K U Fröhlich
- Oxygen stress: a regulator of apoptosis in yeastF Madeo
Physiologisch Chemisches Institut, Universitat Tubingen, 72076 Tubingen, Germany
J Cell Biol 145:757-67. 1999..These results suggest that the generation of oxygen radicals is a key event in the ancestral apoptotic pathway and offer an explanation for the mechanism of bax-induced apoptosis in the absence of any established apoptotic gene in yeast...
- Apoptosis in yeast--a monocellular organism exhibits altruistic behaviourK U Fröhlich
Physiologisch Chemisches Institut, Universitat Tubingen, Hoppe Seyler Strasse 4, 72076, Tubingen, Germany
FEBS Lett 473:6-9. 2000..Later, cells developed mechanisms to purposely produce reactive oxygen species as a regulator of apoptosis. Yeast may become an important model to investigate the conserved steps of apoptosis...
- An AAA family treeK U Fröhlich
Physiologisch Chemisches Institut, Hoppe Seyler Strasse 4, Tubingen, Germany
J Cell Sci 114:1601-2. 2001
- Identification of the regions of porcine VCP preventing its function in Saccharomyces cerevisiaeF Madeo
Physiologisch Chemisches Institut, Universitat Tubingen, Germany
Gene 204:145-51. 1997..In contrast to VCP, Cdc48p contains an almost perfect nuclear targeting sequence in this region. Exchange of the C-terminal Cdc48p domain for the C-terminus of VCP leads to normal viability of the cell, even at low expression levels...
- The ATPase activity of purified CDC48p from Saccharomyces cerevisiae shows complex dependence on ATP-, ADP-, and NADH-concentrations and is completely inhibited by NEMK U Fröhlich
Physiologisch Chemisches Institut, Tubingen, Germany
Biochim Biophys Acta 1253:25-32. 1995..By electron microscopy, the enzyme was shown to consist of hexameric ring structures similar to its vertebrate homologue...
- A yeast mutant showing diagnostic markers of early and late apoptosisF Madeo
Physiologisch Chemisches Institut, , , Germany
J Cell Biol 139:729-34. 1997..Saccharomyces cerevisiae may prove a suitable model to trace the roots of apoptosis...