R A Claus
Affiliation: Friedrich Schiller University
Chung H, Witt C, Hurtado Oliveros J, Wickel J, Gräler M, Lupp A, et al
. Acid Sphingomyelinase Inhibition Stabilizes Hepatic Ceramide Content and Improves Hepatic Biotransformation Capacity in a Murine Model of Polymicrobial Sepsis. Int J Mol Sci. 2018;19: pubmed publisher
Claus R, Dorer M, Bunck A, Deigner H. Inhibition of sphingomyelin hydrolysis: targeting the lipid mediator ceramide as a key regulator of cellular fate. Curr Med Chem. 2009;16:1978-2000 pubmed
..Herein, we focus on the biochemical background and the action of pharmacologically interesting compounds capable of interfering with sphingomyelinases and outline their potential implications for medicinal chemistry. ..
Rittirsch D, Schoenborn V, Lindig S, Wanner E, Sprengel K, GÃ¼nkel S, et al
. Improvement of prognostic performance in severely injured patients by integrated clinico-transcriptomics: a translational approach. Crit Care. 2015;19:414 pubmed publisher
..The combination of clinical and transcriptomic markers improves the prognostic performance and may represent a useful tool for individual risk stratification in trauma patients. ..
Horn P, Metzing U, Steidl R, Romeike B, RauchfuÃŸ F, Sponholz C, et al
. Chemerin in peritoneal sepsis and its associations with glucose metabolism and prognosis: a translational cross-sectional study. Crit Care. 2016;20:39 pubmed publisher
..It could be further evaluated as a biomarker to stratify mortality risk of patients with SHG. ..
Claus R, Bunck A, Bockmeyer C, Brunkhorst F, Lösche W, Kinscherf R, et al
. Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis. FASEB J. 2005;19:1719-21 pubmed
..An inhibition of the secreted isoform of sphingomyelinase should be explored further as a potential target in the complicated puzzle of sepsis. ..
Claus R, Bockmeyer C, Budde U, Kentouche K, Sossdorf M, Hilberg T, et al
. Variations in the ratio between von Willebrand factor and its cleaving protease during systemic inflammation and association with severity and prognosis of organ failure. Thromb Haemost. 2009;101:239-47 pubmed
..These findings suggest that ADAMTS13, VWF and related parameters, even in a combined approach, might be useful for the diagnosis and the therapeutic monitoring of patients with sepsis associated thrombotic microangiopathy. ..
Chung H, Kollmey A, Schrepper A, Kohl M, Bläss M, Stehr S, et al
. Adjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction. Int J Mol Sci. 2017;18: pubmed publisher
..In addition, it may be possible to modulate cardiac function during host response by pre-conditioning with the Food and Drug Administration (FDA)-approved drug desipramine. ..
Chung H, Witt C, Jbeily N, Hurtado Oliveros J, Giszas B, Lupp A, et al
. Acid Sphingomyelinase Inhibition Prevents Development of Sepsis Sequelae in the Murine Liver. Sci Rep. 2017;7:12348 pubmed publisher
..In summary, targeting sphingomyelinase with FDA-approved drugs is a novel promising strategy to overcome sepsis-induced liver dysfunction. ..