Carla Winkler

Summary

Affiliation: Fraunhofer Institute of Toxicology and Experimental Medicine
Country: Germany

Publications

  1. pmc Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD
    Carla Winkler
    Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
    Respir Res 12:29. 2011
  2. pmc Allergen particle binding by human primary bronchial epithelial cells is modulated by surfactant protein D
    Carsten Schleh
    Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
    Respir Res 11:83. 2010
  3. doi request reprint Impact of endobronchial allergen provocation on macrophage phenotype in asthmatics
    Carla Winkler
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    BMC Immunol 15:12. 2014
  4. doi request reprint Surfactant protein D modulates pulmonary clearance of pollen starch granules
    Carla Winkler
    Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany
    Exp Lung Res 36:522-30. 2010
  5. pmc Low-dose endotoxin inhalation in healthy volunteers--a challenge model for early clinical drug development
    Ole Janssen
    Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, 30625 Hannover, Germany
    BMC Pulm Med 13:19. 2013
  6. doi request reprint Surfactant and allergic airway inflammation
    Carla Winkler
    Fraunhofer Institute for Experimental Medicine and Toxicology, Hannover, Germany
    Swiss Med Wkly 143:w13818. 2013
  7. doi request reprint Impact of a Met(11)Thr single nucleotide polymorphism of surfactant protein D on allergic airway inflammation in a murine asthma model
    Carla Winkler
    1Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
    Exp Lung Res 40:154-63. 2014

Detail Information

Publications7

  1. pmc Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD
    Carla Winkler
    Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
    Respir Res 12:29. 2011
    ..The origin of SP-D in serum and how serum concentrations are related to pulmonary concentrations under inflammatory conditions is still unclear...
  2. pmc Allergen particle binding by human primary bronchial epithelial cells is modulated by surfactant protein D
    Carsten Schleh
    Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
    Respir Res 11:83. 2010
    ..In the present study, we investigated the uptake of SPP in human primary epithelial cells and the potential modulation by SP-D. The patho-physiological consequence was evaluated by measurement of pro-inflammatory mediators...
  3. doi request reprint Impact of endobronchial allergen provocation on macrophage phenotype in asthmatics
    Carla Winkler
    Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
    BMC Immunol 15:12. 2014
    ..In the present study we phenotypically characterized macrophages with regard to M2 polarization in mice, a human in vitro and a human ex vivo model with primary lung cells after endobronchial provocation...
  4. doi request reprint Surfactant protein D modulates pulmonary clearance of pollen starch granules
    Carla Winkler
    Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany
    Exp Lung Res 36:522-30. 2010
    ..In conclusion, SP-D increased PSG-positive cells in vitro and accelerated PSG binding/uptake in vivo. The observed effects were limited to cellular clearance mechanisms and did not affect the total clearance of PSGs from the lung...
  5. pmc Low-dose endotoxin inhalation in healthy volunteers--a challenge model for early clinical drug development
    Ole Janssen
    Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, 30625 Hannover, Germany
    BMC Pulm Med 13:19. 2013
    ..It was therefore the aim of this study to test the effect and reproducibility of a low-dose LPS challenge (20,000 E.U.; 2 μg) using a flow- and volume-controlled inhalation technique to increase LPS deposition...
  6. doi request reprint Surfactant and allergic airway inflammation
    Carla Winkler
    Fraunhofer Institute for Experimental Medicine and Toxicology, Hannover, Germany
    Swiss Med Wkly 143:w13818. 2013
    ....
  7. doi request reprint Impact of a Met(11)Thr single nucleotide polymorphism of surfactant protein D on allergic airway inflammation in a murine asthma model
    Carla Winkler
    1Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
    Exp Lung Res 40:154-63. 2014
    ..MiR-21 and 155 are differentially regulated in transgenic mice in response to allergic inflammation. Further studies are required to elucidate the impact of this SNP on inflammatory conditions of the lung. ..