Cornelius Jungheinrich

Summary

Affiliation: Fresenius Kabi
Country: Germany

Publications

  1. ncbi Pharmacokinetics of hydroxyethyl starch
    Cornelius Jungheinrich
    Clinical Research, Medical Scientific Affairs, Fresenius Kabi, Bad Homburg, Germany
    Clin Pharmacokinet 44:681-99. 2005
  2. ncbi The pharmacokinetics and tolerability of an intravenous infusion of the new hydroxyethyl starch 130/0.4 (6%, 500 mL) in mild-to-severe renal impairment
    Cornelius Jungheinrich
    Clinical Research, Fresenius Kabi, 61346 Bad Homburg, Germany
    Anesth Analg 95:544-51, table of contents. 2002
  3. ncbi Volume efficacy and reduced influence on measures of coagulation using hydroxyethyl starch 130/0.4 (6%) with an optimised in vivo molecular weight in orthopaedic surgery : a randomised, double-blind study
    Cornelius Jungheinrich
    Clinical Research, Fresenius Kabi, Bad Homburg, Germany
    Drugs R D 5:1-9. 2004
  4. ncbi Repetitive large-dose infusion of the novel hydroxyethyl starch 130/0.4 in patients with severe head injury
    Thomas A Neff
    Institute of Anesthesiology, University Hospital, Zurich, Switzerland
    Anesth Analg 96:1453-9, table of contents. 2003
  5. ncbi Volume replacement therapy during major orthopedic surgery using Voluven (hydroxyethyl starch 130/0.4) or hetastarch
    Sweeta D Gandhi
    Department of Anesthesiology, Clement J Zablocki Veterans Affairs Medical Center and the Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 106:1120-7. 2007
  6. doi The effects of hydroxyethyl starch 130/0.4 (6%) on blood loss and use of blood products in major surgery: a pooled analysis of randomized clinical trials
    Sibylle A Kozek-Langenecker
    Department of Special Anesthesiology and Pain Management, Vienna Medical University, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Anesth Analg 107:382-90. 2008

Detail Information

Publications6

  1. ncbi Pharmacokinetics of hydroxyethyl starch
    Cornelius Jungheinrich
    Clinical Research, Medical Scientific Affairs, Fresenius Kabi, Bad Homburg, Germany
    Clin Pharmacokinet 44:681-99. 2005
    ..5. Influence on coagulation is minimal with hydroxyethyl starch 130/0.4, and no adverse effects on kidney function have been observed even with large repetitive doses when used according to the product information...
  2. ncbi The pharmacokinetics and tolerability of an intravenous infusion of the new hydroxyethyl starch 130/0.4 (6%, 500 mL) in mild-to-severe renal impairment
    Cornelius Jungheinrich
    Clinical Research, Fresenius Kabi, 61346 Bad Homburg, Germany
    Anesth Analg 95:544-51, table of contents. 2002
    ..6 mg/mL). We conclude that HES 130/0.4 (500 mL 6%) can be safely administered to patients even with severe renal impairment, as long as urine flow is preserved, without plasma accumulation...
  3. ncbi Volume efficacy and reduced influence on measures of coagulation using hydroxyethyl starch 130/0.4 (6%) with an optimised in vivo molecular weight in orthopaedic surgery : a randomised, double-blind study
    Cornelius Jungheinrich
    Clinical Research, Fresenius Kabi, Bad Homburg, Germany
    Drugs R D 5:1-9. 2004
    ..Different types of hydroxyethyl starch (HES) affect blood coagulation differently. We studied the effects of HES 130/0.4 on coagulation in major orthopaedic surgery in relation to the pharmacological parameter in vivo molecular weight...
  4. ncbi Repetitive large-dose infusion of the novel hydroxyethyl starch 130/0.4 in patients with severe head injury
    Thomas A Neff
    Institute of Anesthesiology, University Hospital, Zurich, Switzerland
    Anesth Analg 96:1453-9, table of contents. 2003
    ..4 group despite the large HES doses administered. We conclude that HES 130/0.4 can safely be used in critically ill head trauma patients over several days at doses of up to 70 mL x kg(-1) x d(-1)...
  5. ncbi Volume replacement therapy during major orthopedic surgery using Voluven (hydroxyethyl starch 130/0.4) or hetastarch
    Sweeta D Gandhi
    Department of Anesthesiology, Clement J Zablocki Veterans Affairs Medical Center and the Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 106:1120-7. 2007
    ..4; Fresenius Kabi, Bad Homburg, Germany) and hetastarch (HES 670/0.75 in saline) for intravascular volume replacement therapy during major orthopedic surgery...
  6. doi The effects of hydroxyethyl starch 130/0.4 (6%) on blood loss and use of blood products in major surgery: a pooled analysis of randomized clinical trials
    Sibylle A Kozek-Langenecker
    Department of Special Anesthesiology and Pain Management, Vienna Medical University, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Anesth Analg 107:382-90. 2008
    ..To test this hypothesis, we analyzed pooled data from all available studies in major surgery comparing 6% HES 130/0.4 and 6% HES 200/0.5 from waxy maize starch...