A Henke

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. ncbi request reprint DNA immunization--a new chance in vaccine research?
    A Henke
    Institute of Virology, Medical Center, Friedrich Schiller University, Winzerlaer Str 10, 07745 Jena, Germany
    Med Microbiol Immunol 191:187-90. 2002
  2. ncbi request reprint Vaccination procedures against Coxsackievirus-induced heart disease
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center at the Friedrich Schiller University Jena, Hans Knöll Strasse 2, D 07740 Jena, Germany
    Expert Rev Vaccines 2:805-15. 2003
  3. ncbi request reprint Direct interferon-gamma-mediated protection caused by a recombinant coxsackievirus B3
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Winzerlaer Strasse 10, D 07745 Jena, Germany
    Virology 315:335-44. 2003
  4. ncbi request reprint Co-expression of interleukin-2 by a bicistronic plasmid increases the efficacy of DNA immunization to prevent influenza virus infections
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Jena, Germany
    Intervirology 49:249-52. 2006
  5. doi request reprint Characterization of the protective capability of a recombinant coxsackievirus B3 variant expressing interferon-gamma
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Jena, Germany
    Viral Immunol 21:38-48. 2008
  6. ncbi request reprint Recombinant coxsackievirus vectors for prevention and therapy of virus-induced heart disease
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans Knöll Strasse 2, D 07745 Jena, Germany
    Int J Med Microbiol 298:127-34. 2008
  7. doi request reprint Coxsackievirus B3 vaccines: use as an expression vector for prevention of myocarditis
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans Knöll Street 2, Jena D 07745, Germany
    Expert Rev Vaccines 7:1557-67. 2008
  8. ncbi request reprint The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva
    A Henke
    Institute of Virology, Medical Center, Friedrich Schiller University Jena, Winzerlaer Strasse 10, D 07745 Jena, Germany
    Virology 289:15-22. 2001
  9. pmc Expression of immunoregulatory cytokines by recombinant coxsackievirus B3 variants confers protection against virus-caused myocarditis
    A Henke
    Institute of Virology, Medical Center, Friedrich Schiller University, D 07745 Jena, Germany
    J Virol 75:8187-94. 2001
  10. pmc Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva
    A Henke
    Institute of Virology, Medical Center, Friedrich Schiller University Jena, Germany
    J Virol 74:4284-90. 2000

Collaborators

Detail Information

Publications53

  1. ncbi request reprint DNA immunization--a new chance in vaccine research?
    A Henke
    Institute of Virology, Medical Center, Friedrich Schiller University, Winzerlaer Str 10, 07745 Jena, Germany
    Med Microbiol Immunol 191:187-90. 2002
    ..g., the possible integration of plasmid DNA into host chromosomes. In summary, the results concerning the efficiency of DNA vaccination demonstrate clearly that these new vaccines may have a promising future in human immunization...
  2. ncbi request reprint Vaccination procedures against Coxsackievirus-induced heart disease
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center at the Friedrich Schiller University Jena, Hans Knöll Strasse 2, D 07740 Jena, Germany
    Expert Rev Vaccines 2:805-15. 2003
    ..In particular, the application of an interferon-gamma-expressing recombinant Coxsackievirus variant against Coxsackievirus B3-induced myocarditis has been effective...
  3. ncbi request reprint Direct interferon-gamma-mediated protection caused by a recombinant coxsackievirus B3
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Winzerlaer Strasse 10, D 07745 Jena, Germany
    Virology 315:335-44. 2003
    ..This direct effect was not restricted to the homologous virus. In vitro, cocultivation of CVB3(IFN-gamma)-infected cells induced a reduction of CVB3H3 replication and virus-induced cytopathogenicity...
  4. ncbi request reprint Co-expression of interleukin-2 by a bicistronic plasmid increases the efficacy of DNA immunization to prevent influenza virus infections
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Jena, Germany
    Intervirology 49:249-52. 2006
    ....
  5. doi request reprint Characterization of the protective capability of a recombinant coxsackievirus B3 variant expressing interferon-gamma
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Jena, Germany
    Viral Immunol 21:38-48. 2008
    ..Using a murine model of CVB3-induced myocarditis, other aspects of the CVB3/IFN-gamma application as a vaccine were studied concerning route of administration, age, and presence of a pre-existing immune response...
  6. ncbi request reprint Recombinant coxsackievirus vectors for prevention and therapy of virus-induced heart disease
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans Knöll Strasse 2, D 07745 Jena, Germany
    Int J Med Microbiol 298:127-34. 2008
    ..The local and simultaneous expression of an immuno-relevant cytokine by the virus itself induces a strong and long-lasting immune response which protects laboratory animals against lethal infections...
  7. doi request reprint Coxsackievirus B3 vaccines: use as an expression vector for prevention of myocarditis
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans Knöll Street 2, Jena D 07745, Germany
    Expert Rev Vaccines 7:1557-67. 2008
    ....
  8. ncbi request reprint The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva
    A Henke
    Institute of Virology, Medical Center, Friedrich Schiller University Jena, Winzerlaer Strasse 10, D 07745 Jena, Germany
    Virology 289:15-22. 2001
    ..Together, these results show that the interaction between VP2 of CVB3H3 and Siva is a highly specific process involving distinct amino acids on both proteins that most likely influence the outcome of CVB3-caused disease...
  9. pmc Expression of immunoregulatory cytokines by recombinant coxsackievirus B3 variants confers protection against virus-caused myocarditis
    A Henke
    Institute of Virology, Medical Center, Friedrich Schiller University, D 07745 Jena, Germany
    J Virol 75:8187-94. 2001
    ..This study demonstrates that expression of immunoregulatory cytokines during CVB3 replication simultaneously protects mice against a lethal disease and prevents virus-caused tissue destruction...
  10. pmc Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva
    A Henke
    Institute of Virology, Medical Center, Friedrich Schiller University Jena, Germany
    J Virol 74:4284-90. 2000
    ..It has been proposed that Siva is involved in the CD27/CD70-transduced apoptosis. Therefore, we suggest a molecular mechanism through which apoptotic events contributes to CVB3-caused pathogenesis...
  11. ncbi request reprint Co-expression of interleukin-2 to increase the efficacy of DNA vaccine-mediated protection in coxsackievirus B3-infected mice
    Andreas Henke
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, D 07740 Jena, Germany
    Antiviral Res 64:131-6. 2004
    ..Here, we report that the co-expression of the immune-stimulatory interleukin-2 (IL-2) can increase the efficacy of the inoculated DNA vaccine depending on the route of administration and the mouse strain used...
  12. ncbi request reprint DNA vaccine-mediated immune responses in Coxsackie virus B3-infected mice
    A Henke
    Institute of Virology, Medical Center, Friedrich Schiller University, Winzerlaer Str 10, D 07745 Jena, Germany
    Antiviral Res 49:49-54. 2001
    ..In summary, our results indicate that the induction of B cell and/or T cell memory in vaccinated mice prior to challenge is responsible for the protection observed...
  13. ncbi request reprint Detection of porcine enteroviruses by nRT-PCR: differentiation of CPE groups I-III with specific primer sets
    R Zell
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, Winzerlaer Str 10, 07745 Jena, Germany
    J Virol Methods 88:205-18. 2000
    ....
  14. ncbi request reprint Functional features of the bovine enterovirus 5'-non-translated region
    R Zell
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, Jena, Germany
    J Gen Virol 80:2299-309. 1999
    ....
  15. pmc Porcine teschoviruses comprise at least eleven distinct serotypes: molecular and evolutionary aspects
    R Zell
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, 07745 Jena, Germany
    J Virol 75:1620-31. 2001
    ..Sequencing of field isolates collected from animals presenting with neurological disorders prove that other serotypes than PTV-1 may also cause polioencephalomyelitis of swine...
  16. pmc Variability of immediate-early gene 62 in german varicella-zoster virus wild-type strains
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
    J Clin Microbiol 47:3717-20. 2009
    ..M1 strains in Germany display a uniform ORF 62 pattern, suggesting that these strains were introduced from Africa and/or Asia via few sources during the last years...
  17. doi request reprint Monitoring prevalence of varicella-zoster virus clades in Germany
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Jena University Hospital, Hans Knoell Strasse 2, 07745, Jena, Germany
    Med Microbiol Immunol 200:99-107. 2011
    ..In primary VZV infection, nearly 20% of clade 1 has been replaced by clade 5 that might spread more effectively in the population than the European VZV clades...
  18. doi request reprint Genotypes of varicella-zoster virus wild-type strains in Germany
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Jena, Germany
    J Med Virol 80:1123-30. 2008
    ..The possible recombinant could not be classified definitely by the scattered SNP method used and, therefore, has to be confirmed by full-genome sequencing studies...
  19. ncbi request reprint Chemotactic activity of serum obtained from patients with idiopathic dilated cardiomyopathy
    H H Sigusch
    University of Jena, Department of Internal Medicine, Division of Cardiology, 07740 Jena, Germany
    Pharmazie 61:706-9. 2006
    ..05) associated with significantly higher circulating MCP-1 levels. Sera obtained from IDCM patients show a high chemotactic activity associated with significantly elevated circulating MCP-1...
  20. doi request reprint Phenotypic and genotypic characterization of acyclovir-resistant clinical isolates of herpes simplex virus
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, German Reference Laboratory for HSV and VZV, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, 07745 Jena, Germany
    Antiviral Res 86:246-52. 2010
    ..g. site-directed mutagenesis experiments are required to characterize mutations of the TK and DNA pol genes in ACV-resistant viral strains as part of viral gene polymorphism or as cause of drug resistance...
  21. ncbi request reprint Analysis of repeat units in the R2 region among different Oka varicella-zoster virus vaccine strains and wild-type strains in Germany
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Jena, Germany
    Intervirology 50:40-4. 2007
    ..The present study compared the number of R2 repeat units in six different Oka strains and in 54 varicella-zoster virus (VZV) wild-type strains isolated from patients with varicella or zoster in Germany...
  22. ncbi request reprint Genotyping of different varicella vaccine strains
    A Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
    J Clin Virol 37:109-17. 2006
    ..These findings need attention since mutations in the vaccine strain could result in changes of virulence and efficacy of the vaccine...
  23. ncbi request reprint Attachment of coxsackievirus B3 variants to various cell lines: mapping of phenotypic differences to capsid protein VP1
    M Schmidtke
    Institute for Virology, Medical Center at the Friedrich Schiller University, Winzerlaer Str 10, Jena D 07745, Germany
    Virology 275:77-88. 2000
    ..Moreover, the lytic replication of CVB3 PD and the hybrid virus in various nonpermissive rodent cell lines indicates that cell surface molecules other than CAR and DAF may be involved in attachment of this variant to cell surfaces...
  24. ncbi request reprint Application of genome sequence information to the classification of bovine enteroviruses: the importance of 5'- and 3'-nontranslated regions
    R Zell
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, Jena, Germany
    Virus Res 51:213-29. 1997
    ..For rhinoviruses, the existence of two virus clusters was confirmed...
  25. pmc Heparan sulfates and coxsackievirus-adenovirus receptor: each one mediates coxsackievirus B3 PD infection
    A E Zautner
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University Jena, University Medical Center, Winzerlaer Strasse 10, D 07745 Jena, Germany
    J Virol 77:10071-7. 2003
    ..These results demonstrate that the amino acid substitutions in the viral capsid protein VP1 enable CVB3 PD to use specific modified HS as an entry receptor in addition to CAR...
  26. ncbi request reprint Pre-emptive therapy with rituximab for prevention of Epstein-Barr virus-associated lymphoproliferative disease after hematopoietic stem cell transplantation
    B Gruhn
    Department of Pediatrics, University of Jena, Jena, Germany
    Bone Marrow Transplant 31:1023-5. 2003
    ..In all three patients, no EBV-associated LPD occurred. We conclude that pre-emptive therapy with rituximab appears to be effective for prevention of EBV-associated LPD after HSCT...
  27. ncbi request reprint Global climate change and the emergence/re-emergence of infectious diseases
    Roland Zell
    Institute for Virology and Antiviral Therapy, Medical Center at the Friedrich Schiller University, Jena, Germany
    Int J Med Microbiol 293:16-26. 2004
    ..The complexity of not yet fully understood pathogen transmission dynamics with numerous variables might be an explanation of the problems in assessing the risk factors...
  28. ncbi request reprint Influence of pan-caspase inhibitors on coxsackievirus B3-infected CD19+ B lymphocytes
    Nadine Jarasch
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans Knöll Str 2, 07745 Jena, Germany
    Apoptosis 12:1633-43. 2007
    ..This proportion could be decreased up to 45%, if 3 days p. i. mice were intravenously treated with the pan-caspase inhibitors Z-VAD-FMK or Q-VD-OPH. These data were compared with results obtained from CVB3-infected human Raji cells...
  29. ncbi request reprint The non-coding region of BK subtype II viruses
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans Knoell Str 2, 07745 Jena, Germany
    Virus Genes 36:27-9. 2008
    ..Sequence comparisons revealed that the archetypal configuration of subtype I strain WW seems to be predominant among BKV subtypes...
  30. ncbi request reprint Poly(rC)-binding protein 2 interacts with the oligo(rC) tract of coxsackievirus B3
    Roland Zell
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University, Hans Knoell Strasse 2, D 07745 Jena, Germany
    Biochem Biophys Res Commun 366:917-21. 2008
    ..In the presence of 3C proteinase, cloverleaf RNA (1-87) interacts with PCBP2...
  31. ncbi request reprint Novel reassortant of swine influenza H1N2 virus in Germany
    Roland Zell
    Institut für Virologie und Antivirale Therapie, Universitatsklinikum, Friedrich Schiller Universitat, Hans Knöll Str 2, D 07745 Jena, Germany
    J Gen Virol 89:271-6. 2008
    ..Genome sequencing revealed the novel combination of the human-like HAH1 gene of European porcine H1N2 influenza viruses and the NAN2 gene of European porcine H3N2 viruses...
  32. ncbi request reprint Susceptibility of coxsackievirus B3 laboratory strains and clinical isolates to the capsid function inhibitor pleconaril: antiviral studies with virus chimeras demonstrate the crucial role of amino acid 1092 in treatment
    Michaela Schmidtke
    Institute of Virology and Antiviral Therapy, Medical Centre of the Friedrich Schiller University Jena, Hans Knoell Str 2, D 07740 Jena, Germany
    J Antimicrob Chemother 56:648-56. 2005
    ..This study was designed to better understand the polymorphism of the hydrophobic pocket in CVB3 laboratory strains and clinical isolates and its implications for treatment with the capsid function inhibitor pleconaril...
  33. pmc Biological significance of a human enterovirus B-specific RNA element in the 3' nontranslated region
    Ingrid Merkle
    Institute of Virology, Friedrich Schiller University, D 07745 Jena, Germany
    J Virol 76:9900-9. 2002
    ..However, the heart tissue from mice infected with the recombinant virus showed only slight signs of myocarditis. These results suggest that the enterovirus B-like-specific Z domain plays a role in coxsackievirus-induced pathogenesis...
  34. doi request reprint Evolution of four BK virus subtypes
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
    Infect Genet Evol 8:632-43. 2008
    ..Another approach, external calibration by linking BKV divergence to the evolution of mammals, was rejected as it advances BKV divergence prior to the emergence of modern humans...
  35. pmc Sequencing of porcine enterovirus groups II and III reveals unique features of both virus groups
    Andi Krumbholz
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, 07745 Jena, Germany
    J Virol 76:5813-21. 2002
    ..A reclassification of this group into a new picornavirus genus is suggested. PEV group III viruses are typical enteroviruses. They differ from other enteroviruses by a prolonged stem-loop D of the 5'-cloverleaf structure...
  36. pmc Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C
    Roland Zell
    Institut fur Virologie, Klinikum der Friedrich Schiller Universität, Jena, Germany
    RNA 8:188-201. 2002
    ..Binding assays using mutated versions of CVB3 and HRV14 cloverleaf RNAs suggest that the presence of structural features rather than a defined sequence motif of loop D are important for 3C proteinase-RNA interaction...
  37. ncbi request reprint Prevalence of PB1-F2 of influenza A viruses
    Roland Zell
    Institute of Virology and Antiviral Therapy, Medical Center at Friedrich Schiller University, Hans Knoell Str 2, D 07745 Jena, Germany
    J Gen Virol 88:536-46. 2007
    ..This indicates similar properties and function of porcine and human FLUAV PB1-F2...
  38. ncbi request reprint Antiviral effects of pan-caspase inhibitors on the replication of coxsackievirus B3
    Ulrike Martin
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Jena, Germany
    Apoptosis 12:525-33. 2007
    ..A delayed release of cytochrome c into the cytoplasm was detected in Q-VD-OPH-treated CVB3-infected cells pointing to an involvement of caspases in the initial steps of mitochondrial membrane-permeabilization...
  39. ncbi request reprint Genotyping of varicella-zoster virus strains after serial passages in cell culture
    Andreas Sauerbrei
    Institute of Virology and Antiviral Therapy, Friedrich Schiller University of Jena, Hans Knoell Strasse 2, D 07745 Jena, Germany
    J Virol Methods 145:80-3. 2007
    ..For rapid diagnostic identification of vaccine versus wild-type strains, the RFLP profile that is stable within several cell culture passages can be determined using DNA prepared from clinical specimens...
  40. pmc A novel cGUUAg tetraloop structure with a conserved yYNMGg-type backbone conformation from cloverleaf 1 of bovine enterovirus 1 RNA
    Yvonne Ihle
    Molekulare Biophysik NMR Spektroskopie, , D 07745 Jena, Germany
    Nucleic Acids Res 33:2003-11. 2005
    ..Ohlenschlager, J. Wohnert, E. Bucci, S. Seitz, S. Hafner, R. Ramachandran, R. Zell and M. Gorlach (2004) Structure, 12, 237-248] that the proteinase 3C(pro) recognizes structure rather than sequence...
  41. ncbi request reprint Interferon-gamma-induced activation of nitric oxide-mediated antiviral activity of macrophages caused by a recombinant coxsackievirus B3
    Nadine Jarasch
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Hans Knöll Str 2, D 07745 Jena, Germany
    Viral Immunol 18:355-64. 2005
    ..In addition, the expression of IFN-gamma by CVB3/IFN-gamma contributes to protect mice from lethal infections by iNOS induction in murine peritoneal macrophages, viral load reduction, and pancreatic tissue protection...
  42. ncbi request reprint A short PNA targeting coxsackievirus B3 5'-nontranslated region prevents virus-induced cytolysis
    Domenica Musumeci
    Istituto di Biostrutture e Bioimmagini, CNR, I 80134 Naples, Italy
    J Pept Sci 12:161-70. 2006
    ..The results obtained by studying the interaction of such PNA with their RNA target, the entrance into the cell and the viral inhibition are herein presented...
  43. ncbi request reprint Nitric oxide donors inhibit the coxsackievirus B3 proteinases 2A and 3C in vitro, virus production in cells, and signs of myocarditis in virus-infected mice
    Roland Zell
    Institute for Virology, Medical Center at the Friedrich Schiller University, Winzerlaer Strasse 10, 07745 Jena, Germany
    Med Microbiol Immunol 193:91-100. 2004
    ....
  44. ncbi request reprint Linkage map of protein-protein interactions of Porcine teschovirus
    Roland Zell
    Institute for Virology and Antiviral Therapy, Hans Knöll Str 2, D 07745 Jena, Germany
    J Gen Virol 86:2763-8. 2005
    ..Unlike the poliovirus 3C, the teschovirus 3C proteinase dimerizes and interacts with 2BC, 3CD and 3D. The strongest interactions were observed for L-3C, L-3CD and 3C-3CD...
  45. ncbi request reprint Molecular-based reclassification of the bovine enteroviruses
    Roland Zell
    Institute for Virology and Antiviral Therapy, Hans Knöll Str 2, 07745 Jena, Germany
    J Gen Virol 87:375-85. 2006
    ..Incongruent phylogenies of the 5'-non-translated region, the capsid proteins and the 3D polymerase indicate frequent intraserotypic and interserotypic recombination within the non-capsid and the capsid region of the BEV genome...
  46. ncbi request reprint Comparison of a LightCycler-based real-time PCR for quantitation of Epstein-Barr viral load in different clinical specimens with semiquantitative PCR
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University Jena, Jena, Germany
    J Med Virol 78:598-607. 2006
    ..Positive specimens containing more than 500 copies/10(5) cells are measured for exact values by real-time PCR. To circumvent inhibitory effects of cellular DNA, measurements should be carried out generally with 50-10 ng DNA...
  47. ncbi request reprint Detection of porcine teschoviruses and enteroviruses by LightCycler real-time PCR
    Andi Krumbholz
    Institut für Virologie und Antivirale Therapie, Klinikum der Friedrich Schiller Universität, Winzerlaer Str 10, Jena 07745, Germany
    J Virol Methods 113:51-63. 2003
    ..Viruses of the PEV CPE group III can be distinguished from the closely related swine vesicular disease virus (SVDV)...
  48. ncbi request reprint Amantadine resistance among porcine H1N1, H1N2, and H3N2 influenza A viruses isolated in Germany between 1981 and 2001
    Michaela Schmidtke
    Institute of Virology and Antiviral Therapy, Medical Centre of the Friedrich Schiller University Jena, Jena, Germany
    Intervirology 49:286-93. 2006
    ..Therefore, drug susceptibility monitoring appears to be warranted for effective application of those drugs...
  49. ncbi request reprint The structure of the stemloop D subdomain of coxsackievirus B3 cloverleaf RNA and its interaction with the proteinase 3C
    Oliver Ohlenschläger
    Institut für Molekulare Biotechnologie eV, Bentenbergstr 100813, D 07745 Jena, Germany
    Structure 12:237-48. 2004
    ..The binding of 3Cpro to SLD requires the integrity of those structural elements, strongly suggesting that 3Cpro recognizes a structural motif instead of a specific sequence...
  50. ncbi request reprint Characterization of coxsackievirus B3-caused apoptosis under in vitro conditions
    Ulrike Martin
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University Jena, Winzerlaer Str 10, 07745 Jena, Germany
    Med Microbiol Immunol 193:133-9. 2004
    ..These in vitro results indicate that the induction of apoptosis during CVB3H3 infection is based on the interaction between the capsid protein VP2 and the proapoptotic protein Siva, independently from the complex situation in vivo...
  51. ncbi request reprint Prevalence of BK virus subtype I in Germany
    Andi Krumbholz
    Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University Jena, Jena, Germany
    J Med Virol 78:1588-98. 2006
    ..For the genotyping region, a relationship of BKV subgroups to disease patterns like hemorrhagic cystitis or tubulointerstitial nephritis could not be demonstrated...
  52. ncbi request reprint RNA interaction and cleavage of poly(C)-binding protein 2 by hepatitis A virus protease
    Bo Zhang
    Institute of Medical Molecular Biology, University of Lubeck, Germany
    Biochem Biophys Res Commun 364:725-30. 2007
    ..The results suggest that during HAV infection PCBP2 cleavage might specifically down-regulate viral protein synthesis, thereby giving way to viral RNA synthesis...
  53. pmc Influenza A virus PB1-F2 gene
    Roland Zell
    Emerg Infect Dis 12:1607-8; author reply 1608-9. 2006