Tobias W Fischer

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. ncbi request reprint Histologic methods to show UV-induced changes in the hairless mouse: tips and tricks
    Irina Kelm
    Am J Dermatopathol 24:454-6. 2002
  2. ncbi request reprint Percutaneous penetration of topically applied melatonin in a cream and an alcoholic solution
    T W Fischer
    Department of Dermatology and Allergology, Friedrich Schiller University Jena, Jena, Gemany
    Skin Pharmacol Physiol 17:190-4. 2004
  3. ncbi request reprint Assessment of 'dry skin': current bioengineering methods and test designs
    T W Fischer
    Department of Dermatology, Friedrich Schiller University, Jena, Germany
    Skin Pharmacol Appl Skin Physiol 14:183-95. 2001
  4. ncbi request reprint Melatonin suppresses reactive oxygen species induced by UV irradiation in leukocytes
    Tobias W Fischer
    Department of Dermatology and Allergology, Friedrich Schiller University Jena, Jena, Germany
    J Pineal Res 37:107-12. 2004
  5. ncbi request reprint Melatonin increases anagen hair rate in women with androgenetic alopecia or diffuse alopecia: results of a pilot randomized controlled trial
    T W Fischer
    Department of Dermatology and Allergology, Friedrich Schiller University, Erfurter Strasse 35, D 07740 Jena, Germany
    Br J Dermatol 150:341-5. 2004
  6. ncbi request reprint Melatonin suppresses reactive oxygen species in UV-irradiated leukocytes more than vitamin C and trolox
    Tobias W Fischer
    Department of Dermatology and Allergology, Friedrich Schiller University Jena, Jena, Germany
    Skin Pharmacol Appl Skin Physiol 15:367-73. 2002
  7. ncbi request reprint [Hair loss in internal medical illnesses]
    T W Fischer
    Universitäts Klinik für Dermatologie und dermatologische Allergologie, Friedrich Schiller Universitat Jena, Jena
    Ther Umsch 59:238-42. 2002
  8. ncbi request reprint Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro
    T W Fischer
    Department of Dermatology and Allergology, Friedrich Schiller University, Jena, Germany
    Int J Dermatol 46:27-35. 2007
  9. doi request reprint Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair
    Tobias W Fischer
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, Lubeck, Germany
    Exp Dermatol 17:713-30. 2008
  10. doi request reprint Profiling the response of human hair follicles to ultraviolet radiation
    Zhongfa Lu
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, Lubeck, Germany
    J Invest Dermatol 129:1790-804. 2009

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Histologic methods to show UV-induced changes in the hairless mouse: tips and tricks
    Irina Kelm
    Am J Dermatopathol 24:454-6. 2002
  2. ncbi request reprint Percutaneous penetration of topically applied melatonin in a cream and an alcoholic solution
    T W Fischer
    Department of Dermatology and Allergology, Friedrich Schiller University Jena, Jena, Gemany
    Skin Pharmacol Physiol 17:190-4. 2004
    ..No increase of melatonin above the physiological range was observed...
  3. ncbi request reprint Assessment of 'dry skin': current bioengineering methods and test designs
    T W Fischer
    Department of Dermatology, Friedrich Schiller University, Jena, Germany
    Skin Pharmacol Appl Skin Physiol 14:183-95. 2001
    ..Newly developed cosmetic products have to be investigated for safety and efficacy. Modern bioengineering methods are suitable to fulfill these challenges...
  4. ncbi request reprint Melatonin suppresses reactive oxygen species induced by UV irradiation in leukocytes
    Tobias W Fischer
    Department of Dermatology and Allergology, Friedrich Schiller University Jena, Jena, Germany
    J Pineal Res 37:107-12. 2004
    ..The results confirm that the clinically observed UV protective effects of melatonin may be at least partially based on its radical scavenging properties...
  5. ncbi request reprint Melatonin increases anagen hair rate in women with androgenetic alopecia or diffuse alopecia: results of a pilot randomized controlled trial
    T W Fischer
    Department of Dermatology and Allergology, Friedrich Schiller University, Erfurter Strasse 35, D 07740 Jena, Germany
    Br J Dermatol 150:341-5. 2004
    ..The effect of melatonin on hair growth in humans has not been investigated so far...
  6. ncbi request reprint Melatonin suppresses reactive oxygen species in UV-irradiated leukocytes more than vitamin C and trolox
    Tobias W Fischer
    Department of Dermatology and Allergology, Friedrich Schiller University Jena, Jena, Germany
    Skin Pharmacol Appl Skin Physiol 15:367-73. 2002
    ..001). In the small concentration range, a linear dose-response relationship was found and melatonin showed the strongest radical suppression (IC(50) = 0.21 mM) followed by vitamin C (IC(50) = 0.26 mM) and trolox (IC(50) = 1.03 mM)...
  7. ncbi request reprint [Hair loss in internal medical illnesses]
    T W Fischer
    Universitäts Klinik für Dermatologie und dermatologische Allergologie, Friedrich Schiller Universitat Jena, Jena
    Ther Umsch 59:238-42. 2002
    ..Treatment and diagnosis of the systemic disease is recommended to be performed in cooperation with experts of internal medicine, oncologists and specialists of endocrinology...
  8. ncbi request reprint Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro
    T W Fischer
    Department of Dermatology and Allergology, Friedrich Schiller University, Jena, Germany
    Int J Dermatol 46:27-35. 2007
    ..Here, the hair organ culture model was used to investigate the effects of testosterone and caffeine; the latter being a promising candidate for hair growth stimulation...
  9. doi request reprint Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair
    Tobias W Fischer
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, Lubeck, Germany
    Exp Dermatol 17:713-30. 2008
    ..After listing a number of key open questions, we conclude by defining particularly important, clinically relevant perspectives for how melatonin may become therapeutically exploitable in cutaneous medicine...
  10. doi request reprint Profiling the response of human hair follicles to ultraviolet radiation
    Zhongfa Lu
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, Lubeck, Germany
    J Invest Dermatol 129:1790-804. 2009
    ....
  11. ncbi request reprint Diagnostic odyssey of a cutaneous mycobacteriosis rare in central Europe
    Tobias W Fischer
    Department of Dermatology and Allergology, Friedrich Schiller University, Jena, Germany
    Dermatology 205:289-92. 2002
    ..In case of abscessing cutaneous infection, M. chelonae should be considered in the differential diagnosis of prolonged disease when common antibiotics are not effective after 2-4 weeks of treatment...
  12. pmc Aberrant expression and secretion of heat shock protein 90 in patients with bullous pemphigoid
    Stefan Tukaj
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    PLoS ONE 8:e70496. 2013
    ..These findings suggest that Hsp90 may play a pathophysiological role and represent a novel potential treatment target in BP. ..
  13. doi request reprint Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2'-deoxyguanosine) in ex vivo human skin
    Tobias W Fischer
    Department of Dermatology, Allergology and Venerology, University of Lubeck, Lubeck, Germany
    J Pineal Res 54:303-12. 2013
    ..Thus, melatonin was shown to play a crucial role as a potent antioxidant and DNA protectant against UVR-induced oxidative damage in human skin...
  14. doi request reprint Development of a short-term human full-thickness skin organ culture model in vitro under serum-free conditions
    Konrad Kleszczyński
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Arch Dermatol Res 304:579-87. 2012
    ..This model therefore might be used for research related to, e.g., short-term experimentally induced inflammation, UV-induced structural and functional damage, wound healing and substance penetration...
  15. ncbi request reprint Melatonin and the hair follicle
    Tobias W Fischer
    Department of Dermatology, University Hospital Schleswig Holstein, University of Lubeck, Lubeck, Germany
    J Pineal Res 44:1-15. 2008
    ....
  16. doi request reprint Distinct barrier integrity phenotypes in filaggrin-related atopic eczema following sequential tape stripping and lipid profiling
    Irena Angelova-Fischer
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Exp Dermatol 20:351-6. 2011
    ..Whereas the barrier characteristics in FLG mutation carriers under baseline conditions have been investigated, there are only limited data on the permeability barrier function in filaggrin-AD under compromised conditions...
  17. pmc On the role of melatonin in skin physiology and pathology
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, Health Science Center, University of Tennessee, Memphis, TN 38103, USA
    Endocrine 27:137-48. 2005
    ..Furthermore, melatonin could have a role in protection against solar radiation or even in the management of skin diseases...
  18. ncbi request reprint Constitutive and UV-induced metabolism of melatonin in keratinocytes and cell-free systems
    Tobias W Fischer
    Department of Patholology and Laboratory Medicine, University of Tennessee Health Science Center, 930 Madison Ave, Memphis, Tennessee 38163, USA
    FASEB J 20:1564-6. 2006
    ..The additional biological activity of these individual melatonin metabolites increases the spectrum of potential actions of the recently identified cutaneous melatoninergic system...