Research Topics
| M GleiSummaryAffiliation: Friedrich Schiller University Country: Germany Publications
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Detail Information
Publications
Influence of prebiotics and antioxidants in bread on the immune system, antioxidative status and antioxidative capacity in male smokers and non-smokersChristiane Seidel
Friedrich Schiller University, Institute of Nutrition, Dornburger Strasse 24 29, D 07743 Jena, Germany
Br J Nutr 97:349-56. 2007....
Associations between dietary habits and body mass index with gut microbiota composition and fecal water genotoxicity: an observational study in African American and Caucasian American volunteersVolker Mai
Microbiology and Cell Science, Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA
Nutr J 8:49. 2009..Diet might change the composition and the activities of the intestinal microbiota, in turn affecting fecal genotoxicity/mutagenicity that is thought to be associated with carcinogenesis...- Defensin alpha 6 (DEFA 6) overexpression threshold of over 60 fold can distinguish between adenoma and fully blown colon carcinoma in individual patientsMariya Y Radeva
Leibniz Institute for Age Research Fritz Lipmann Institute, Beutenbergstr 11, 07745 Jena, Germany
BMC Cancer 10:588. 2010..It is known that alpha-defensin expression is enhanced in colon cancer. However, the expression of human alpha defensin 6 (DEFA 6) in earlier stages, such as adenoma, has so far not yet been studied in a patient resolved manner... - Hemoglobin and hemin induce DNA damage in human colon tumor cells HT29 clone 19A and in primary human colonocytesMichael Glei
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Dornburger Str 25, D 07743 Jena, Germany
Mutat Res 594:162-71. 2006..Thus, hemoglobin/hemin, whether available from red meat or from bowel bleeding, may pose genotoxic and cytotoxic risks to human colon cells, both of which contribute to initiation and progression of colorectal carcinogenesis... - The main catechin of green tea, (-)-epigallocatechin-3-gallate (EGCG), reduces bleomycin-induced DNA damage in human leucocytesM Glei
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Dornburger Street 25, D 07743 Jena, Germany
Toxicol In Vitro 20:295-300. 2006..Together the findings support the hypotheses that EGCG acts protective in human cells... - Both wheat (Triticum aestivum) bran arabinoxylans and gut flora-mediated fermentation products protect human colon cells from genotoxic activities of 4-hydroxynonenal and hydrogen peroxideMichael Glei
Department of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich Schiller University Jena, Dornburger Strasse 25, 07743 Jena, Germany
J Agric Food Chem 54:2088-95. 2006..Thus, increases in SCFAs were not reflected by enhanced functional effects. The conclusion is that fermentation mixtures contain modulatory compounds that arise from the feces and might add to the effectiveness of SCFAs... - Assessment of DNA damage and its modulation by dietary and genetic factors in smokers using the Comet assay: a biomarker modelM Glei
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Jena, Germany
Biomarkers 10:203-17. 2005..Stratification of data by genotype enhanced specificity/sensitivity of the intervention effects and contributed important information on the role of susceptibility... - Bread enriched with green coffee extract has chemoprotective and antigenotoxic activities in human cellsMichael Glei
Friedrich Schiller University Jena Department of Nutritional Toxicology, Institute for Nutrition, Jena, Germany
Nutr Cancer 56:182-92. 2006..Supplementation also increases ChA content and antioxidative capacity. The treatment of the cells with supplemented bread increases resistance of colon and liver cells against H(2)O(2), a source of oxidative stress... 
Use of Comet-FISH in the study of DNA damage and repair: reviewMichael Glei
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University Jena, Dornburger Street 24, 07743 Jena, Germany
Mutat Res 681:33-43. 2009....- Ferric iron is genotoxic in non-transformed and preneoplastic human colon cellsY Knöbel
Institute of Nutrition, Department of Nutritional Toxicology, Friedrich Schiller University, Dornburger Str 25, 07743 Jena, Germany
Food Chem Toxicol 45:804-11. 2007.... - Carob fibre compounds modulate parameters of cell growth differently in human HT29 colon adenocarcinoma cells than in LT97 colon adenoma cellsS Klenow
Friedrich Schiller University Jena, Department of Nutritional Toxicology, Institute of Nutrition, Dornburger Strasse 24, 07743 Jena, Germany
Food Chem Toxicol 46:1389-97. 2008..The differently modulated growth of human colon cell lines was more related to proliferation rates and impairment of DNA-synthesis than to H2O2 formation... - Initial in vitro toxicity testing of functional foods rich in catechins and anthocyanins in human cellsM Glei
Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Str 25, 07743 Jena, Germany
Toxicol In Vitro 17:723-9. 2003..It also allows comparing responses of complex samples and individual compounds, which is important since effects from protective food ingredients can be masked by accompanying toxic components... - Culturing explanted colon crypts highly improves viability of primary non-transformed human colon epithelial cellsA Wilhelm
Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Strasse 24, 07743 Jena, Germany
Toxicol In Vitro 26:133-41. 2012.... - Ferric iron increases ROS formation, modulates cell growth and enhances genotoxic damage by 4-hydroxynonenal in human colon tumor cellsY Knöbel
Institute for Nutrition, Department of Nutritional Toxicology, Biological Pharmaceutical Faculty, Friedrich Schiller University, Dornburger Str 25, 07743 Jena, Germany
Toxicol In Vitro 20:793-800. 2006..Carcinogenic risks from ferric iron could be derived also from lower concentrations, which enhance tumor cell growth and cause progenotoxic effects... - Isoflavonoids and lignans have different potentials to modulate oxidative genetic damage in human colon cellsB L Pool-Zobel
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Dornburger Strabetae 25, 07743 Jena, Germany
Carcinogenesis 21:1247-52. 2000..The genotoxic effects of genistein deserve further investigation... - The effect of probiotics on faecal microbiota and genotoxic activity of faecal water in patients with atopic dermatitis: a randomized, placebo-controlled studyA Roessler
Institute of Nutrition, Department of Nutritional Physiology, Friedrich Schiller University, Dornburger Str 24, 07743 Jena, Germany
Clin Nutr 31:22-9. 2012..Colonic microbiota is involved in the etiology of colon cancer according to several reports. Studies also indicate that the microbiota differs between atopic patients and healthy subjects... - Modulation of detoxification enzymes by watercress: in vitro and in vivo investigations in human peripheral blood cellsThomas Hofmann
Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Str 24, 07743, Jena, Germany
Eur J Nutr 48:483-91. 2009..Epidemiological studies indicate that consumption of cruciferous vegetables (CV) can reduce the risk of cancer. Supposed mechanisms are partly the inhibition of phase I and the induction of phase II enzymes... - Butyrate suppresses mRNA increase of osteopontin and cyclooxygenase-2 in human colon tumor tissueF Jahns
Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Straße 24, 07743 Jena, Germany
Carcinogenesis 32:913-20. 2011..For the first time, our data reveal new insights into the chemoprotective potential of butyrate by showing the suppression of OPN and COX-2 mRNA in primary human colon tissue with the strongest effects observed in tumors... - Uranyl nitrilotriacetate, a stabilized salt of uranium, is genotoxic in nontransformed human colon cells and in the human colon adenoma cell line LT97Yuonne Knöbel
Department of Nutritional Toxicology, Institute for Nutrition, Institute for Human Genetics and Anthropology, Friedrich Schiller University Jena, 07743 Jena, Germany
Toxicol Sci 93:286-97. 2006..It may be concluded that uranium compounds could increase alimentary genotoxic exposure in humans if they reach the food chain in sufficient amounts... - beta-Carotene reduces bleomycin-induced genetic damage in human lymphocytesMichael Glei
Institute for Nutrition, Friedrich Schiller University, Dornburger Str. 25, Jena, D-07743, Germany
Toxicol Appl Pharmacol 179:65-73. 2002..Therefore, beta-carotene accounts for only part of the protection observed in vivo with carotenoid-rich vegetable juices... - Iron-overload induces oxidative DNA damage in the human colon carcinoma cell line HT29 clone 19AMichael Glei
Department of Nutritional Toxicology, Institute of Nutrition, Friedrich-Schiller-University, Dornburger Street 25, 07743 Jena, Germany
Mutat Res 519:151-61. 2002..g. from red meat) relative to the concentrations of antioxidants (from plant foods) in the gut are now needed to determine the optimal balance of food intake that will reduce exposure to this type of colon cancer risk factor... - Colon cancer risk factors from nutritionJens Berlau
Dept of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich Schiller University of Jena, Dornburger Strasse 25, 07743 Jena, Germany
Anal Bioanal Chem 378:737-43. 2004..Knowledge of individual susceptibility will also make it possible to recognise risks and design more specific nutritional recommendations... - Butyrate is only one of several growth inhibitors produced during gut flora-mediated fermentation of dietary fibre sourcesGabriele Beyer-Sehlmeyer
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Dornburger Str. 25, D-07743 Jena, Germany
Br J Nutr 90:1057-70. 2003.... - 2-Dodecylcyclobutanone, a radiolytic product of palmitic acid, is genotoxic in primary human colon cells and in cells from preneoplastic lesionsNadine Knoll
Department of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich Schiller University, Dornburger Strasse 25, D-07743 Jena, Germany
Mutat Res 594:10-9. 2006..These findings provide additional evidence that this compound may be regarded as a possible risk factor for processes in colon carcinogenesis related to initiation and progression... - New revival of an old biomarker: characterisation of buccal cells and determination of genetic damage in the isolated fraction of viable leucocytesKerstin Osswald
Department of Nutritional Toxicology, Institute of Nutrition, Friedrich-Schiller-University Jena, Domburger Street, 25, 07743 Jena, Germany
Mutat Res 544:321-9. 2003..The cells are useful targets of non-invasive biomarkers, which could be incorporated as tools in many types of intervention studies... - Apple polyphenols and products formed in the gut differently inhibit survival of human cell lines derived from colon adenoma (LT97) and carcinoma (HT29)Selvaraju Veeriah
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Dornburger Strasse 25, D 07743 Jena, Germany
J Agric Food Chem 55:2892-900. 2007..The F-AEs were approximately 3-fold less bioactive than the corresponding AEs, pointing to a loss of chemoprotective properties through fermentation... - Comet fluorescence in situ hybridization analysis for oxidative stress-induced DNA damage in colon cancer relevant genesMichael Glei
Institute for Nutrition, Dornburger Strasse 25, Friedrich Schiller University Jena, 07743 Jena, Germany
Toxicol Sci 96:279-84. 2007..This new experimental approach facilitates studies on effects of nutrition-related carcinogens in relevant target genes... - Genotoxicity of 4-hydroxy-2-nonenal in human colon tumor cells is associated with cellular levels of glutathione and the modulation of glutathione S-transferase A4 expression by butyrateNadine Knoll
Department of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich Schiller University, Dornburger Strasse 25, D-07743 Jena, Germany
Toxicol Sci 86:27-35. 2005..Since HNE contributes to colon carcinogenesis, the favorable modulation of the GSH/GST system by butyrate may contribute to chemoprevention and reduction of the risks... - Fecal water as a non-invasive biomarker in nutritional intervention: comparison of preparation methods and refinement of different endpointsAnnett Klinder
Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University, Jena, Germany
Nutr Cancer 57:158-67. 2007..The higher volumes of FW obtained by preparation method B greatly enhance the perspectives of measuring different types of biological parameters and using these to disclose activities related to cancer development... - Blood mononucleocytes are sensitive to the DNA damaging effects of iron overload--in vitro and ex vivo results with human and rat cellsEunju Park
Department of Food and Nutrition, Kyungnam University, 449 Wolyoung dong, Masan 631 701, South Korea
Mutat Res 619:59-67. 2007..The measurement of DNA damage in human leucocytes could be used as a sensitive biomarker to study iron overload in vivo in humans and thus to determine whether supplementation results in genotoxic risk...