A Stolzing

Summary

Affiliation: Fraunhofer Institute of Toxicology and Experimental Medicine
Country: Germany

Publications

  1. doi request reprint Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies
    A Stolzing
    Kroto Research Institute, North Campus, University of Sheffield, UK
    Mech Ageing Dev 129:163-73. 2008
  2. pmc Influence of murine mesenchymal stem cells on proliferation, phenotype, vitality, and cytotoxicity of murine cytokine-induced killer cells in coculture
    Martin Bach
    Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany Universitätsklinik Leipzig, Department für Innere Medizin, Neurologie und Dermatologie, Sektion Rheumatologie, Leipzig, Germany
    PLoS ONE 9:e88115. 2014
  3. pmc Effect of age and diabetes on the response of mesenchymal progenitor cells to fibrin matrices
    A Stolzing
    Department of Cell Therapy, Fraunhofer Institute for Cell Therapy, Perlickstra β e 1, 04103 Leipzig, Germany
    Int J Biomater 2011:378034. 2011
  4. doi request reprint Suspension cultures of bone-marrow-derived mesenchymal stem cells: effects of donor age and glucose level
    Alexandra Stolzing
    Fraunhofer Institute for Cell Therapy and Immunology IZI, Department of Cell Therapy, Leipzig, Germany
    Stem Cells Dev 21:2718-23. 2012
  5. pmc Effect of different freezing rates during cryopreservation of rat mesenchymal stem cells using combinations of hydroxyethyl starch and dimethylsulfoxide
    Yahaira Naaldijk
    Fraunhofer Institute for Cell Therapy and Immunology, Perlickstrasse 1, Leipzig, 04103, Germany
    BMC Biotechnol 12:49. 2012
  6. pmc Microglia differentiation using a culture system for the expansion of mice non-adherent bone marrow stem cells
    Arnd Hinze
    Fraunhofer Institute for Cell Therapy and Immunology, Perlickstraße 1, 04103, Leipzig, Germany
    J Inflamm (Lond) 9:12. 2012
  7. pmc The cannabinoid receptors agonist WIN55212-2 inhibits macrophageal differentiation and alters expression and phosphorylation of cell cycle control proteins
    Katrin Paulsen
    Division of Cellbiology, Institute of Anatomy, Faculty of Medicine, University of Zurich, Switzerland
    Cell Commun Signal 9:33. 2011
  8. doi request reprint Hydroxyethylstarch in cryopreservation - mechanisms, benefits and problems
    A Stolzing
    Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany
    Transfus Apher Sci 46:137-47. 2012
  9. pmc Angiogenic properties of aged adipose derived mesenchymal stem cells after hypoxic conditioning
    Anastasia Efimenko
    Department of Biological and Medical Chemistry, Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia
    J Transl Med 9:10. 2011
  10. pmc Differentiation of mouse bone marrow derived stem cells toward microglia-like cells
    Arnd Hinze
    Fraunhofer Institute for Cell Therapy and Immunology IZI, Perlickstrasse 1, 04103, Leipzig, Germany
    BMC Cell Biol 12:35. 2011

Collaborators

  • A Scutt
  • Arnd Hinze
  • Jurgen Hescheler
  • E Jones
  • Dennis McGonagle
  • J Speakman
  • C Franceschi
  • F Licastro
  • Martin Bach
  • Yahaira Naaldijk
  • Christoph Schimmelpfennig
  • Tilman Grune
  • Katrin Paulsen
  • Anastasia Efimenko
  • Stephan Fricke
  • Michele Mishto
  • Sebastian Sethe
  • Andrea Ernst
  • Colin Selman
  • Viktoriya Fedorova
  • Marek Staude
  • Oliver Ullrich
  • Natalia Kalinina
  • Svantje Tauber
  • Ralf Hass
  • Nadine Goelz
  • Johanna Timm
  • Claudia Dumrese
  • Ekaterina Starostina
  • Frank Emmrich
  • Nadja Hilger
  • Manuela Ackermann
  • Guido Hildebrandt
  • Manja Kamprad
  • Claudia Pösel
  • Peter Ruschpler
  • Jutta Jahns
  • Ulrich Sack
  • Liana Spazzafumo
  • Claudia Ligorio
  • Annalisa Pession
  • Thomas Ohm
  • Elena Bellavista
  • Martina Chiappelli
  • Benedetta Nacmias
  • Sandro Sorbi
  • Aurelia Santoro
  • Grit Sandig
  • Manuela Jakstadt
  • Jane S McLaren

Detail Information

Publications23

  1. doi request reprint Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies
    A Stolzing
    Kroto Research Institute, North Campus, University of Sheffield, UK
    Mech Ageing Dev 129:163-73. 2008
    ..Furthermore, there is an age-related decline in overall BM MSC "fitness" which might lead to problems when using autologous aged MSC for cell-based therapies...
  2. pmc Influence of murine mesenchymal stem cells on proliferation, phenotype, vitality, and cytotoxicity of murine cytokine-induced killer cells in coculture
    Martin Bach
    Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany Universitätsklinik Leipzig, Department für Innere Medizin, Neurologie und Dermatologie, Sektion Rheumatologie, Leipzig, Germany
    PLoS ONE 9:e88115. 2014
    ..Further investigations with DiD-labelled MSCs revealed that the observed disappearance of MSCs appears not to be due to differentiation processes. ..
  3. pmc Effect of age and diabetes on the response of mesenchymal progenitor cells to fibrin matrices
    A Stolzing
    Department of Cell Therapy, Fraunhofer Institute for Cell Therapy, Perlickstra β e 1, 04103 Leipzig, Germany
    Int J Biomater 2011:378034. 2011
    ..MSC were expanded on these scaffolds and analysed. MSC showed an increased self-renewal on soft surfaces. Old and diabetic cells lost the ability to react to these signals and can no longer adapt to the changed environment...
  4. doi request reprint Suspension cultures of bone-marrow-derived mesenchymal stem cells: effects of donor age and glucose level
    Alexandra Stolzing
    Fraunhofer Institute for Cell Therapy and Immunology IZI, Department of Cell Therapy, Leipzig, Germany
    Stem Cells Dev 21:2718-23. 2012
    ..These data indicate that rat adult bone marrow harbors a population of pluripotent Na-BM-MSCs that appear to be relatively unaffected by ageing during in vitro expansion in suspension...
  5. pmc Effect of different freezing rates during cryopreservation of rat mesenchymal stem cells using combinations of hydroxyethyl starch and dimethylsulfoxide
    Yahaira Naaldijk
    Fraunhofer Institute for Cell Therapy and Immunology, Perlickstrasse 1, Leipzig, 04103, Germany
    BMC Biotechnol 12:49. 2012
    ..Post-thaw viability, phenotype and osteogenic differentiation capacity of MSCs were analysed...
  6. pmc Microglia differentiation using a culture system for the expansion of mice non-adherent bone marrow stem cells
    Arnd Hinze
    Fraunhofer Institute for Cell Therapy and Immunology, Perlickstraße 1, 04103, Leipzig, Germany
    J Inflamm (Lond) 9:12. 2012
    ..abstract:..
  7. pmc The cannabinoid receptors agonist WIN55212-2 inhibits macrophageal differentiation and alters expression and phosphorylation of cell cycle control proteins
    Katrin Paulsen
    Division of Cellbiology, Institute of Anatomy, Faculty of Medicine, University of Zurich, Switzerland
    Cell Commun Signal 9:33. 2011
    ....
  8. doi request reprint Hydroxyethylstarch in cryopreservation - mechanisms, benefits and problems
    A Stolzing
    Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany
    Transfus Apher Sci 46:137-47. 2012
    ..However, we suggest that the most common admixture ratio of HES and DMSO in cryoprotectant solutions has been established by historical happenstance and requires further investigation and optimization...
  9. pmc Angiogenic properties of aged adipose derived mesenchymal stem cells after hypoxic conditioning
    Anastasia Efimenko
    Department of Biological and Medical Chemistry, Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia
    J Transl Med 9:10. 2011
    ..We therefore analysed the effects of age on age markers and angiogenic properties of ADSC. Hypoxic conditioning was investigated as a form of angiogenic stimulation...
  10. pmc Differentiation of mouse bone marrow derived stem cells toward microglia-like cells
    Arnd Hinze
    Fraunhofer Institute for Cell Therapy and Immunology IZI, Perlickstrasse 1, 04103, Leipzig, Germany
    BMC Cell Biol 12:35. 2011
    ..Furthermore, we looked at the effects of FMS-like tyrosine kinase 3 ligand (Flt3L), astrocyte-conditioned medium (ACM) and GM-CSF on the differentiation to microglia-like cells...
  11. ncbi request reprint Fusion and regenerative therapies: is immortality really recessive?
    Alexandra Stolzing
    Fraunhofer Institute for Cell Therapy and Immunology, Deutscher Platz 53, Leipzig, Germany
    Rejuvenation Res 10:571-86. 2007
    ..The outlook is concluded with a discussion of the next research milestones and the potential hazards of fusion therapies...
  12. pmc Allogeneic non-adherent bone marrow cells facilitate hematopoietic recovery but do not lead to allogeneic engraftment
    Stephan Fricke
    Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany
    PLoS ONE 4:e6157. 2009
    ..Therefore, the effects of murine bone marrow derived NA-BMCs were investigated with regard to engraftment capacities in allogeneic and syngeneic stem cell transplantation using transgenic, human CD4(+), murine CD4(-/-), HLA-DR3(+) mice...
  13. ncbi request reprint Stressed stem cells: Temperature response in aged mesenchymal stem cells
    Alexandra Stolzing
    Department of Engineering Material, Centre for Tissue Engineering and Biomaterials, University of Sheffield, Sheffield, UK
    Stem Cells Dev 15:478-87. 2006
    ..The results suggest that a 'hormesis' theory of stress response can be extended to MSCs, but that cooling cultivation temperature stress produces positive effects in young cells only...
  14. ncbi request reprint Age-related impairment of mesenchymal progenitor cell function
    Alexandra Stolzing
    Centre for Biomaterials and Tissue Engineering, Department of Engineering Materials, University of Sheffield, North Campus, Sheffield, S3 7HQ, UK
    Aging Cell 5:213-24. 2006
    ....
  15. ncbi request reprint Watch your notch: a link between aging and stem cell fate?
    Alexandra Stolzing
    Centre for Biomaterials and Tissue Engineering, University of Sheffield, UK
    Rejuvenation Res 7:9-11. 2004
  16. ncbi request reprint Aging of mesenchymal stem cells
    Sebastian Sethe
    Sheffield Institute of Biotechnological Law and Ethics, University of Sheffield, UK
    Ageing Res Rev 5:91-116. 2006
    ..Thus, mesenchymal stem cells emerge as both subject to and key mediators of organismal aging...
  17. ncbi request reprint Glucose-induced replicative senescence in mesenchymal stem cells
    Alexandra Stolzing
    Kroto Research Institute, University of Sheffield, Sheffield, United Kingdom
    Rejuvenation Res 9:31-5. 2006
    ..Reduction in glucose concentrations led to decreased apoptosis and an increased rate of MSC proliferation and increased the number and size of fibroblastic colonies in the colony-forming unit assay...
  18. ncbi request reprint Effect of reduced culture temperature on antioxidant defences of mesenchymal stem cells
    Alexandra Stolzing
    Kroto Research Institute, Department of Engineering Materials, University of Sheffield, Sheffield S3 7HQ, UK
    Free Radic Biol Med 41:326-38. 2006
    ....
  19. doi request reprint Diabetes induced changes in rat mesenchymal stem cells
    Alexandra Stolzing
    Kroto Research Institute, Centre for Biomaterials and Tissue Engineering, North Campus, University of Sheffield, Sheffield, UK alexandra stolzing izi fraunhofer de
    Cells Tissues Organs 191:453-65. 2010
    ..Therefore, direct effects on MSCs may be responsible for some of the orthopaedic effects associated with diabetes...
  20. ncbi request reprint Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains
    Michele Mishto
    Department of Experimental Pathology, University of Bologna, 40126 Bologna, Italy
    Neurobiol Aging 27:54-66. 2006
    ....
  21. ncbi request reprint Chronically active: activation of microglial proteolysis in ageing and neurodegeneration
    Alexandra Stolzing
    Centre for Biomaterials and Tissue Engineering, Sheffield University, UK
    Redox Rep 10:207-13. 2005
    ..In ageing, proteolytic effectiveness is diminished, while microglial cells are chronically activated and lose the oxidative burst ability, possibly supporting a 'vicious circle' of macrophage-induced neurodegeneration...
  22. ncbi request reprint Antioxidants effectively prevent oxidation-induced protein damage in OLN 93 cells
    Andrea Ernst
    Neuroscience Research Center, Medical Faculty Charité, Humboldt University, Berlin, Germany
    Arch Biochem Biophys 421:54-60. 2004
    ..Therefore, we concluded that the excessive oxidative damage of oligodendrocytes and their protein pool can be prevented by the usage of antioxidants...
  23. ncbi request reprint The consequences of acute cold exposure on protein oxidation and proteasome activity in short-tailed field voles, microtus agrestis
    Colin Selman
    Aberdeen Centre for Energy Expenditure and Obesity ACERO, Department of Zoology, Aberdeen University, UK
    Free Radic Biol Med 33:259-65. 2002
    ..This protection may be a very important factor in sustaining uncoupled respiration, which underpins nonshivering thermogenesis at cold temperatures...