K U Fröhlich

Summary

Country: Germany

Publications

  1. pmc Oxygen stress: a regulator of apoptosis in yeast
    F Madeo
    Physiologisch Chemisches Institut, Universitat Tubingen, 72076 Tubingen, Germany
    J Cell Biol 145:757-67. 1999
  2. ncbi request reprint Apoptosis in yeast--a monocellular organism exhibits altruistic behaviour
    K U Fröhlich
    Physiologisch Chemisches Institut, Universitat Tubingen, Hoppe Seyler Strasse 4, 72076, Tubingen, Germany
    FEBS Lett 473:6-9. 2000
  3. ncbi request reprint An AAA family tree
    K U Fröhlich
    Physiologisch Chemisches Institut, Hoppe Seyler Strasse 4, Tubingen, Germany
    J Cell Sci 114:1601-2. 2001
  4. ncbi request reprint Identification of the regions of porcine VCP preventing its function in Saccharomyces cerevisiae
    F Madeo
    Physiologisch Chemisches Institut, Universitat Tubingen, Germany
    Gene 204:145-51. 1997
  5. ncbi request reprint The ATPase activity of purified CDC48p from Saccharomyces cerevisiae shows complex dependence on ATP-, ADP-, and NADH-concentrations and is completely inhibited by NEM
    K U Fröhlich
    Physiologisch Chemisches Institut, Tubingen, Germany
    Biochim Biophys Acta 1253:25-32. 1995
  6. pmc A yeast mutant showing diagnostic markers of early and late apoptosis
    F Madeo
    Physiologisch Chemisches Institut, , , Germany
    J Cell Biol 139:729-34. 1997

Collaborators

  • D H Wolf
  • F Madeo
  • E Frohlich
  • M Ligr
  • S J Sigrist
  • M Grey
  • J Schlauer

Detail Information

Publications6

  1. pmc Oxygen stress: a regulator of apoptosis in yeast
    F Madeo
    Physiologisch Chemisches Institut, Universitat Tubingen, 72076 Tubingen, Germany
    J Cell Biol 145:757-67. 1999
    ..These results suggest that the generation of oxygen radicals is a key event in the ancestral apoptotic pathway and offer an explanation for the mechanism of bax-induced apoptosis in the absence of any established apoptotic gene in yeast...
  2. ncbi request reprint Apoptosis in yeast--a monocellular organism exhibits altruistic behaviour
    K U Fröhlich
    Physiologisch Chemisches Institut, Universitat Tubingen, Hoppe Seyler Strasse 4, 72076, Tubingen, Germany
    FEBS Lett 473:6-9. 2000
    ..Later, cells developed mechanisms to purposely produce reactive oxygen species as a regulator of apoptosis. Yeast may become an important model to investigate the conserved steps of apoptosis...
  3. ncbi request reprint An AAA family tree
    K U Fröhlich
    Physiologisch Chemisches Institut, Hoppe Seyler Strasse 4, Tubingen, Germany
    J Cell Sci 114:1601-2. 2001
  4. ncbi request reprint Identification of the regions of porcine VCP preventing its function in Saccharomyces cerevisiae
    F Madeo
    Physiologisch Chemisches Institut, Universitat Tubingen, Germany
    Gene 204:145-51. 1997
    ..In contrast to VCP, Cdc48p contains an almost perfect nuclear targeting sequence in this region. Exchange of the C-terminal Cdc48p domain for the C-terminus of VCP leads to normal viability of the cell, even at low expression levels...
  5. ncbi request reprint The ATPase activity of purified CDC48p from Saccharomyces cerevisiae shows complex dependence on ATP-, ADP-, and NADH-concentrations and is completely inhibited by NEM
    K U Fröhlich
    Physiologisch Chemisches Institut, Tubingen, Germany
    Biochim Biophys Acta 1253:25-32. 1995
    ..By electron microscopy, the enzyme was shown to consist of hexameric ring structures similar to its vertebrate homologue...
  6. pmc A yeast mutant showing diagnostic markers of early and late apoptosis
    F Madeo
    Physiologisch Chemisches Institut, , , Germany
    J Cell Biol 139:729-34. 1997
    ..Saccharomyces cerevisiae may prove a suitable model to trace the roots of apoptosis...