K J Bar

Summary

Affiliation: Friedrich Schiller University
Country: Germany

Publications

  1. pmc The influence of negative mood on heart rate complexity measures and baroreflex sensitivity in healthy subjects
    Ralf Köbele
    Department of Psychiatry, Friedrich Schiller University, Jena, Germany
    Indian J Psychiatry 52:42-7. 2010
  2. ncbi request reprint Sport specificity of mental disorders: the issue of sport psychiatry
    Karl Jürgen Bär
    Pain and Autonomic Integrative Research PAIR, Department of Psychiatry and Psychotherapy, University Hospital Jena, Philosophenweg 3, 07743, Jena, Germany
    Eur Arch Psychiatry Clin Neurosci 263:S205-10. 2013
  3. pmc Exercise reveals the interrelation of physical fitness, inflammatory response, psychopathology, and autonomic function in patients with schizophrenia
    Stefanie Ostermann
    Department of Psychiatry and Psychotherapy, University Hospital, Jena, Germany
    Schizophr Bull 39:1139-49. 2013
  4. doi request reprint Insular dysfunction and descending pain inhibition in anorexia nervosa
    K J Bar
    Pain and Autonomics Integrative Research PAIR, Department of Psychiatry and Psychotherapy, University Hospital Jena, Jena, Germany
    Acta Psychiatr Scand 127:269-78. 2013
  5. doi request reprint Thresholds and perception of cold pain, heat pain, and the thermal grill illusion in patients with major depressive disorder
    Michael Karl Boettger
    Institute of Physiology I, Jena, Germany
    Psychosom Med 75:281-7. 2013
  6. doi request reprint [The processing of pain in psychiatric diseases]
    K J Bar
    Klinik fur Psychiatrie und Psychotherapie, AG Pain and Autonomic Integrative Research PAIR, Universitatsklinikum Jena, Philosophenweg 3, 07743 Jena, Deutschland
    Nervenarzt 83:1385-90. 2012
  7. pmc The phrenic component of acute schizophrenia--a name and its physiological reality
    Karl Jürgen Bär
    Pain and Autonomic Integrative Research, Department of Psychiatry and Psychotherapy, University Hospital, Jena, Germany
    PLoS ONE 7:e33459. 2012
  8. ncbi request reprint Influence of galantamine on vasomotor reactivity in Alzheimer's disease and vascular dementia due to cerebral microangiopathy
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University Jena, Philosophenweg 3, 07743 Jena, Germany
    Stroke 38:3186-92. 2007
  9. ncbi request reprint Relationship between cardiovagal modulation and psychotic state in patients with paranoid schizophrenia
    Karl Jürgen Bär
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University, Jena, Germany
    Psychiatry Res 157:255-7. 2008
  10. doi request reprint Cardiovagal modulation upon postural change is altered in Huntington's disease
    K J Bar
    Department of Psychiatry, Friedrich Schiller University, Jena, Germany
    Eur J Neurol 15:869-71. 2008

Detail Information

Publications48

  1. pmc The influence of negative mood on heart rate complexity measures and baroreflex sensitivity in healthy subjects
    Ralf Köbele
    Department of Psychiatry, Friedrich Schiller University, Jena, Germany
    Indian J Psychiatry 52:42-7. 2010
    ..We have previously shown that the Mood Induction Procedure (MIP) in healthy subjects alters pain perception and thalamic activity during pain perception...
  2. ncbi request reprint Sport specificity of mental disorders: the issue of sport psychiatry
    Karl Jürgen Bär
    Pain and Autonomic Integrative Research PAIR, Department of Psychiatry and Psychotherapy, University Hospital Jena, Philosophenweg 3, 07743, Jena, Germany
    Eur Arch Psychiatry Clin Neurosci 263:S205-10. 2013
    ....
  3. pmc Exercise reveals the interrelation of physical fitness, inflammatory response, psychopathology, and autonomic function in patients with schizophrenia
    Stefanie Ostermann
    Department of Psychiatry and Psychotherapy, University Hospital, Jena, Germany
    Schizophr Bull 39:1139-49. 2013
    ..Results of inflammatory parameters are suggestive of a reduced activity of the anti-inflammatory cholinergic pathway in patients, leading to a pro-inflammatory state. ..
  4. doi request reprint Insular dysfunction and descending pain inhibition in anorexia nervosa
    K J Bar
    Pain and Autonomics Integrative Research PAIR, Department of Psychiatry and Psychotherapy, University Hospital Jena, Jena, Germany
    Acta Psychiatr Scand 127:269-78. 2013
    ..Reduced perception of pain is a well-established phenomenon in patients with anorexia nervosa (AN). We tested the hypothesis that altered processing of pain within the insula might account for reduced perception of pain...
  5. doi request reprint Thresholds and perception of cold pain, heat pain, and the thermal grill illusion in patients with major depressive disorder
    Michael Karl Boettger
    Institute of Physiology I, Jena, Germany
    Psychosom Med 75:281-7. 2013
    ..The aim of this study was to use this technique to gain further insights into the altered pain perception in major depressive disorder (MDD)...
  6. doi request reprint [The processing of pain in psychiatric diseases]
    K J Bar
    Klinik fur Psychiatrie und Psychotherapie, AG Pain and Autonomic Integrative Research PAIR, Universitatsklinikum Jena, Philosophenweg 3, 07743 Jena, Deutschland
    Nervenarzt 83:1385-90. 2012
    ..Thus, pain research might be able to alter our view on autonomic regulation, which is putatively associated with increased cardiac mortality of the disease...
  7. pmc The phrenic component of acute schizophrenia--a name and its physiological reality
    Karl Jürgen Bär
    Pain and Autonomic Integrative Research, Department of Psychiatry and Psychotherapy, University Hospital, Jena, Germany
    PLoS ONE 7:e33459. 2012
    ..These results are invaluable for researchers studying changes of biological signals prone to the influence of breathing rate and rhythm (e.g., functional imaging)...
  8. ncbi request reprint Influence of galantamine on vasomotor reactivity in Alzheimer's disease and vascular dementia due to cerebral microangiopathy
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University Jena, Philosophenweg 3, 07743 Jena, Germany
    Stroke 38:3186-92. 2007
    ..We aimed to assess vasomotor reactivity in patients with Alzheimer's disease and vascular dementia due to microangiopathy using transcranial Doppler sonography and near-infrared spectroscopy during a CO(2) exposition task...
  9. ncbi request reprint Relationship between cardiovagal modulation and psychotic state in patients with paranoid schizophrenia
    Karl Jürgen Bär
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University, Jena, Germany
    Psychiatry Res 157:255-7. 2008
    ..Mainly we found that patients displaying stronger psychotic symptoms as assessed by the Brief Psychiatric Rating Scale exhibit more severe cardiac ANS disturbances compared with controls...
  10. doi request reprint Cardiovagal modulation upon postural change is altered in Huntington's disease
    K J Bar
    Department of Psychiatry, Friedrich Schiller University, Jena, Germany
    Eur J Neurol 15:869-71. 2008
    ..Cardiac autonomic nervous system (ANS) dysfunction in Huntington's disease (HD) might affect both the sympathetic and parasympathetic branch of the ANS...
  11. doi request reprint Reduced cardio-respiratory coupling in acute alcohol withdrawal
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University, Philosophenweg 3, Jena, Germany
    Drug Alcohol Depend 98:210-7. 2008
    ..Since linear analysis of heart rate variability may not be entirely adequate to detect such autonomic dysfunction in acute alcohol withdrawal, we applied novel non-linear parameters and measures for cardio-respiratory coupling...
  12. doi request reprint The interaction between pupil function and cardiovascular regulation in patients with acute schizophrenia
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University, Philosophenweg 3, 07743 Jena, Germany
    Clin Neurophysiol 119:2209-13. 2008
    ..In this study, we tested the hypothesis that the autonomic dysregulation at the heart is reflected in the regulation of the pupillary light reflex...
  13. doi request reprint Influence of olanzapine on QT variability and complexity measures of heart rate in patients with schizophrenia
    Karl Jürgen Bär
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University, Jena, Germany
    J Clin Psychopharmacol 28:694-8. 2008
    ..Further studies are warranted to gain more insight into cardiac regulation in schizophrenia and the effect of novel antipsychotics...
  14. doi request reprint Correlations between the autonomic modulation of heart rate, blood pressure and the pupillary light reflex in healthy subjects
    Karl Jürgen Bär
    Department of Psychiatry, University Hospital, Jena, Germany
    J Neurol Sci 279:9-13. 2009
    ..Examinations as described here might add to the diagnosis of autonomic dysfunction and reveal differential patterns in certain disease states...
  15. pmc Autonomic dysfunction in unaffected first-degree relatives of patients suffering from schizophrenia
    Karl Jürgen Bär
    Department of Psychiatry and Psychotherapy, University Hospital Jena, Philosophenweg 3, 07743 Jena, Germany
    Schizophr Bull 36:1050-8. 2010
    ..In addition, these findings may be of value to identify the high-risk group of patients' relatives in regards to serious cardiovascular events so that early preventive measures can be taken...
  16. doi request reprint Is successful electroconvulsive therapy related to stimulation of the vagal system?
    Karl Jürgen Bär
    Department of Psychiatry and Psychotherapy, University Hospital, Jena, Germany
    J Affect Disord 125:323-9. 2010
    ..While the exact underlying mechanisms are under debate, a role for the sympathetic response upon ECT has been suggested. When assessing patients with MDD for autonomic function, however, a loss of vagal function is prominent...
  17. doi request reprint Reduced cardio-respiratory coupling after treatment with nortriptyline in contrast to S-citalopram
    Karl Jürgen Bär
    Klinik fur Psychiatrie und Psychotherapie, Friedrich Schiller Universitat Jena, Germany
    J Affect Disord 127:266-73. 2010
    ..We sought to examine the hypothesis that nortriptyline treatment will be associated with a decrease in heart rate variability and coupling between heart rate and respiration compared to treatment with S-citalopram...
  18. doi request reprint Pseudohypoalgesia on the skin: a novel view on the paradox of pain perception in depression
    Karl Jürgen Bär
    Department of Psychiatry and Psychotherapy, Philosophenweg 3, University Hospital, Jena, Germany
    J Clin Psychopharmacol 31:103-7. 2011
    ..Thus, our results might change the view on the paradox of pain perception in major depression because increased heat pain thresholds are associated with augmented pain perception in the disease...
  19. ncbi request reprint Lateralization of pupillary light reflex parameters
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller Universitat Jena, Philosophenweg 3, 07743 Jena, Germany
    Clin Neurophysiol 116:790-8. 2005
    ..The aim of this study was to determine differing reactions of the left and right eyes with regard to pupillary light reflex (PLR) parameters...
  20. ncbi request reprint [Pain perception is not influenced by altered autonomic function in major depression]
    Karl Jürgen Bär
    Klinik fur Psychiatrie und Psychotherapie, Friedrich Schiller Universitat Jena, Philosophenweg 3, 07743 Jena
    Psychiatr Prax 34:S309-13. 2007
    ..Depression is a common comorbidity of chronic pain and chronic pain represents a common additional symptom of depressed patients. The physiological basis is unknown...
  21. ncbi request reprint Non-linear complexity measures of heart rate variability in acute schizophrenia
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University, Jena, Philosophenweg 3, 07743 Jena, Germany
    Clin Neurophysiol 118:2009-15. 2007
    ..One way to detect adaptive capabilities and thus stability of regulation is to measure complexity of heart rate fluctuations, with more complex heart rate fluctuations indicating better adaptability of the underlying system...
  22. ncbi request reprint Acute psychosis leads to increased QT variability in patients suffering from schizophrenia
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University Jena, Philosophenweg 3, 07743 Jena, Germany
    Schizophr Res 95:115-23. 2007
    ..The correlation of positive symptoms with QT variability might indicate high sympathetic cardiac activity in these patients, which might be associated with increased cardiovascular mortality...
  23. ncbi request reprint Decreased sensitivity to experimental pain in adjustment disorder
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, 07743 Jena, Germany
    Eur J Pain 10:467-71. 2006
    ..Although the underlying pathology is elusive it is likely that the mechanisms for reduced pain sensitivity are comparable in MDD and AD...
  24. ncbi request reprint Pain perception in major depression depends on pain modality
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, 07743 Jena, Germany
    Pain 117:97-103. 2005
    ..This knowledge may enable us to understand and ultimately treat pain complaints more appropriately in depressed patients...
  25. ncbi request reprint Loss of efferent vagal activity in acute schizophrenia
    K J Bar
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, 07743 Jena, Germany
    J Psychiatr Res 39:519-27. 2005
    ..Future studies are warranted to investigate the interaction between cardiac autonomic function and schizophrenia and to identify patients on risk...
  26. ncbi request reprint Painful hallucinations and somatic delusions in a patient with the possible diagnosis of neuroborreliosis
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University of Jena, Jena, Germany
    Clin J Pain 21:362-3. 2005
    ..Although this patient might have suffered from late-onset schizophrenia with painful hallucinations right from the start of her disease, the case highlights psychiatric complications that might be associated with neuroborreliosis...
  27. ncbi request reprint The influence of major depression and its treatment on heart rate variability and pupillary light reflex parameters
    Karl Jürgen Bär
    Departments of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, 07743 Jena, Germany
    J Affect Disord 82:245-52. 2004
    ..Former studies of autonomic dysfunction in major depression have shown inconclusive results...
  28. ncbi request reprint Influence of gender and hemispheric lateralization on heat pain perception in major depression
    K J Bar
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, 07743 Jena, Germany
    J Psychiatr Res 37:345-53. 2003
    ..Altered pain processing at brain stem level might only partially be responsible for the observed finding...
  29. ncbi request reprint Serial positron emission tomographic findings in an atypical presentation of fatal familial insomnia
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller Universität of Jena, Germany
    Arch Neurol 59:1815-8. 2002
    ..Although insomnia and dysautonomia have been described as hallmarks of the disease, there is substantial variability in clinical presentation...
  30. ncbi request reprint Changes of pain perception, autonomic function, and endocrine parameters during treatment of anorectic adolescents
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University, Jena, Germany
    J Am Acad Child Adolesc Psychiatry 45:1068-76. 2006
    ..To gain more insight into the pathology, the authors investigated pain perception, autonomic function, and endocrine parameters before and during successful treatment of adolescent AN patients...
  31. ncbi request reprint Reduced baroreflex sensitivity in acute alcohol withdrawal syndrome and in abstained alcoholics
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University, Philosophenweg 3, 07743 Jena, Germany
    Drug Alcohol Depend 85:66-74. 2006
    ..The distinct decrease of BRS in AWS and in long-term abstained subjects described here is of importance since similar alterations have been identified as independent prognostic factors for cardiac mortality in other diseases...
  32. ncbi request reprint Decreased baroreflex sensitivity in acute schizophrenia
    Karl Jürgen Bär
    Dept of Psychiatry, Friedrich Schiller University, 07743 Jena, Germany
    J Appl Physiol (1985) 102:1051-6. 2007
    ..Future studies are warranted to examine the role of the sympathetic system and possible autonomic differences in hyperarousal induced by anxiety and/or external stressful events...
  33. ncbi request reprint Heart rate variability and sympathetic skin response in male patients suffering from acute alcohol withdrawal syndrome
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University of Jena, Jena, Germany
    Alcohol Clin Exp Res 30:1592-8. 2006
    ..In contrast to many neurochemical studies of sympathetic activation during AW, only very few studies investigated autonomic balance using neurophysiological methods...
  34. ncbi request reprint Increased QT interval variability index in acute alcohol withdrawal
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University, Philosophenweg 3, 07743 Jena, Germany
    Drug Alcohol Depend 89:259-66. 2007
    ..As the QT interval reflects the most critical phase for the generation of reentry and thus for arrhythmia, we examined QT variability in patients suffering from acute alcohol withdrawal...
  35. ncbi request reprint Increased prefrontal activation during pain perception in major depression
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University, Philosophenweg 3, Jena, Germany
    Biol Psychiatry 62:1281-7. 2007
    ....
  36. ncbi request reprint Differences between heart rate and blood pressure variability in schizophrenia
    Karl Jürgen Bär
    Department of Psychiatry, Friedrich Schiller University, Jena, Germany
    Biomed Tech (Berl) 51:237-9. 2006
    ..Furthermore, blood pressure was significantly higher compared to controls, whereas its variability was unchanged. We conclude that our results reflect autonomic cardiovascular dysregulation in acute schizophrenia...
  37. ncbi request reprint Perception for ischemic pain shows similarities in adjustment disorder and major depression
    M K Boettger
    Institute of Physiology I, Friedrich Schiller University Jena, Teichgraben 8, 07743, Jena, Germany
    Eur J Pain 11:819-22. 2007
    ..This adds weight to the assumption that depressive symptomatology might alter pain sensitivity in this subtype of AD since symptoms are milder, yet comparable to MDD...
  38. doi request reprint Increased cold and heat pain thresholds influence the thermal grill illusion in schizophrenia
    M K Boettger
    Institute of Physiology I, Teichgraben 8, University Hospital, Jena, Germany
    Eur J Pain 17:200-9. 2013
    ..One method to examine central integrative processes of pain perception is the thermal grill illusion (TGI), in which interlacing cold and warm bars create the illusion of a painful sensation...
  39. ncbi request reprint Linear and nonlinear methods for analyses of cardiovascular variability in bipolar disorders
    A Voss
    Department of Medical Engineering, University of Applied Sciences Jena, Jena, Germany
    Bipolar Disord 8:441-52. 2006
    ..Therefore, the application of a multivariate approach is preferable...
  40. doi request reprint The deceleration capacity - a new measure of heart rate variability evaluated in patients with schizophrenia and antipsychotic treatment
    A Birkhofer
    Technische Universitat Munchen, Klinik fur Psychiatrie und Psychotherapie, Ismaninger Str 22, 81675 Munchen, Germany
    Eur Psychiatry 28:81-6. 2013
    ..The aim of the present paper was to calculate DC in patients with schizophrenia and to compare this measure with established parameters of heart rate variability (HRV)...
  41. doi request reprint Cardiovascular and cardiorespiratory coupling in unmedicated schizophrenic patients in comparison to healthy subjects
    S Schulz
    University of Applied Sciences Jena, Department of Medical Engineering and Biotechnology, Jena, Germany
    Conf Proc IEEE Eng Med Biol Soc 2012:3664-7. 2012
    ..Nevertheless, there are less information about the interrelationships of the cardiovascular and respiratory systems in schizophrenia...
  42. doi request reprint Connectivity analysis of somatosensory evoked potentials in patients with major depression. Analysis of connectivity
    L Leistritz
    Institute of Medical Statistics, Computer Sciences and Documentation, Friedrich Schiller University of Jena, Bachstr 18, 07743 Jena, Germany
    Methods Inf Med 49:484-91. 2010
    ....
  43. ncbi request reprint Pentosidine and N(epsilon)-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementia
    K J Bar
    Department of Psychiatry, Friedrich Schiller University of Jena, Philosophenweg 3, 07743 Jena, Germany
    Neurobiol Aging 24:333-8. 2003
    ..It is concluded that AGE proteins are differentially affected in these types of dementia, depending on the specific neuropathology. Furthermore, measurements of AGE products in vivo should rely on CSF rather than blood samples...
  44. ncbi request reprint The expression and localization of somatostatin receptors in dorsal root ganglion neurons of normal and monoarthritic rats
    K J Bar
    Klinik fur Psychiatrie, Friedrich Schiller Universitat Jena, Philosophenweg 3, D 07740 Jena, Germany
    Neuroscience 127:197-206. 2004
    ..The reduction in the proportion of neuronal profiles with sst(2(a)) immunoreactivity suggests that inhibition of neuronal activity by somatostatin is reduced during painful arthritis...
  45. doi request reprint [Hereditary Alzheimer's disease with amyloid angiopathy caused by amyloid precursor protein locus]
    H Axer
    Klinik fur Psychiatrie und Psychotherapie, Friedrich Schiller Universitat, Jena, Deutschland
    Nervenarzt 80:62-3, 65-7. 2009
    ..In conjunction with a family history suggestive of hereditary dementia, such a constellation should lead to enhanced gene analysis...
  46. ncbi request reprint Motor cortex disinhibition in Alzheimer's disease
    J Liepert
    Department of Neurology, Friedrich Schiller University, Jena, Germany
    Clin Neurophysiol 112:1436-41. 2001
    ..To explore subclinical disturbances in the motor cortex of patients with Alzheimer's disease (AD)...
  47. pmc Rationale and baseline characteristics of PREVENT: a second-generation intervention trial in subjects at-risk (prodromal) of developing first-episode psychosis evaluating cognitive behavior therapy, aripiprazole, and placebo for the prevention of psychosi
    Andreas Bechdolf
    Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Schizophr Bull 37:S111-21. 2011
    ..When the final results of the trial are available, PREVENT will substantially expand the current limited evidence base for best clinical practice in people at-risk (prodromal) of first-episode psychosis...