Peter Friedl

Summary

Country: Germany

Publications

  1. pmc Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis
    Katarina Wolf
    Department of Dermatology, University of Wurzburg, 97080 Wurzburg, Germany
    J Cell Biol 160:267-77. 2003
  2. ncbi Diversity in immune-cell interactions: states and functions of the immunological synapse
    Peter Friedl
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Trends Cell Biol 14:557-67. 2004
  3. ncbi Collective cell migration in morphogenesis and cancer
    Peter Friedl
    Molecular Cell Dynamics Laboratory, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, 97089 Würzburg, Germany
    Int J Dev Biol 48:441-9. 2004
  4. ncbi Dynamic imaging of cellular interactions with extracellular matrix
    Peter Friedl
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Josef Schneider Strasse 2, 97080, Germany
    Histochem Cell Biol 122:183-90. 2004
  5. ncbi Prespecification and plasticity: shifting mechanisms of cell migration
    Peter Friedl
    Molecular Cell Dynamics Laboratory, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, and the Department of Dermatology, University of Wurzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    Curr Opin Cell Biol 16:14-23. 2004
  6. ncbi Tuning immune responses: diversity and adaptation of the immunological synapse
    Peter Friedl
    Rudolf Virchow Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Wurzburg 97080, Germany
    Nat Rev Immunol 5:532-45. 2005
  7. ncbi CD4+ T lymphocytes migrating in three-dimensional collagen lattices lack focal adhesions and utilize beta1 integrin-independent strategies for polarization, interaction with collagen fibers and locomotion
    P Friedl
    Institute of Immunology, University of Witten Herdecke, Witten, Germany
    Eur J Immunol 28:2331-43. 1998
  8. ncbi TCR triggering on the move: diversity of T-cell interactions with antigen-presenting cells
    Peter Friedl
    Department of Dermatology, University of Wuerzburg, Wuerzburg, Germany
    Immunol Rev 186:83-9. 2002
  9. ncbi The biology of cell locomotion within three-dimensional extracellular matrix
    P Friedl
    Department of Dermatology, University of Wuerzburg, Germany
    Cell Mol Life Sci 57:41-64. 2000
  10. pmc T cell migration in three-dimensional extracellular matrix: guidance by polarity and sensations
    P Friedl
    Department of Dermatology, University of Wurzburg, Germany
    Dev Immunol 7:249-66. 2000

Collaborators

Detail Information

Publications47

  1. pmc Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis
    Katarina Wolf
    Department of Dermatology, University of Wurzburg, 97080 Wurzburg, Germany
    J Cell Biol 160:267-77. 2003
    ....
  2. ncbi Diversity in immune-cell interactions: states and functions of the immunological synapse
    Peter Friedl
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Trends Cell Biol 14:557-67. 2004
    ....
  3. ncbi Collective cell migration in morphogenesis and cancer
    Peter Friedl
    Molecular Cell Dynamics Laboratory, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, 97089 Würzburg, Germany
    Int J Dev Biol 48:441-9. 2004
    ..This review highlights cellular and molecular principles of collective migration in the context of morphogenic tissue patterning and tumor cell invasion...
  4. ncbi Dynamic imaging of cellular interactions with extracellular matrix
    Peter Friedl
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Josef Schneider Strasse 2, 97080, Germany
    Histochem Cell Biol 122:183-90. 2004
    ..Dynamic 3D imaging has revealed an unexpected degree of dynamics and turnover of cell adhesion and migration as well as basic mechanisms that lead to proteolytic remodeling of connective tissue by stromal cells and invading tumor cells...
  5. ncbi Prespecification and plasticity: shifting mechanisms of cell migration
    Peter Friedl
    Molecular Cell Dynamics Laboratory, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, and the Department of Dermatology, University of Wurzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    Curr Opin Cell Biol 16:14-23. 2004
    ....
  6. ncbi Tuning immune responses: diversity and adaptation of the immunological synapse
    Peter Friedl
    Rudolf Virchow Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Wurzburg 97080, Germany
    Nat Rev Immunol 5:532-45. 2005
    ..These diverse interaction modes might define a molecular code, in which the differences in timing, spacing and molecular composition of the signalling platform determine the outcome of T-cell-APC interactions...
  7. ncbi CD4+ T lymphocytes migrating in three-dimensional collagen lattices lack focal adhesions and utilize beta1 integrin-independent strategies for polarization, interaction with collagen fibers and locomotion
    P Friedl
    Institute of Immunology, University of Witten Herdecke, Witten, Germany
    Eur J Immunol 28:2331-43. 1998
    ....
  8. ncbi TCR triggering on the move: diversity of T-cell interactions with antigen-presenting cells
    Peter Friedl
    Department of Dermatology, University of Wuerzburg, Wuerzburg, Germany
    Immunol Rev 186:83-9. 2002
    ..Herein we develop a model on scanning encounters between T cells and APCs that includes the simultaneous engagement of T-cell leading edge and uropod and implicates a serial receptor triggering mode in cell-cell recognition...
  9. ncbi The biology of cell locomotion within three-dimensional extracellular matrix
    P Friedl
    Department of Dermatology, University of Wuerzburg, Germany
    Cell Mol Life Sci 57:41-64. 2000
    ..In conclusion, depending on the cellular composition and tissue context of migration, diverse cellular and molecular migration strategies can be developed by different cell types...
  10. pmc T cell migration in three-dimensional extracellular matrix: guidance by polarity and sensations
    P Friedl
    Department of Dermatology, University of Wurzburg, Germany
    Dev Immunol 7:249-66. 2000
    ..It is therefore likely that, within the tissues, besides chemotactic or haptotactic gradients, the preformed matrix structure has an important impact on T cell trafficking and positioning in health and disease...
  11. ncbi Cell migration strategies in 3-D extracellular matrix: differences in morphology, cell matrix interactions, and integrin function
    P Friedl
    Department of Dermatology, University of Wurzburg, Germany
    Microsc Res Tech 43:369-78. 1998
    ....
  12. ncbi Interaction of T cells with APCs: the serial encounter model
    P Friedl
    Cell Migration Laboratory, Dept of Dermatology, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Trends Immunol 22:187-91. 2001
    ..Here, we develop a serial encounter model of T-cell activation and discuss how the summation of multiple signals provides an efficient strategy to control an ongoing immune response...
  13. ncbi Integrins, cell matrix interactions and cell migration strategies: fundamental differences in leukocytes and tumor cells
    P Friedl
    Institute of Immunology, University of Witten Herdecke, Germany
    Cell Adhes Commun 6:225-36. 1998
    ..In conclusion, an adhesion-dependent and reorganizing migration type employed by melanoma cells may be distinct from largely integrin-independent and non-reorganizing migration strategies used by leukocytes...
  14. ncbi Amoeboid leukocyte crawling through extracellular matrix: lessons from the Dictyostelium paradigm of cell movement
    P Friedl
    Cell Migration Laboratory, Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    J Leukoc Biol 70:491-509. 2001
    ..We describe central aspects of amoeboid movement in leukocytes and the implications for leukocyte crawling and positioning strategies within interstitial tissues...
  15. doi A dynamic immunological synapse mediates homeostatic TCR-dependent and -independent signaling
    Julian Storim
    Department of Dermatology and Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Germany
    Eur J Immunol 40:2741-50. 2010
    ..Thus a dynamic immunological synapse with distinct signaling sectors enables moving T cells to serially sample resident tissue cells and acquire molecular information "en passant"...
  16. ncbi Release of cell fragments by invading melanoma cells
    Christian Mayer
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    Eur J Cell Biol 83:709-15. 2004
    ..The deposition of cell fragments may further represent a disregulated detachment strategy with implications for neoplastic cell behavior, such as the paracrine effects on neighbor cells or a negative impact on immune effector cells...
  17. doi Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model
    Stephanie Alexander
    Department of Dermatology, Venerology, and Allergology and Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
    Histochem Cell Biol 130:1147-54. 2008
    ..This modified window model will be suited to address mechanisms of cancer invasion and metastasis, and related experimental therapy...
  18. ncbi Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion
    Katarina Wolf
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Nat Cell Biol 9:893-904. 2007
    ..Thus, invasive migration and proteolytic ECM remodelling are interdependent processes that control tissue micropatterning and macropatterning and, consequently, individual and collective cell migration...
  19. ncbi Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases
    Katarina Wolf
    Department of Dermatology, University of Wurzburg, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    Blood 102:3262-9. 2003
    ..Together, amoeboid shape change and contact guidance provide constitutive protease-independent mechanisms for leukocyte trafficking through interstitial tissues that are insensitive toward pharmacologic protease inhibitors...
  20. doi Mechanotransduction of mesenchymal melanoma cell invasion into 3D collagen lattices: filopod-mediated extension-relaxation cycles and force anisotropy
    Josefine Starke
    Department of Dermatology, University of Wurzburg, Josef Schneider Str 2, 87080 Würzburg, Germany
    Exp Cell Res 319:2424-33. 2013
    ..Combined live-cell fluorescence and reflection microscopy of the leading edge thus reveals step-wise caterpillar-like extension-retraction cycles that underlie mesenchymal migration in 3D tissue. ..
  21. ncbi Reconstructing leukocyte migration in 3D extracellular matrix by time-lapse videomicroscopy and computer-assisted tracking
    Peter Friedl
    Department of Dermatology, University of Wuerzburg, Wuerzburg, Germany
    Methods Mol Biol 239:77-90. 2004
  22. ncbi Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategies
    Yael Hegerfeldt
    Department of Dermatology, University of Wurzburg, 97080 Wurzburg, Germany
    Cancer Res 62:2125-30. 2002
    ..The conversion from beta1-integrin-dependent collective movement to beta1-integrin-independent single-cell motility suggests efficient cellular and molecular plasticity in tumor cell migration strategies...
  23. doi Cancer invasion and the microenvironment: plasticity and reciprocity
    Peter Friedl
    Department of Cell Biology, Radboud University Nijmegen Medical Centre, 6500 HC Nijmegen, The Netherlands
    Cell 147:992-1009. 2011
    ..The resulting "plasticity" contributes to the generation of diverse cancer invasion routes and programs, enhanced tumor heterogeneity, and ultimately sustained metastatic dissemination...
  24. doi Determinants of leader cells in collective cell migration
    Antoine A Khalil
    Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    Integr Biol (Camb) 2:568-74. 2010
    ..We here classify molecular and mechanical mechanisms of leading function in collective cell migration during morphogenesis and wound repair and discuss how these are recapitulated during collective invasion of cancer cells...
  25. ncbi Functional imaging of pericellular proteolysis in cancer cell invasion
    Katarina Wolf
    Department of Dermatology, Rudolf Virchow Center, DFG Center for Experimental Biomedicine, University of Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
    Biochimie 87:315-20. 2005
    ....
  26. pmc MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation
    Svenja Meierjohann
    Department of Physiological Chemistry I, Biocenter, University of Wurzburg, Am Hubland, 97074 Wuerzburg, Germany
    Mol Cancer 9:201. 2010
    ..The purpose of this study was to examine RTK-driven three-dimensional migration of melanocytes and the pro-tumorigenic role of matrix metalloproteases for melanocytes and melanoma cells...
  27. doi Tube travel: the role of proteases in individual and collective cancer cell invasion
    Peter Friedl
    Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Germany
    Cancer Res 68:7247-9. 2008
    ..These findings develop our understanding of invasive processes in cancer and how to attack them by interfering with MMP-14 activity...
  28. ncbi Biological second and third harmonic generation microscopy
    Peter Friedl
    University of Wurzburg, Wurzburg, Germany
    Curr Protoc Cell Biol . 2007
    ..Multimodal multiphoton microscopy using HHGM together with two-photon excited fluorescence will develop into a key approach to real-time imaging of cell dynamics in the context of live tissues...
  29. ncbi Molecular mechanisms of cancer cell invasion and plasticity
    Katarina Wolf
    Rudolf Virchow Centre, DFG Centre for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    Br J Dermatol 154:11-5. 2006
    ..These adaptation responses show an unexpected degree of plasticity resulting in migratory 'escape' strategies after pharmacotherapeutic intervention by prompting alternative mechanisms of cancer cell dissemination in tissues...
  30. ncbi Confocal reflection imaging of 3D fibrin polymers
    Anke Hartmann
    Department of Dermatology and Rudolf Virchow Center for Experimental Biomedicine, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Blood Cells Mol Dis 36:191-3. 2006
    ..In conclusion, confocal reflection microscopy is a valuable technique for real-time monitoring of the remodeling of fibrin matrices, such as during thrombus formation, wound healing, and tumor formation...
  31. ncbi Tumour-cell invasion and migration: diversity and escape mechanisms
    Peter Friedl
    Department of Dermatology, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Nat Rev Cancer 3:362-74. 2003
    ..Learning more about the cellular and molecular basis of these different migration/invasion programmes will help us to understand how cancer cells disseminate and lead to new treatment strategies...
  32. doi Transplantation of autologous keratinocyte suspension in fibrin matrix to chronic venous leg ulcers: improved long-term healing after removal of the fibrin carrier
    Anke Hartmann
    Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    Dermatol Surg 34:922-9. 2008
    ..Parallel in vitro culture was used to validate keratinocyte survival and apoptosis in fibrin compared to collagen matrix carrier...
  33. doi Cancer invasion and resistance: interconnected processes of disease progression and therapy failure
    Stephanie Alexander
    Department of Dermatology and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wuerzburg, Wuerzburg, Germany
    Trends Mol Med 18:13-26. 2012
    ..We also discuss their interdependencies and the implications for therapeutic dual- or multi-pathway targeting...
  34. ncbi Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition
    Andreas Fischer
    Department of Physiological Chemistry I, Biocenter, University of Wurzburg, Wurzburg, Germany
    Circ Res 100:856-63. 2007
    ..Thus, the Hey gene family shows overlap in controlling Notch induced endocardial epithelial to mesenchymal transition, a process critical for valve and septum formation...
  35. ncbi Genomic instability of micronucleated cells revealed by single-cell comparative genomic hybridization
    Andrea Imle
    Rudolf Virchow Center for Experimental Biomedicine, Department of Dermatology, Universtiy Würzburg, Germany
    Cytometry A 75:562-8. 2009
    ..Thus, single-cell selection of defined nuclear states is amenable to single-cell CGH and here provides first insight into the aberration drift and genomic diversity in cancer cells with and without micronuclei...
  36. ncbi Influence of corneal collagen crosslinking with riboflavin and ultraviolet-a irradiation on excimer laser surgery
    Daniel Kampik
    Department of Ophthalmology, University of Wurzburg, Wurzburg, Germany
    Invest Ophthalmol Vis Sci 51:3929-34. 2010
    ..This study was conducted to investigate whether CXL influences ablation rate, flap thickness, and refractive results of excimer laser procedures ex vivo...
  37. doi Infrared multiphoton microscopy: subcellular-resolved deep tissue imaging
    Volker Andresen
    University of Wurzburg, Rudolf Virchow Center for Experimental Biomedicine, Department of Dermatology, Venerology, and Allergology, Wurzburg, Germany
    Curr Opin Biotechnol 20:54-62. 2009
    ..Furthermore, it still provides subcellular resolution at depths of several hundred micrometers and thus will enhance long-term live cell and deep tissue microscopy...
  38. ncbi Impaired induction of adhesion molecule expression in immortalized endothelial cells leads to functional defects in dynamic interactions with lymphocytes
    Gertie J Oostingh
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine and Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    J Invest Dermatol 127:2253-8. 2007
    ..The immortalized endothelial cells tested here have lost functions that are required for dynamic interactions with immune cells and that are common to primary endothelial cells...
  39. ncbi p53 family members in myogenic differentiation and rhabdomyosarcoma development
    Hakan Cam
    Molecular Tumor Biology Group, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, 97078 Wurzburg, Germany
    Cancer Cell 10:281-93. 2006
    ..DeltaNp73 is frequently overexpressed in rhabdomyosarcoma and essential for tumor progression in vivo. These findings establish differentiation control as a key tumor suppressor activity of the p53 family...
  40. ncbi Dynamic imaging of the immune system
    Peter Friedl
    Curr Opin Immunol 16:389-93. 2004
  41. ncbi A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivo
    Matthias Gunzer
    German Research Centre for Biotechnology, Junior Research Group Immunodynamics, Mascheroder Weg 1, 38124 Braunschweig, Germany
    Blood 104:2801-9. 2004
    ..Thereby, more dynamic interaction kinetics is positively correlated with higher T-cell priming efficiency...
  42. pmc Stathmin activity influences sarcoma cell shape, motility, and metastatic potential
    Barbara Belletti
    Division of Experimental Oncology 2, Division of Pathology, and Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS Aviano 33081, Italy
    Mol Biol Cell 19:2003-13. 2008
    ..Our results indicate that stathmin plays a significant role in tumor metastasis formation, a finding that could lead to exploitation of stathmin as a target of new antimetastatic drugs...
  43. ncbi Cell fusion: new mechanisms of plasticity in cancer?
    Peter Friedl
    Lancet Oncol 6:916-8. 2005
  44. ncbi Development of an in vitro blood-brain barrier model based on immortalized porcine brain microvascular endothelial cells
    Regina Lauer
    Institute of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, Vienna 1090, Austria
    Farmaco 59:133-7. 2004
    ..Permeability studies with a set of three benzodiazepines further supported this finding...
  45. ncbi Human endothelial cells selectively express large amounts of pancreatic-type ribonuclease (RNase 1)
    Julien B P Landré
    INSERM EPI 0113, Universite Bordeaux I, Avenue des Facultes, Talence, France
    J Cell Biochem 86:540-52. 2002
    ..The selective strong release of pancreatic-type RNase by endothelial cells suggests that it is endowed with non-digestive functions and involved in vascular homeostasis...
  46. ncbi The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism
    Katharina Uhlenbrock
    Department of Structural Biology, Max Planck Institute of Molecular Physiology, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    J Cell Sci 117:4863-71. 2004
    ..The reverse transition from mesenchymal invasive to a resident epithelial-like phenotype implicates a role for Tiam1/Rac signaling in the control of cell-cell contacts through a novel ALCAM-mediated mechanism...
  47. ncbi Interstitial leukocyte migration and immune function
    Peter Friedl
    Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525GA Nijmegen, 6500 HB Nijmegen, The Netherlands
    Nat Immunol 9:960-9. 2008
    ..Here, we review mechanisms of leukocyte migration and sensing involved in diapedesis, tissue-based interstitial migration and egress, immune cell positioning in inflammation, and emerging therapeutic interference strategies...