Research Topics
Species | S FrantzSummaryCountry: Germany Publications
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Publications
Tissue inhibitor of metalloproteinases levels in patients with chronic heart failure: an independent predictor of mortalityS Frantz
Department of Internal Medicine I, Center of Cardiovascular Medicine, University of Wurzburg, Wurzburg, Germany
Eur J Heart Fail 10:388-95. 2008..Matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) are involved in cardiac remodelling. The prognostic utility of TIMP is unknown in chronic heart failure (CHF)...
Detrimental effects of testosterone on post-myocardial infarction remodelling in female ratsS Frantz
Universitat Wurzburg, Medizinische Klinik und Poliklinik I, Germany
J Physiol Pharmacol 58:717-27. 2007..In conclusion, chronic anabolic T treatment causes myocardial hypertrophy under basal conditions and adversely affects left ventricular remodeling following myocardial infarction in female rats...- Innate immunity and the heartStefan Frantz
Medizinische Klinik der Universität Würzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
Curr Pharm Des 11:1279-90. 2005..e., the "Expanded Self-Non-Self" and the "Danger" theories of immune activation)... - Transforming growth factor beta inhibition increases mortality and left ventricular dilatation after myocardial infarctionStefan Frantz
Medizinische Klinik und Poliklinik I, Herz Kreislaufzentrum, Universitatsklinikum Wurzburg, 97080, Wurzburg, Germany
Basic Res Cardiol 103:485-92. 2008..The detrimental effects of TGF-beta inhibition may be mediated by alterations in extracellular matrix remodeling... - Left ventricular remodeling after myocardial infarction in mice with targeted deletion of the NADPH oxidase subunit gp91PHOXStefan Frantz
Medizinische Universitätsklinik Würzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
Basic Res Cardiol 101:127-32. 2006..Since NADPH oxidases are a major source of reactive oxygen species in the heart, we studied left ventricular remodeling after myocardial infarction in mice with targeted deletion of the NADPH oxidase subunit gp91(phox)... - Toll-like receptor signaling in the ischemic heartStefan Frantz
Medizinische Klinik und Poliklinik I, Herzkreislauf Zentrum, Universitatsklinikum Wurzburg, Wurzburg, Germany
Front Biosci 13:5772-9. 2008..Herein we review the experimental and clinical evidence for the involvement of TLR and its downstream signaling molecules in cardiac ischemic injury... - Absence of NF-kappaB subunit p50 improves heart failure after myocardial infarctionStefan Frantz
Medizinische Klinik und Poliklinik I, Herzkreislauf Zentrum, Universitat Wurzburg, Germany
FASEB J 20:1918-20. 2006..Therefore, we investigated left ventricular remodeling in mice with a targeted deletion of the NF-kappaB subunit p50/NF-kappaB1 after myocardial infarction... 
Role of p38 mitogen-activated protein kinase in cardiac remodellingS Frantz
Medizinische Klinik und Poliklinik I, Herz Kreislaufzentrum, Universitat Wurzburg, Germany
Br J Pharmacol 150:130-5. 2007..We therefore evaluated the effect of the selective p38 MAPK inhibitor SB 239063 on progression of left ventricular remodelling after myocardial infarction (MI) in rats...- [Obesity and heart failure]S Frantz
Herzkreislauf Zentrum, Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
Internist (Berl) 49:389-90, 392-3. 2008..Therapeutic approaches include weight control by dietary intervention and exercise, as well as bariatric surgery for the morbidly obese. Heart failure treatment should otherwise follow the general heart failure guidelines... - Tissue-specific effects of the nuclear factor kappaB subunit p50 on myocardial ischemia-reperfusion injuryStefan Frantz
Medizinische Klinik und Poliklinik I, Herz Kreislaufzentrum, Universitat Wurzburg, Wurzburg, Germany
Am J Pathol 171:507-12. 2007..Bone marrow transplantation experiments indicate that impaired NF-kappaB activation in p50 KO leukocytes attenuates cardiac damage... - Mechanisms of disease: Toll-like receptors in cardiovascular diseaseStefan Frantz
Universitat Wurzburg, Medizinische Klinik und Poliklinik I, Herzkreislauf Zentrum, Wurzburg, Germany
Nat Clin Pract Cardiovasc Med 4:444-54. 2007..Here we review the rapid progress that has been made in this field, which has improved our understanding of vascular as well as myocardial TLR function in basic and clinical science... - Effect of chronic heart failure on nuclear factor kappa B in peripheral leukocytesStefan Frantz
Medizinische Klinik der Universität Würzburg, Germany
Am J Cardiol 94:671-3. 2004..In patients with stable heart failure with no obvious other reason for NF-kappaB activation, NF-kappaB was significantly activated... - The eNOS enhancer AVE 9488: a novel cardioprotectant against ischemia reperfusion injuryS Frantz
Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
Basic Res Cardiol 104:773-9. 2009..2 +/- 0.5 vs. 0.8 +/- 0.07 micromol/l, P = 0.0003). Thus pharmacological interventions addressed to increase eNOS-derived NO production constitute a promising therapeutic approach to prevent myocardial ischemia/reperfusion injury... - High dose aspirin and left ventricular remodeling after myocardial infarction: aspirin and myocardial infarctionAnna Adamek
Medizinische Klinik und Poliklinik I der Universität Würzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
Basic Res Cardiol 102:334-40. 2007..High-dose aspirin inhibits cytokine activation. Therefore, we tested the influence of high-dose aspirin treatment on left ventricular remodeling in mice after myocardial infarction... - Pharmacological pre- and post-conditioning with the sphingosine-1-phosphate receptor modulator FTY720 after myocardial ischaemia-reperfusionU Hofmann
Department of Internal Medicine I, University Hospital Wuerzburg, Wurzburg, Germany
Br J Pharmacol 160:1243-51. 2010..Therefore, we tested the hypothesis that pharmacological post-conditioning with FTY720 reduces infarct size after myocardial ischaemia-reperfusion in vivo... - [Primary diagnosis of heart failure in ambulatory and hospitalized patients]S Stork
Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Schwerpunkt Kardiologie an der PoliklinikKlinikstr 6 8
Dtsch Med Wochenschr 133:636-41. 2008..As a primary diagnostic aim, the underlying cause of heart failure should be determined in all subjects because the therapeutic strategy may depend on this information... - Repetitive postprandial hyperglycemia increases cardiac ischemia/reperfusion injury: prevention by the alpha-glucosidase inhibitor acarboseStefan Frantz
, , Germany
FASEB J 19:591-3. 2005..In summary, repetitive postprandial hyperglycemia increases ischemia/reperfusion damage. This effect can be prevented by treatment with the alpha-glucosidase inhibitor acarbose... - Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in miceAnna Adamek
Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Germany
Eur J Pharmacol 571:51-4. 2007..In summary, inhibition of 5-lipoxygenase does not affect cardiac ischemia-reperfusion injury but the post-ischemic inflammatory response... - Post-infarct remodelling: contribution of wound healing and inflammationStefan Frantz
Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
Cardiovasc Res 81:474-81. 2009..Healing in the heart occurs in overlapping phases. Herein, we review the inflammatory phase as a trigger of tissue formation... - Prevention of hypertensive crises in rats induced by acute and chronic norepinephrine excessD Weismann
Department of Internal Medicine I, University of Wurzburg, Wurzburg, Germany
Horm Metab Res 42:803-8. 2010..POB was the most effective drug used in monotherapy, but BP stabilization was superior using a combination of POB pretreatment with a continuous nifedipine infusion in this model... - [Radiation-induced pacemaker malfunction]S Frantz
Medizinische Universitätsklinik Würzburg Josef Schneider Str 2 97080 Würzburg, Germany
Z Kardiol 92:415-7. 2003..Radiation can substantially damage pacemaker electronics. We report here a case, with loss of communication after radiation therapy... - Low circulating androgens and mortality risk in heart failureG Güder
Medizinische Klinik und Poliklinik I Herz Kreislaufzentrum, Klinikum der Universität Würzburg, Oberdurrbacher Strasse 6, D 97080 Wurzburg, Germany
Heart 96:504-9. 2010..The pathophysiological implications of this phenomenon, however, have not been fully elucidated. This clinical study investigated the significance of low serum androgen levels in HF... - Impact of different bone marrow cell preparations on left ventricular remodelling after experimental myocardial infarctionStefan Frantz
Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Germany
Eur J Heart Fail 10:119-24. 2008..Since the specific characteristics of different BM cell subsets could influence their therapeutic potential we determined the effect of different BM cell populations on left ventricular remodelling after MI... - Sustained activation of nuclear factor kappa B and activator protein 1 in chronic heart failureStefan Frantz
Medizinische Universitätsklinik Würzburg, Germany
Cardiovasc Res 57:749-56. 2003.... - Peroxisome proliferator activated-receptor agonism and left ventricular remodeling in mice with chronic myocardial infarctionStefan Frantz
Medizinische Klinik der Universität Würzburg, Germany
Br J Pharmacol 141:9-14. 2004..5. In conclusion, PPARgamma activation did not adversely affect left ventricular remodeling and survival in mice with chronic MI. However, we were also not able to identify a protective effect of pioglitazone... - Electrocardiography and outcome in patients with diabetes mellitus on maintenance hemodialysisVera Krane
University of Wurzburg, Department of Medicine, Division of Nephrology, University Clinic, Josef Schneider Str 2, D 97080 Wurzburg, Germany
Clin J Am Soc Nephrol 4:394-400. 2009..However, respective systematic evaluations are absent. Thus, the authors investigated whether routine ECG findings add prognostic information to standard risk assessment in hemodialysis... - Rosuvastatin reduces platelet activation in heart failure: role of NO bioavailabilityAndreas Schafer
Medizinische Klinik and Poliklinik I, Universitatsklinikum Wurzburg, Bayerische Julius Maximilians Universität Würzburg, Germany
Arterioscler Thromb Vasc Biol 25:1071-7. 2005..We investigated whether 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibition would beneficially modulate vascular NO bioavailability and platelet activation in experimental CHF... - Healing after myocardial infarctionGeorg Ertl
Medizinische Universitätsklinik Würzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
Cardiovasc Res 66:22-32. 2005.... - Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusionUlrich Hofmann
Department of Internal Medicine I, University of Wurzburg, Medizinische Klinik und Poliklinik I, Josef Schneider Str 2, D 97080 Wurzburg, Germany
Cardiovasc Res 83:285-93. 2009..We tested the hypothesis that pharmacological S1P receptor agonists improve recovery of function when applied with reperfusion... - Administration of testosterone is associated with a reduced susceptibility to myocardial ischemiaFrank Callies
Department of Endocrinology, Medical University Hospital Wuerzburg, 97080 Wuerzburg, Germany
Endocrinology 144:4478-83. 2003..In conclusion, administration of testosterone significantly improves recovery from global ischemia. These beneficial effects are associated with an attenuation of reperfusion induced [Ca2+]i overload... - Bone marrow molecular alterations after myocardial infarction: Impact on endothelial progenitor cellsThomas Thum
Medizinische Klinik I, Kardiologie, Universitatsklinikum Wurzburg, Julius Maximilians Universitat, Josef Schneider Str 2, 97080 Wurzburg, Germany
Cardiovasc Res 70:50-60. 2006..However, potential underlying mechanisms have not yet been investigated... - Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosisFrank Weidemann
University Clinic of Internal Medicine I Center for Cardiovascular Disease, University of Wurzburg, 97080 Wurzburg, Germany
Circulation 120:577-84. 2009.... - A sebaceous tumor in a patient with acquired immunodeficiency syndromeStefan Frantz
Medizinische Universitaetsklinik, Universitaet Wuerzburg, Josef Schneider Str 2, D 97080 Wuerzburg, Germany
Eur J Med Res 7:135-7. 2002..An association of AIDS and a solitary, large sebaceous adenoma has not been described yet. This emphasizes the role of an intact immune system in the suppression of benign and malignant tumors. tubular adenoma; tumor; AIDS.. - [From cardiovascular risk to chronic heart failure]G Ertl
Medizinische Klinik und Poliklinik I, , Josef-Schneider Strasse 2, 97080, , Germany
Internist (Berl) 49:387-8. 2008 - HMG CoA reductase inhibition and left ventricular mass in hypertrophic cardiomyopathy: a randomized placebo-controlled pilot studyJ Bauersachs
Medizinische Klinik und Poliklinik I, Kardiologie, Julius Maximilians Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
Eur J Clin Invest 37:852-9. 2007..We investigated the effect of the hydroxymethylglutaryl coenzyme A reductase inhibitor atorvastatin on left ventricular (LV) mass in patients with hypertrophic cardiomyopathy in a randomized placebo-controlled double-blind pilot study... - Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarctionMatthias Nahrendorf
Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Wurzburg, Germany
Circulation 113:1196-202. 2006..We hypothesized that clotting factor XIII (FXIII), a transglutaminase involved in wound healing, may play an important role in MI given prior clinical and mouse model data... - Reverse epidemiology in systolic and nonsystolic heart failure: cumulative prognostic benefit of classical cardiovascular risk factorsGülmisal Güder
Medizinische Klinik und Poliklinik I, University Hospital Wurzburg, Wurzburg, Germany
Circ Heart Fail 2:563-71. 2009..We estimated the prognostic role of these risk factors in unselected patients with heart failure... - Cardiac beta1-adrenoceptor autoantibodies in human heart disease: rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) StudyNikolas Deubner
Department of Internal Medicine I, Centre of Cardiovascular Medicine, University of Wurzburg, University Hospital Wurzburg, Klinikstrasse 6 8, 97070 Wurzburg, Germany
Eur J Heart Fail 12:753-62. 2010.... - Conditional neuronal nitric oxide synthase overexpression impairs myocardial contractilityNatalie Burkard
Department of Internal Medicine I, University of Wuerzburg, Wuerzburg, Germany
Circ Res 100:e32-44. 2007..We suggest that nNOS might suppress the function of L-type Ca(2+)-channels and in turn reduces Ca(2+)-transients which accounts for the negative inotropic effect... - Carbon monoxide, but not endothelin-1, plays a major role for the hepatic microcirculation in a murine model of early systemic inflammationChristian Wunder
, , , Germany
Crit Care Med 33:2323-31. 2005.... - Complementary and incremental mortality risk prediction by cortisol and aldosterone in chronic heart failureGülmisal Güder
University of Wurzburg, Department of Internal Medicine I, Center for Cardiovascular Medicine, Klinikstrasse 6 8, D 97070 Wurzburg, Germany
Circulation 115:1754-61. 2007..The prognostic significance of cortisol that may also bind and activate the mineralocorticoid receptor in chronic heart failure is unknown... - Caught in the act: in vivo molecular imaging of the transcription factor NF-kappaB after myocardial infarctionJochen Tillmanns
, Germany
Biochem Biophys Res Commun 342:773-4. 2006..Thus, in vivo measurement of the activation of NF-kappaB is feasible. NF-kappaB activity might play an important role for the remodeling process... - Toll-like receptors as potential therapeutic targets in cardiac dysfunctionUlrich Hofmann
University Hospital Wurzburg, Department of Internal Medicine I, Oberdürrbacherstraße 6, 97080 Wurzburg, Germany
Expert Opin Ther Targets 15:753-65. 2011..However, the relevance of TLRs as therapeutic targets remains to be defined as clinical data is sparse... - Innate immunity and angiogenesisStefan Frantz
Genzyme Corporation, Cambridge, Mass 01701-9322, USA
Circ Res 96:15-26. 2005.... - Nitric oxide, cell death, and heart failureJun-Ichi Oyama
Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA
Heart Fail Rev 7:327-34. 2002.... - Effect of testosterone on post-myocardial infarction remodeling and functionMatthias Nahrendorf
Medical University Hospital Wuerzburg, Josef-Schneider-Strasse 2, 97080 Wuerzburg, Germany
Cardiovasc Res 57:370-8. 2003..Testosterone treatment had no detrimental effects following MI. Reduced wall stress and LVEDP may even improve long-term outcome... - Targeted deletion of caspase-1 reduces early mortality and left ventricular dilatation following myocardial infarctionStefan Frantz
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, MA 02115, Boston, USA
J Mol Cell Cardiol 35:685-94. 2003.... - Increased myocardial oxygen consumption by TNF-alpha is mediated by a sphingosine signaling pathwayUlrich Hofmann
Department of Medicine/Cardiology, , Germany
Am J Physiol Heart Circ Physiol 284:H2100-5. 2003..Exogenous sphingosine mimicked the TNF-alpha effect on mechanics and energetics. We conclude that TNF-alpha impairs the economy of chemomechanical energy transduction primarily through a sphingosine-mediated pathway... - Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharideJie Fan
Department of Surgery, University Health Network, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
J Immunol 168:5252-9. 2002.... - Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/AktRyuji Fukazawa
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Mol Cell Cardiol 35:1473-9. 2003..Treatment with the erbB2 antibody had no effect on anthracycline-induced apoptosis. Thus, NRG-1beta protects against anthracycline-induced apoptosis via erbB4-dependent activation of the PI3-kinase/Akt pathway... - Wound model of myocardial infarctionGeorg Ertl
Am J Physiol Heart Circ Physiol 288:H981-3. 2005 - A role for caspase-1 in heart failureSabine Merkle
Rudolf Virchow Center, Deutsche Forschungsgemeinschaft Research Center for Experimental Biomedicine, Wuerzburg, Germany
Circ Res 100:645-53. 2007..Our findings support a functional role for caspase-1-mediated myocardial apoptosis contributing to the progression of heart failure...