Research Topics
Genomes and Genes
| Peter FriedlSummaryCountry: Germany Publications
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Detail Information
Publications
CD4+ T lymphocytes migrating in three-dimensional collagen lattices lack focal adhesions and utilize beta1 integrin-independent strategies for polarization, interaction with collagen fibers and locomotionP Friedl
Institute of Immunology, University of Witten Herdecke, Witten, Germany
Eur J Immunol 28:2331-43. 1998....- Dynamic imaging of cellular interactions with extracellular matrixPeter Friedl
Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Josef Schneider Strasse 2, 97080, Germany
Histochem Cell Biol 122:183-90. 2004..Dynamic 3D imaging has revealed an unexpected degree of dynamics and turnover of cell adhesion and migration as well as basic mechanisms that lead to proteolytic remodeling of connective tissue by stromal cells and invading tumor cells... - Tuning immune responses: diversity and adaptation of the immunological synapsePeter Friedl
Rudolf Virchow Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Wurzburg 97080, Germany
Nat Rev Immunol 5:532-45. 2005..These diverse interaction modes might define a molecular code, in which the differences in timing, spacing and molecular composition of the signalling platform determine the outcome of T-cell-APC interactions... - TCR triggering on the move: diversity of T-cell interactions with antigen-presenting cellsPeter Friedl
Department of Dermatology, University of Wuerzburg, Wuerzburg, Germany
Immunol Rev 186:83-9. 2002..Herein we develop a model on scanning encounters between T cells and APCs that includes the simultaneous engagement of T-cell leading edge and uropod and implicates a serial receptor triggering mode in cell-cell recognition... - Collective cell migration in morphogenesis and cancerPeter Friedl
Molecular Cell Dynamics Laboratory, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, 97089 Würzburg, Germany
Int J Dev Biol 48:441-9. 2004..This review highlights cellular and molecular principles of collective migration in the context of morphogenic tissue patterning and tumor cell invasion... - Diversity in immune-cell interactions: states and functions of the immunological synapsePeter Friedl
Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
Trends Cell Biol 14:557-67. 2004.... - Amoeboid leukocyte crawling through extracellular matrix: lessons from the Dictyostelium paradigm of cell movementP Friedl
Cell Migration Laboratory, Department of Dermatology, University of Wurzburg, Wurzburg, Germany
J Leukoc Biol 70:491-509. 2001..We describe central aspects of amoeboid movement in leukocytes and the implications for leukocyte crawling and positioning strategies within interstitial tissues... - Interaction of T cells with APCs: the serial encounter modelP Friedl
Cell Migration Laboratory, Dept of Dermatology, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
Trends Immunol 22:187-91. 2001..Here, we develop a serial encounter model of T-cell activation and discuss how the summation of multiple signals provides an efficient strategy to control an ongoing immune response... 
T cell migration in three-dimensional extracellular matrix: guidance by polarity and sensationsP Friedl
Department of Dermatology, University of Wurzburg, Germany
Dev Immunol 7:249-66. 2000..It is therefore likely that, within the tissues, besides chemotactic or haptotactic gradients, the preformed matrix structure has an important impact on T cell trafficking and positioning in health and disease...- The biology of cell locomotion within three-dimensional extracellular matrixP Friedl
Department of Dermatology, University of Wuerzburg, Germany
Cell Mol Life Sci 57:41-64. 2000..In conclusion, depending on the cellular composition and tissue context of migration, diverse cellular and molecular migration strategies can be developed by different cell types... - Cell migration strategies in 3-D extracellular matrix: differences in morphology, cell matrix interactions, and integrin functionP Friedl
Department of Dermatology, University of Wurzburg, Germany
Microsc Res Tech 43:369-78. 1998.... - Integrins, cell matrix interactions and cell migration strategies: fundamental differences in leukocytes and tumor cellsP Friedl
Institute of Immunology, University of Witten Herdecke, Germany
Cell Adhes Commun 6:225-36. 1998..In conclusion, an adhesion-dependent and reorganizing migration type employed by melanoma cells may be distinct from largely integrin-independent and non-reorganizing migration strategies used by leukocytes... - Prespecification and plasticity: shifting mechanisms of cell migrationPeter Friedl
Molecular Cell Dynamics Laboratory, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, and the Department of Dermatology, University of Wurzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
Curr Opin Cell Biol 16:14-23. 2004.... 
A dynamic immunological synapse mediates homeostatic TCR-dependent and -independent signalingJulian Storim
Department of Dermatology and Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Germany
Eur J Immunol 40:2741-50. 2010..Thus a dynamic immunological synapse with distinct signaling sectors enables moving T cells to serially sample resident tissue cells and acquire molecular information "en passant"...- Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasionKatarina Wolf
Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
Nat Cell Biol 9:893-904. 2007..Thus, invasive migration and proteolytic ECM remodelling are interdependent processes that control tissue micropatterning and macropatterning and, consequently, individual and collective cell migration... - Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber modelStephanie Alexander
Department of Dermatology, Venerology, and Allergology and Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
Histochem Cell Biol 130:1147-54. 2008..This modified window model will be suited to address mechanisms of cancer invasion and metastasis, and related experimental therapy... - Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteasesKatarina Wolf
Department of Dermatology, , Josef-Schneider-Str 2, 97080 Wuerzburg, Germany
Blood 102:3262-9. 2003..Together, amoeboid shape change and contact guidance provide constitutive protease-independent mechanisms for leukocyte trafficking through interstitial tissues that are insensitive toward pharmacologic protease inhibitors... - Release of cell fragments by invading melanoma cellsChristian Mayer
Rudolf-Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, , , Germany
Eur J Cell Biol 83:709-15. 2004..The deposition of cell fragments may further represent a disregulated detachment strategy with implications for neoplastic cell behavior, such as the paracrine effects on neighbor cells or a negative impact on immune effector cells... 
Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysisKatarina Wolf
Department of Dermatology, , , Germany
J Cell Biol 160:267-77. 2003....- Reconstructing leukocyte migration in 3D extracellular matrix by time-lapse videomicroscopy and computer-assisted trackingPeter Friedl
Department of Dermatology, University of Wuerzburg, Wuerzburg, Germany
Methods Mol Biol 239:77-90. 2004 - Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategiesYael Hegerfeldt
Department of Dermatology, , , Germany
Cancer Res 62:2125-30. 2002..The conversion from beta1-integrin-dependent collective movement to beta1-integrin-independent single-cell motility suggests efficient cellular and molecular plasticity in tumor cell migration strategies... - Cancer invasion and the microenvironment: plasticity and reciprocityPeter Friedl
Department of Cell Biology, Radboud University Nijmegen Medical Centre, 6500 HC Nijmegen, The Netherlands
Cell 147:992-1009. 2011..The resulting "plasticity" contributes to the generation of diverse cancer invasion routes and programs, enhanced tumor heterogeneity, and ultimately sustained metastatic dissemination... - Determinants of leader cells in collective cell migrationAntoine A Khalil
Department of Dermatology, University of Wurzburg, Wurzburg, Germany
Integr Biol (Camb) 2:568-74. 2010..We here classify molecular and mechanical mechanisms of leading function in collective cell migration during morphogenesis and wound repair and discuss how these are recapitulated during collective invasion of cancer cells... - Functional imaging of pericellular proteolysis in cancer cell invasionKatarina Wolf
Department of Dermatology, Rudolf Virchow Center, DFG Center for Experimental Biomedicine, University of Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
Biochimie 87:315-20. 2005.... - MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferationSvenja Meierjohann
Department of Physiological Chemistry I, Biocenter, University of Wurzburg, Am Hubland, 97074 Wuerzburg, Germany
Mol Cancer 9:201. 2010..The purpose of this study was to examine RTK-driven three-dimensional migration of melanocytes and the pro-tumorigenic role of matrix metalloproteases for melanocytes and melanoma cells... - Tube travel: the role of proteases in individual and collective cancer cell invasionPeter Friedl
Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Germany
Cancer Res 68:7247-9. 2008..These findings develop our understanding of invasive processes in cancer and how to attack them by interfering with MMP-14 activity... - Molecular mechanisms of cancer cell invasion and plasticityKatarina Wolf
Rudolf Virchow Centre, DFG Centre for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Wurzburg, Germany
Br J Dermatol 154:11-5. 2006..These adaptation responses show an unexpected degree of plasticity resulting in migratory 'escape' strategies after pharmacotherapeutic intervention by prompting alternative mechanisms of cancer cell dissemination in tissues... - Biological second and third harmonic generation microscopyPeter Friedl
University of Wurzburg, Wurzburg, Germany
Curr Protoc Cell Biol . 2007..Multimodal multiphoton microscopy using HHGM together with two-photon excited fluorescence will develop into a key approach to real-time imaging of cell dynamics in the context of live tissues... - Tumour-cell invasion and migration: diversity and escape mechanismsPeter Friedl
Department of Dermatology, , Josef-Schneider-Str. 2, , Germany
Nat Rev Cancer 3:362-74. 2003..Learning more about the cellular and molecular basis of these different migration/invasion programmes will help us to understand how cancer cells disseminate and lead to new treatment strategies... - Cancer invasion and resistance: interconnected processes of disease progression and therapy failureStephanie Alexander
Department of Dermatology and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wuerzburg, Wuerzburg, Germany
Trends Mol Med 18:13-26. 2012..We also discuss their interdependencies and the implications for therapeutic dual- or multi-pathway targeting... - Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transitionAndreas Fischer
Department of Physiological Chemistry I, Biocenter, University of Wurzburg, Wurzburg, Germany
Circ Res 100:856-63. 2007..Thus, the Hey gene family shows overlap in controlling Notch induced endocardial epithelial to mesenchymal transition, a process critical for valve and septum formation... - Influence of corneal collagen crosslinking with riboflavin and ultraviolet-a irradiation on excimer laser surgeryDaniel Kampik
Department of Ophthalmology, University of Wurzburg, Wurzburg, Germany
Invest Ophthalmol Vis Sci 51:3929-34. 2010..This study was conducted to investigate whether CXL influences ablation rate, flap thickness, and refractive results of excimer laser procedures ex vivo... - Genomic instability of micronucleated cells revealed by single-cell comparative genomic hybridizationAndrea Imle
Rudolf Virchow Center for Experimental Biomedicine, Department of Dermatology, Universtiy Würzburg, Germany
Cytometry A 75:562-8. 2009..Thus, single-cell selection of defined nuclear states is amenable to single-cell CGH and here provides first insight into the aberration drift and genomic diversity in cancer cells with and without micronuclei... - Impaired induction of adhesion molecule expression in immortalized endothelial cells leads to functional defects in dynamic interactions with lymphocytesGertie J Oostingh
Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Wurzburg, Germany
J Invest Dermatol 127:2253-8. 2007..The immortalized endothelial cells tested here have lost functions that are required for dynamic interactions with immune cells and that are common to primary endothelial cells... - Transplantation of autologous keratinocyte suspension in fibrin matrix to chronic venous leg ulcers: improved long-term healing after removal of the fibrin carrierAnke Hartmann
Department of Dermatology, University of Wurzburg, Wurzburg, Germany
Dermatol Surg 34:922-9. 2008..Parallel in vitro culture was used to validate keratinocyte survival and apoptosis in fibrin compared to collagen matrix carrier... - Infrared multiphoton microscopy: subcellular-resolved deep tissue imagingVolker Andresen
University of Wurzburg, Rudolf Virchow Center for Experimental Biomedicine, Department of Dermatology, Venerology, and Allergology, Wurzburg, Germany
Curr Opin Biotechnol 20:54-62. 2009..Furthermore, it still provides subcellular resolution at depths of several hundred micrometers and thus will enhance long-term live cell and deep tissue microscopy... - Confocal reflection imaging of 3D fibrin polymersAnke Hartmann
Department of Dermatology and Rudolf Virchow Center for Experimental Biomedicine, , Josef-Schneider-Str. 2, , Germany
Blood Cells Mol Dis 36:191-3. 2006..In conclusion, confocal reflection microscopy is a valuable technique for real-time monitoring of the remodeling of fibrin matrices, such as during thrombus formation, wound healing, and tumor formation... - p53 family members in myogenic differentiation and rhabdomyosarcoma developmentHakan Cam
Molecular Tumor Biology Group, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, 97078 Wurzburg, Germany
Cancer Cell 10:281-93. 2006..DeltaNp73 is frequently overexpressed in rhabdomyosarcoma and essential for tumor progression in vivo. These findings establish differentiation control as a key tumor suppressor activity of the p53 family... - Dynamic imaging of the immune systemPeter Friedl
Curr Opin Immunol 16:389-93. 2004 - Stathmin activity influences sarcoma cell shape, motility, and metastatic potentialBarbara Belletti
Division of Experimental Oncology 2, Division of Pathology, and Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS Aviano 33081, Italy
Mol Biol Cell 19:2003-13. 2008..Our results indicate that stathmin plays a significant role in tumor metastasis formation, a finding that could lead to exploitation of stathmin as a target of new antimetastatic drugs... - A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivoMatthias Gunzer
German Research Centre for Biotechnology, Junior Research Group Immunodynamics, Mascheroder Weg 1, 38124 Braunschweig, Germany
Blood 104:2801-9. 2004..Thereby, more dynamic interaction kinetics is positively correlated with higher T-cell priming efficiency... - Human endothelial cells selectively express large amounts of pancreatic-type ribonuclease (RNase 1)Julien B P Landré
INSERM EPI 0113, Universite Bordeaux I, Avenue des Facultes, Talence, France
J Cell Biochem 86:540-52. 2002..The selective strong release of pancreatic-type RNase by endothelial cells suggests that it is endowed with non-digestive functions and involved in vascular homeostasis... - Development of an in vitro blood-brain barrier model based on immortalized porcine brain microvascular endothelial cellsRegina Lauer
Institute of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, Vienna 1090, Austria
Farmaco 59:133-7. 2004..Permeability studies with a set of three benzodiazepines further supported this finding... - The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanismKatharina Uhlenbrock
Department of Structural Biology, Max Planck Institute of Molecular Physiology, Otto Hahn Strasse 11, 44227 Dortmund, Germany
J Cell Sci 117:4863-71. 2004..The reverse transition from mesenchymal invasive to a resident epithelial-like phenotype implicates a role for Tiam1/Rac signaling in the control of cell-cell contacts through a novel ALCAM-mediated mechanism... - Cell fusion: new mechanisms of plasticity in cancer?Peter Friedl
Lancet Oncol 6:916-8. 2005 - Interstitial leukocyte migration and immune functionPeter Friedl
Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525GA Nijmegen, 6500 HB Nijmegen, The Netherlands
Nat Immunol 9:960-9. 2008..Here, we review mechanisms of leukocyte migration and sensing involved in diapedesis, tissue-based interstitial migration and egress, immune cell positioning in inflammation, and emerging therapeutic interference strategies...