Marina A Freudenberg

Summary

Country: Germany

Publications

  1. doi request reprint Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: benefits and hazards of LPS hypersensitivity
    Marina A Freudenberg
    Max Planck Institute for Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
    Immunobiology 213:193-203. 2008
  2. pmc Differential contribution of Toll-like receptors 4 and 2 to the cytokine response to Salmonella enterica serovar Typhimurium and Staphylococcus aureus in mice
    Annalisa Lembo
    Max Planck Institut fur Immunbiologie, Stubeweg 51, 79108 Freiburg, Germany
    Infect Immun 71:6058-62. 2003
  3. doi request reprint Absence of TRIF signaling in lipopolysaccharide-stimulated murine mast cells
    Simone Keck
    Max Planck Institute of Immunobiology and Epigenetics, D 79108 Freiburg, Germany
    J Immunol 186:5478-88. 2011
  4. ncbi request reprint Stage of primary infection with lymphocytic choriomeningitis virus determines predisposition or resistance of mice to secondary bacterial infections
    Marina Gumenscheimer
    Max Planck Institut fur Immunbiologie, Stubeweg 51, 79 108 Freiburg Br, Germany
    Med Microbiol Immunol 196:79-88. 2007
  5. doi request reprint Innate, antigen-independent role for T cells in the activation of the immune system by Propionibacterium acnes
    Sandrine Tchaptchet
    Max Planck Institute for Immunobiology, Freiburg, Germany
    Eur J Immunol 40:2506-16. 2010
  6. pmc Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions
    Gyorgy Fejer
    Max Planck Institute of Immunobiology and Epigenetics, D 79108 Freiburg, Germany
    Proc Natl Acad Sci U S A 110:E2191-8. 2013
  7. pmc Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo
    Gyorgy Fejer
    Max Planck Institute for Immunobiology, Freiburg, Germany
    PLoS Pathog 4:e1000208. 2008
  8. ncbi request reprint Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice
    Christoph Kalis
    Max Planck Institut fur Immunbiologie, Stubeweg 51, 79108 Freiburg, Germany
    Eur J Immunol 33:798-805. 2003
  9. ncbi request reprint Production of IL-12, IL-23 and IL-27p28 by bone marrow-derived conventional dendritic cells rather than macrophages after LPS/TLR4-dependent induction by Salmonella Enteritidis
    Sabine Siegemund
    Institute of Immunology, College of Veterinary Medicine, An den Tierkliniken 11, 04103, Leipzig, Germany
    Immunobiology 212:739-50. 2007
  10. ncbi request reprint TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease
    Bei Liu
    Department of Immunology, Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, CT 06030 1601, USA
    J Immunol 177:6880-8. 2006

Collaborators

  • Michael Huber
  • Emilio Jirillo
  • Antje Prasse
  • Elena Voronov
  • Hermann Wagner
  • Christian Bogdan
  • Bernd Hildenbrand
  • BRUCE A BEUTLER
  • Ivan Mitov
  • S Akira
  • Thilo Jakob
  • S F Martin
  • Chris Galanos
  • Gyorgy Fejer
  • Sandrine Tchaptchet
  • Marina Gumenscheimer
  • Christoph Kalis
  • Simone Keck
  • Simone Antoniazi
  • Pascale Kropf
  • Zsolt Ruzsics
  • Annalisa Lembo
  • Susana Minguet
  • Nikolaus Freudenberg
  • Sabine Siegemund
  • Bei Liu
  • Reinhard K Straubinger
  • Gottfried Alber
  • Nicole Schuetze
  • Helen P Price
  • Ingrid Muller
  • Deborah F Smith
  • Bernd Echtenacher
  • Mareike Dorothee Wegner
  • Ildiko Gyory
  • Lars Dölken
  • Ron N Apte
  • Olivia Prazeres da Costa
  • Thomas Manke
  • Robert Schneider
  • Peggy Engelhard
  • Nora Branzk
  • Idan Cohen
  • Ines Muller
  • Iva Savic
  • Peter J Nielsen
  • Wolfgang W A Schamel
  • Jörg Kirberg
  • Ulrike Schleicher
  • Jan Liese
  • Elaine P Dopfer
  • Lisa Drechsel
  • Nicola Imelli
  • Careen Pollmer
  • Anne Krug
  • Wolfgang W Schamel
  • Urs F Greber
  • Michael Reth
  • Nicole Schütze
  • Markus M Simon
  • Sandra Balkow
  • Manfred B Lutz
  • Ping L Zhang
  • Yi Yang
  • Ruslan Medzhitov
  • Zihai Li
  • Jie Dai
  • Uwe Mueller
  • Sabine Schoeneberger
  • Antje Heit
  • Shanti Herath
  • Manuel Modolell
  • Benoit Kanzler
  • Daniela N Männel
  • Alexander Poltorak
  • Karin Weigl
  • Renate Urbaschek
  • Vincenzo Mitolo
  • Carsten J Kirschning

Detail Information

Publications22

  1. doi request reprint Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: benefits and hazards of LPS hypersensitivity
    Marina A Freudenberg
    Max Planck Institute for Immunobiology, Stubeweg 51, D 79108 Freiburg, Germany
    Immunobiology 213:193-203. 2008
    ..Finally, the effects of pre-existing hypersensitivity on the course and outcome of a super-infection with Salmonella typhimurium or Listeria monocytogenes are summarized...
  2. pmc Differential contribution of Toll-like receptors 4 and 2 to the cytokine response to Salmonella enterica serovar Typhimurium and Staphylococcus aureus in mice
    Annalisa Lembo
    Max Planck Institut fur Immunbiologie, Stubeweg 51, 79108 Freiburg, Germany
    Infect Immun 71:6058-62. 2003
    ..Gram-negative bacteria induced cytokines primarily via TLR4; the contribution of TLR2 was only minor. Neither TLR4 nor, surprisingly, TLR2 was required in the MyD88-dependent response to Staphylococcus aureus...
  3. doi request reprint Absence of TRIF signaling in lipopolysaccharide-stimulated murine mast cells
    Simone Keck
    Max Planck Institute of Immunobiology and Epigenetics, D 79108 Freiburg, Germany
    J Immunol 186:5478-88. 2011
    ..These results show how the response to the same microbial ligand using the same receptor can be regulated in different cell types of the innate immune system...
  4. ncbi request reprint Stage of primary infection with lymphocytic choriomeningitis virus determines predisposition or resistance of mice to secondary bacterial infections
    Marina Gumenscheimer
    Max Planck Institut fur Immunbiologie, Stubeweg 51, 79 108 Freiburg Br, Germany
    Med Microbiol Immunol 196:79-88. 2007
    ....
  5. doi request reprint Innate, antigen-independent role for T cells in the activation of the immune system by Propionibacterium acnes
    Sandrine Tchaptchet
    Max Planck Institute for Immunobiology, Freiburg, Germany
    Eur J Immunol 40:2506-16. 2010
    ..Thus, under microbial pressure, different T-cell types, independent of their antigen specificity, exert NK-cell-like functions, which contribute decisively to the activation of the innate immune system...
  6. pmc Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions
    Gyorgy Fejer
    Max Planck Institute of Immunobiology and Epigenetics, D 79108 Freiburg, Germany
    Proc Natl Acad Sci U S A 110:E2191-8. 2013
    ..In conclusion, Max Planck Institute cells offer an useful tool to study macrophage biology and for biomedical science...
  7. pmc Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo
    Gyorgy Fejer
    Max Planck Institute for Immunobiology, Freiburg, Germany
    PLoS Pathog 4:e1000208. 2008
    ..The hypersensitivity to components of the microbial flora and invading pathogens may in part explain the toxic side effects of adenoviral gene therapy and contribute to the pathogenesis of adenoviral disease...
  8. ncbi request reprint Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice
    Christoph Kalis
    Max Planck Institut fur Immunbiologie, Stubeweg 51, 79108 Freiburg, Germany
    Eur J Immunol 33:798-805. 2003
    ..In macrophages, investigation of the LPS-induced cytokine (IL-6) response revealed a linear relationship between the response and the logarithm of TLR4-MD-2 levels...
  9. ncbi request reprint Production of IL-12, IL-23 and IL-27p28 by bone marrow-derived conventional dendritic cells rather than macrophages after LPS/TLR4-dependent induction by Salmonella Enteritidis
    Sabine Siegemund
    Institute of Immunology, College of Veterinary Medicine, An den Tierkliniken 11, 04103, Leipzig, Germany
    Immunobiology 212:739-50. 2007
    ..Taken together, our results point to cDC rather than MPhi as the major producers of the IL-12 family members during in vitro infection with SE. The mechanisms of recognition of SE, however, appear to be the same for cDC and MPhi...
  10. ncbi request reprint TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease
    Bei Liu
    Department of Immunology, Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, CT 06030 1601, USA
    J Immunol 177:6880-8. 2006
    ..Our study has revealed that increased TLR4 signaling alone without exogenous insult can break immunological tolerance. It provides a strong experimental evidence for TLR4 dysregulation as an etiology of lupus-like renal disease...
  11. ncbi request reprint Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling
    Marina A Freudenberg
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    J Immunol 169:1665-8. 2002
    ..This pathway participates in the induction of IFN-gamma by Gram-negative bacteria and is therefore expected to play a role whenever IFN-alpha or IFN-beta and IL-18 are produced concomitantly during bacterial, viral, or other infections...
  12. ncbi request reprint IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella enteritidis and the impact of IL-10 in bone marrow-derived macrophages
    Nicole Schuetze
    Institute of Immunology, College of Veterinary Medicine and Biotechnological Biomedical Center BBZ, University of Leipzig, An den Tierkliniken 11, 04103 Leipzig, Germany
    Int Immunol 17:649-59. 2005
    ..In this context, the cytokine mRNA up-regulation by whole Salmonella Enteritidis is mediated chiefly by TLR4, but depends on additional pattern recognition receptors other than TLR2 expressed by macrophages...
  13. pmc Beneficial or deleterious effects of a preexisting hypersensitivity to bacterial components on the course and outcome of infection
    Marina Gumenscheimer
    Max Planck Institut fur Immunbiologie, 79 108 Freiburg, Germany
    Infect Immun 70:5596-603. 2002
    ..A similar P. acnes priming of mice had a protective, but no deleterious effect on a subsequent L. monocytogenes infection. This effect was IFN-gamma dependent but independent of LBP...
  14. ncbi request reprint Role of interferons in LPS hypersensitivity
    Marina A Freudenberg
    Max Planck Institut fü r Immunbiologie, Freiburg, Germany
    J Endotoxin Res 9:308-12. 2003
    ..The IFN-alpha/beta-dependent pathway is expected to play a role whenever IFN-alpha or IFN-beta, and IL-18 are produced concomitantly during infection...
  15. ncbi request reprint Treatment of experimental sepsis-induced immunoparalysis with TNF
    Bernd Echtenacher
    Institute for Pathology Tumor Immunology, University of Regensburg, Regensburg, Germany
    Immunobiology 208:381-9. 2003
    ..These results demonstrate that impaired TNF production capacity can account for some aspects of immunoparalysis, however, diagnostic parameters are required for a safe TNF substitution therapy...
  16. doi request reprint Enhanced B-cell activation mediated by TLR4 and BCR crosstalk
    Susana Minguet
    Molecular Immunology, Institute of Biology III, University of Freiburg and Max Planck Institute for Immunobiology, Freiburg, Germany
    Eur J Immunol 38:2475-87. 2008
    ..In contrast, co-engagement of TLR4 and BCR by antigen-coupled LPS synergistically enhances activation of B cells, pointing out attractive targets for signalling crosstalk in B lymphocytes...
  17. pmc Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity
    Stefan F Martin
    Allergy Research Group, Department of Dermatology, University Medical Center Freiburg, D 79104 Freiburg, Germany
    J Exp Med 205:2151-62. 2008
    ..Finally, CHS was inducible in germ-free wild-type and IL-12Rbeta2-deficient mice, but not in germ-free TLR4/IL-12Rbeta2 double deficient mice, suggesting that the necessary TLR activation may proceed via endogenous ligands...
  18. ncbi request reprint IFN-y enhances T(H)1 polarisation of monocyte-derived dendritic cells matured with clinical-grade cytokines using serum-free conditions
    Bernd Hildenbrand
    Department of Clinical Research, Tumour Biology Center, D 79106 Freiburg, Germany
    Anticancer Res 28:1467-76. 2008
    ..In conclusion, our work demonstrates that addition of INF-gamma to clinical-grade cytokine cocktails readily matures MoDCs and enhances their T(H)1 polarisation efficiently under serum-free conditions...
  19. pmc Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major
    Pascale Kropf
    Faculty of Medicine, Department of Immunology, Imperial College London, London, United Kingdom
    Infect Immun 72:1920-8. 2004
    ..This is the first study showing that TLR4 contributes to the effective control of Leishmania infection in vivo...
  20. pmc Chemokine gene expression in toll-like receptor-competent and -deficient mice infected with Leishmania major
    Simone Antoniazi
    Imperial College London, Faculty of Medicine, Department of Immunology, Norfolk Place, London W2 1PG, United Kingdom
    Infect Immun 72:5168-74. 2004
    ..Different patterns of expression were detected depending on the time postinfection, but there was little variation in the expression of these four chemokines in the presence or absence of TLR4...
  21. ncbi request reprint Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes
    Christoph Kalis
    Max Planck Institut fur Immunbiologie, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
    J Immunol 174:4295-300. 2005
    ..Because IFN-gamma is a key mediator of these effects, and enhanced IFN-gamma mRNA expression was absent in spleen and liver of P. acnes-primed TLR9(-/-) mice, we conclude that TLR9 is required for the induction of IFN-gamma by P. acnes...
  22. ncbi request reprint R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells
    Michael Huber
    Molecular Immunology, Institute for Biology III, Albert Ludwigs University Freiburg, Freiburg, Germany
    Eur J Immunol 36:701-11. 2006
    ....