Research Topics
Species | J LiepertSummaryAffiliation: Friedrich Schiller University Country: Germany Publications
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Detail Information
Publications
Motor plasticity induced by synchronized thumb and foot movementsJ Liepert
Neurologische Universitatsklinik, Friedrich Schiller University, Jena, Germany
Exp Brain Res 125:435-9. 1999..We conclude that a short-lasting training of synchronous movements induces modulations of motor output maps which probably occur due to interactions between hand and foot representation areas in the motor cortex...- Task-dependent changes of intracortical inhibitionJ Liepert
Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Exp Brain Res 118:421-6. 1998..Additionally, our data further supports the idea that ICI and ICF may be controlled independently... - Motor cortex plasticity during constraint-induced movement therapy in stroke patientsJ Liepert
Department of Neurology, Friedrich Schiller University of Jena, Germany
Neurosci Lett 250:5-8. 1998..The data therefore demonstrate a CNS correlate of therapy-induced recovery of function after nervous system damage in humans... - Plasticity of cortical hand muscle representation in patients with hemifacial spasmJ Liepert
Department of Neurology, Friedrich Schiller University Jena, Germany
Neurosci Lett 272:33-6. 1999..The results indicate activity dependent interactions between hand and face representations in the adult human motor cortex... - Mapping plastic brain changes after acute lesionsJ Liepert
Department of Neurology, Friedrich Schiller University, Jena, Germany
Curr Opin Neurol 12:709-13. 1999..Recent research focused not only on lesion-induced plasticity, but also on therapy-induced reorganization of the brain. Data from animal experiments has expanded our knowledge of mechanisms that underlie plastic changes... - Motor cortex disinhibition in acute strokeJ Liepert
Department of Neurology, Friedrich Schiller University, D 07743, Jena, Germany
Clin Neurophysiol 111:671-6. 2000..To test whether a disinhibition occurs in the human motor cortex after stroke... - Treatment-induced cortical reorganization after stroke in humansJ Liepert
Department of Neurology, Friedrich Schiller University of Jena, Germany
Stroke 31:1210-6. 2000..The aim of the present study was to evaluate reorganization in the motor cortex of stroke patients that was induced with an efficacious rehabilitation treatment... - Motor cortex excitability after thalamic infarctionJ Liepert
Department of Neurology, University Hospital Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
Clin Neurophysiol 116:1621-7. 2005..We examined 8 patients with hemihypesthesia due to an ischemic thalamic lesion to explore the effects of a central sensory dysfunction on motor cortex excitability... - Interhemispheric effects of high and low frequency rTMS in healthy humansA Gorsler
Department of Neurology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Clin Neurophysiol 114:1800-7. 2003..We investigated whether repetitive transcranial magnetic stimulation (rTMS) applied to the right motor cortex modified the excitability of the unstimulated left motor cortex... - Inhibition of ipsilateral motor cortex during phasic generation of low forceJ Liepert
Department of Neurology, Friedrich Schiller University Jena, Jena, Germany
Clin Neurophysiol 112:114-21. 2001..To study the effect of different types of unilateral pinch grips on excitability of the ipsilateral motor cortex... - Modulation of motor cortex excitability induced by pinch grip repetitionA Gorsler
Department of Neurology, University Hospital, Hamburg Eppendorf, Germany
J Neural Transm 111:1005-16. 2004..These changes are distinct and independent of each other. Motor training has an interhemispheric effect on intracortical excitability... - Abnormal motor cortex organization contralateral to early upper limb amputation in humansC Dettmers
Neurologie, Friedrich Schiller Universitat, Jena, Germany
Neurosci Lett 263:41-4. 1999..In addition to previous functional studies, these new structural data suggest that maturation of the central sulcus develops in response to daily practice of the contralateral hand, possibly until adolescence... - Disinhibition of somatosensory and motor cortex in mitochondriopathy without myoclonusJ Liepert
Department of Neurology, Friedrich Schiller University of Jena, Jena, Germany
Clin Neurophysiol 112:917-22. 2001..To test electrophysiologically, if patients with mitochondriopathy but without evidence of myocloni have subclinical signs of disinhibition in motor and somatosensory cortices... - Motor excitability and motor behaviour after modafinil ingestion--a double-blind placebo-controlled cross-over trialJ Liepert
Department of Neurology, University Hospital Eppendorf, Hamburg, Germany
J Neural Transm 111:703-11. 2004..Thus, this study does not demonstrate significant differences between a single dose of modafinil and placebo in healthy subjects... - Motor cortex plasticity during forced-use therapy in stroke patients: a preliminary studyJ Liepert
Department of Neurology, Friedrich Schiller University, Jena, Germany
J Neurol 248:315-21. 2001..Due to the small number of patients and the lack of a control group, these results are preliminary observations and require replication in a larger sample... - Motor cortex excitability and fatigue in multiple sclerosis: a transcranial magnetic stimulation studyJ Liepert
Department of Neurology, University Hospital Eppendorf, Hamburg, Germany
Mult Scler 11:316-21. 2005..We conclude that MS patients with fatigue have an impairment of inhibitory circuits in their primary motor cortex. The results also indicate that fatigue severity is associated with an exercise-induced reduction of membrane excitability... - No effect of a levodopa single dose on motor performance and motor excitability in chronic stroke. A double-blind placebo-controlled cross-over pilot studyC Restemeyer
Department of Neurology, University Medical Center Eppendorf, Hamburg, Germany
Restor Neurol Neurosci 25:143-50. 2007..Drugs that modulate neuronal transmission can influence motor recovery after stroke. Here, we tested if a single dose of levodopa could improve motor functions and change motor excitability in a group of chronic stroke patients... - Riluzole suppresses motor cortex facilitation in correlation to its plasma level. A study using transcranial magnetic stimulationP Schwenkreis
Department of Neurology, Buerkle de la Camp Platz 1, Ruhr University Bochum, BG Kliniken Bergmannsheil, 44789 Bochum, Germany
Exp Brain Res 135:293-9. 2000..The most probable mechanism involves an effect on glutamatergic synaptic transmission... - Motor cortex excitability after cerebellar infarctionJ Liepert
Department of Neurology, University Hospital Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
Stroke 35:2484-8. 2004..We investigated if the location of a cerebellar infarction was crucial for changes of motor cortex excitability and if the electrophysiological findings were correlated with motor performance... - Chronic dose effects of reboxetine on motor skill acquisition and cortical excitabilityR Lange
Department of Neurology, University Freiburg, Freiburg, Germany
J Neural Transm 114:1085-9. 2007..In this study, we tested if a chronic dose application of RBX improved motor skill acquisition and modulated cortical excitability... - The influence of lorazepam on somatosensory-evoked fast frequency (600 Hz) activity in MEGJ Haueisen
Department of Neurology, Biomagnetisches Zentrum, Friedrich Schiller Universitat Jena, Philosophenweg 3, 07740, Jena, Germany
Brain Res 874:10-4. 2000..The source strengths of both N20m and 600-Hz bursts were significantly increased. Our results provide evidence for two components of the 600-Hz activity with a different generator structure... - Motor cortex disinhibition in Alzheimer's diseaseJ Liepert
Department of Neurology, Friedrich Schiller University, Jena, Germany
Clin Neurophysiol 112:1436-41. 2001..To explore subclinical disturbances in the motor cortex of patients with Alzheimer's disease (AD)... - Structural and functional cortical abnormalities after upper limb amputation during childhoodF Hamzei
Department of Neurology, Friedrich-Schiller-University, Jena, Germany
Neuroreport 12:957-62. 2001..Therefore, arm amputation in childhood affects functional organization as well as anatomical structure in both hemispheres... - Orally administered atropine enhances motor cortex excitability: a transcranial magnetic stimulation study in human subjectsJ Liepert
Department of Neurology, Friedrich Schiller University, Jena, Germany
Neurosci Lett 300:149-52. 2001..Thus, an antagonist of pre- and postsynaptic muscarinic receptors increased excitability in the human motor cortex in a dose-dependent manner, indicating an influence of the cholinergic system on motor cortex excitation... 
Motor system abnormalities in hereditary spastic paraparesis type 4 (SPG4) depend on the type of mutation in the spastin geneD Bonsch
Institut für Klinische Chemie und Laboratoriumsdiagnostik, Universitatsklinikum Jena, D 07740 Jena, Germany
J Neurol Neurosurg Psychiatry 74:1109-12. 2003..A variety of mutations have been identified within the SPG4 gene product, spastin...- [Repetitive transcranial magnetic stimulation (rTMS) in the acute and long-term therapy of refractory depression--a case report]S Smesny
Klinik für Psychiatrie der Friedrich Schiller Universität Jena, Philosophenweg 3, 07740 Jena
Nervenarzt 72:734-8. 2001..The rTMS treatments and psychotherapeutic counseling have been continued on an outpatient basis. Thus, pharmaco- and psychotherapeutic interventions combined with rTMS led to persistent symptom remission and social reintegration... - Lesion-induced and training-induced brain reorganizationJ Liepert
Department of Neurology, University Hospital Eppendorf, D 20246 Hamburg, Germany
Restor Neurol Neurosci 22:269-77. 2004..We examined if distinct ischemic brain lesions are associated with a specific pattern of excitability changes. We also investigated the effects of a rehabilitative therapy on motor excitability... - Transcranial magnetic stimulation in neurorehabilitationJ Liepert
Department of Neurology, University Hospital Eppendorf, Hamburg, Germany
Acta Neurochir Suppl 93:71-4. 2005..Some evidence is emerging that the application of low frequency repetitive TMS over the non-lesioned hemisphere improves neglect phenomena by down-regulation of the excitability of the non-lesioned hemisphere... - Fatigue suppresses ipsilateral intracortical facilitationT Baumer
Department of Neurology, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
Exp Brain Res 146:467-73. 2002..These results indicate interhemispheric interactions between the two motor cortices that are still effective after cessation of movements... - Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFEHans Christoph Diener
Department of Neurology, University of Duisburg Essen, Essen, Germany
Lancet Neurol 7:875-84. 2008..The putative neuroprotective effects of antiplatelet compounds and the angiotensin II receptor antagonist telmisartan were investigated in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial...