S Frantz

Summary

Country: Germany

Publications

  1. doi request reprint Tissue inhibitor of metalloproteinases levels in patients with chronic heart failure: an independent predictor of mortality
    S Frantz
    Department of Internal Medicine I, Center of Cardiovascular Medicine, University of Wurzburg, Wurzburg, Germany
    Eur J Heart Fail 10:388-95. 2008
  2. pmc Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy
    Peter M Benz
    Institute of Physiology I, University of Wurzburg, D 97070 Wurzburg, Germany
    Cell Commun Signal 11:56. 2013
  3. pmc 5-Lipoxygenase facilitates healing after myocardial infarction
    Nadja Blömer
    Department of Internal Medicine I, University Hospital Wurzburg, Wurzburg, Germany
    Basic Res Cardiol 108:367. 2013
  4. doi request reprint Monocytes/macrophages prevent healing defects and left ventricular thrombus formation after myocardial infarction
    Stefan Frantz
    Department of Internal Medicine I, University Hospital Wurzburg, Comprehensive Heart Failure Center, University of Wurzburg, Oberdürrbacher Straße 6, 97080 Wurzburg, Germany
    FASEB J 27:871-81. 2013
  5. ncbi request reprint Toll-like receptor signaling in the ischemic heart
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Herzkreislauf Zentrum, Universitatsklinikum Wurzburg, Wurzburg, Germany
    Front Biosci 13:5772-9. 2008
  6. ncbi request reprint Innate immunity and the heart
    Stefan Frantz
    Medizinische Klinik der Universität Würzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Curr Pharm Des 11:1279-90. 2005
  7. ncbi request reprint Left ventricular remodeling after myocardial infarction in mice with targeted deletion of the NADPH oxidase subunit gp91PHOX
    Stefan Frantz
    Medizinische Universitätsklinik Würzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Basic Res Cardiol 101:127-32. 2006
  8. doi request reprint [Obesity and heart failure]
    S Frantz
    Herzkreislauf Zentrum, Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
    Internist (Berl) 49:389-90, 392-3. 2008
  9. ncbi request reprint Absence of NF-kappaB subunit p50 improves heart failure after myocardial infarction
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Herzkreislauf Zentrum, Universitat Wurzburg, Germany
    FASEB J 20:1918-20. 2006
  10. pmc Role of p38 mitogen-activated protein kinase in cardiac remodelling
    S Frantz
    Medizinische Klinik und Poliklinik I, Herz Kreislaufzentrum, Universitat Wurzburg, Germany
    Br J Pharmacol 150:130-5. 2007

Detail Information

Publications56

  1. doi request reprint Tissue inhibitor of metalloproteinases levels in patients with chronic heart failure: an independent predictor of mortality
    S Frantz
    Department of Internal Medicine I, Center of Cardiovascular Medicine, University of Wurzburg, Wurzburg, Germany
    Eur J Heart Fail 10:388-95. 2008
    ..Matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) are involved in cardiac remodelling. The prognostic utility of TIMP is unknown in chronic heart failure (CHF)...
  2. pmc Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy
    Peter M Benz
    Institute of Physiology I, University of Wurzburg, D 97070 Wurzburg, Germany
    Cell Commun Signal 11:56. 2013
    ..In the present study, we analyzed the physiological functions of Mena and VASP in the heart and also investigated the role of the proteins in the organization of cytoplasmic actin networks...
  3. pmc 5-Lipoxygenase facilitates healing after myocardial infarction
    Nadja Blömer
    Department of Internal Medicine I, University Hospital Wurzburg, Wurzburg, Germany
    Basic Res Cardiol 108:367. 2013
    ..In conclusion, a lack or inhibition of 5-LOX increases mortality after MI because of healing defects. This is not mediated by a change in local blood flow, but through an altered inflammation and/or fibroblast function. ..
  4. doi request reprint Monocytes/macrophages prevent healing defects and left ventricular thrombus formation after myocardial infarction
    Stefan Frantz
    Department of Internal Medicine I, University Hospital Wurzburg, Comprehensive Heart Failure Center, University of Wurzburg, Oberdürrbacher Straße 6, 97080 Wurzburg, Germany
    FASEB J 27:871-81. 2013
    ..In summary, monocytes/macrophages are of central importance for healing after MI. Impaired monocyte/macrophage function appears to be an unrecognized new pathophysiological mechanism for left ventricular thrombus development after MI...
  5. ncbi request reprint Toll-like receptor signaling in the ischemic heart
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Herzkreislauf Zentrum, Universitatsklinikum Wurzburg, Wurzburg, Germany
    Front Biosci 13:5772-9. 2008
    ..Herein we review the experimental and clinical evidence for the involvement of TLR and its downstream signaling molecules in cardiac ischemic injury...
  6. ncbi request reprint Innate immunity and the heart
    Stefan Frantz
    Medizinische Klinik der Universität Würzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Curr Pharm Des 11:1279-90. 2005
    ..e., the "Expanded Self-Non-Self" and the "Danger" theories of immune activation)...
  7. ncbi request reprint Left ventricular remodeling after myocardial infarction in mice with targeted deletion of the NADPH oxidase subunit gp91PHOX
    Stefan Frantz
    Medizinische Universitätsklinik Würzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Basic Res Cardiol 101:127-32. 2006
    ..Since NADPH oxidases are a major source of reactive oxygen species in the heart, we studied left ventricular remodeling after myocardial infarction in mice with targeted deletion of the NADPH oxidase subunit gp91(phox)...
  8. doi request reprint [Obesity and heart failure]
    S Frantz
    Herzkreislauf Zentrum, Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
    Internist (Berl) 49:389-90, 392-3. 2008
    ..Therapeutic approaches include weight control by dietary intervention and exercise, as well as bariatric surgery for the morbidly obese. Heart failure treatment should otherwise follow the general heart failure guidelines...
  9. ncbi request reprint Absence of NF-kappaB subunit p50 improves heart failure after myocardial infarction
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Herzkreislauf Zentrum, Universitat Wurzburg, Germany
    FASEB J 20:1918-20. 2006
    ..Therefore, we investigated left ventricular remodeling in mice with a targeted deletion of the NF-kappaB subunit p50/NF-kappaB1 after myocardial infarction...
  10. pmc Role of p38 mitogen-activated protein kinase in cardiac remodelling
    S Frantz
    Medizinische Klinik und Poliklinik I, Herz Kreislaufzentrum, Universitat Wurzburg, Germany
    Br J Pharmacol 150:130-5. 2007
    ..We therefore evaluated the effect of the selective p38 MAPK inhibitor SB 239063 on progression of left ventricular remodelling after myocardial infarction (MI) in rats...
  11. ncbi request reprint Detrimental effects of testosterone on post-myocardial infarction remodelling in female rats
    S Frantz
    Universitat Wurzburg, Medizinische Klinik und Poliklinik I, Germany
    J Physiol Pharmacol 58:717-27. 2007
    ..In conclusion, chronic anabolic T treatment causes myocardial hypertrophy under basal conditions and adversely affects left ventricular remodeling following myocardial infarction in female rats...
  12. ncbi request reprint Mechanisms of disease: Toll-like receptors in cardiovascular disease
    Stefan Frantz
    Universitat Wurzburg, Medizinische Klinik und Poliklinik I, Herzkreislauf Zentrum, Wurzburg, Germany
    Nat Clin Pract Cardiovasc Med 4:444-54. 2007
    ..Here we review the rapid progress that has been made in this field, which has improved our understanding of vascular as well as myocardial TLR function in basic and clinical science...
  13. pmc Tissue-specific effects of the nuclear factor kappaB subunit p50 on myocardial ischemia-reperfusion injury
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Herz Kreislaufzentrum, Universitat Wurzburg, Wurzburg, Germany
    Am J Pathol 171:507-12. 2007
    ..Bone marrow transplantation experiments indicate that impaired NF-kappaB activation in p50 KO leukocytes attenuates cardiac damage...
  14. ncbi request reprint Transforming growth factor beta inhibition increases mortality and left ventricular dilatation after myocardial infarction
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Herz Kreislaufzentrum, Universitatsklinikum Wurzburg, 97080, Wurzburg, Germany
    Basic Res Cardiol 103:485-92. 2008
    ..However, data regarding the function of TGF-beta after ischemic injury are inconclusive...
  15. ncbi request reprint Effect of chronic heart failure on nuclear factor kappa B in peripheral leukocytes
    Stefan Frantz
    Medizinische Klinik der Universität Würzburg, Germany
    Am J Cardiol 94:671-3. 2004
    ..In patients with stable heart failure with no obvious other reason for NF-kappaB activation, NF-kappaB was significantly activated...
  16. doi request reprint The eNOS enhancer AVE 9488: a novel cardioprotectant against ischemia reperfusion injury
    S Frantz
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Basic Res Cardiol 104:773-9. 2009
    ..2 +/- 0.5 vs. 0.8 +/- 0.07 micromol/l, P = 0.0003). Thus pharmacological interventions addressed to increase eNOS-derived NO production constitute a promising therapeutic approach to prevent myocardial ischemia/reperfusion injury...
  17. ncbi request reprint High dose aspirin and left ventricular remodeling after myocardial infarction: aspirin and myocardial infarction
    Anna Adamek
    Medizinische Klinik und Poliklinik I der Universität Würzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Basic Res Cardiol 102:334-40. 2007
    ..High-dose aspirin inhibits cytokine activation. Therefore, we tested the influence of high-dose aspirin treatment on left ventricular remodeling in mice after myocardial infarction...
  18. ncbi request reprint Complement C3c as a biomarker in heart failure
    A Frey
    Department of Internal Medicine I, University Hospital Wurzburg, Oberdürrbacher Straße 6, 97080 Wurzburg, Germany Comprehensive Heart Failure Center, University of Wurzburg, Straubmühlweg 2a, Haus A9, 97078 Wurzburg, Germany
    Mediators Inflamm 2013:716902. 2013
    ..Animals lacking parts of the complement system are protected from adverse remodeling. Based on these data, we hypothesized that peripheral complement levels could be a good marker for adverse remodeling and prognosis in patients with HF...
  19. pmc Pharmacological pre- and post-conditioning with the sphingosine-1-phosphate receptor modulator FTY720 after myocardial ischaemia-reperfusion
    U Hofmann
    Department of Internal Medicine I, University Hospital Wuerzburg, Wurzburg, Germany
    Br J Pharmacol 160:1243-51. 2010
    ..Therefore, we tested the hypothesis that pharmacological post-conditioning with FTY720 reduces infarct size after myocardial ischaemia-reperfusion in vivo...
  20. doi request reprint [Primary diagnosis of heart failure in ambulatory and hospitalized patients]
    S Stork
    Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Schwerpunkt Kardiologie an der PoliklinikKlinikstr 6 8
    Dtsch Med Wochenschr 133:636-41. 2008
    ..As a primary diagnostic aim, the underlying cause of heart failure should be determined in all subjects because the therapeutic strategy may depend on this information...
  21. ncbi request reprint Repetitive postprandial hyperglycemia increases cardiac ischemia/reperfusion injury: prevention by the alpha-glucosidase inhibitor acarbose
    Stefan Frantz
    Medizinische Klinik der Universität Würzburg, Wurzburg, Germany
    FASEB J 19:591-3. 2005
    ..In summary, repetitive postprandial hyperglycemia increases ischemia/reperfusion damage. This effect can be prevented by treatment with the alpha-glucosidase inhibitor acarbose...
  22. ncbi request reprint Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice
    Anna Adamek
    Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Germany
    Eur J Pharmacol 571:51-4. 2007
    ..In summary, inhibition of 5-lipoxygenase does not affect cardiac ischemia-reperfusion injury but the post-ischemic inflammatory response...
  23. pmc Post-infarct remodelling: contribution of wound healing and inflammation
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Cardiovasc Res 81:474-81. 2009
    ..Healing in the heart occurs in overlapping phases. Herein, we review the inflammatory phase as a trigger of tissue formation...
  24. ncbi request reprint HMG CoA reductase inhibition and left ventricular mass in hypertrophic cardiomyopathy: a randomized placebo-controlled pilot study
    J Bauersachs
    Medizinische Klinik und Poliklinik I, Kardiologie, Julius Maximilians Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Eur J Clin Invest 37:852-9. 2007
    ..We investigated the effect of the hydroxymethylglutaryl coenzyme A reductase inhibitor atorvastatin on left ventricular (LV) mass in patients with hypertrophic cardiomyopathy in a randomized placebo-controlled double-blind pilot study...
  25. doi request reprint Prevention of hypertensive crises in rats induced by acute and chronic norepinephrine excess
    D Weismann
    Department of Internal Medicine I, University of Wurzburg, Wurzburg, Germany
    Horm Metab Res 42:803-8. 2010
    ..POB was the most effective drug used in monotherapy, but BP stabilization was superior using a combination of POB pretreatment with a continuous nifedipine infusion in this model...
  26. ncbi request reprint [Radiation-induced pacemaker malfunction]
    S Frantz
    Medizinische Universitätsklinik Würzburg Josef Schneider Str 2 97080 Würzburg, Germany
    Z Kardiol 92:415-7. 2003
    ..Radiation can substantially damage pacemaker electronics. We report here a case, with loss of communication after radiation therapy...
  27. doi request reprint Low circulating androgens and mortality risk in heart failure
    G Güder
    Medizinische Klinik und Poliklinik I Herz Kreislaufzentrum, Klinikum der Universität Würzburg, Oberdurrbacher Strasse 6, D 97080 Wurzburg, Germany
    Heart 96:504-9. 2010
    ..The pathophysiological implications of this phenomenon, however, have not been fully elucidated. This clinical study investigated the significance of low serum androgen levels in HF...
  28. doi request reprint Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosis
    Frank Weidemann
    University Clinic of Internal Medicine I Center for Cardiovascular Disease, University of Wurzburg, 97080 Wurzburg, Germany
    Circulation 120:577-84. 2009
    ....
  29. ncbi request reprint Protective effects of sphingosine-1-phosphate receptor agonist treatment after myocardial ischaemia-reperfusion
    Ulrich Hofmann
    Department of Internal Medicine I, University of Wurzburg, Medizinische Klinik und Poliklinik I, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Cardiovasc Res 83:285-93. 2009
    ..We tested the hypothesis that pharmacological S1P receptor agonists improve recovery of function when applied with reperfusion...
  30. pmc Electrocardiography and outcome in patients with diabetes mellitus on maintenance hemodialysis
    Vera Krane
    University of Wurzburg, Department of Medicine, Division of Nephrology, University Clinic, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Clin J Am Soc Nephrol 4:394-400. 2009
    ..However, respective systematic evaluations are absent. Thus, the authors investigated whether routine ECG findings add prognostic information to standard risk assessment in hemodialysis...
  31. doi request reprint Impact of different bone marrow cell preparations on left ventricular remodelling after experimental myocardial infarction
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Germany
    Eur J Heart Fail 10:119-24. 2008
    ..Since the specific characteristics of different BM cell subsets could influence their therapeutic potential we determined the effect of different BM cell populations on left ventricular remodelling after MI...
  32. ncbi request reprint Administration of testosterone is associated with a reduced susceptibility to myocardial ischemia
    Frank Callies
    Department of Endocrinology, Medical University Hospital Wuerzburg, 97080 Wuerzburg, Germany
    Endocrinology 144:4478-83. 2003
    ..In conclusion, administration of testosterone significantly improves recovery from global ischemia. These beneficial effects are associated with an attenuation of reperfusion induced [Ca2+]i overload...
  33. ncbi request reprint A sebaceous tumor in a patient with acquired immunodeficiency syndrome
    Stefan Frantz
    Medizinische Universitaetsklinik, Universitaet Wuerzburg, Josef Schneider Str 2, D 97080 Wuerzburg, Germany
    Eur J Med Res 7:135-7. 2002
    ..An association of AIDS and a solitary, large sebaceous adenoma has not been described yet. This emphasizes the role of an intact immune system in the suppression of benign and malignant tumors. tubular adenoma; tumor; AIDS..
  34. ncbi request reprint Sustained activation of nuclear factor kappa B and activator protein 1 in chronic heart failure
    Stefan Frantz
    Medizinische Universitätsklinik Würzburg, Germany
    Cardiovasc Res 57:749-56. 2003
    ....
  35. pmc Peroxisome proliferator activated-receptor agonism and left ventricular remodeling in mice with chronic myocardial infarction
    Stefan Frantz
    Medizinische Klinik der Universität Würzburg, Germany
    Br J Pharmacol 141:9-14. 2004
    ..5. In conclusion, PPARgamma activation did not adversely affect left ventricular remodeling and survival in mice with chronic MI. However, we were also not able to identify a protective effect of pioglitazone...
  36. ncbi request reprint Rosuvastatin reduces platelet activation in heart failure: role of NO bioavailability
    Andreas Schafer
    Medizinische Klinik and Poliklinik I, Universitatsklinikum Wurzburg, Bayerische Julius Maximilians Universität Würzburg, Germany
    Arterioscler Thromb Vasc Biol 25:1071-7. 2005
    ..We investigated whether 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibition would beneficially modulate vascular NO bioavailability and platelet activation in experimental CHF...
  37. ncbi request reprint Healing after myocardial infarction
    Georg Ertl
    Medizinische Universitätsklinik Würzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Cardiovasc Res 66:22-32. 2005
    ....
  38. ncbi request reprint Bone marrow molecular alterations after myocardial infarction: Impact on endothelial progenitor cells
    Thomas Thum
    Medizinische Klinik I, Kardiologie, Universitatsklinikum Wurzburg, Julius Maximilians Universitat, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Cardiovasc Res 70:50-60. 2006
    ..However, potential underlying mechanisms have not yet been investigated...
  39. doi request reprint [From cardiovascular risk to chronic heart failure]
    G Ertl
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Josef Schneider Strasse 2, 97080, Wurzburg, Germany
    Internist (Berl) 49:387-8. 2008
  40. doi request reprint Reverse epidemiology in systolic and nonsystolic heart failure: cumulative prognostic benefit of classical cardiovascular risk factors
    Gülmisal Güder
    Medizinische Klinik und Poliklinik I, University Hospital Wurzburg, Wurzburg, Germany
    Circ Heart Fail 2:563-71. 2009
    ..We estimated the prognostic role of these risk factors in unselected patients with heart failure...
  41. ncbi request reprint Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarction
    Matthias Nahrendorf
    Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Wurzburg, Germany
    Circulation 113:1196-202. 2006
    ..We hypothesized that clotting factor XIII (FXIII), a transglutaminase involved in wound healing, may play an important role in MI given prior clinical and mouse model data...
  42. ncbi request reprint Carbon monoxide, but not endothelin-1, plays a major role for the hepatic microcirculation in a murine model of early systemic inflammation
    Christian Wunder
    Klinik und Poliklinik für Anästhesiologie, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    Crit Care Med 33:2323-31. 2005
    ..However, the role of carbon monoxide and endothelin-1 and its receptors endothelin receptor A and endothelin receptor B in the deranged liver microcirculation during early systemic inflammation remains unclear...
  43. ncbi request reprint Conditional neuronal nitric oxide synthase overexpression impairs myocardial contractility
    Natalie Burkard
    Department of Internal Medicine I, University of Wuerzburg, Wuerzburg, Germany
    Circ Res 100:e32-44. 2007
    ..We suggest that nNOS might suppress the function of L-type Ca(2+)-channels and in turn reduces Ca(2+)-transients which accounts for the negative inotropic effect...
  44. doi request reprint Cardiac beta1-adrenoceptor autoantibodies in human heart disease: rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) Study
    Nikolas Deubner
    Department of Internal Medicine I, Centre of Cardiovascular Medicine, University of Wurzburg, University Hospital Wurzburg, Klinikstrasse 6 8, 97070 Wurzburg, Germany
    Eur J Heart Fail 12:753-62. 2010
    ....
  45. ncbi request reprint Caught in the act: in vivo molecular imaging of the transcription factor NF-kappaB after myocardial infarction
    Jochen Tillmanns
    Medizinische Klinik der Universität Würzburg, Germany
    Biochem Biophys Res Commun 342:773-4. 2006
    ..Thus, in vivo measurement of the activation of NF-kappaB is feasible. NF-kappaB activity might play an important role for the remodeling process...
  46. ncbi request reprint Complementary and incremental mortality risk prediction by cortisol and aldosterone in chronic heart failure
    Gülmisal Güder
    University of Wurzburg, Department of Internal Medicine I, Center for Cardiovascular Medicine, Klinikstrasse 6 8, D 97070 Wurzburg, Germany
    Circulation 115:1754-61. 2007
    ..The prognostic significance of cortisol that may also bind and activate the mineralocorticoid receptor in chronic heart failure is unknown...
  47. doi request reprint Toll-like receptors as potential therapeutic targets in cardiac dysfunction
    Ulrich Hofmann
    University Hospital Wurzburg, Department of Internal Medicine I, Oberdürrbacherstraße 6, 97080 Wurzburg, Germany
    Expert Opin Ther Targets 15:753-65. 2011
    ..In addition to their role in response to microbial infections, evidence suggests that TLRs can also recognize endogenous ligands and may play a role in mediating cardiomyocyte cell death and survival after non-infectious injury...
  48. ncbi request reprint Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide
    Jie Fan
    Department of Surgery, University Health Network, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
    J Immunol 168:5252-9. 2002
    ....
  49. ncbi request reprint Nitric oxide, cell death, and heart failure
    Jun ichi Oyama
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA, USA
    Heart Fail Rev 7:327-34. 2002
    ....
  50. ncbi request reprint Increased myocardial oxygen consumption by TNF-alpha is mediated by a sphingosine signaling pathway
    Ulrich Hofmann
    Department of Medicine Cardiology, University of Wurzburg, Germany
    Am J Physiol Heart Circ Physiol 284:H2100-5. 2003
    ..Exogenous sphingosine mimicked the TNF-alpha effect on mechanics and energetics. We conclude that TNF-alpha impairs the economy of chemomechanical energy transduction primarily through a sphingosine-mediated pathway...
  51. ncbi request reprint Effect of testosterone on post-myocardial infarction remodeling and function
    Matthias Nahrendorf
    Medical University Hospital Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
    Cardiovasc Res 57:370-8. 2003
    ..Moreover, testosterone (T) treatment is increasingly used in elderly males. Therefore, we examined effects of chronic anabolic T administration on left ventricular (LV) remodeling after myocardial infarction (MI)...
  52. ncbi request reprint Targeted deletion of caspase-1 reduces early mortality and left ventricular dilatation following myocardial infarction
    Stefan Frantz
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, MA 02115, Boston, USA
    J Mol Cell Cardiol 35:685-94. 2003
    ....
  53. ncbi request reprint Innate immunity and angiogenesis
    Stefan Frantz
    Genzyme Corporation, Cambridge, Mass 01701 9322, USA
    Circ Res 96:15-26. 2005
    ....
  54. ncbi request reprint Wound model of myocardial infarction
    Georg Ertl
    Am J Physiol Heart Circ Physiol 288:H981-3. 2005
  55. ncbi request reprint Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt
    Ryuji Fukazawa
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Mol Cell Cardiol 35:1473-9. 2003
    ..Treatment with the erbB2 antibody had no effect on anthracycline-induced apoptosis. Thus, NRG-1beta protects against anthracycline-induced apoptosis via erbB4-dependent activation of the PI3-kinase/Akt pathway...
  56. ncbi request reprint A role for caspase-1 in heart failure
    Sabine Merkle
    Rudolf Virchow Center, Deutsche Forschungsgemeinschaft Research Center for Experimental Biomedicine, Wuerzburg, Germany
    Circ Res 100:645-53. 2007
    ..Our findings support a functional role for caspase-1-mediated myocardial apoptosis contributing to the progression of heart failure...