Gert E Hein

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. pmc Leflunomide in the treatment of patients with early rheumatoid arthritis--results of a prospective non-interventional study
    Herbert Kellner
    Division of Rheumatology, Center for Inflammatory Joint Diseases, KH Neuwittelsbach, Romanstr 9, 80639 Munich, Germany
    Clin Rheumatol 29:913-20. 2010
  2. pmc Patients with rheumatoid arthritis have an altered circulatory aggrecan profile
    Jean C Rousseau
    Inserm Unit 831, University of Lyon, Pavillon F, Hopital E Herriot, Lyon, France
    BMC Musculoskelet Disord 9:74. 2008
  3. pmc Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells
    Sybille Franke
    Department Internal Medicine III, Jena University Hospital, Erlanger Allee 101, Jena, 07740, Germany
    Arthritis Res Ther 11:R136. 2009
  4. pmc Advanced glycation end product modification of bone proteins and bone remodelling: hypothesis and preliminary immunohistochemical findings
    G Hein
    Department of Internal Medicine III, Rheumatology and Osteology, Friedrich Schiller, University Jena, Germany
    Ann Rheum Dis 65:101-4. 2006
  5. doi request reprint Influence of Rituximab on markers of bone remodeling in patients with rheumatoid arthritis: a prospective open-label pilot study
    Gert Hein
    Department of Internal Medicine III, University Hospital Jena, Erlanger Allee 101, 07740, Jena, Germany
    Rheumatol Int 31:269-72. 2011
  6. ncbi request reprint [Particular features of steroid-induced osteoporosis]
    G E Hein
    Rheumatologie and Osteologie, Klinik für Innere Medizin III des Klinikums der Friedrich Schiller Universität, 07740 Jena
    Orthopade 36:708, 710-3. 2007
  7. doi request reprint sRANKL and OPG in serum and synovial fluid of patients with rheumatoid arthritis in comparison to non-destructive chronic arthritis
    Gert E Hein
    Department of Internal Medicine III, Section of Rheumatology and Osteology, Friedrich Schiller University, Jena, Germany
    Rheumatol Int 28:765-9. 2008
  8. ncbi request reprint Advanced glycation end-products pentosidine and N epsilon-carboxymethyllysine are elevated in serum of patients with osteoporosis
    G Hein
    Friedrich Schiller University of Jena, Department of Internal Medicine, Germany
    Rheumatology (Oxford) 42:1242-6. 2003
  9. ncbi request reprint The advanced glycation end product pentosidine correlates to IL-6 and other relevant inflammatory markers in rheumatoid arthritis
    Gert E Hein
    Rheumatology and Osteology, Department of Internal Medicine III, Friedrich Schiller University of Jena, 07740 Jena, Germany
    Rheumatol Int 26:137-41. 2005
  10. ncbi request reprint Glycation endproducts in osteoporosis--is there a pathophysiologic importance?
    Gert E Hein
    Division of Rheumatology and Osteology, Department of Internal Medicine III, Friedrich Schiller University of Jena, Germany
    Clin Chim Acta 371:32-6. 2006

Detail Information

Publications41

  1. pmc Leflunomide in the treatment of patients with early rheumatoid arthritis--results of a prospective non-interventional study
    Herbert Kellner
    Division of Rheumatology, Center for Inflammatory Joint Diseases, KH Neuwittelsbach, Romanstr 9, 80639 Munich, Germany
    Clin Rheumatol 29:913-20. 2010
    ..Interestingly, the DAS28-remission rate achieved was similar to the rate seen with methotrexate or biologic therapy in other studies...
  2. pmc Patients with rheumatoid arthritis have an altered circulatory aggrecan profile
    Jean C Rousseau
    Inserm Unit 831, University of Lyon, Pavillon F, Hopital E Herriot, Lyon, France
    BMC Musculoskelet Disord 9:74. 2008
    ..We investigated, whether measurement of aggrecan and fragments thereof in serum, could be used as biomarkers for joint-disease in RA patients and furthermore characterized the fragments found in the circulation...
  3. pmc Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells
    Sybille Franke
    Department Internal Medicine III, Jena University Hospital, Erlanger Allee 101, Jena, 07740, Germany
    Arthritis Res Ther 11:R136. 2009
    ..The present study investigates a potential influence of AGE-modified bovine serum albumin (AGE-BSA) on cell growth, and on the expression of proinflammatory and osteoclastogenic markers in cultured FLS...
  4. pmc Advanced glycation end product modification of bone proteins and bone remodelling: hypothesis and preliminary immunohistochemical findings
    G Hein
    Department of Internal Medicine III, Rheumatology and Osteology, Friedrich Schiller, University Jena, Germany
    Ann Rheum Dis 65:101-4. 2006
    ..The process of bone remodelling is disturbed in the development of osteoporosis...
  5. doi request reprint Influence of Rituximab on markers of bone remodeling in patients with rheumatoid arthritis: a prospective open-label pilot study
    Gert Hein
    Department of Internal Medicine III, University Hospital Jena, Erlanger Allee 101, 07740, Jena, Germany
    Rheumatol Int 31:269-72. 2011
    ..In contrast, it appears that Rtx lowered osteoclast activity often found increased in active rheumatoid arthritis contributing to osteoporosis in this disease...
  6. ncbi request reprint [Particular features of steroid-induced osteoporosis]
    G E Hein
    Rheumatologie and Osteologie, Klinik für Innere Medizin III des Klinikums der Friedrich Schiller Universität, 07740 Jena
    Orthopade 36:708, 710-3. 2007
    ....
  7. doi request reprint sRANKL and OPG in serum and synovial fluid of patients with rheumatoid arthritis in comparison to non-destructive chronic arthritis
    Gert E Hein
    Department of Internal Medicine III, Section of Rheumatology and Osteology, Friedrich Schiller University, Jena, Germany
    Rheumatol Int 28:765-9. 2008
    ....
  8. ncbi request reprint Advanced glycation end-products pentosidine and N epsilon-carboxymethyllysine are elevated in serum of patients with osteoporosis
    G Hein
    Friedrich Schiller University of Jena, Department of Internal Medicine, Germany
    Rheumatology (Oxford) 42:1242-6. 2003
    ..To investigate serum levels of the advanced glycation end-products (AGEs) pentosidine and N epsilon-carboxymethyllysine (CML) in patients classified into different osteoporosis subgroups according to histomorphometric data...
  9. ncbi request reprint The advanced glycation end product pentosidine correlates to IL-6 and other relevant inflammatory markers in rheumatoid arthritis
    Gert E Hein
    Rheumatology and Osteology, Department of Internal Medicine III, Friedrich Schiller University of Jena, 07740 Jena, Germany
    Rheumatol Int 26:137-41. 2005
    ....
  10. ncbi request reprint Glycation endproducts in osteoporosis--is there a pathophysiologic importance?
    Gert E Hein
    Division of Rheumatology and Osteology, Department of Internal Medicine III, Friedrich Schiller University of Jena, Germany
    Clin Chim Acta 371:32-6. 2006
    ..Investigations conducted by other groups, as well as ours, support the hypothesis that bone protein glycation influences osteoclasts (bone resorption) and osteoblasts (bone formation)...
  11. ncbi request reprint [Collagen breakdown in ankylosing spondylitis-relationship to disease related parameters]
    C Bölzner
    Klinik für Innere Medizin IV, Rheumatologisches Forschungslabor, Erlanger Allee 101, 07740 Jena, Germany
    Z Rheumatol 62:459-67. 2003
    ....
  12. ncbi request reprint Effect of transplantation on bone: osteoporosis after liver and multivisceral transplantation
    M Hommann
    Department of General and Visceral Surgery, Friedrich Schiller University Jena, Jena, Germany
    Transplant Proc 34:2296-8. 2002
  13. ncbi request reprint Multi-site quantitative ultrasound compared to dual energy X-ray absorptiometry in rheumatoid arthritis: effects of body mass index and inflamed soft tissue on reproducibility
    A Pfeil
    Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Erlanger Allee 101, Jena 07747, Germany
    Rheumatol Int 26:1084-90. 2006
    ..The application of multi-site QUS seems to be restricted for patients with active inflammation based on soft tissue alteration in RA and for healthy individuals with pronounced body mass...
  14. ncbi request reprint [The osteoporosis patient with renal insufficiency: what has to be taken into account in the selection and administration of antiosteoporosis medication?]
    G Lehmann
    Funktionsbereich Rheumatologie Osteologie, Klinik Innere Medizin III der Friedrich Schiller Universität, Jena
    Z Rheumatol 65:378, 380-2. 2006
    ..Efficiancy of the selective estrogen receptor modulator (SERM) raloxifene is not altered by renal function...
  15. ncbi request reprint The response of skin perfusion and of rheological and immunological variables to intravenous prostanoid administration in Raynaud's phenomenon secondary to collagenosis
    S Drinda
    Division of Rheumatology and Osteology, Department of Clinical Medicine III, Friedrich Schiller University Jena, Germany
    Vasa 34:243-9. 2005
    ..In subjective terms, intravenous administration of these agents produces success in more than 50% of patients. The therapeutic outcome of clinical administration of alprostadil or iloprost may vary from individual to individual...
  16. ncbi request reprint Peripheral bone status in rheumatoid arthritis evaluated by digital X-ray radiogrammetry and compared with multisite quantitative ultrasound
    J Bottcher
    Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Jena, Germany
    Calcif Tissue Int 78:25-34. 2006
    ..6% (radius) and -3.9% (phalanx). DXR revealed a significant reduction of DXR-BMD as well as DXR-MCI dependent on the severity of RA and surpassed multisite QUS as a promising diagnostic tool...
  17. ncbi request reprint Soluble receptor activator of NFkappa B-ligand and osteoprotegerin in rheumatoid arthritis - relationship with bone mineral density, disease activity and bone turnover
    P Oelzner
    Division of Rheumatology and Osteology, Department of Internal Medicine III, Friedrich Schiller University, Jena, Germany
    Clin Rheumatol 26:2127-35. 2007
    ....
  18. ncbi request reprint Osteoprotegerin reduces the loss of periarticular bone mass in primary and secondary spongiosa but does not influence inflammation in rat antigen-induced arthritis
    T Neumann
    Department of Internal Medicine III, Friedrich Schiller University of Jena, Division of Rheumatology Osteology, Erlanger Allee 101, 07740 Jena, Germany
    Inflamm Res 55:32-9. 2006
    ..To assess the effect of osteoprotegerin (OPG) on joint swelling, synovial inflammation and cartilage destruction, periarticular and axial bone volume, and bone turnover in rat antigen-induced arthritis (AIA)...
  19. doi request reprint Combination therapy with dexamethasone and osteoprotegerin protects against arthritis-induced bone alterations in antigen-induced arthritis of the rat
    P Oelzner
    Department of Internal Medicine III, University Hospital of Jena, Jena, Germany
    Inflamm Res 59:731-41. 2010
    ..To investigate the influence of a combined therapy consisting of dexamethasone and osteoprotegerin (OPG) on bone alterations and disease activity in antigen-induced arthritis (AIA) in the rat...
  20. doi request reprint [Is the guideline, "Management of early rheumatoid arthritis," being followed in a rheumatism center?]
    M Hartmann
    Universitatsklinikum Jena, Erlanger Allee 101, 07747 Jena
    Dtsch Med Wochenschr 133:1721-4. 2008
    ..It was the aim of this study to examine how and to what extent the external S3 guideline "Management of Early Rheumatoid Arthritis" was applied in a rheumatism center...
  21. ncbi request reprint [The mechanism of bone loss in rheumatoid arthritis. Description based on a case report]
    P Oelzner
    Selbständiger Funktionsbereich Rheumatologie and Osteologie, Klinik fur Innere Medizin III, Universitatsklinikum Jena, Erlanger Allee 101, 07740 Jena
    Z Rheumatol 66:337-40. 2007
    ..This case report shows a close relationship between disease activity and bone turnover in RA and indicates that early investigation and therapy of disturbances of bone metabolism in RA are necessary...
  22. ncbi request reprint Digital X-ray radiogrammetry combined with semiautomated analysis of joint space widths as a new diagnostic approach in rheumatoid arthritis: a cross-sectional and longitudinal study
    J Bottcher
    Friedrich Schiller University Jena, Jena, Germany
    Arthritis Rheum 52:3850-9. 2005
    ....
  23. ncbi request reprint Digital radiogrammetry as a new diagnostic tool for estimation of disease-related osteoporosis in rheumatoid arthritis compared with pQCT
    J Bottcher
    Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Erlanger Allee 101, 07747, Jena, Germany
    Rheumatol Int 25:457-64. 2005
    ....
  24. ncbi request reprint Is there a psoriatic osteopathy? -- the activity of bone resorption in psoriatics is related to inflammatory joint process
    G Hein
    Rheumatologie and Osteologie, Klinik für Innere Medizin IV, Erlanger Allee 101, D 07740 Jena, Germany
    Eur J Med Res 4:187-92. 1999
    ..Our biochemical results do not demonstrate a complete agreement with former scintigraphic or histological investigations of other authors and own histomorphological results...
  25. ncbi request reprint High-dose clodronate therapy prevents joint destruction in chronic antigen-induced arthritis of the rat but inhibits bone formation at the axial skeleton
    P Oelzner
    Department of Internal Medicine IV, Friedrich Schiller University of Jena, Germany
    Inflamm Res 49:424-33. 2000
    ..To investigate the effects of clodronate on clinical disease activity, inflammatory alterations and cartilage destruction, periarticular and axial bone volume and bone turnover in chronic antigen-induced arthritis (AIA; day 28)...
  26. ncbi request reprint Clinical manifestation of POEMS syndrome with features of connective tissue disease
    T Eidner
    Department of Internal Medicine IV, Friedrich Schiller University of Jena, Germany
    Clin Rheumatol 20:70-2. 2001
    ..This case emphasises the need to consider POEMS syndrome as a differential diagnosis in patients with signs of connective tissue disease and polyneuropathy...
  27. ncbi request reprint High phosphorus intake only slightly affects serum minerals, urinary pyridinium crosslinks and renal function in young women
    M Grimm
    Friedrich Schiller University, Institute of Nutritional Science, Jena, Germany
    Eur J Clin Nutr 55:153-61. 2001
    ..Assessment of the physiological effects of a diet rich in phosphorus in young women...
  28. pmc Mosaic chromosomal aberrations in synovial fibroblasts of patients with rheumatoid arthritis, osteoarthritis, and other inflammatory joint diseases
    R W Kinne
    Experimental Rheumatology Unit, Friedrich Schiller University Jena, Winzerlaer Str 10, D 07745 Jena, Germany
    Arthritis Res 3:319-30. 2001
    ..Thus, although of possible functional relevance for the pathologic role of SFB in RA, these alterations probably reflect a common response to chronic inflammatory stress in rheumatic diseases...
  29. ncbi request reprint [Rare association of acute febrile neutrophilic dermatosis (Sweet syndrome) with rheumatoid arthritis]
    J Kaufmann
    Klinik für Innere Medizin IV Funktionsbereich Rheumatologie und Osteologie Friedrich Schiller Universität Jena Postfach 07740 Jena, Germany
    Z Rheumatol 60:263-9. 2001
    ..We review Sweet's syndrome with regard to pathogenesis and associated disorders...
  30. ncbi request reprint Monarthritis of the ankle as manifestation of a calcaneal metastasis of bronchogenic carcinoma
    J Kaufmann
    Clinic of Internal Medicine IV, Departement of Rheumatology and Osteology, Friedrich Schiller University of Jena, Germany
    Scand J Rheumatol 30:363-5. 2001
    ..This case demonstrates possible difficulties in the early differential diagnosis of acute monarthritis, and will be discussed with respect to the few reports on foot acrometastases...
  31. pmc Identification of the advanced glycation end products N(epsilon)-carboxymethyllysine in the synovial tissue of patients with rheumatoid arthritis
    S Drinda
    Department of Internal Medicine IV, Friedrich Schiller University Jena, Germany
    Ann Rheum Dis 61:488-92. 2002
    ..In serum and synovial fluid of patients with rheumatoid arthritis (RA) raised AGE levels have been found...
  32. ncbi request reprint Interleukin-6, soluble interleukin-2-receptor and soluble interleukin-6-receptor in sera of patients with rheumatoid arthritis: influences of disease activity and drug therapy
    S Franke
    Klinik für Innere Medizin IV, Funktionsbereich Rheumatologie und Osteologie, Erlanger Allee 101, Jena D 07740, Germany
    Eur J Med Res 2:401-6. 1997
    ..In conclusion, the results provide some arguments in favour of combined drug therapies, which might possibly enhance the effectiveness of RA therapy...
  33. ncbi request reprint [Influence of body constitution on bone mineral density measured by digital radiogrammetry]
    J Bottcher
    Institut für Diagnostische und Interventionelle Radiologie, Friedrich Schiller Universitat Jena
    Rofo 177:197-203. 2005
    ..This study investigates the influence of body constitution on BMD of healthy adults as calculated by DXR...
  34. ncbi request reprint [Clinical trial for differentiation between corticoid-induced osteoporosis and periarticular demineralization via digital radiogrammetry in patients suffering from rheumatoid arthritis]
    J Bottcher
    Institut für Diagnostische und Interventionelle Radiologie, Friedrich Schiller Universitat Jena, Erlanger Allee 101, 07747 Jena, Germany
    Z Rheumatol 63:473-82. 2004
    ....
  35. ncbi request reprint Potential clinical relevance of digital radiogrammetry for quantification of periarticular bone demineralization in patients suffering from rheumatoid arthritis depending on severity and compared with DXA
    J Bottcher
    Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Bachstrasse 18, 07740 Jena, Germany
    Eur Radiol 14:631-7. 2004
    ..The DXR-based BMD calculation seems to be able to distinguish severity and progress of the disease in contrast to those of DXA at lumbar spine and total femur...
  36. ncbi request reprint Investigations of bone turnover in renal osteopathy
    A Muller
    Rheumatologie und Osteologie, Klinik für Innere Medizin IV, Rheumalabor, Erlanger Allee 101, 07740 Jena, Germany
    Eur J Med Res 4:78-84. 1999
    ..With regard to bone turnover urinary crosslink measurements are of minor importance in CRF. In contrast, serum measurements could be helpful in revealing bone resorption both in patients with CRF and those under dialysis treatment...
  37. ncbi request reprint Anti-C1q antibodies and antiendothelial cell antibodies in systemic lupus erythematosus - relationship with disease activity and renal involvement
    P Oelzner
    Friedrich Schiller University of Jena, Jena, Germany
    Clin Rheumatol 22:271-8. 2003
    ..Absence of anti-dsDNA Ab excludes active nephritis; positive findings of both anti-dsDNA Ab and anti-C1q Ab are of relatively high specificity for active nephritis...
  38. ncbi request reprint Hydroxypyridinium collagen crosslinks in serum, urine, synovial fluid and synovial tissue in patients with rheumatoid arthritis compared with osteoarthritis
    J Kaufmann
    Department of Internal Medicine IV, University of Jena, Germany
    Rheumatology (Oxford) 42:314-20. 2003
    ....
  39. ncbi request reprint Are advanced glycation end-product-modified proteins of pathogenetic importance in fibromyalgia?
    G Hein
    Department of Internal Medicine IV, Rheumatology and Osteology, Friedrich Schiller University of Jena, 07740 Jena, Germany
    Rheumatology (Oxford) 41:1163-7. 2002
    ..To quantify the serum levels of the advanced glycation end-product (AGE) pentosidine in 41 patients with fibromyalgia (FM) and 46 healthy controls. The formation of pentosidine is closely related to oxidative stress...
  40. doi request reprint Effects of long-term immobilisation on cortical bone mass after traumatic amputation of the phalanges estimated by digital X-ray radiogrammetry
    M L SCHAFER
    Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Erlanger Allee 101, 07747, Jena, Germany
    Osteoporos Int 19:1291-9. 2008
    ..Digital X-ray radiogrammetry (DXR) seems to quantify cortical demineralisation caused by circular saw amputation already few days after accident...
  41. ncbi request reprint Decreased RAGE expression in peripheral blood mononuclear cells of patients with rheumatoid arthritis
    S Drinda
    Department of Internal Medicine III, Division of Gastroenterology, Friedrich Schiller University, D 07740 Jena, Germany
    Clin Exp Rheumatol 27:483-90. 2009
    ....