Christian Gaser

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. ncbi Structural correlates of psychopathological symptom dimensions in schizophrenia: a voxel-based morphometric study
    Nikolaos Koutsouleris
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Neuroimage 39:1600-12. 2008
  2. pmc Computational morphometry for detecting changes in brain structure due to development, aging, learning, disease and evolution
    Daniel Mietchen
    Structural Brain Mapping Group, Department of Psychiatry, University of Jena D 07743 Jena, Germany
    Front Neuroinform 3:25. 2009
  3. pmc Substantial and reversible brain gray matter reduction but no acute brain lesions in ultramarathon runners: experience from the TransEurope-FootRace Project
    Wolfgang Freund
    Department of Diagnostic and Interventional Radiology, University Hospitals Ulm, Albert Einstein Allee 23, 89081 Ulm, Germany
    BMC Med 10:170. 2012
  4. doi Deformation-based brain morphometry in rats
    Christian Gaser
    Hans Berger Clinic for Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany
    Neuroimage 63:47-53. 2012
  5. ncbi Ventricular enlargement in schizophrenia related to volume reduction of the thalamus, striatum, and superior temporal cortex
    Christian Gaser
    Department of Psychiatry, Friedrich Schiller University of Jena, Germany
    Am J Psychiatry 161:154-6. 2004
  6. ncbi Neuroanatomy of "hearing voices": a frontotemporal brain structural abnormality associated with auditory hallucinations in schizophrenia
    Christian Gaser
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, D 07743 Jena, Germany
    Cereb Cortex 14:91-6. 2004
  7. doi The visual cortex in schizophrenia: alterations of gyrification rather than cortical thickness--a combined cortical shape analysis
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Brain Struct Funct 218:51-8. 2013
  8. doi Increased parahippocampal and lingual gyrification in first-episode schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Schizophr Res 123:137-44. 2010
  9. ncbi Frequency domains of resting state default mode network activity in schizophrenia
    Gianluca Mingoia
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, D 07743 Jena, Germany
    Psychiatry Res 214:80-2. 2013
  10. doi Local cortical surface complexity maps from spherical harmonic reconstructions
    Rachel A Yotter
    Department of Psychiatry, Friedrich Schiller University, Jena, Germany
    Neuroimage 56:961-73. 2011

Detail Information

Publications49

  1. ncbi Structural correlates of psychopathological symptom dimensions in schizophrenia: a voxel-based morphometric study
    Nikolaos Koutsouleris
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Neuroimage 39:1600-12. 2008
    ..Thus, structural heterogeneity in schizophrenia may relate to specific patterns of GMD reductions that possibly share a common prefrontal-perisylvian pattern of structural brain alterations...
  2. pmc Computational morphometry for detecting changes in brain structure due to development, aging, learning, disease and evolution
    Daniel Mietchen
    Structural Brain Mapping Group, Department of Psychiatry, University of Jena D 07743 Jena, Germany
    Front Neuroinform 3:25. 2009
    ....
  3. pmc Substantial and reversible brain gray matter reduction but no acute brain lesions in ultramarathon runners: experience from the TransEurope-FootRace Project
    Wolfgang Freund
    Department of Diagnostic and Interventional Radiology, University Hospitals Ulm, Albert Einstein Allee 23, 89081 Ulm, Germany
    BMC Med 10:170. 2012
    ..The effects of this endurance run on brain volume changes but also possible formation of brain edema or new lesions were explored by repeated magnetic resonance imaging (MRI) studies...
  4. doi Deformation-based brain morphometry in rats
    Christian Gaser
    Hans Berger Clinic for Neurology, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany
    Neuroimage 63:47-53. 2012
    ..The results support the utility of DBM based on commonly available clinical whole-body scanners for highly sensitive morphometric studies on rats...
  5. ncbi Ventricular enlargement in schizophrenia related to volume reduction of the thalamus, striatum, and superior temporal cortex
    Christian Gaser
    Department of Psychiatry, Friedrich Schiller University of Jena, Germany
    Am J Psychiatry 161:154-6. 2004
    ..The authors investigated whether ventricular enlargement is related to regionally specific volume loss...
  6. ncbi Neuroanatomy of "hearing voices": a frontotemporal brain structural abnormality associated with auditory hallucinations in schizophrenia
    Christian Gaser
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, D 07743 Jena, Germany
    Cereb Cortex 14:91-6. 2004
    ....
  7. doi The visual cortex in schizophrenia: alterations of gyrification rather than cortical thickness--a combined cortical shape analysis
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Brain Struct Funct 218:51-8. 2013
    ..The present findings of hypergyria are highly indicative for a disrupted corticogenesis of these visual key regions and might constitute a relevant anatomical basis for visual processing deficits in schizophrenia...
  8. doi Increased parahippocampal and lingual gyrification in first-episode schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Schizophr Res 123:137-44. 2010
    ....
  9. ncbi Frequency domains of resting state default mode network activity in schizophrenia
    Gianluca Mingoia
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, D 07743 Jena, Germany
    Psychiatry Res 214:80-2. 2013
    ..Power spectrum analysis showed a significant diagnosis × frequency interaction and higher power in one frequency band, indicating an alteration of DMN frequency spectrum in schizophrenia...
  10. doi Local cortical surface complexity maps from spherical harmonic reconstructions
    Rachel A Yotter
    Department of Psychiatry, Friedrich Schiller University, Jena, Germany
    Neuroimage 56:961-73. 2011
    ..These results are discussed in terms of previously published findings. Finally, the anatomical implications of a reduced FD are highlighted through comparison of two subjects with vastly different complexity maps...
  11. doi Default mode network activity in schizophrenia studied at resting state using probabilistic ICA
    Gianluca Mingoia
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany
    Schizophr Res 138:143-9. 2012
    ..These findings suggest that aberrant default mode network connectivity contributes to regional functional pathology in schizophrenia and bears significance for core symptoms...
  12. pmc Aging effects on regional brain structural changes in schizophrenia
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University of Jena, Philosophenweg 3, D 07743 Jena, Germany
    Schizophr Bull 38:838-44. 2012
    ..Although mostly conceptualized as a neurodevelopmental disorder, there is an increasing interest in progressive changes of cognitive deficits and brain structure and function in schizophrenia across the life span...
  13. ncbi Estimating local surface complexity maps using spherical harmonic reconstructions
    Rachel Aine Yotter
    Friedrich Schiller University, Department of Psychiatry, Jahnstr 3, 07743 Jena, Germany
    Med Image Comput Comput Assist Interv 13:169-76. 2010
    ..The global FD for the right hemisphere in the schizophrenic group was significantly lower than that in controls. Local FD maps showed that the lower complexity was mainly due to differences in the prefrontal cortex...
  14. doi Glutamate receptor δ 1 (GRID1) genetic variation and brain structure in schizophrenia
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743 Jena, Germany
    J Psychiatr Res 46:1531-9. 2012
    ....
  15. doi Reduced cortical thickness in first episode schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Schizophr Res 116:204-9. 2010
    ..In an extension of these earlier studies, we used an entire cortex vertex-wise approach and an automated clustering for the detection and exact quantification of cortical thickness alterations in first episode schizophrenia...
  16. doi Auditory hallucinations and brain structure in schizophrenia: voxel-based morphometric study
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University of Jena, Philosophenweg 3, D 07743 Jena, Germany
    Br J Psychiatry 196:412-3. 2010
    ..This study extends previous region-of-interest studies demonstrating main effects of auditory hallucinations related to modality-specific superior temporal areas including primary and secondary auditory cortices...
  17. doi Possibilities and limitations for high resolution small animal MRI on a clinical whole-body 3T scanner
    Karl Heinz Herrmann
    Medical Physics Group, Institute for Diagnostic and Interventional Radiology I, Jena University Hospital, Jena, Germany
    MAGMA 25:233-44. 2012
    ..To investigate the potential of a clinical 3 T scanner to perform MRI of small rodents...
  18. doi Brain structural trajectories over the adult lifespan
    Gabriel Ziegler
    Department of Psychiatry, Structural Brain Mapping Group, University of Jena, Jena, Germany
    Hum Brain Mapp 33:2377-89. 2012
    ..We propose a hypothesis in relation to the functional role of these brain regions that may explain these results...
  19. doi Distinct pattern of brain structural deficits in subsyndromes of schizophrenia delineated by psychopathology
    Igor Nenadic
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, D 07743 Jena, Germany
    Neuroimage 49:1153-60. 2010
    ..8% accuracy classifying any given scan to one of the subgroups. Patterns of psychopathology are meaningful parameters in reducing heterogeneity of brain morphological endophenotypes in schizophrenia...
  20. doi Topological correction of brain surface meshes using spherical harmonics
    Rachel Aine Yotter
    Department of Psychiatry, Friedrich Schiller University, Jena, Germany
    Hum Brain Mapp 32:1109-24. 2011
    ..The entire process takes 6-8 min of computation time. Further improvements are discussed, especially regarding the use of the T1-weighted image to make corrections...
  21. doi Cortical thickness and central surface estimation
    Robert Dahnke
    Department of Psychiatry, University of Jena, Jahnstrasse 3, D 07743 Jena, Germany
    Neuroimage 65:336-48. 2013
    ..The results indicate that both the quality and computational cost of our method are comparable, and may be superior in certain respects, to existing approaches...
  22. ncbi Processing of temporal information and the basal ganglia: new evidence from fMRI
    Igor Nenadic
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, 07740 Jena, Germany
    Exp Brain Res 148:238-46. 2003
    ..Further investigations are needed to delineate the differential contributions of the striatum and other areas to timing...
  23. ncbi Increased local gyrification mapped in Williams syndrome
    Christian Gaser
    Department of Psychiatry, University of Jena, Jena, Germany
    Neuroimage 33:46-54. 2006
    ..The observed gyrification abnormalities in individuals with WS might be related to dysfunctions in neuronal circuits and consequently contribute to the distinct cognitive and behavioral profile accompanying the disorder...
  24. doi Brain maturation: predicting individual BrainAGE in children and adolescents using structural MRI
    Katja Franke
    Department of Psychiatry, Jena University Hospital, 07743 Jena, Germany
    Neuroimage 63:1305-12. 2012
    ..For the first time, the present study provides a validated reference curve for structural brain maturation during childhood and adolescence, based on structural MRI data...
  25. doi Heterogeneity of brain structural variation and the structural imaging endophenotypes in schizophrenia
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany
    Neuropsychobiology 66:44-9. 2012
    ....
  26. doi Algorithms to improve the reparameterization of spherical mappings of brain surface meshes
    Rachel A Yotter
    Department of Psychiatry, Friedrich Schiller University, Jena, Germany
    J Neuroimaging 21:e134-47. 2011
    ..We show that our corrected spherical maps improve reparameterization of the cortical surface mesh, such that the distance error measures between the original and reparameterized surface are significantly decreased...
  27. ncbi Transient activation of a somatosensory area in painful hallucinations shown by fMRI
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, D 07740 Jena, Germany
    Neuroreport 13:805-8. 2002
    ..This finding demonstrates elevated brain activity in a somatosensory area accompanying painful somatic hallucinations...
  28. doi Anosmia leads to a loss of gray matter in cortical brain areas
    Thomas Bitter
    Department of Otorhinolaryngology, Friedrich Schiller University, Lessingstrasse 2, D 07740 Jena, Germany
    Chem Senses 35:407-15. 2010
    ..To our knowledge, this is the first study on persisting structural changes in cortical GM volume after complete olfactory loss...
  29. ncbi Phospholipase A2 activity is associated with structural brain changes in schizophrenia
    Stefan Smesny
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Jena, Germany
    Neuroimage 52:1314-27. 2010
    ....
  30. ncbi Gray and white matter reduction in hyposmic subjects--A voxel-based morphometry study
    Thomas Bitter
    Department of Otorhinolaryngology, Friedrich Schiller University, Jena, Germany
    Brain Res 1347:42-7. 2010
    ..The pattern of gray matter alterations was similar to that known from anosmic subjects with a lower extent. To our knowledge, we report here for the first time on white matter volume alterations in patients with olfactory deficit...
  31. ncbi Phonological processing in dyslexic children: a study combining functional imaging and event related potentials
    Petra Georgiewa
    Department of Child and Adolescent Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3 5, D 07740, Jena, Germany
    Neurosci Lett 318:5-8. 2002
    ..Both the fMRI and the ERP results support differences in phonological processing between dyslexic and normal-reading children...
  32. doi Enhanced tactile resolution of the contralateral side after surgery and regional anesthesia of the hand
    Elke Gaser
    Department of Anesthesiology and Intensive Care, University Hospital, Friedrich Schiller University Jena, Jena, Germany
    Neuroreport 21:1013-7. 2010
    ..When comparing with the control group (10 individuals), only the regional anesthesia group showed significantly increased tactile resolution at both the time points (P<0.01 and P<0.05), postoperatively...
  33. doi Cortical surface complexity in frontal and temporal areas varies across subgroups of schizophrenia
    Igor Nenadic
    Department of Psychiatry and Psychotherapy, Jena University Hospital, Friedrich Schiller University Jena, Jena, Germany
    Hum Brain Mapp 35:1691-9. 2014
    ..Our findings suggest regional heterogeneity of cortical folding complexity, which might be related to biological subgroups of schizophrenia with differing degrees of altered cortical developmental pathology...
  34. ncbi Topological correction of brain surface meshes using spherical harmonics
    Rachel Aine Yotter
    Friedrich Schiller University, Department of Psychiatry, Jahnstr 3, 07745 Jena, Germany
    Med Image Comput Comput Assist Interv 12:125-32. 2009
    ..In conclusion, the spherical harmonics approach is a direct, computationally fast method to correct topological errors...
  35. pmc Models of the aging brain structure and individual decline
    Gabriel Ziegler
    Structural Brain Mapping Group, Department of Psychiatry, Jena University Hospital Jena, Germany
    Front Neuroinform 6:3. 2012
    ..Together these methods afford analysis of aging brain structure in relation to behavioral, health, or cognitive parameters...
  36. pmc Changes in brain size during the menstrual cycle
    Georg Hagemann
    Hans Berger Clinic for Neurology, University Hospital Jena, Jena, Germany
    PLoS ONE 6:e14655. 2011
    ..Recently, activity-induced short-term structural plasticity of the brain was demonstrated, challenging the view that the brain is as rigid as formerly believed...
  37. doi Estimating the age of healthy subjects from T1-weighted MRI scans using kernel methods: exploring the influence of various parameters
    Katja Franke
    Department of Psychiatry, University of Jena, Jena, Germany
    Neuroimage 50:883-92. 2010
    ..Applying the framework to people with mild AD resulted in a mean brain age gap estimate (BrainAGE) score of +10 years...
  38. doi Gray matter increase induced by practice correlates with task-specific activation: a combined functional and morphometric magnetic resonance imaging study
    Rüdiger Ilg
    Department of Neurology, Technische Universitat Munchen, 81675 Munich, Germany
    J Neurosci 28:4210-5. 2008
    ..We speculate that practice-related gray matter signal changes in MRI are primarily related to synaptic remodeling within specific processing areas...
  39. ncbi Functional anatomy of pitch memory--an fMRI study with sparse temporal sampling
    Nadine Gaab
    Department of Neurology, Music and Neuroimaging Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Neuroimage 19:1417-26. 2003
    ..The SMG and the dorsolateral cerebellum may play a critical role in short-term storage of pitch information and the continuous pitch discrimination necessary for performing this pitch memory task...
  40. ncbi Improvement-related functional plasticity following pitch memory training
    Nadine Gaab
    Department of Neurology, Neuroimaging Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Neuroimage 31:255-63. 2006
    ..It is most likely that the activation of the SMG reflects its importance in the short-term storage of auditory material, and it was this activation that best differentiated between subjects' levels of performance...
  41. doi Template-O-Matic: a toolbox for creating customized pediatric templates
    Marko Wilke
    Department of Pediatric Neurology and Developmental Medicine, Children s Hospital, University of Tubingen, Germany
    Neuroimage 41:903-13. 2008
    ..We compare the performance of this approach with the current method of template generation and discuss the implications of our approach...
  42. ncbi Brain structures differ between musicians and non-musicians
    Christian Gaser
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 23:9240-5. 2003
    ..However, only future experiments can determine the relative contribution of predisposition and practice...
  43. ncbi Identifying patients with obsessive-compulsive disorder using whole-brain anatomy
    Carles Soriano-Mas
    Institut d Alta Tecnologia PRBB, CRC Corporació Sanitària, Passeig Maritim 25 29, Barcelona 08003, Spain
    Neuroimage 35:1028-37. 2007
    ..Nevertheless, the anatomical characterization of individual patients may ultimately provide the psychiatrist with relevant biological information...
  44. pmc Changes in gray matter induced by learning--revisited
    Joenna Driemeyer
    Department of Systems Neuroscience, University of Hamburg UKE, Hamburg, Germany
    PLoS ONE 3:e2669. 2008
    ..A better understanding of the temporal parameters may help to elucidate to what extent this type of cortical plasticity contributes to fast adapting cortical processes that may be relevant to learning...
  45. ncbi Striatal gray matter loss in Huntington's disease is leftward biased
    Mark Mühlau
    Department of Neurology, Technische Universitat Munchen, Munich, Germany
    Mov Disord 22:1169-73. 2007
    ..Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward-biased gray matter loss in HD...
  46. ncbi Gray matter decrease of the anterior cingulate cortex in anorexia nervosa
    Mark Mühlau
    Department of Neurology, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    Am J Psychiatry 164:1850-7. 2007
    ..The authors examined region-specific gray matter changes and global cerebral volumes in recovered patients with anorexia nervosa...
  47. doi Training-induced brain structure changes in the elderly
    Janina Boyke
    Department of Systems Neuroscience, University of Hamburg, D 22046 Hamburg, Germany
    J Neurosci 28:7031-5. 2008
    ..In addition, elderly volunteers who learned to juggle showed transient increases in gray matter in the hippocampus on the left side and in the nucleus accumbens bilaterally...
  48. doi Limbic and frontal cortical degeneration is associated with psychiatric symptoms in PINK1 mutation carriers
    Kathrin Reetz
    Department of Neurology, University of Luebeck, Luebeck, Germany
    Biol Psychiatry 64:241-7. 2008
    ..Mutations in the PINK1 gene can cause Parkinson's disease and are frequently associated with psychiatric symptoms that might even precede motor signs...
  49. pmc Mapping the relationship between cortical convolution and intelligence: effects of gender
    Eileen Luders
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7334, USA
    Cereb Cortex 18:2019-26. 2008
    ..This might lead to the development of sexually dimorphic information processing strategies and affect the relationship between intelligence and cortical convolution...