Kathrin Koch

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. doi Structure-function relationships in the context of reinforcement-related learning: a combined diffusion tensor imaging-functional magnetic resonance imaging study
    K Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuroscience 168:190-9. 2010
  2. doi Neural correlates of emotion recognition in schizophrenia
    Ute Habel
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstr 30, D 52074 Aachen, Germany
    Schizophr Res 122:113-23. 2010
  3. doi Age-dependent visuomotor performance and white matter structure: a DTI study
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743 Jena, Germany
    Brain Struct Funct 218:1075-84. 2013
  4. doi Disrupted white matter connectivity is associated with reduced cortical thickness in the cingulate cortex in schizophrenia
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Jahnstr 3, Jena, Germany
    Cortex 49:722-9. 2013
  5. doi Aberrant anterior cingulate activation in obsessive-compulsive disorder is related to task complexity
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, University Hospital Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuropsychologia 50:958-64. 2012
  6. doi White matter structure and symptom dimensions in obsessive-compulsive disorder
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, University Hospital Jena, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    J Psychiatr Res 46:264-70. 2012
  7. doi Disrupted white matter integrity of corticopontine-cerebellar circuitry in schizophrenia
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jahnstr 3, Philosophenweg 3, 07740, Jena, Germany
    Eur Arch Psychiatry Clin Neurosci 260:419-26. 2010
  8. pmc Association between learning capabilities and practice-related activation changes in schizophrenia
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Schizophr Bull 36:486-95. 2010
  9. doi Altered error-related activity in patients with schizophrenia
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuropsychologia 47:2843-9. 2009
  10. doi The neural correlates of reward-related trial-and-error learning: an fMRI study with a probabilistic learning task
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
    Learn Mem 15:728-32. 2008

Detail Information

Publications43

  1. doi Structure-function relationships in the context of reinforcement-related learning: a combined diffusion tensor imaging-functional magnetic resonance imaging study
    K Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuroscience 168:190-9. 2010
    ..These findings indicate that interindividual variations in white matter characteristics within the normal population might be linked to neuronal activation and critically influence individual learning performance...
  2. doi Neural correlates of emotion recognition in schizophrenia
    Ute Habel
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstr 30, D 52074 Aachen, Germany
    Schizophr Res 122:113-23. 2010
    ....
  3. doi Age-dependent visuomotor performance and white matter structure: a DTI study
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743 Jena, Germany
    Brain Struct Funct 218:1075-84. 2013
    ..However, these interindividual variations do not explain the observed association between age and TMT performance. ..
  4. doi Disrupted white matter connectivity is associated with reduced cortical thickness in the cingulate cortex in schizophrenia
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Jahnstr 3, Jena, Germany
    Cortex 49:722-9. 2013
    ..Neurodevelopmental models propose a close linkage between gray matter alterations and white matter deficits. However, there are no studies investigating alterations in cortical thickness in relation to white matter connectivity changes...
  5. doi Aberrant anterior cingulate activation in obsessive-compulsive disorder is related to task complexity
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, University Hospital Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuropsychologia 50:958-64. 2012
    ..However, findings regarding the underlying neural substrates are heterogeneous. Moreover, the influence of cognitive demand on the severity of these deficits and associated activation alterations is a matter of debate...
  6. doi White matter structure and symptom dimensions in obsessive-compulsive disorder
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, University Hospital Jena, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    J Psychiatr Res 46:264-70. 2012
    ..Hence, different symptom dimensions must be taken into account in order to disentangle the neurobiological underpinnings of OCD...
  7. doi Disrupted white matter integrity of corticopontine-cerebellar circuitry in schizophrenia
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jahnstr 3, Philosophenweg 3, 07740, Jena, Germany
    Eur Arch Psychiatry Clin Neurosci 260:419-26. 2010
    ..They corroborate preceding findings of white matter structural deficits in mainly long-ranging association fibers and provide first evidence for neuroplastic changes in terms of an increased directionality in more inferior fiber tracts...
  8. pmc Association between learning capabilities and practice-related activation changes in schizophrenia
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Schizophr Bull 36:486-95. 2010
    ..The findings also suggest that successful learners can better compensate potentially interfering effects exerted by disorder-related psychopathology...
  9. doi Altered error-related activity in patients with schizophrenia
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuropsychologia 47:2843-9. 2009
    ..Thus, present results clearly indicate that disorder-characteristic activation abnormalities become manifest during dysfunctional executive processing even when the moderating effect of performance is largely eliminated...
  10. doi The neural correlates of reward-related trial-and-error learning: an fMRI study with a probabilistic learning task
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
    Learn Mem 15:728-32. 2008
    ..In contrast, learning on the basis of predictable stimulus-outcome associations enables the brain to reduce resources in association with the processes of prediction...
  11. doi Altered activation in association with reward-related trial-and-error learning in patients with schizophrenia
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jahnstr, Philosophenweg 3, 07740 Jena, Germany
    Neuroimage 50:223-32. 2010
    ..They moreover suggest that the activation deficits which patients exhibit in association with the processing of reinforcement might constitute the basis for the learning deficits and their accompanying activation alterations...
  12. doi Fronto-striatal hypoactivation during correct information retrieval in patients with schizophrenia: an fMRI study
    K Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuroscience 153:54-62. 2008
    ..Given the relevant role of the caudate and the ACC in dopaminergically mediated executive processing, the results bear crucial implications for the psychopathology of schizophrenia...
  13. ncbi Temporal modeling demonstrates preserved overlearning processes in schizophrenia: an fMRI study
    K Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuroscience 146:1474-83. 2007
    ..Our data suggest that in subacute patients learning and associated decreases in cerebral activation brought about by short-term practice are left unimpaired...
  14. doi Neural activation and radial diffusivity in schizophrenia: combined fMRI and diffusion tensor imaging study
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Germany
    Br J Psychiatry 198:223-9. 2011
    ..Most studies have investigated changes in fractional anisotropy, whereas alterations in radial or axial diffusivity have barely been investigated until now...
  15. doi Emotion-cognition interactions in schizophrenia
    Ute Habel
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    World J Biol Psychiatry 11:934-44. 2010
    ..This may have clinical implications in mental illnesses, such as schizophrenia, where negative emotions often prevail. Experimentally this influence can be studied by using olfactory emotion induction...
  16. ncbi White matter abnormalities and brain activation in schizophrenia: a combined DTI and fMRI study
    Ralf G M Schlösser
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University, 07743 Jena, Germany
    Schizophr Res 89:1-11. 2007
    ..It highlights a potential relationship between anatomical changes in a frontal-temporal anatomical circuit and functional alterations in the prefrontal cortex...
  17. ncbi Inefficient executive cognitive control in schizophrenia is preceded by altered functional activation during information encoding: an fMRI study
    Ralf G M Schlösser
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Neuropsychologia 46:336-47. 2008
    ..These results could be explained by increased top-down control processing from prefrontal cortex as a compensation for functional deficits occurring during encoding...
  18. ncbi Gender differences in the cognitive control of emotion: An fMRI study
    Kathrin Koch
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Neuropsychologia 45:2744-54. 2007
    ..These results provide new insights in gender-specific cerebral mechanisms...
  19. doi Reduced anterior cingulate cognitive activation is associated with prefrontal-temporal cortical thinning in schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
    Biol Psychiatry 71:146-53. 2012
    ..Therefore, this study investigated the association of anterior cingulate cognitive activation and cortical thickness in schizophrenia combining functional magnetic resonance imaging (fMRI) and surface-based morphometry...
  20. doi Psychopathological correlates of the entorhinal cortical shape in schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
    Eur Arch Psychiatry Clin Neurosci 260:351-8. 2010
    ..As cortical folding is a stable neuroanatomical parameter terminated in early neonatal stages, our data give reason to assume that the vulnerability to develop psychotic symptoms might be manifest at an early level of brain maturation...
  21. doi Reduced cortical thickness in first episode schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Schizophr Res 116:204-9. 2010
    ..In an extension of these earlier studies, we used an entire cortex vertex-wise approach and an automated clustering for the detection and exact quantification of cortical thickness alterations in first episode schizophrenia...
  22. ncbi Temporal changes in neural activation during practice of information retrieval from short-term memory: an fMRI study
    Kathrin Koch
    Department of Psychiatry, University of Jena, Philosophenweg 3, 07740 Jena, Germany
    Brain Res 1107:140-50. 2006
    ..The temporal changes in brain activation patterns could be attributed to enhanced efficiency of information processing as a result of cognitive practice...
  23. doi The visual cortex in schizophrenia: alterations of gyrification rather than cortical thickness--a combined cortical shape analysis
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Brain Struct Funct 218:51-8. 2013
    ..The present findings of hypergyria are highly indicative for a disrupted corticogenesis of these visual key regions and might constitute a relevant anatomical basis for visual processing deficits in schizophrenia...
  24. doi Increased parahippocampal and lingual gyrification in first-episode schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Schizophr Res 123:137-44. 2010
    ....
  25. doi Complex pattern of cortical thinning in schizophrenia: results from an automated surface based analysis of cortical thickness
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, Jena, Germany
    Psychiatry Res 182:134-40. 2010
    ..This pattern is consistent with a disruption of neurofunctional networks previously implicated in the pathophysiology of schizophrenia...
  26. pmc Differential effects of serotonergic and noradrenergic antidepressants on brain activity during a cognitive control task and neurofunctional prediction of treatment outcome in patients with depression
    Gerd Wagner
    Department of Psychiatry and Psychotherapy, University of Jena, Germany
    J Psychiatry Neurosci 35:247-57. 2010
    ..We predicted that pretreatment hyperactivity in the rostral anterior cingulate cortex would predict better treatment outcomes...
  27. doi ADC changes in schizophrenia: a diffusion-weighted imaging study
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University of Jena, Philosophenweg 3, 07743, Jena, Germany
    Eur Arch Psychiatry Clin Neurosci 261:213-6. 2011
    ..Changes in other parameters like fractional anisotropy (FA) might be a more sensitive indicator of white matter pathology in this disorder...
  28. ncbi The influence of olfactory-induced negative emotion on verbal working memory: individual differences in neurobehavioral findings
    Ute Habel
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Brain Res 1152:158-70. 2007
    ..Results confirm the importance of incorporating individual differences in emotion processing and its interaction with cognitive functions in neuroimaging...
  29. doi Prefrontal cortical thickness in depressed patients with high-risk for suicidal behavior
    Gerd Wagner
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Centre for Neuroimaging, Jahnstr 3, 07740 Jena, Germany
    J Psychiatr Res 46:1449-55. 2012
    ..This alteration may constitute the neurobiological basis for an increased predisposition to suicidal behavior...
  30. doi Assessing the neural basis of uncertainty in perceptual category learning through varying levels of distortion
    Reka Daniel
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University of Jena, Jahnstrasse 3, 07743 Jena, Germany
    J Cogn Neurosci 23:1781-93. 2011
    ..This study characterizes the cortico-striatal network underlying the classification of distorted visual patterns that is directly related to decision uncertainty...
  31. ncbi Metacognition and reflexivity in patients with schizophrenia
    Tilo T J Kircher
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Psychopathology 40:254-60. 2007
    ..Many patients with schizophrenia demonstrate a lack of insight into their disorder and often do not complain about their cognitive impairments. This might be due to generally reduced metacognitive abilities...
  32. doi Association between white matter fiber structure and reward-related reactivity of the ventral striatum
    Kathrin Koch
    Department of Neuroradiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743 Jena, Germany
    Hum Brain Mapp 35:1469-76. 2014
    ..Hum Brain Mapp 35:1469-1476, 2014. © 2013 Wiley Periodicals, Inc. ..
  33. doi Multimodal functional and structural imaging investigations in psychosis research
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07740 Jena, Germany
    Eur Arch Psychiatry Clin Neurosci 262:S97-106. 2012
    ..Here, investigating the genetic foundations of brain pathology relationships is a major challenge for future multimodal imaging applications in psychosis research...
  34. pmc Reduced cortical thickness is associated with the glutamatergic regulatory gene risk variant DAOA Arg30Lys in schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
    Neuropsychopharmacology 36:1747-53. 2011
    ..Our finding thus underlines the importance of DAOA and related glutamatergic processes as a putative target for therapeutic interventions in schizophrenia...
  35. ncbi Interaction of negative olfactory stimulation and working memory in schizophrenia patients: development and evaluation of a behavioral neuroimaging task
    Frank Schneider
    Department of Psychiatry and Psychotherapy, University of Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Psychiatry Res 144:123-30. 2006
    ..The present data indicate a differential effect of negative mood induction on working memory performance in schizophrenia patients and healthy subjects...
  36. pmc Self-referential processing influences functional activation during cognitive control: an fMRI study
    Gerd Wagner
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Centre for Neuroimaging, Jahnstr 3, 07740 Jena, Germany
    Soc Cogn Affect Neurosci 8:828-37. 2013
    ....
  37. ncbi Impairment in the specificity of emotion processing in schizophrenia
    Frank Schneider
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstr 30, 52074 Aachen, Germany
    Am J Psychiatry 163:442-7. 2006
    ..The authors also sought to establish whether the deficit affects sensitivity or specificity of performance...
  38. doi Structural brain alterations in patients with major depressive disorder and high risk for suicide: evidence for a distinct neurobiological entity?
    Gerd Wagner
    Department of Psychiatry and Psychotherapy, University of Jena, Jena, Germany
    Neuroimage 54:1607-14. 2011
    ....
  39. pmc Enhanced rostral anterior cingulate cortex activation during cognitive control is related to orbitofrontal volume reduction in unipolar depression
    Gerd Wagner
    Department of Psychiatry, University of Jena, Ersatztext Jena, Germany
    J Psychiatry Neurosci 33:199-208. 2008
    ....
  40. doi Fronto-cingulate effective connectivity in obsessive compulsive disorder: a study with fMRI and dynamic causal modeling
    Ralf G M Schlösser
    Department of Psychiatry, University of Jena, Germany
    Hum Brain Mapp 31:1834-50. 2010
    ..These findings are consistent with an overactive error control system in OCD subserving suppression of prepotent responses during decision-making...
  41. ncbi The special involvement of the rostrolateral prefrontal cortex in planning abilities: an event-related fMRI study with the Tower of London paradigm
    Gerd Wagner
    Department of Psychiatry, University of Jena, Germany
    Neuropsychologia 44:2337-47. 2006
    ....
  42. pmc Exercise reveals the interrelation of physical fitness, inflammatory response, psychopathology, and autonomic function in patients with schizophrenia
    Stefanie Ostermann
    Department of Psychiatry and Psychotherapy, University Hospital, Jena, Germany
    Schizophr Bull 39:1139-49. 2013
    ..Results of inflammatory parameters are suggestive of a reduced activity of the anti-inflammatory cholinergic pathway in patients, leading to a pro-inflammatory state. ..
  43. pmc The phrenic component of acute schizophrenia--a name and its physiological reality
    Karl Jürgen Bär
    Pain and Autonomic Integrative Research, Department of Psychiatry and Psychotherapy, University Hospital, Jena, Germany
    PLoS ONE 7:e33459. 2012
    ..These results are invaluable for researchers studying changes of biological signals prone to the influence of breathing rate and rhythm (e.g., functional imaging)...