Gernot Marx

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. ncbi request reprint Venous oximetry
    Gernot Marx
    Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller Universität, Jena, Germany
    Curr Opin Crit Care 12:263-8. 2006
  2. pmc Dextran-70 to modulate inflammatory response after cardiopulmonary bypass: potential for a novel approach?
    Tobias Schuerholz
    Crit Care 11:163. 2007
  3. ncbi request reprint Blood volume measurements using an integrated fiberoptic monitoring system in a porcine septic shock model
    Gernot Marx
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena Germany, Erlanger Allee 101, D 07747 Jena, Germany
    Crit Care Med 34:1483-8. 2006
  4. ncbi request reprint Comparison of cardiac output measurements by arterial trans-cardiopulmonary and pulmonary arterial thermodilution with direct Fick in septic shock
    G Marx
    Friedrich Schiller University, Department of Anaesthesiology and Intensive Care Medicine, Jena, Germany
    Eur J Anaesthesiol 22:129-34. 2005
  5. ncbi request reprint Urosepsis: from the intensive care viewpoint
    G Marx
    Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller Universität, Erlanger Allee 101, Jena, Germany
    Int J Antimicrob Agents 31:S79-84. 2008
  6. ncbi request reprint [New approaches to intensive care for sepsis]
    G Marx
    Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller Universitat Jena
    Chirurg 76:845-55. 2005
  7. ncbi request reprint [Intensive insulin therapy in critically ill patients--contra]
    Gernot Marx
    Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller Universitat Jena
    Dtsch Med Wochenschr 131:2481. 2006
  8. ncbi request reprint Acute short-term hyperglycemia impairs platelet receptor expression even in healthy adults in vitro
    Tobias Schuerholz
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University, Jena, Germany
    Med Sci Monit 14:BR294-8. 2008
  9. ncbi request reprint Effect of Drotrecogin alfa (activated) on platelet receptor expression in vitro
    Tobias Schuerholz
    Clinic of Anaesthesia and Intensive Care, Friedrich Schiller University, Erlanger Alle 101, D 07743 Jena, Germany
    Platelets 18:373-8. 2007
  10. doi request reprint Characterization of buccal microvascular response in patients with septic shock
    Yasser Sakr
    Department of Anaesthesiology and Intensive Care, Friedrich Schiller University Hospital, Jena, Germany
    Eur J Anaesthesiol 27:388-94. 2010

Detail Information

Publications32

  1. ncbi request reprint Venous oximetry
    Gernot Marx
    Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller Universität, Jena, Germany
    Curr Opin Crit Care 12:263-8. 2006
    ..This review discusses recent data on the impact of using venous oximetry by obtaining mixed venous oxygen saturation or central venous oxygen saturation as useful monitoring parameters in critically ill patients...
  2. pmc Dextran-70 to modulate inflammatory response after cardiopulmonary bypass: potential for a novel approach?
    Tobias Schuerholz
    Crit Care 11:163. 2007
    ..In this context, Gombocz and colleagues investigated the potential anti-inflammatory effect of dextran-70. Their results suggest that compared to gelatine, dextran-70 reduces the inflammatory response in patients after CPB...
  3. ncbi request reprint Blood volume measurements using an integrated fiberoptic monitoring system in a porcine septic shock model
    Gernot Marx
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena Germany, Erlanger Allee 101, D 07747 Jena, Germany
    Crit Care Med 34:1483-8. 2006
    ..To compare the accuracy of an integrated fiberoptic monitoring system using transpulmonary thermo-dye dilution technique to measure blood volume (BV) with standard method using chromium-51-tagged erythrocytes in septic shock...
  4. ncbi request reprint Comparison of cardiac output measurements by arterial trans-cardiopulmonary and pulmonary arterial thermodilution with direct Fick in septic shock
    G Marx
    Friedrich Schiller University, Department of Anaesthesiology and Intensive Care Medicine, Jena, Germany
    Eur J Anaesthesiol 22:129-34. 2005
    ....
  5. ncbi request reprint Urosepsis: from the intensive care viewpoint
    G Marx
    Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller Universität, Erlanger Allee 101, Jena, Germany
    Int J Antimicrob Agents 31:S79-84. 2008
    ..Time to initiation of therapy is crucial for surviving sepsis. Implementing new medical evidence in this context into daily clinical intensive care remains a major hurdle...
  6. ncbi request reprint [New approaches to intensive care for sepsis]
    G Marx
    Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller Universitat Jena
    Chirurg 76:845-55. 2005
    ....
  7. ncbi request reprint [Intensive insulin therapy in critically ill patients--contra]
    Gernot Marx
    Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller Universitat Jena
    Dtsch Med Wochenschr 131:2481. 2006
  8. ncbi request reprint Acute short-term hyperglycemia impairs platelet receptor expression even in healthy adults in vitro
    Tobias Schuerholz
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University, Jena, Germany
    Med Sci Monit 14:BR294-8. 2008
    ..The aim of the present study was to examine effects of an acute hyperglycemia on platelet receptor expression in non-diabetic healthy individuals in vitro...
  9. ncbi request reprint Effect of Drotrecogin alfa (activated) on platelet receptor expression in vitro
    Tobias Schuerholz
    Clinic of Anaesthesia and Intensive Care, Friedrich Schiller University, Erlanger Alle 101, D 07743 Jena, Germany
    Platelets 18:373-8. 2007
    ..Thus, a direct drug-platelet interaction seems unlikely...
  10. doi request reprint Characterization of buccal microvascular response in patients with septic shock
    Yasser Sakr
    Department of Anaesthesiology and Intensive Care, Friedrich Schiller University Hospital, Jena, Germany
    Eur J Anaesthesiol 27:388-94. 2010
    ..The aim of the present study was to characterize the buccal microvascular response in patients with septic shock using combined laser Doppler flowmetry/visual light spectroscopy measurements...
  11. ncbi request reprint Attenuation of capillary leakage by hydroxyethyl starch (130/0.42) in a porcine model of septic shock
    Gernot Marx
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Jena, Germany
    Crit Care Med 34:3005-10. 2006
    ..Recently, a new HES with a low molecular weight (130 kD) and lower molar substitution (0.42) has been developed. In this study, we compared effects of HES 130/0.42 and HES 200/0.5 on capillary leakage in porcine septic shock...
  12. ncbi request reprint Hydrocortisone does not affect major platelet receptors in inflammation in vitro
    Tobias Schuerholz
    Clinic of Anesthesiology and Intensive Care, Friedrich Schiller University Jena, Erlanger Allee 101, D 07747 Jena, Germany
    Steroids 72:609-13. 2007
    ..The aim of the present study was to examine effects of hydrocortisone on platelet receptor expression in healthy individuals and septic patients in vitro...
  13. pmc Hydroxyethylstarch impairs renal function and induces interstitial proliferation, macrophage infiltration and tubular damage in an isolated renal perfusion model
    Lars Hüter
    Department of Anaesthesiology and Intensive Care Medicine, University of Jena, Erlanger Allee, Jena, Germany
    Crit Care 13:R23. 2009
    ..The aim of the study was to evaluate some of the underlying pathomechanisms of hydroxyethylstarch (HES) induced adverse effects on renal function using 24 porcine kidneys in an isolated perfusion model over six hours...
  14. ncbi request reprint Successful treatment of an aggressive non-Hodgkin's lymphoma associated with acute respiratory insufficiency using extracorporeal membrane oxygenation
    Anas Aboud
    Department of Cardiothoracic Surgery, Friedrich Schiller University, Jena, Germany
    Interact Cardiovasc Thorac Surg 7:173-4. 2008
    ..We report a case of successful extracorporeal membrane oxygenation treatment in a 43-year-old woman with acute respiratory insufficiency due to a huge mediastinal non-Hodgkin's tumor...
  15. ncbi request reprint Terminal complement complex in septic shock with capillary leakage: marker of complement activation?
    T Schuerholz
    Friedrich Schiller University, Department of Anaesthesiology and Intensive Care, Jena, Germany
    Eur J Anaesthesiol 22:541-7. 2005
    ..The aim of this study was to evaluate the value of terminal complement complex (C5b-9) plasma levels as a marker for complement activation in septic shock with concomitant capillary leak syndrome...
  16. doi request reprint Exanthema in Legionnaires' disease mimicking a severe cutaneous drug reaction
    M Ziemer
    Department of Dermatology, Friedrich Schiller University of Jena, Jena, Germany
    Clin Exp Dermatol 34:e72-4. 2009
    ..L. pneumophila infection was verified during the course of the disease...
  17. ncbi request reprint Reliability of continuous cardiac output determination by pulse-contour analysis in porcine septic shock
    T Schuerholz
    Department of Anaesthesiology and Intensive Care, Friedrich Schiller University, Jena, Germany
    Acta Anaesthesiol Scand 50:407-13. 2006
    ..Pulse-contour analysis represents a technique for cardiac output (CO)-measurement and allows continuously monitoring trends in CO. We evaluated reliability of pulse-contour CO (COpc) in septic shock...
  18. doi request reprint ADAMTS13 activity is decreased in a septic porcine model. Significance for glomerular thrombus deposition
    Clemens L Bockmeyer
    Department of Anaesthesiology and Intensive Care, Jena University Hospital, Jena, Germany
    Thromb Haemost 105:145-53. 2011
    ..Therefore, this porcine model seems to be appropriate for performing functional and therapeutic studies in sepsis-associated ADAMTS13 deficiency...
  19. pmc The German quality indicators in intensive care medicine 2013--second edition
    Jan Peter Braun
    Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Germany
    Ger Med Sci 11:Doc09. 2013
    ..These updated quality indicators are part of the Peer Review in intensive care medicine. The next update of the quality indicators is due in 2016. ..
  20. doi request reprint Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial
    Frank M Brunkhorst
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University, Jena, Germany
    JAMA 307:2390-9. 2012
    ..Early appropriate antimicrobial therapy leads to lower mortality rates associated with severe sepsis. The role of empirical combination therapy comprising at least 2 antibiotics of different mechanisms remains controversial...
  21. doi request reprint Impact of stable PGI₂ analog iloprost on early graft viability after liver transplantation: a pilot study
    Erik Bärthel
    Department of General, Visceral and Vascular Surgery, Friedrich Schiller University, Jena, Germany
    Clin Transplant 26:E38-47. 2012
    ..The aim of this study was to analyze the effect of the continuously administered prostaglandin I(2) analog iloprost on allograft function after LT...
  22. doi request reprint The value of rotation thromboelastometry to monitor disturbed perioperative haemostasis and bleeding risk in patients with cardiopulmonary bypass
    Mike Reinhöfer
    Institute for Transfusion Medicine, Clinic for Anaesthesiology and Intensive Care Medicine, Division for Cardiothoracic Surgery, University Hospital Jena, Jena, Germany
    Blood Coagul Fibrinolysis 19:212-9. 2008
    ..In contrast, intraoperative administration of red blood cells impaired haemostasis. ROTEM can provide a more detailed diagnostic basis enabling a focused therapy to cardiac surgery patients with high bleeding risk...
  23. doi request reprint Effects of staff training on the care of mechanically ventilated patients: a prospective cohort study
    F Bloos
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Jena, Erlanger Allee 101, 07747 Jena, Germany
    Br J Anaesth 103:232-7. 2009
    ..The goal of this study was to assess whether staff training in pre-defined interventions (bundle) improves the quality of care in mechanically ventilated patients...
  24. ncbi request reprint Management of sepsis
    T Schuerholz
    Clinic of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University, Jena, Germany
    Minerva Anestesiol 74:181-95. 2008
    ..High quality management tools are necessary to bring evidence-based therapy to the bedside. With respect to recently published studies, the importance of the time taken to improve the outcome of sepsis can not be overemphasized...
  25. ncbi request reprint Effects of hydroxyethyl starch administration on renal function in critically ill patients
    Y Sakr
    Friedrich Schiller University, Jena, Germany
    Br J Anaesth 98:216-24. 2007
    ..We investigated the effect of HES administration on renal function in critically ill patients enrolled in a large multicentre observational European study...
  26. ncbi request reprint Bioequivalence comparison between hydroxyethyl starch 130/0.42/6 : 1 and hydroxyethyl starch 130/0.4/9 : 1
    G Lehmann
    Department of Anaesthesiology and Intensive Care Medicine, Rhoen Hospital Bad Berka, Kapellendorf, Germany
    Drugs R D 8:229-40. 2007
    ..42/6 : 1), altered in molar substitution and C2/C6 ratio, is bioequivalent to the former standard HES preparation (130/0.4/9 : 1)...
  27. ncbi request reprint [Early evaluation of neurological prognosis and therapy after cardiopulmonary resuscitation: current opportunities and clinical implications]
    A Ragoschke-Schumm
    Institut für Diagnostische und Interventionelle Radiologie, Jena, Germany
    Nervenarzt 78:937-43. 2007
    ..In summary, the prognosis in patients with cerebral anoxy and cardiopulmonary resuscitation remains poor. Treatment with hypothermia for 24 h is recommended...
  28. ncbi request reprint Continuous monitoring of central venous oxygen saturation in neonates and small infants: in vitro evaluation of two different oximetry catheters
    Dirk Huber
    Zentrum Anasthesiologie, Medizinische Hochschule Hannover, Germany
    Paediatr Anaesth 16:1257-61. 2006
    ..Therefore, we compared oxygen saturation measurements with thin fiberoptic oximetry catheters and standard blood gas oximetry in an in vitro setting...
  29. ncbi request reprint Resuscitation from septic shock with capillary leakage: hydroxyethyl starch (130 kd), but not Ringer's solution maintains plasma volume and systemic oxygenation
    Gernot Marx
    Department of Anaesthesia, University of Liverpool, Liverpool L69 3GA, United Kingdom
    Shock 21:336-41. 2004
    ..40% +/- 14%, P < 0.05) than RS animals. In this porcine septic shock model with concomitant capillary leakage syndrome, resuscitation with HES 130 kD but not RS could maintain PV and preserve systemic hemodynamics and oxygenation...
  30. ncbi request reprint Hemodynamic changes during acute elevation of intra-abdominal pressure in rabbits
    Robert Sumpelmann
    Medizinische Hochschule Hannover, Zentrum Anasthesiologie, Hannover, Germany
    Paediatr Anaesth 16:1262-7. 2006
    ..The aim of this study was to investigate hemodynamic changes during elevation of IAP using an experimental setting, which mirrors anatomical and physiological conditions of neonates and small infants as closely as possible...
  31. ncbi request reprint Correlation of oxygen delivery with central venous oxygen saturation, mean arterial pressure and heart rate in piglets
    Wilhelm A Osthaus
    Zentrum Anasthesiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Paediatr Anaesth 16:944-7. 2006
    ..Therefore, we investigated the correlation of ScvO(2) with cardiac index (CI) and DO(2) and in comparison the more common monitored parameters heart rate (HR) and mean arterial pressure (MAP) with DO(2) in an animal experimental setting...
  32. ncbi request reprint Activated protein C induces the release of microparticle-associated endothelial protein C receptor
    Margarita Pérez-Casal
    Roald Dahl Haemostasis and Thrombosis Centre and Department of Anaesthesia and Intensive Care Medicine, Royal Liverpool University Hospital, Liverpool L7 8XP, UK
    Blood 105:1515-22. 2005
    ..This novel observation could provide new insights into the consequences of APC therapy in the septic patient...