Thomas Kamradt

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. ncbi The role and clinical implications of G6PI in experimental models of rheumatoid arthritis
    Thomas Kamradt
    Institut fur Immunologie, Klinikum der Friedrich Schiller Universitat Jena, Jena, Germany
    Arthritis Res Ther 7:20-8. 2005
  2. ncbi Immunization with an immunodominant self-peptide derived from glucose-6-phosphate isomerase induces arthritis in DBA/1 mice
    Lisa Bruns
    Universitatsklinikum Jena, Institut fur Immunologie, Leutragraben 3, Jena, Germany
    Arthritis Res Ther 11:R117. 2009
  3. ncbi Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis
    Oliver Frey
    Institut fur Immunologie, Universitatsklinikum Jena, Jena 07743, Germany
    Ann Rheum Dis 69:1495-501. 2010
  4. ncbi Regulatory T cells control the transition from acute into chronic inflammation in glucose-6-phosphate isomerase-induced arthritis
    Oliver Frey
    Institut fur Immunologie, Universitatsklinikum Jena, Leutragraben, Germany
    Ann Rheum Dis 69:1511-8. 2010
  5. ncbi Ameliorated course of glucose-6-phosphate isomerase (G6PI)-induced arthritis in IFN-γ receptor knockout mice exposes an arthritis-promoting role of IFN-γ
    Oliver Frey
    Institute of Immunology, Jena University Hospital, Jena, Germany
    J Autoimmun 36:161-9. 2011
  6. ncbi PI3Kγ deficiency delays the onset of experimental autoimmune encephalomyelitis and ameliorates its clinical outcome
    Luciana Berod
    Institute for Immunology, University Hospital Jena, Friedrich Schiller University Jena, Jena, Germany
    Eur J Immunol 41:833-44. 2011
  7. ncbi B cell depletion reduces the number of autoreactive T helper cells and prevents glucose-6-phosphate isomerase-induced arthritis
    Oliver Frey
    Institute of Immunology, Jena University Hospital, Jena, Germany
    PLoS ONE 6:e24718. 2011
  8. ncbi C-Kit controls IL-1β-induced effector functions in HMC-cells
    Sebastian Drube
    Institut fur Immunologie, Universitätsklinikum Jena Friedrich Schiller Universität Jena, 07743 Jena, Germany
    Eur J Pharmacol 675:57-62. 2012
  9. ncbi The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells
    Sebastian Drube
    Institut fur Immunologie, Universitatsklinikum Jena, Jena, Germany
    Blood 115:3899-906. 2010

Collaborators

Detail Information

Publications9

  1. ncbi The role and clinical implications of G6PI in experimental models of rheumatoid arthritis
    Thomas Kamradt
    Institut fur Immunologie, Klinikum der Friedrich Schiller Universitat Jena, Jena, Germany
    Arthritis Res Ther 7:20-8. 2005
    ....
  2. ncbi Immunization with an immunodominant self-peptide derived from glucose-6-phosphate isomerase induces arthritis in DBA/1 mice
    Lisa Bruns
    Universitatsklinikum Jena, Institut fur Immunologie, Leutragraben 3, Jena, Germany
    Arthritis Res Ther 11:R117. 2009
    ..We aimed at identifying arthritogenic G6PI peptides...
  3. ncbi Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis
    Oliver Frey
    Institut fur Immunologie, Universitatsklinikum Jena, Jena 07743, Germany
    Ann Rheum Dis 69:1495-501. 2010
    ..Glucose-6-phosphate isomerase (G6PI)-induced arthritis requires T and B lymphocytes. It was hypothesised that blocking ICOS/ICOSL interactions ameliorates G6PI-induced arthritis and reduces G6PI-specific B and T lymphocyte responses...
  4. ncbi Regulatory T cells control the transition from acute into chronic inflammation in glucose-6-phosphate isomerase-induced arthritis
    Oliver Frey
    Institut fur Immunologie, Universitatsklinikum Jena, Leutragraben, Germany
    Ann Rheum Dis 69:1511-8. 2010
    ..It was hypothesised that regulatory T cells (Tregs) are involved in remission and their role in G6PI-induced arthritis was investigated...
  5. ncbi Ameliorated course of glucose-6-phosphate isomerase (G6PI)-induced arthritis in IFN-γ receptor knockout mice exposes an arthritis-promoting role of IFN-γ
    Oliver Frey
    Institute of Immunology, Jena University Hospital, Jena, Germany
    J Autoimmun 36:161-9. 2011
    ....
  6. ncbi PI3Kγ deficiency delays the onset of experimental autoimmune encephalomyelitis and ameliorates its clinical outcome
    Luciana Berod
    Institute for Immunology, University Hospital Jena, Friedrich Schiller University Jena, Jena, Germany
    Eur J Immunol 41:833-44. 2011
    ..These findings demonstrate that PI3Kγ contributes to the development of autoimmune CNS inflammation...
  7. ncbi B cell depletion reduces the number of autoreactive T helper cells and prevents glucose-6-phosphate isomerase-induced arthritis
    Oliver Frey
    Institute of Immunology, Jena University Hospital, Jena, Germany
    PLoS ONE 6:e24718. 2011
    ..B cell depletion prevents but does not cure G6PI-induced arthritis. Arthritis prevention upon B cell depletion is associated with a drastic reduction in the number of G6PI-specific effector Th cells...
  8. ncbi C-Kit controls IL-1β-induced effector functions in HMC-cells
    Sebastian Drube
    Institut fur Immunologie, Universitätsklinikum Jena Friedrich Schiller Universität Jena, 07743 Jena, Germany
    Eur J Pharmacol 675:57-62. 2012
    ..Therefore, c-Kit is an important regulator of IL-1 receptor 1-induced signalling and effector functions in HMC-cells...
  9. ncbi The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells
    Sebastian Drube
    Institut fur Immunologie, Universitatsklinikum Jena, Jena, Germany
    Blood 115:3899-906. 2010
    ..We found that c-Kit and IL-1RAcP interact constitutively and that IL-33R joins this complex upon ligand binding. Our findings support a model in which signals from seemingly disparate receptors are integrated for full cellular responses...