, Philosophenweg 3, D 07743 Jena, Germany
    Schizophr Bull 38:838-44. 2012
  5. doi request reprint Distinct pattern of brain structural deficits in subsyndromes of schizophrenia delineated by psychopathology
    Igor Nenadic
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, D 07743 Jena, Germany
    Neuroimage 49:1153-60. 2010
  6. doi request reprint ADC changes in schizophrenia: a diffusion-weighted imaging study
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University of Jena, Philosophenweg 3, 07743, Jena, Germany
    Eur Arch Psychiatry Clin Neurosci 261:213-6. 2011
  7. ncbi request reprint Processing of temporal information and the basal ganglia: new evidence from fMRI
    Igor Nenadic
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, 07740 Jena, Germany
    Exp Brain Res 148:238-46. 2003
  8. doi request reprint Auditory hallucinations and brain structure in schizophrenia: voxel-based morphometric study
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University of Jena, Philosophenweg 3, D 07743 Jena, Germany
    Br J Psychiatry 196:412-3. 2010
  9. doi request reprint Targeting brain regions and symptoms: neuronal single-unit recordings and deep brain stimulation in obsessive-compulsive disorder
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University of Jena, Philosophenweg 3, D 07743 Jena, Germany
    Biol Psychiatry 63:542-3. 2008
  10. ncbi request reprint White matter abnormalities and brain activation in schizophrenia: a combined DTI and fMRI study
    Ralf G M Schlösser
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University, 07743 Jena, Germany
    Schizophr Res 89:1-11. 2007

Detail Information

Publications38

  1. doi request reprint Effects of olanzapine on 31P MRS metabolic markers in schizophrenia
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany
    Hum Psychopharmacol 28:91-3. 2013
    ..This suggests a shift in high-energy phosphates (rather than phospholipids), possibly related to normalisation of functioning in these areas...
  2. doi request reprint Glutamate receptor δ 1 (GRID1) genetic variation and brain structure in schizophrenia
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743 Jena, Germany
    J Psychiatr Res 46:1531-9. 2012
    ....
  3. doi request reprint Heterogeneity of brain structural variation and the structural imaging endophenotypes in schizophrenia
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany
    Neuropsychobiology 66:44-9. 2012
    ....
  4. pmc Aging effects on regional brain structural changes in schizophrenia
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University of Jena, Philosophenweg 3, D 07743 Jena, Germany
    Schizophr Bull 38:838-44. 2012
    ..Although mostly conceptualized as a neurodevelopmental disorder, there is an increasing interest in progressive changes of cognitive deficits and brain structure and function in schizophrenia across the life span...
  5. doi request reprint Distinct pattern of brain structural deficits in subsyndromes of schizophrenia delineated by psychopathology
    Igor Nenadic
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, D 07743 Jena, Germany
    Neuroimage 49:1153-60. 2010
    ..8% accuracy classifying any given scan to one of the subgroups. Patterns of psychopathology are meaningful parameters in reducing heterogeneity of brain morphological endophenotypes in schizophrenia...
  6. doi request reprint ADC changes in schizophrenia: a diffusion-weighted imaging study
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University of Jena, Philosophenweg 3, 07743, Jena, Germany
    Eur Arch Psychiatry Clin Neurosci 261:213-6. 2011
    ..Changes in other parameters like fractional anisotropy (FA) might be a more sensitive indicator of white matter pathology in this disorder...
  7. ncbi request reprint Processing of temporal information and the basal ganglia: new evidence from fMRI
    Igor Nenadic
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, 07740 Jena, Germany
    Exp Brain Res 148:238-46. 2003
    ..Further investigations are needed to delineate the differential contributions of the striatum and other areas to timing...
  8. doi request reprint Auditory hallucinations and brain structure in schizophrenia: voxel-based morphometric study
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University of Jena, Philosophenweg 3, D 07743 Jena, Germany
    Br J Psychiatry 196:412-3. 2010
    ..This study extends previous region-of-interest studies demonstrating main effects of auditory hallucinations related to modality-specific superior temporal areas including primary and secondary auditory cortices...
  9. doi request reprint Targeting brain regions and symptoms: neuronal single-unit recordings and deep brain stimulation in obsessive-compulsive disorder
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University of Jena, Philosophenweg 3, D 07743 Jena, Germany
    Biol Psychiatry 63:542-3. 2008
  10. ncbi request reprint White matter abnormalities and brain activation in schizophrenia: a combined DTI and fMRI study
    Ralf G M Schlösser
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University, 07743 Jena, Germany
    Schizophr Res 89:1-11. 2007
    ..It highlights a potential relationship between anatomical changes in a frontal-temporal anatomical circuit and functional alterations in the prefrontal cortex...
  11. ncbi request reprint Inefficient executive cognitive control in schizophrenia is preceded by altered functional activation during information encoding: an fMRI study
    Ralf G M Schlösser
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuropsychologia 46:336-47. 2008
    ..These results could be explained by increased top-down control processing from prefrontal cortex as a compensation for functional deficits occurring during encoding...
  12. doi request reprint Reduced anterior cingulate cognitive activation is associated with prefrontal-temporal cortical thinning in schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
    Biol Psychiatry 71:146-53. 2012
    ..Therefore, this study investigated the association of anterior cingulate cognitive activation and cortical thickness in schizophrenia combining functional magnetic resonance imaging (fMRI) and surface-based morphometry...
  13. doi request reprint Reduced cortical thickness in first episode schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Schizophr Res 116:204-9. 2010
    ..In an extension of these earlier studies, we used an entire cortex vertex-wise approach and an automated clustering for the detection and exact quantification of cortical thickness alterations in first episode schizophrenia...
  14. doi request reprint Psychopathological correlates of the entorhinal cortical shape in schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
    Eur Arch Psychiatry Clin Neurosci 260:351-8. 2010
    ..As cortical folding is a stable neuroanatomical parameter terminated in early neonatal stages, our data give reason to assume that the vulnerability to develop psychotic symptoms might be manifest at an early level of brain maturation...
  15. doi request reprint Default mode network activity in schizophrenia studied at resting state using probabilistic ICA
    Gianluca Mingoia
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany
    Schizophr Res 138:143-9. 2012
    ..These findings suggest that aberrant default mode network connectivity contributes to regional functional pathology in schizophrenia and bears significance for core symptoms...
  16. doi request reprint Complex pattern of cortical thinning in schizophrenia: results from an automated surface based analysis of cortical thickness
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, Jena, Germany
    Psychiatry Res 182:134-40. 2010
    ..This pattern is consistent with a disruption of neurofunctional networks previously implicated in the pathophysiology of schizophrenia...
  17. doi request reprint Increased parahippocampal and lingual gyrification in first-episode schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Schizophr Res 123:137-44. 2010
    ....
  18. doi request reprint The visual cortex in schizophrenia: alterations of gyrification rather than cortical thickness--a combined cortical shape analysis
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Brain Struct Funct 218:51-8. 2013
    ..The present findings of hypergyria are highly indicative for a disrupted corticogenesis of these visual key regions and might constitute a relevant anatomical basis for visual processing deficits in schizophrenia...
  19. doi request reprint Altered error-related activity in patients with schizophrenia
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuropsychologia 47:2843-9. 2009
    ..Thus, present results clearly indicate that disorder-characteristic activation abnormalities become manifest during dysfunctional executive processing even when the moderating effect of performance is largely eliminated...
  20. ncbi request reprint Metabolic mapping using 2D 31P-MR spectroscopy reveals frontal and thalamic metabolic abnormalities in schizophrenia
    Stefan Smesny
    Department of Psychiatry, Friedrich Schiller University Jena, Philosophenweg 3, D 07743 Jena, Germany
    Neuroimage 35:729-37. 2007
    ..Results support the notion of disturbed phospholipid turnover in schizophrenia, probably unrelated to prior pharmacological treatment, and associated with increased energy demand...
  21. doi request reprint Phospholipase A₂ activity in first episode schizophrenia: associations with symptom severity and outcome at week 12
    Stefan Smesny
    Department of Psychiatry, Friedrich Schiller University Jena, Jena, Germany
    World J Biol Psychiatry 12:598-607. 2011
    ..This study investigates if inPLA₂ activity is associated with symptoms severity and treatment response in first episode schizophrenia (FES)...
  22. doi request reprint Frequency domains of resting state default mode network activity in schizophrenia
    Gianluca Mingoia
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, D 07743 Jena, Germany
    Psychiatry Res 214:80-2. 2013
    ..Power spectrum analysis showed a significant diagnosis × frequency interaction and higher power in one frequency band, indicating an alteration of DMN frequency spectrum in schizophrenia...
  23. ncbi request reprint Neuroanatomy of "hearing voices": a frontotemporal brain structural abnormality associated with auditory hallucinations in schizophrenia
    Christian Gaser
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, D 07743 Jena, Germany
    Cereb Cortex 14:91-6. 2004
    ....
  24. pmc Reduced cortical thickness is associated with the glutamatergic regulatory gene risk variant DAOA Arg30Lys in schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
    Neuropsychopharmacology 36:1747-53. 2011
    ..Our finding thus underlines the importance of DAOA and related glutamatergic processes as a putative target for therapeutic interventions in schizophrenia...
  25. ncbi request reprint Temporal changes in neural activation during practice of information retrieval from short-term memory: an fMRI study
    Kathrin Koch
    Department of Psychiatry, University of Jena, Philosophenweg 3, 07740 Jena, Germany
    Brain Res 1107:140-50. 2006
    ..The temporal changes in brain activation patterns could be attributed to enhanced efficiency of information processing as a result of cognitive practice...
  26. doi request reprint Local cortical surface complexity maps from spherical harmonic reconstructions
    Rachel A Yotter
    Department of Psychiatry, Friedrich Schiller University, Jena, Germany
    Neuroimage 56:961-73. 2011
    ..These results are discussed in terms of previously published findings. Finally, the anatomical implications of a reduced FD are highlighted through comparison of two subjects with vastly different complexity maps...
  27. doi request reprint Thalamocortical connectivity during resting state in schizophrenia
    Carsten M Klingner
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743, Jena, Germany
    Eur Arch Psychiatry Clin Neurosci 264:111-9. 2014
    ..These results emphasize the functional importance of the thalamus in the pathophysiology of schizophrenia. ..
  28. ncbi request reprint Transient activation of a somatosensory area in painful hallucinations shown by fMRI
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, D 07740 Jena, Germany
    Neuroreport 13:805-8. 2002
    ..This finding demonstrates elevated brain activity in a somatosensory area accompanying painful somatic hallucinations...
  29. doi request reprint Phospholipase A2 activity is associated with structural brain changes in schizophrenia
    Stefan Smesny
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
    Neuroimage 52:1314-27. 2010
    ....
  30. doi request reprint Alterations of niacin skin sensitivity in recurrent unipolar depressive disorder
    Stefan Smesny
    Department of Psychiatry, University of Jena, Philosophenweg 3, D 07740 Jena, Germany
    J Affect Disord 124:335-40. 2010
    ..This study aimed to clarify whether a disturbance of niacin skin flushing occurs also in depression, and to identify patient characteristics for those who might benefit from PUFA supplementation...
  31. ncbi request reprint Serial positron emission tomographic findings in an atypical presentation of fatal familial insomnia
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller Universität of Jena, Germany
    Arch Neurol 59:1815-8. 2002
    ..Although insomnia and dysautonomia have been described as hallmarks of the disease, there is substantial variability in clinical presentation...
  32. ncbi request reprint Estimating local surface complexity maps using spherical harmonic reconstructions
    Rachel Aine Yotter
    Friedrich Schiller University, Department of Psychiatry, Jahnstr 3, 07743 Jena, Germany
    Med Image Comput Comput Assist Interv 13:169-76. 2010
    ..The global FD for the right hemisphere in the schizophrenic group was significantly lower than that in controls. Local FD maps showed that the lower complexity was mainly due to differences in the prefrontal cortex...
  33. ncbi request reprint Ventricular enlargement in schizophrenia related to volume reduction of the thalamus, striatum, and superior temporal cortex
    Christian Gaser
    Department of Psychiatry, Friedrich Schiller University of Jena, Germany
    Am J Psychiatry 161:154-6. 2004
    ..The authors investigated whether ventricular enlargement is related to regionally specific volume loss...
  34. doi request reprint Cortical surface complexity in frontal and temporal areas varies across subgroups of schizophrenia
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany
    Hum Brain Mapp 35:1691-9. 2014
    ..Hum Brain Mapp 35:1691-1699, 2014. © 2013 Wiley Periodicals, Inc. ..
  35. pmc Skin ceramide alterations in first-episode schizophrenia indicate abnormal sphingolipid metabolism
    Stefan Smesny
    Department of Psychiatry, Jena University Hospital, Jena, Germany
    Schizophr Bull 39:933-41. 2013
    ..Given recent findings showing amelioration of psychopathology using fatty acid supplementation, our findings also bear relevance for sphingolipids as potential biomarkers of the disease...
  36. doi request reprint Habituation within the somatosensory processing hierarchy
    Carsten M Klingner
    Department of Neurology, University of Jena, Jena, Germany
    Behav Brain Res 225:432-6. 2011
    ....
  37. pmc Frontal-striatal-thalamic mediodorsal nucleus dysfunction in schizophrenia-spectrum patients during sensorimotor gating
    Erin A Hazlett
    Department of Psychiatry, Box 1505, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroimage 42:1164-77. 2008
    ..Dysfunctional FST activation, particularly in the caudate may underlie PPI abnormalities in schizophrenia-spectrum patients...
  38. ncbi request reprint Differential metabolic rates in prefrontal and temporal Brodmann areas in schizophrenia and schizotypal personality disorder
    Monte S Buchsbaum
    Neuroscience PET Laboratory, Department of Psychiatry, Mt Sinai School of Medicine, Box 1505, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Schizophr Res 54:141-50. 2002
    ..Metabolic rates in Brodmann area 10 were distinctly higher in SPD patients than in either normal volunteers or schizophrenic patients...