Andi Krumbholz

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. pmc Sequencing of porcine enterovirus groups II and III reveals unique features of both virus groups
    Andi Krumbholz
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, 07745 Jena, Germany
    J Virol 76:5813-21. 2002
  2. doi request reprint Prevalence of hepatitis E virus-specific antibodies in humans with occupational exposure to pigs
    Andi Krumbholz
    Department of Virology and Antiviral Therapy, Jena University Hospital, 07740, Jena, Germany
    Med Microbiol Immunol 201:239-44. 2012
  3. ncbi request reprint The non-coding region of BK subtype II viruses
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans Knoell Str 2, 07745 Jena, Germany
    Virus Genes 36:27-9. 2008
  4. doi request reprint Epstein-Barr virus-associated pneumonia and bronchiolitis obliterans syndrome in a lung transplant recipient
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Jena University Hospital Friedrich Schiller University Jena, Jena, Germany
    Med Microbiol Immunol 199:317-22. 2010
  5. ncbi request reprint Prevalence of BK virus subtype I in Germany
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University Jena, Jena, Germany
    J Med Virol 78:1588-98. 2006
  6. ncbi request reprint Comparison of a LightCycler-based real-time PCR for quantitation of Epstein-Barr viral load in different clinical specimens with semiquantitative PCR
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University Jena, Jena, Germany
    J Med Virol 78:598-607. 2006
  7. doi request reprint Current knowledge on PB1-F2 of influenza A viruses
    Andi Krumbholz
    Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University Jena, Hans Knoell Strasse 2, 07745, Jena, Germany
    Med Microbiol Immunol 200:69-75. 2011
  8. ncbi request reprint Phylogenetics, evolution, and medical importance of polyomaviruses
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
    Infect Genet Evol 9:784-99. 2009
  9. ncbi request reprint Age-related and regional differences in the prevalence of hepatitis E virus-specific antibodies in pigs in Germany
    Andi Krumbholz
    Institute for Infection Medicine, Christian Albrecht University of Kiel and University Medical Center Schleswig Holstein, Campus Kiel, 24105 Kiel, Germany Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University Jena, 07740 Jena, Germany Electronic address
    Vet Microbiol 167:394-402. 2013
  10. ncbi request reprint Prevalence of antibodies to swine influenza viruses in humans with occupational exposure to pigs, Thuringia, Germany, 2008-2009
    Andi Krumbholz
    Department of Virology and Antiviral Therapy, Jena University Hospital, Jena, Germany
    J Med Virol 82:1617-25. 2010

Collaborators

Detail Information

Publications24

  1. pmc Sequencing of porcine enterovirus groups II and III reveals unique features of both virus groups
    Andi Krumbholz
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, 07745 Jena, Germany
    J Virol 76:5813-21. 2002
    ..A reclassification of this group into a new picornavirus genus is suggested. PEV group III viruses are typical enteroviruses. They differ from other enteroviruses by a prolonged stem-loop D of the 5'-cloverleaf structure...
  2. doi request reprint Prevalence of hepatitis E virus-specific antibodies in humans with occupational exposure to pigs
    Andi Krumbholz
    Department of Virology and Antiviral Therapy, Jena University Hospital, 07740, Jena, Germany
    Med Microbiol Immunol 201:239-44. 2012
    ..e. borderline or positive) against HEV. Thus, an increased risk of HEV infection in humans occupationally exposed to pigs and particularly for slaughterers (41.7%; 10/24) was demonstrated...
  3. ncbi request reprint The non-coding region of BK subtype II viruses
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans Knoell Str 2, 07745 Jena, Germany
    Virus Genes 36:27-9. 2008
    ..Sequence comparisons revealed that the archetypal configuration of subtype I strain WW seems to be predominant among BKV subtypes...
  4. doi request reprint Epstein-Barr virus-associated pneumonia and bronchiolitis obliterans syndrome in a lung transplant recipient
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Jena University Hospital Friedrich Schiller University Jena, Jena, Germany
    Med Microbiol Immunol 199:317-22. 2010
    ..The clinical situation improved soon after re-transplantation, and the EBV load detected in the lower respiratory tract decreased significantly...
  5. ncbi request reprint Prevalence of BK virus subtype I in Germany
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University Jena, Jena, Germany
    J Med Virol 78:1588-98. 2006
    ..For the genotyping region, a relationship of BKV subgroups to disease patterns like hemorrhagic cystitis or tubulointerstitial nephritis could not be demonstrated...
  6. ncbi request reprint Comparison of a LightCycler-based real-time PCR for quantitation of Epstein-Barr viral load in different clinical specimens with semiquantitative PCR
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University Jena, Jena, Germany
    J Med Virol 78:598-607. 2006
    ..Positive specimens containing more than 500 copies/10(5) cells are measured for exact values by real-time PCR. To circumvent inhibitory effects of cellular DNA, measurements should be carried out generally with 50-10 ng DNA...
  7. doi request reprint Current knowledge on PB1-F2 of influenza A viruses
    Andi Krumbholz
    Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University Jena, Hans Knoell Strasse 2, 07745, Jena, Germany
    Med Microbiol Immunol 200:69-75. 2011
    ..These properties could contribute to an enhanced pathogenicity. However, the underlying mechanism is not fully understood yet. New data suggest that some effects of PB1-F2 are strain-specific and host-specific...
  8. ncbi request reprint Phylogenetics, evolution, and medical importance of polyomaviruses
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
    Infect Genet Evol 9:784-99. 2009
    ..Finally, we reveal that the hypothesis of a strict codivergence of polyomaviruses with their respective hosts does not represent a realistic assumption in light of phylogenetic findings presented here...
  9. ncbi request reprint Age-related and regional differences in the prevalence of hepatitis E virus-specific antibodies in pigs in Germany
    Andi Krumbholz
    Institute for Infection Medicine, Christian Albrecht University of Kiel and University Medical Center Schleswig Holstein, Campus Kiel, 24105 Kiel, Germany Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University Jena, 07740 Jena, Germany Electronic address
    Vet Microbiol 167:394-402. 2013
    ..The presence of anti-HEV-free herds may indicate that it is feasible to establish and sustain HEV-free pig herds. HEV seroprevalence still depends on the assay used for testing. This demonstrates an urgent need for test validation. ..
  10. ncbi request reprint Prevalence of antibodies to swine influenza viruses in humans with occupational exposure to pigs, Thuringia, Germany, 2008-2009
    Andi Krumbholz
    Department of Virology and Antiviral Therapy, Jena University Hospital, Jena, Germany
    J Med Virol 82:1617-25. 2010
    ..All increased hemagglutination-inhibition titers of the control group may be explained by cross-reactivity with seasonal influenza virus strains, as all these sera also reacted with human strains...
  11. ncbi request reprint Reassortants of the pandemic (H1N1) 2009 virus and establishment of a novel porcine H1N2 influenza virus, lineage in Germany
    Jeannette Lange
    Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University Jena, Hans Knöll Str 2, 07745 Jena, Germany
    Vet Microbiol 167:345-56. 2013
    ..The most frequent genotype emerged at least three times independently, one of which (Papenburg lineage) established a stable infection chain and became more prevalent in pigs than pdmH1N1 in Germany. ..
  12. doi request reprint Evolution of four BK virus subtypes
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
    Infect Genet Evol 8:632-43. 2008
    ..Another approach, external calibration by linking BKV divergence to the evolution of mammals, was rejected as it advances BKV divergence prior to the emergence of modern humans...
  13. doi request reprint Ongoing evolution of swine influenza viruses: a novel reassortant
    Roland Zell
    Institut für Virologie und Antivirale Therapie, Universitatsklinikum, Friedrich Schiller Universitat, Hans Knöll Str 2, 07745, Jena, Germany
    Arch Virol 153:2085-92. 2008
    ..Analysis of GenBank sequence data reveals numerous reassortment events in recent years, demonstrating ongoing evolution of swine influenza viruses...
  14. ncbi request reprint Prevalence of PB1-F2 of influenza A viruses
    Roland Zell
    Institute of Virology and Antiviral Therapy, Medical Center at Friedrich Schiller University, Hans Knoell Str 2, D 07745 Jena, Germany
    J Gen Virol 88:536-46. 2007
    ..This indicates similar properties and function of porcine and human FLUAV PB1-F2...
  15. doi request reprint Serological response to influenza A H1N1 vaccine (Pandemrix®) and seasonal influenza vaccine 2009/2010 in renal transplant recipients and in hemodialysis patients
    Undine Ott
    KfH Nierenzentrum, Jena, Germany
    Med Microbiol Immunol 201:297-302. 2012
    ..However, more than a half of these patients did not develop seroprotective antibody levels. Thus, new vaccines and altered vaccination regimes are likely necessary to achieve relevant antibody levels in these patient groups...
  16. ncbi request reprint Molecular-based reclassification of the bovine enteroviruses
    Roland Zell
    Institute for Virology and Antiviral Therapy, Hans Knöll Str 2, 07745 Jena, Germany
    J Gen Virol 87:375-85. 2006
    ..Incongruent phylogenies of the 5'-non-translated region, the capsid proteins and the 3D polymerase indicate frequent intraserotypic and interserotypic recombination within the non-capsid and the capsid region of the BEV genome...
  17. doi request reprint Isolation and molecular characterization of a second serotype of the encephalomyocarditis virus
    Anja Philipps
    Department of Virology and Antiviral Therapy, Jena University Hospital, Friedrich Schiller University, Hans Knoell Str 2, 07745 Jena, Germany
    Vet Microbiol 161:49-57. 2012
    ..In contrast to the theilovirus sero-/genotypes that show a narrow host range, EMCV-1 infects a wide variety of hosts. The host range of EMCV-2 remains to be determined...
  18. ncbi request reprint Amantadine resistance among porcine H1N1, H1N2, and H3N2 influenza A viruses isolated in Germany between 1981 and 2001
    Michaela Schmidtke
    Institute of Virology and Antiviral Therapy, Medical Centre of the Friedrich Schiller University Jena, Jena, Germany
    Intervirology 49:286-93. 2006
    ..Therefore, drug susceptibility monitoring appears to be warranted for effective application of those drugs...
  19. ncbi request reprint Novel reassortant of swine influenza H1N2 virus in Germany
    Roland Zell
    Institut für Virologie und Antivirale Therapie, Universitatsklinikum, Friedrich Schiller Universitat, Hans Knöll Str 2, D 07745 Jena, Germany
    J Gen Virol 89:271-6. 2008
    ..Genome sequencing revealed the novel combination of the human-like HAH1 gene of European porcine H1N2 influenza viruses and the NAN2 gene of European porcine H3N2 viruses...
  20. ncbi request reprint Within-host influenza dynamics: a small-scale mathematical modeling approach
    Himanshu Manchanda
    Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Jena, Germany Jena University Hospital, Department of Virology and Antiviral Therapy, Jena, Germany
    Biosystems 118:51-9. 2014
    ....
  21. doi request reprint Cardioprotective effect of NO-metoprolol in murine coxsackievirus B3-induced myocarditis
    Brigitte Glück
    Department of Virology and Antiviral Therapy, Jena University Hospital, Jena, Germany
    J Med Virol 82:2043-52. 2010
    ..The results indicate that NO-metoprolol treatment has a greater therapeutic benefit than metoprolol...
  22. ncbi request reprint Impact of global warming on viral diseases: what is the evidence?
    Roland Zell
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University Jena, Hans Knoell Street 2, D 07745 Jena, Germany
    Curr Opin Biotechnol 19:652-60. 2008
    ..Coupled ocean/atmosphere circulations and 'global change' that also includes shifting of demographic, social, and economical conditions are important drivers of viral disease variability whereas global warming at best contributes...
  23. ncbi request reprint Detection of porcine teschoviruses and enteroviruses by LightCycler real-time PCR
    Andi Krumbholz
    Institut für Virologie und Antivirale Therapie, Klinikum der Friedrich Schiller Universität, Winzerlaer Str 10, Jena 07745, Germany
    J Virol Methods 113:51-63. 2003
    ..Viruses of the PEV CPE group III can be distinguished from the closely related swine vesicular disease virus (SVDV)...
  24. pmc Influenza A virus PB1-F2 gene
    Roland Zell
    Emerg Infect Dis 12:1607-8; author reply 1608-9. 2006