Affiliation: Fraunhofer Institute of Toxicology and Experimental Medicine
Sewald K, Braun A. Assessment of immunotoxicity using precision-cut tissue slices. Xenobiotica. 2013;43:84-97 pubmed publisher
..Respiratory hypersensitivity and inflammation are further highlighted aspects of this review. Immunotoxicity assessment currently is of limited use in other tissue models, which are therefore described only briefly within this review. ..
Koch A, Saran S, Tran D, Klebba FÃ¤rber S, Thiesler H, Sewald K, et al
. Murine precision-cut liver slices (PCLS): a new tool for studying tumor microenvironments and cell signaling ex vivo. Cell Commun Signal. 2014;12:73 pubmed publisher
..This method may also prove useful for identification of genes in liver-resident cells that support cancer invasion by using PCLS from transgenic liver. ..
Neuhaus V, Danov O, Konzok S, Obernolte H, Dehmel S, Braubach P, et al
. Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices. J Vis Exp. 2018;: pubmed publisher
..Therefore, the results presented here are preliminary, even though they show the potential of human PCLS as a valuable tool in respiratory research. ..
Hess A, Wang Lauenstein L, Braun A, Kolle S, Landsiedel R, Liebsch M, et al
. Prevalidation of the ex-vivo model PCLS for prediction of respiratory toxicity. Toxicol In Vitro. 2016;32:347-61 pubmed publisher
..Two prediction models (two-group classification model, prediction of LC50 by IC50) were developed and showed promising results. ..