Research Topics

Genomes and Genes


U Dahmen


Affiliation: Friedrich Schiller University
Country: Germany


  1. Rauchfuß F, Helble J, Bruns J, Dirsch O, Dahmen U, Ardelt M, et al. Biocellulose for Incisional Hernia Repair-An Experimental Pilot Study. Nanomaterials (Basel). 2019;9: pubmed publisher
    ..This is the firstin vivo study describing biocellulose as a suitable mesh for the repair of ventral hernia in twodifferent hernia models. The material seems to be a promising option for solving actual problems inmodern hernia surgery. ..
  2. Xie C, Wei W, Zhang T, Dirsch O, Dahmen U. Monitoring of systemic and hepatic hemodynamic parameters in mice. J Vis Exp. 2014;:e51955 pubmed publisher
    ..In conclusion, this procedure is reliable in the hands of an experienced micro-surgeon but should be limited to experiments where mice are absolutely needed. ..
  3. Schwen L, Wei W, Gremse F, Ehling J, Wang L, Dahmen U, et al. Algorithmically generated rodent hepatic vascular trees in arbitrary detail. J Theor Biol. 2015;365:289-300 pubmed publisher
    ..Having successfully adapted the CCO algorithm to the rodent model organism, the resulting individual-specific refined hepatic vascular trees can now be used for advanced modeling involving, e.g., detailed blood flow simulations. ..
  4. Grasreiner D, Dahmen U, Settmacher U. Specialty preferences and influencing factors: a repeated cross-sectional survey of first- to sixth-year medical students in Jena, Germany. BMC Med Educ. 2018;18:103 pubmed publisher
    ..Doing so could increase the chance to attract the number of physicians needed to ensure adequate medical care in the field of interest, according to the growing health needs of the population. ..
  5. Tekbas A, Huebner J, Settmacher U, Dahmen U. Plants and Surgery: The Protective Effects of Thymoquinone on Hepatic Injury-A Systematic Review of In Vivo Studies. Int J Mol Sci. 2018;19: pubmed publisher
    ..Almost no side effects were reported irrespective of a large dose range, suggesting a wide therapeutic window. These results give rise to the expectation that TQ could evolve to a novel powerful drug to reduce hepatic injury. ..
  6. Xie C, Wei W, Schenk A, Schwen L, Zafarnia S, Schwier M, et al. Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice. J Vis Exp. 2016;: pubmed publisher
    ..This technique has the potential to be extensively applied to studies concerning vascular anatomy and growth in various animal and disease models. ..
  7. Mußbach F, Dahmen U, Dirsch O, Settmacher U. [Liver engineering as a new source of donor organs : A systematic review]. Chirurg. 2016;87:504-13 pubmed publisher
    ..The existing results emphasize the potential of this new and promising strategy to create organs for transplantation in the future. ..
  8. Wei W, Zhang T, Zafarnia S, Schenk A, Xie C, Kan C, et al. Establishment of a rat model: Associating liver partition with portal vein ligation for staged hepatectomy. Surgery. 2016;159:1299-307 pubmed publisher
    ..The lack of a dense vascular network between the portalized and deportalized lobes may play an important role in accelerating regeneration and atrophy augmentation. ..
  9. request reprint
    Terbonssen T, Settmacher U, Wurst C, Dirsch O, Dahmen U. Attitude towards organ donation in German medical students. Langenbecks Arch Surg. 2016;401:1231-1239 pubmed
    ..This advocates initiating information campaigns even in population groups with strong medical background. ..

More Information


  1. Schwen L, Homeyer A, Schwier M, Dahmen U, Dirsch O, Schenk A, et al. Zonated quantification of steatosis in an entire mouse liver. Comput Biol Med. 2016;73:108-18 pubmed publisher
    ..Besides being a descriptive research tool, this quantification could perspectively complement diagnosis based on visual assessment of histological images. ..
  2. Zhang T, Wei W, Dirsch O, Krüger T, Kan C, Xie C, et al. Identification of Proteins Interacting with Cytoplasmic High-Mobility Group Box 1 during the Hepatocellular Response to Ischemia Reperfusion Injury. Int J Mol Sci. 2017;18: pubmed publisher
    ..This finding may help to better understand the cellular response to IRI in the liver and to identify novel molecular targets for reducing ischemic injury. ..
  3. Richter B, Sanger C, Mussbach F, Scheuerlein H, Settmacher U, Dahmen U. Benefit of an implanted solid barrier for the feasibility of a sequence of three different hepato-biliary operations in a small animal model. J Visc Surg. 2017;154:321-328 pubmed publisher
    ..It should be considered to implant a mechanical barrier in a sequence of more than two surgical interventions in an experimental model in order to assure the feasibility of the final operation. ..
  4. Arlt J, Wei W, Xie C, Homeyer A, Settmacher U, Dahmen U, et al. Modulation of hepatic perfusion did not improve recovery from hepatic outflow obstruction. BMC Pharmacol Toxicol. 2017;18:50 pubmed publisher
    ..Transient relative reduction of portal pressure did not result in a reduction of hepatic damage. This might be explained by the development of portal hyperperfusion which was accompanied by arterial hypoperfusion. ..
  5. Kan C, Liu A, Fang H, Dirsch O, Dahmen U, Boettcher M. Induction of autophagy reduces ischemia/reperfusion injury in steatotic rat livers. J Surg Res. 2017;216:207-218 pubmed publisher
    ..Simultaneous modulation of GSK3b and ERK1/2 pathways might be an interesting strategy to reduce IRI in steatotic livers with an impairment of autophagy. ..
  6. Terbonssen T, Settmacher U, Dirsch O, Dahmen U. [Knowledge, trust, and the decision to donate organs : A comparison of medical students and students of other disciplines in Germany]. Chirurg. 2018;89:131-137 pubmed publisher
    ..In cases of a low level of knowledge, confidence is even more important. Therefore, organ donation campaigns should focus on increasing knowledge and fostering trust. ..