Heike Bunjes

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. ncbi request reprint Incorporation of the model drug ubidecarenone into solid lipid nanoparticles
    H Bunjes
    Friedrich Schiller University Jena, Department of Pharmaceutical Technology, Germany
    Pharm Res 18:287-93. 2001
  2. ncbi request reprint Saturated phospholipids promote crystallization but slow down polymorphic transitions in triglyceride nanoparticles
    Heike Bunjes
    Friedrich Schiller University Jena, Institute of Pharmacy, Department of Pharmaceutical Technology, Lessingstrasse 8, D 07743 Jena, Germany
    J Control Release 107:229-43. 2005
  3. doi request reprint The physical state of lipid nanoparticles influences their effect on in vitro cell viability
    Silvia Petersen
    Department of Pharmaceutical Technology, Institute of Pharmacy, Friedrich Schiller Universitat Jena, Jena, Germany
    Eur J Pharm Biopharm 79:150-61. 2011
  4. doi request reprint Poly(vinyl alcohol) as emulsifier stabilizes solid triglyceride drug carrier nanoparticles in the alpha-modification
    Karin M Rosenblatt
    Department of Pharmaceutical Technology, Friedrich Schiller Universitat Jena, Lessingstrasse 8, 07743 Jena, Germany
    Mol Pharm 6:105-20. 2009
  5. doi request reprint Influence of stabilizer systems on the properties and phase behavior of supercooled smectic nanoparticles
    Judith Kuntsche
    Friedrich Schiller Universitat Jena, Institute of Pharmacy, Department of Pharmaceutical Technology, Lessingstrasse 8, D 07743 Jena, Germany
    J Colloid Interface Sci 350:229-39. 2010
  6. ncbi request reprint Effect of drug loading on the transformation of vesicular into cubic nanoparticles during heat treatment of aqueous monoolein/poloxamer dispersions
    Gert Wörle
    Friedrich Schiller University Jena, Institute of Pharmacy, Department of Pharmaceutical Technology, Jena, Germany
    Eur J Pharm Biopharm 63:128-33. 2006
  7. doi request reprint Supercooled smectic nanoparticles: influence of the matrix composition and in vitro cytotoxicity
    Judith Kuntsche
    Lehrstuhl für Pharmazeutische Technologie, Friedrich Schiller Universitat Jena, Lessingstr 8, D 07743 Jena, Germany
    Eur J Pharm Sci 38:238-48. 2009
  8. doi request reprint Cryogenic transmission electron microscopy (cryo-TEM) for studying the morphology of colloidal drug delivery systems
    Judith Kuntsche
    Martin Luther Universitat Halle Wittenberg, Institute of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Wolfgang Langenbeck Str 4, D 06120 Halle Saale, Germany
    Int J Pharm 417:120-37. 2011
  9. ncbi request reprint Visualizing the structure of triglyceride nanoparticles in different crystal modifications
    Heike Bunjes
    Department of Pharmaceutical Technology, Institute of Pharmacy, Friedrich Schiller University Jena, Lessingstrasse 8, 07743 Jena, Germany
    Langmuir 23:4005-11. 2007
  10. ncbi request reprint Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy
    Katja Jores
    Institute of Pharmacy, Department of Pharmaceutical Technology, Free University of Berlin, Kelchstr 31, 12169 Berlin, Germany
    J Control Release 95:217-27. 2004

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Incorporation of the model drug ubidecarenone into solid lipid nanoparticles
    H Bunjes
    Friedrich Schiller University Jena, Department of Pharmaceutical Technology, Germany
    Pharm Res 18:287-93. 2001
    ..The dispersions are studied with respect to their drug loading capacity, localization and physical state of the drug as well as to potential changes of the nanoparticle properties due to interactions between drug and triglyceride matrix...
  2. ncbi request reprint Saturated phospholipids promote crystallization but slow down polymorphic transitions in triglyceride nanoparticles
    Heike Bunjes
    Friedrich Schiller University Jena, Institute of Pharmacy, Department of Pharmaceutical Technology, Lessingstrasse 8, D 07743 Jena, Germany
    J Control Release 107:229-43. 2005
    ..The possibility to prepare triglyceride nanoparticles stable in specific modifications offers new opportunities to study effects of polymorphic form on colloidal stability, drug loading and release properties of such dispersions...
  3. doi request reprint The physical state of lipid nanoparticles influences their effect on in vitro cell viability
    Silvia Petersen
    Department of Pharmaceutical Technology, Institute of Pharmacy, Friedrich Schiller Universitat Jena, Jena, Germany
    Eur J Pharm Biopharm 79:150-61. 2011
    ..The low viability caused by poloxamer 188-stabilized particles could be correlated with a strong cell uptake which was investigated by confocal laser scanning microscopy...
  4. doi request reprint Poly(vinyl alcohol) as emulsifier stabilizes solid triglyceride drug carrier nanoparticles in the alpha-modification
    Karin M Rosenblatt
    Department of Pharmaceutical Technology, Friedrich Schiller Universitat Jena, Lessingstrasse 8, 07743 Jena, Germany
    Mol Pharm 6:105-20. 2009
    ..g., in comparison with nanoparticles in the more stable beta-modification) on pharmaceutically important parameters such as drug load and drug release...
  5. doi request reprint Influence of stabilizer systems on the properties and phase behavior of supercooled smectic nanoparticles
    Judith Kuntsche
    Friedrich Schiller Universitat Jena, Institute of Pharmacy, Department of Pharmaceutical Technology, Lessingstrasse 8, D 07743 Jena, Germany
    J Colloid Interface Sci 350:229-39. 2010
    ..g. polyethylene glycol chains) of the emulsifier may also play a significant role...
  6. ncbi request reprint Effect of drug loading on the transformation of vesicular into cubic nanoparticles during heat treatment of aqueous monoolein/poloxamer dispersions
    Gert Wörle
    Friedrich Schiller University Jena, Institute of Pharmacy, Department of Pharmaceutical Technology, Jena, Germany
    Eur J Pharm Biopharm 63:128-33. 2006
    ....
  7. doi request reprint Supercooled smectic nanoparticles: influence of the matrix composition and in vitro cytotoxicity
    Judith Kuntsche
    Lehrstuhl für Pharmazeutische Technologie, Friedrich Schiller Universitat Jena, Lessingstr 8, D 07743 Jena, Germany
    Eur J Pharm Sci 38:238-48. 2009
    ..The supercooled smectic nanoparticle formulations display a good overall cell compatibility although in some cases their cytotoxicity was slightly higher than that of Lipofundin MCT...
  8. doi request reprint Cryogenic transmission electron microscopy (cryo-TEM) for studying the morphology of colloidal drug delivery systems
    Judith Kuntsche
    Martin Luther Universitat Halle Wittenberg, Institute of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Wolfgang Langenbeck Str 4, D 06120 Halle Saale, Germany
    Int J Pharm 417:120-37. 2011
    ....
  9. ncbi request reprint Visualizing the structure of triglyceride nanoparticles in different crystal modifications
    Heike Bunjes
    Department of Pharmaceutical Technology, Institute of Pharmacy, Friedrich Schiller University Jena, Lessingstrasse 8, 07743 Jena, Germany
    Langmuir 23:4005-11. 2007
    ..For the first time, not only was information on the internal structure of solid triglyceride nanoparticles obtained from freeze-fracture electron micrographs but also details were observed by cryoelectron microscopy...
  10. ncbi request reprint Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy
    Katja Jores
    Institute of Pharmacy, Department of Pharmaceutical Technology, Free University of Berlin, Kelchstr 31, 12169 Berlin, Germany
    J Control Release 95:217-27. 2004
    ..Very short diffusion pathways in platelets, increased water-lipid interfaces and low drug incorporation in crystalline lipids are the drawback of SLN and NLC compared to conventional nanoemulsions...
  11. ncbi request reprint Drug release from differently structured monoolein/poloxamer nanodispersions studied with differential pulse polarography and ultrafiltration at low pressure
    Karin M Rosenblatt
    Department of Pharmaceutical Technology, Institute of Pharmacy, Friedrich Schiller University Jena, Lessingstrasse 8, 07743 Jena, Germany
    J Pharm Sci 96:1564-75. 2007
    ..Both release methods were suitable to monitor the rapid appearance of the releasable drug in the release medium...
  12. ncbi request reprint Transformation of vesicular into cubic nanoparticles by autoclaving of aqueous monoolein/poloxamer dispersions
    Gert Wörle
    Institute of Pharmacy, Department of Pharmaceutical Technology, Friedrich Schiller University Jena, Lessingstrasse 8, D 07743 Jena, Germany
    Eur J Pharm Sci 27:44-53. 2006
    ....
  13. doi request reprint Flow cytometry as a new approach to investigate drug transfer between lipid particles
    Silvia Petersen
    Department of Pharmaceutical Technology, Institute of Pharmacy, Friedrich Schiller Universitat Jena, Jena, Germany
    Mol Pharm 7:350-63. 2010
    ..Additional detailed experiments will, however, be necessary to elucidate the prevalent transfer mechanisms completely...
  14. doi request reprint Preparation and characterization of nanoparticles based on dextran-drug conjugates
    Stephanie Hornig
    Center of Excellence for Polysaccharide Research, Friedrich Schiller Universitat Jena, Humboldtstrasse 10, D 07743 Jena, Germany
    J Colloid Interface Sci 338:56-62. 2009
    ..Therefore, a defined tuning of the DS value may allow the adjustment of the pH-dependent hydrolysis rate and, hence, the release of the drugs...
  15. ncbi request reprint Influence of emulsifiers on the crystallization of solid lipid nanoparticles
    Heike Bunjes
    Friedrich Schiller Universitat Jena, Institute of Pharmacy, Department of Pharmaceutical Technology, Lessingstrasse 8, 07743 Jena, Germany
    J Pharm Sci 92:1509-20. 2003
    ..These results indicate that major rearrangements still may take place in solid lipid nanoparticles after recrystallization...
  16. ncbi request reprint Thermotropic liquid crystalline drugs
    Heike Bunjes
    Friedrich Schiller University Jena, Institute of Pharmacy, Department of Pharmaceutical Technology, Jena, Germany
    J Pharm Pharmacol 57:807-16. 2005
    ..The review closes with a brief discussion of the unusual properties of drug mesophases and a potential use of drugs and excipients in this fourth state of matter...
  17. ncbi request reprint Characterization of lipid nanoparticles by differential scanning calorimetry, X-ray and neutron scattering
    Heike Bunjes
    Institut fur Pharmazeutische Technologie, Technische Universitat Braunschweig, Mendelssohnstr 1, 38106, Braunschweig, Germany
    Adv Drug Deliv Rev 59:379-402. 2007
    ..Some technical questions concerning the use of the different characterization techniques in the field of LNP research are also addressed...
  18. ncbi request reprint Interaction of lipid nanoparticles with human epidermis and an organotypic cell culture model
    Judith Kuntsche
    Department of Pharmaceutics, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Int J Pharm 354:180-95. 2008
    ....
  19. ncbi request reprint Drug permeability across a phospholipid vesicle-based barrier 2. Characterization of barrier structure, storage stability and stability towards pH changes
    Gøril Eide Flaten
    University of Tromsø, Institute of Pharmacy, Department of Pharmaceutics and Biopharmaceutics, N 9037 Tromsø, Norway
    Eur J Pharm Sci 28:336-43. 2006
    ..Furthermore, because the phospholipid vesicle-based barrier can be stored, larger batches can be produced. This makes the phospholipid vesicle-based barrier more appropriate for high throughput screening...