St Engeli

Summary

Affiliation: Franz Volhard Clinic
Country: Germany

Publications

  1. ncbi Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Hypertens 23:2313-8. 2005
  2. ncbi Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Obes Res 12:9-17. 2004
  3. ncbi Regulation of the nitric oxide system in human adipose tissue
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Charite University Medicine in Berlin, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Lipid Res 45:1640-8. 2004
  4. ncbi [What effect does losing weight have on hypertension?]
    St Engeli
    Franz Volhard Klinik Abteilung für Nephrologie und Hypertensiologie Wiltbergstrasse 50 D 13125 Berlin
    MMW Fortschr Med 145:44. 2003
  5. ncbi The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome?
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Department of Nephrology and Hypertension, Humboldt University of Berlin, Wiltberg Strasse 50, Berlin 13125, Germany
    Int J Biochem Cell Biol 35:807-25. 2003
  6. ncbi Association between adiponectin and mediators of inflammation in obese women
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Diabetes 52:942-7. 2003
  7. pmc Activation of the peripheral endocannabinoid system in human obesity
    Stefan Engeli
    Franz Volhard Clinical Research Center, Charite Campus Buch, 13125 Berlin, Germany
    Diabetes 54:2838-43. 2005
  8. ncbi Weight loss and the renin-angiotensin-aldosterone system
    Stefan Engeli
    Medical Faculty of the Charite, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Berlin, Germany
    Hypertension 45:356-62. 2005
  9. ncbi The endocannabinoid system: body weight and metabolic regulation
    Stefan Engeli
    Franz Volhard Clinical Research Center, University Clinic Charité Campus Buch, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin, Germany
    Clin Cornerstone 8:S24-35. 2006
  10. pmc Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity
    Matthias Bluher
    University of Leipzig, Medical Department III, Philipp Rosenthal Str 27, 04103 Leipzig, Germany
    Diabetes 55:3053-60. 2006

Collaborators

Detail Information

Publications33

  1. ncbi Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Hypertens 23:2313-8. 2005
    ..Treatment recommendations for lean hypertensives may not be simply extrapolated to obese hypertensive persons...
  2. ncbi Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Obes Res 12:9-17. 2004
    ..The aim of this study was to determine whether up-regulation of human adipose 11beta-HSD1 in obesity can also be found at the gene expression level...
  3. ncbi Regulation of the nitric oxide system in human adipose tissue
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Charite University Medicine in Berlin, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Lipid Res 45:1640-8. 2004
    ..Increased eNOS and iNOS expression in adipocytes and local effects of insulin and Ang II may increase adipose tissue production of NO in obesity...
  4. ncbi [What effect does losing weight have on hypertension?]
    St Engeli
    Franz Volhard Klinik Abteilung für Nephrologie und Hypertensiologie Wiltbergstrasse 50 D 13125 Berlin
    MMW Fortschr Med 145:44. 2003
  5. ncbi The adipose-tissue renin-angiotensin-aldosterone system: role in the metabolic syndrome?
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Department of Nephrology and Hypertension, Humboldt University of Berlin, Wiltberg Strasse 50, Berlin 13125, Germany
    Int J Biochem Cell Biol 35:807-25. 2003
    ....
  6. ncbi Association between adiponectin and mediators of inflammation in obese women
    Stefan Engeli
    HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Germany
    Diabetes 52:942-7. 2003
    ....
  7. pmc Activation of the peripheral endocannabinoid system in human obesity
    Stefan Engeli
    Franz Volhard Clinical Research Center, Charite Campus Buch, 13125 Berlin, Germany
    Diabetes 54:2838-43. 2005
    ..Our findings support the presence of a peripheral endocannabinoid system that is upregulated in human obesity...
  8. ncbi Weight loss and the renin-angiotensin-aldosterone system
    Stefan Engeli
    Medical Faculty of the Charite, Franz Volhard Clinic and Max Delbrück Center for Molecular Medicine, HELIOS Klinikum, Berlin, Germany
    Hypertension 45:356-62. 2005
    ..These data suggest that a 5% reduction in body weight can lead to a meaningfully reduced renin-angiotensin-aldosterone system in plasma and adipose tissue, which may contribute to the reduced blood pressure...
  9. ncbi The endocannabinoid system: body weight and metabolic regulation
    Stefan Engeli
    Franz Volhard Clinical Research Center, University Clinic Charité Campus Buch, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin, Germany
    Clin Cornerstone 8:S24-35. 2006
    ....
  10. pmc Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity
    Matthias Bluher
    University of Leipzig, Medical Department III, Philipp Rosenthal Str 27, 04103 Leipzig, Germany
    Diabetes 55:3053-60. 2006
    ..Thus, the endocannabinoid system may represent a primary target for the treatment of abdominal obesity and associated metabolic changes...
  11. ncbi Influence of salt intake on renin-angiotensin and natriuretic peptide system genes in human adipose tissue
    Stefan Engeli
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 48:1103-8. 2006
    ..In contrast, systemic atrial natriuretic peptide and adipose-tissue atrial natriuretic peptide respond similarly to changes in sodium intake...
  12. ncbi Sympathetic vasomotor tone determines blood pressure response to long-term sibutramine treatment
    Karsten Heusser
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    J Clin Endocrinol Metab 92:1560-3. 2007
    ..The serotonin and norepinephrine transporter inhibitor sibutramine is a widely used antiobesity drug. In acute studies, the peripheral sympathomimetic effect of sibutramine was counteracted by a central sympatholytic action...
  13. ncbi Role of the renin-angiotensin- aldosterone system in the metabolic syndrome
    Stefan Engeli
    Franz Volhard Clinical Research Center, Charite Campus Buch, Berlin, Germany
    Contrib Nephrol 151:122-34. 2006
    ..Thus, data from clinical trials clearly suggest that the RAAS plays an important role for the pathophysiology of the Metabolic Syndrome, but the molecular mechanisms are not understood very well at present...
  14. ncbi Resistin gene expression in human adipocytes is not related to insulin resistance
    Jurgen Janke
    Franz Volhard Clinic Charité, the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Obes Res 10:1-5. 2002
    ..Resistin, therefore, has been suggested to play a role in the pathogenesis of insulin resistance...
  15. ncbi European Society of Hypertension Working Group on Obesity: background, aims and perspectives
    Jens Jordan
    Franz Volhard Clinical Research Center and Department of Nephrology, Helios Klinikum Berlin and Medical Faculty of the Charité, Berlin, Germany
    J Hypertens 25:897-900. 2007
  16. ncbi Direct Renin inhibition with aliskiren in obese patients with arterial hypertension
    Jens Jordan
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Hypertension 49:1047-55. 2007
    ..In conclusion, combination treatment with aliskiren is a highly effective and well-tolerated therapeutic option for obese patients with hypertension who fail to achieve blood pressure control with first-line thiazide diuretic treatment...
  17. ncbi GIP receptor mRNA expression in different fat tissue depots in postmenopausal non-diabetic women
    Natalia Rudovich
    Department of Endocrinology, Diabetes and Nutrition, Campus B Franklin, Charite Medicine University of Berlin, Germany
    Regul Pept 142:138-45. 2007
    ..We identified the GIPR gene in human subcutaneous and visceral fat tissues and tested the hypothesis that that the expression of this gene is influenced by central obesity and weight loss...
  18. ncbi Dissociation between adipose nitric oxide synthase expression and tissue metabolism
    Stefan Engeli
    Franz Volhard Clinical Research Center, Charite Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany
    J Clin Endocrinol Metab 92:2706-11. 2007
    ..Nitric oxide synthase (NOS) expression in adipose tissue is increased in obese subjects. The functional relevance is not known...
  19. ncbi The role of renin-angiotensin system blockade in the management of hypertension associated with the cardiometabolic syndrome
    Arya M Sharma
    Michael G deGroote Medical School, McMaster University, Hamilton, Ontario, Canada
    J Cardiometab Syndr 1:29-35. 2006
    ..Randomized, controlled trials conducted specifically in patients with obesity and hypertension are needed to determine the optimal therapeutic approach for these patients...
  20. ncbi Angiotensin type 1 receptor antagonists induce human in-vitro adipogenesis through peroxisome proliferator-activated receptor-gamma activation
    Jurgen Janke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Berlin, Germany
    J Hypertens 24:1809-16. 2006
    ..In clonal animal cells, certain angiotensin receptor blockers (ARB) activate the peroxisome proliferator-activated receptor-gamma (PPARgamma). The aim of this work was to validate that observation in human cells and humans...
  21. ncbi Influence of sibutramine treatment on sympathetic vasomotor tone in obese subjects
    Karsten Heusser
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinkum, Berlin, Germany
    Clin Pharmacol Ther 79:500-8. 2006
    ..Direct measurements of muscle sympathetic nerve activity (MSNA) in sibutramine-treated patients have not been conducted...
  22. ncbi Managing big issues on lean evidence: treating obesity hypertension
    Arya M Sharma
    Nephrol Dial Transplant 17:353-5. 2002
  23. ncbi Hormonal regulation of the human adipose-tissue renin-angiotensin system: relationship to obesity and hypertension
    Kerstin Gorzelniak
    Helios Klinkum Berlin, Franz Volhard Clinic Charité and Max Delbrück Center for Molecular Medicine, Humboldt University of Berlin, Germany
    J Hypertens 20:965-73. 2002
    ..The aim of this work was to study the expression of renin-angiotensin system genes in adipose tissue of obese hypertensive subjects and the hormonal regulation of these genes...
  24. ncbi Mature adipocytes inhibit in vitro differentiation of human preadipocytes via angiotensin type 1 receptors
    Jurgen Janke
    Max Delbruck Center for Molecular Medicine, HELIOS Klinikum Berlin, Franz Volhard Clinic, Medical Faculty of the Charite, Humboldt University of Berlin, Berlin, Germany
    Diabetes 51:1699-707. 2002
    ..Because AGT secretion and Ang II generation are characteristic features of adipogenesis, we postulate a paracrine negative-feedback loop that inhibits further recruitment of preadipocytes by maturing adipocytes...
  25. ncbi Emerging concepts in the pathophysiology and treatment of obesity-associated hypertension
    Stefan Engeli
    Franz Volhard Clinic, Helios Klinikum Buch Charité, Medical Faculty of the Humboldt University Berlin, Germany
    Curr Opin Cardiol 17:355-9. 2002
    ....
  26. ncbi Angiotensin blockade prevents type 2 diabetes by formation of fat cells
    Arya M Sharma
    HELIOS Klinikum Berlin, Franz Volhard Clinic Charité, Humboldt University of Berlin, and Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Hypertension 40:609-11. 2002
    ..Increased formation of adipocytes would counteract the ectopic deposition of lipids in other tissues (muscle, liver, pancreas), thereby improving insulin sensitivity and preventing the development of type 2 diabetes...
  27. pmc Peripheral endocannabinoid system activity in patients treated with sibutramine
    Stefan Engeli
    Franz Volhard Clinical Research Center, Medical Faculty of the Charité and HELIOS Klinikum, Berlin, Germany
    Obesity (Silver Spring) 16:1135-7. 2008
    ..Weight loss interventions may influence obesity-associated risk indirectly through modulation of the peripheral ECS. We investigated the effect of acute and chronic treatment with sibutramine on components of the peripheral ECS...
  28. ncbi Adipose tissue metabolism and CD11b expression on monocytes in obese hypertensives
    Michael Boschmann
    Franz Volhard Clinical Research Center, Charite Campus Buch, HELIOS Klinikum, Berlin, Germany
    Hypertension 46:130-6. 2005
    ..These findings may be explained in part by monocyte/macrophage infiltration of adipose tissue, which appears to interfere with insulin responsiveness...
  29. ncbi Influences of AT1 receptor blockade on tissue metabolism in obese men
    Michael Boschmann
    Franz Volhard Clinical Research Center, Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R219-23. 2006
    ..Endogeneous ANG II may slightly increase adipose tissue lipolysis. The mechanism may promote the redistribution of triglycerides from adipose tissue toward other organs...
  30. ncbi Is there a pathophysiological role for perivascular adipocytes?
    Stefan Engeli
    Am J Physiol Heart Circ Physiol 289:H1794-5. 2005
  31. ncbi Retinol-binding protein 4 in human obesity
    Jurgen Janke
    Franz Volhard Clinical Research Center Haus 129, Charite Campus Buch, Wiltbergstr 50, 13125 Berlin, Germany
    Diabetes 55:2805-10. 2006
    ..Our findings point to profound differences between rodents and humans in the regulation of adipose or circulating RBP4 and challenge the notion that glucose uptake by adipocytes has a dominant role in the regulation of RBP4...
  32. ncbi Does salt restriction change brown adipose tissue thermogenesis?
    Stefan Engeli
    Nutr Metab Cardiovasc Dis 16:88-90. 2006
  33. ncbi No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents
    Timo Dirk Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstr 174, 45147 Essen, Germany
    Mol Genet Metab 90:429-34. 2007
    ..In addition, we confirmed the presence of rs1049353. As these variants could not explain the initial TDT, we conclude that there is no evidence for an association of CNR1 alleles with obesity in our study groups...