U Ziemann

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi request reprint TMS induced plasticity in human cortex
    Ulf Ziemann
    Motor Cortex Laboratory, Department of Neurology, J W Goethe University Frankfurt, Frankfurt am Main, Germany
    Rev Neurosci 15:253-66. 2004
  2. ncbi request reprint Mechanisms underlying mirror movements in Parkinson's disease: a transcranial magnetic stimulation study
    Massimo Cincotta
    Unit of Neurology, Santa Maria Nuova Hospital, Florence, Italy
    Mov Disord 21:1019-25. 2006
  3. doi request reprint Movement-related cortical potentials in patients with Machado-Joseph disease
    Ming Kuei Lu
    Neuroscience Laboratory, Department of Neurology, China Medical University Hospital, No 2, Yuh Der Road, Taichung 404, Taiwan
    Clin Neurophysiol 119:1010-9. 2008
  4. pmc Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients
    Sven Jarius
    Neurocure, Charite University Medicine Berlin, Berlin, Germany
    J Neuroinflammation 9:14. 2012
  5. pmc Safety and clinical outcomes of rituximab therapy in patients with different autoimmune diseases: experience from a national registry (GRAID)
    Hans Peter Tony
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Wurzburg, Klinikstr 6 8, 97070 Wurzburg, Germany
    Arthritis Res Ther 13:R75. 2011
  6. doi request reprint Consensus: Motor cortex plasticity protocols
    Ulf Ziemann
    Department Neurology, Goethe University Frankfurt, Germany
    Brain Stimul 1:164-82. 2008
  7. ncbi request reprint Estimated magnitude and interactions of cortico-motoneuronal and Ia afferent input to spinal motoneurones of the human hand
    Ulf Ziemann
    Motor Cortex Laboratory, Clinic of Neurology, Johann Wolfgang Goethe University of Frankfurt, Schleusenweg 2 16, D 60528 Frankfurt am Main, Germany
    Neurosci Lett 364:48-52. 2004
  8. doi request reprint Transcranial magnetic stimulation at the interface with other techniques: a powerful tool for studying the human cortex
    Ulf Ziemann
    Department of Neurology, Goethe University Frankfurt, Frankfurt am Main, Germany
    Neuroscientist 17:368-81. 2011
  9. ncbi request reprint Pharmacology of TMS
    Ulf Ziemann
    Clinic of Neurology, J W Goethe University Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Suppl Clin Neurophysiol 56:226-31. 2003
  10. ncbi request reprint Learning modifies subsequent induction of long-term potentiation-like and long-term depression-like plasticity in human motor cortex
    Ulf Ziemann
    Motor Cortex Laboratory, Clinic of Neurology, Johann Wolfgang Goethe University, D 60528 Frankfurt am Main, Germany
    J Neurosci 24:1666-72. 2004

Collaborators

Detail Information

Publications79

  1. ncbi request reprint TMS induced plasticity in human cortex
    Ulf Ziemann
    Motor Cortex Laboratory, Department of Neurology, J W Goethe University Frankfurt, Frankfurt am Main, Germany
    Rev Neurosci 15:253-66. 2004
    ..This review focuses on RTMS induced changes in excitability, the potential mechanisms underlying these effects, and the usefulness of this knowledge to gain insight into mechanisms of other processes such as learning...
  2. ncbi request reprint Mechanisms underlying mirror movements in Parkinson's disease: a transcranial magnetic stimulation study
    Massimo Cincotta
    Unit of Neurology, Santa Maria Nuova Hospital, Florence, Italy
    Mov Disord 21:1019-25. 2006
    ..These findings provide converging evidence that, in PD, MMs do not depend on unmasking of ipsilateral projections but are explained by motor output along the crossed corticospinal projection from the mirror M1...
  3. doi request reprint Movement-related cortical potentials in patients with Machado-Joseph disease
    Ming Kuei Lu
    Neuroscience Laboratory, Department of Neurology, China Medical University Hospital, No 2, Yuh Der Road, Taichung 404, Taiwan
    Clin Neurophysiol 119:1010-9. 2008
    ..What is the Bereitschaftspotential? Clin Neurophysiol 2006;117:2341-56) were studied in patients with Machado-Joseph disease (MJD) to elucidate the pathophysiology of voluntary movement...
  4. pmc Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients
    Sven Jarius
    Neurocure, Charite University Medicine Berlin, Berlin, Germany
    J Neuroinflammation 9:14. 2012
    ..However, little is known so far about the clinical impact of AQP4-Ab seropositivity...
  5. pmc Safety and clinical outcomes of rituximab therapy in patients with different autoimmune diseases: experience from a national registry (GRAID)
    Hans Peter Tony
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Wurzburg, Klinikstr 6 8, 97070 Wurzburg, Germany
    Arthritis Res Ther 13:R75. 2011
    ....
  6. doi request reprint Consensus: Motor cortex plasticity protocols
    Ulf Ziemann
    Department Neurology, Goethe University Frankfurt, Germany
    Brain Stimul 1:164-82. 2008
    ....
  7. ncbi request reprint Estimated magnitude and interactions of cortico-motoneuronal and Ia afferent input to spinal motoneurones of the human hand
    Ulf Ziemann
    Motor Cortex Laboratory, Clinic of Neurology, Johann Wolfgang Goethe University of Frankfurt, Schleusenweg 2 16, D 60528 Frankfurt am Main, Germany
    Neurosci Lett 364:48-52. 2004
    ..The weights of these inputs may relate to the specific functions of the different intrinsic hand muscles in skilled finger movements...
  8. doi request reprint Transcranial magnetic stimulation at the interface with other techniques: a powerful tool for studying the human cortex
    Ulf Ziemann
    Department of Neurology, Goethe University Frankfurt, Frankfurt am Main, Germany
    Neuroscientist 17:368-81. 2011
    ..This review provides an up-to-date synopsis of these combined approaches and highlights important examples that have advanced our understanding of how TMS interacts with neuronal networks in the human brain...
  9. ncbi request reprint Pharmacology of TMS
    Ulf Ziemann
    Clinic of Neurology, J W Goethe University Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Suppl Clin Neurophysiol 56:226-31. 2003
    ..Increasing numbers of different forms of cortical inhibition are being discovered, such as SICI (GABAA dependent), CSP (GABAB dependent) and SLAI (cholinergic), and it is very likely that more will follow soon...
  10. ncbi request reprint Learning modifies subsequent induction of long-term potentiation-like and long-term depression-like plasticity in human motor cortex
    Ulf Ziemann
    Motor Cortex Laboratory, Clinic of Neurology, Johann Wolfgang Goethe University, D 60528 Frankfurt am Main, Germany
    J Neurosci 24:1666-72. 2004
    ..The same number of repeated slow thumb abduction movements did not result in learning and had no effects on PAS-induced plasticity. Findings support the view that learning in human M1 occurs through LTP-like mechanisms...
  11. ncbi request reprint Pharmacological modulation of plasticity in the human motor cortex
    Ulf Ziemann
    Department of Neurology, J W Goethe University Frankfurt, Frankfurt am Main, Germany
    Neurorehabil Neural Repair 20:243-51. 2006
    ..It will be argued that these data may be useful for advancing the concepts of pharmacotherapy for recovery after stroke...
  12. ncbi request reprint Cortico-motoneuronal excitation of three hand muscles determined by a novel penta-stimulation technique
    Ulf Ziemann
    Motor Cortex Laboratory, Department of Neurology, Johann Wolfgang Goethe University of Frankfurt, Schleusenweg 2 16, D 60528 Frankfurt am Main, Germany
    Brain 127:1887-98. 2004
    ..The findings strongly suggest that CMS excitation differs between hand muscles and that these differences directly link to capability differences in individuated finger movements...
  13. ncbi request reprint TMS and drugs
    Ulf Ziemann
    Motor Cortex Laboratory, Clinic of Neurology, Johann Wolfgang Goethe University Frankfurt, Schleusenweg 2 16, D 60528 Frankfurt am Main, Germany
    Clin Neurophysiol 115:1717-29. 2004
    ..Finally, TMS or repetitive TMS by themselves may induce changes in endogenous neurotransmitters or neuromodulators. All these possible interactions are the focus of this in-depth review on TMS and drugs...
  14. doi request reprint Modifying motor learning through gating and homeostatic metaplasticity
    Ulf Ziemann
    Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Brain Stimul 1:60-6. 2008
    ..This approach invokes homeostatic metaplasticity. Here we highlight how transcranial brain stimulation can exploit gating and homeostatic metaplasticity to enhance motor learning in healthy subjects and in patients after stroke...
  15. ncbi request reprint LTP-like plasticity in human motor cortex
    Ulf Ziemann
    Department of Neurology, Johann Wolfgang Goethe University of Frankfurt, Schleusenweg 2 16, D 60528 Frankfurt am Main, Germany
    Suppl Clin Neurophysiol 57:702-7. 2004
  16. ncbi request reprint Dual modulating effects of amphetamine on neuronal excitability and stimulation-induced plasticity in human motor cortex
    Ulf Ziemann
    Human Cortical Physiology Section, NINDS, National Institutes of Health, Building 10, Bethesda, MD 20892, USA
    Clin Neurophysiol 113:1308-15. 2002
    ..The objective of the present study is to test the modulating effects of dextro-amphetamine (d-AMP) on excitability and stimulation-induced plasticity in human motor cortex...
  17. ncbi request reprint Hemispheric asymmetry of ipsilateral motor cortex activation during unimanual motor tasks: further evidence for motor dominance
    U Ziemann
    Clinic of Neurology, J W Goethe University, Theodor Stern Kai 7, D 60590, Frankfurt am Main, Germany
    Clin Neurophysiol 112:107-13. 2001
    ..To test to which extent the increase in ipsilateral motor cortex excitability during unimanual motor tasks shows hemispheric asymmetry...
  18. ncbi request reprint Stimulation-induced within-representation and across-representation plasticity in human motor cortex
    Ulf Ziemann
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 1428, USA
    J Neurosci 22:5563-71. 2002
    ..This bidirectional plasticity might be used for purposeful modulation of human cortical function...
  19. ncbi request reprint Long-term potentiation (LTP)-like plasticity and learning in human motor cortex--investigations with transcranial magnetic stimulation (TMS)
    Ulf Ziemann
    Motor Cortex Laboratory, Department of Neurology, Johann Wolfgang Goethe University of Frankfurt, D 60528 Frankfurt am Main, Germany
    Suppl Clin Neurophysiol 59:19-25. 2006
  20. doi request reprint Development of biomarkers for multiple sclerosis as a neurodegenerative disorder
    Ulf Ziemann
    Department of Neurology, Goethe University, Frankfurt am Main, Germany
    Prog Neurobiol 95:670-85. 2011
    ..This paper compiles an up-to-date critical review of the available knowledge of candidate biomarkers of neurodegenerative processes in MS...
  21. ncbi request reprint Modulation of practice-dependent plasticity in human motor cortex
    U Ziemann
    Clinic of Neurology, J W Goethe University, Schleusenweg 2 16, D 60590 Frankfurt am Main, Germany
    Brain 124:1171-81. 2001
    ..We propose that changes in GABA activity may be instrumented to modulate plasticity purposefully; for instance, to enhance plastic change and recovery of function after a lesion in neurological patients...
  22. pmc Dissociation of the pathways mediating ipsilateral and contralateral motor-evoked potentials in human hand and arm muscles
    U Ziemann
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892, USA
    J Physiol 518:895-906. 1999
    ..Other pathways, such as branching of corticomotoneuronal axons, a transcallosal projection or a slow-conducting monosynaptic ipsilateral pathway are very unlikely or can be excluded...
  23. ncbi request reprint Role of the human motor cortex in rapid motor learning
    W Muellbacher
    Medical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1428, USA
    Exp Brain Res 136:431-8. 2001
    ..Since the changes in MEP amplitude were observed only after TMS of M1 but not after direct stimulation of the corticospinal tract, these findings indicate task- and effector-specific involvement of human M1 in rapid motor learning...
  24. ncbi request reprint The alpha2-adrenergic agonist guanfacine reduces excitability of human motor cortex through disfacilitation and increase of inhibition
    Alexei Korchounov
    Clinic of Neurology, Johann Wolfgang Goethe University Frankfurt, Theodor Stern Kai 7, D 60590, Frankfurt, Germany
    Clin Neurophysiol 114:1834-40. 2003
    ..To test the acute effects of the alpha2-adrenoceptor agonist guanfacine (GFC) on motor excitability in intact humans...
  25. ncbi request reprint Physiology of modulation of motor cortex excitability by low-frequency suprathreshold repetitive transcranial magnetic stimulation
    G Heide
    Department of Neurology, Friedrich Schiller University, Erlanger Allee 101, 07740 Jena, Germany
    Exp Brain Res 171:26-34. 2006
    ..Modulation of motor cortical inhibition did not play a role in explaining the rTMS induced changes in MEP amplitude...
  26. ncbi request reprint Subtle hemispheric asymmetry of motor cortical inhibitory tone
    Tihomir V Ilic
    Clinic of Neurology, J W Goethe University Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Clin Neurophysiol 115:330-40. 2004
    ..To test whether a novel paired transcranial magnetic stimulation (TMS) protocol (J Physiol 545.1 (2002) 153) detects hemispheric differences in motor cortical inhibition...
  27. doi request reprint Modulation of preparatory volitional motor cortical activity by paired associative transcranial magnetic stimulation
    Ming Kuei Lu
    Motor Cortex Group, Department of Neurology, Goethe University, Frankfurt am Main, Germany
    Hum Brain Mapp 30:3645-56. 2009
    ..Findings indicate a specific interference of PAS with preparatory volitional motor cortical activity, suggestive of a net result caused by increased M1 excitability and disrupted effective connectivity between premotor areas and M1...
  28. ncbi request reprint Analogous corticocortical inhibition and facilitation in ipsilateral and contralateral human motor cortex representations of the tongue
    W Muellbacher
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA
    J Clin Neurophysiol 18:550-8. 2001
    ..0001). These findings indicate that the ipsilateral and contralateral representations of the tongue are under analogous inhibitory and facilitatory control, possibly by a common intracortical network...
  29. pmc Demonstration of facilitatory I wave interaction in the human motor cortex by paired transcranial magnetic stimulation
    U Ziemann
    Department of Clinical Neurophysiology, University of Gottingen, Human Motor Control Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Physiol 511:181-90. 1998
    ..5. It is concluded that the MEP facilitation after paired TMS, at least for the first MEP peak, is due to facilitatory interaction between I waves, and takes place in the motor cortex at or upstream from the corticospinal neurone...
  30. ncbi request reprint Complex modulation of human motor cortex excitability by the specific serotonin re-uptake inhibitor sertraline
    Tihomir V Ilic
    Department of Neurology, J W Goethe University Frankfurt, Theodor Stern Kai 7, D 60590 Franfurt am Main, Germany
    Neurosci Lett 319:116-20. 2002
    ..These features may improve the signal-to-noise ratio of output cells in human motor cortex...
  31. doi request reprint Hysteresis effects on the input-output curve of motor evoked potentials
    Caroline Möller
    Motor Cortex Group, Department of Neurology, Goethe University, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    Clin Neurophysiol 120:1003-8. 2009
    ..Here we sought to determine hysteresis effects on IO curves, i.e. their short-term dependence on prior corticospinal activation...
  32. doi request reprint Interference of short-interval intracortical inhibition (SICI) and short-interval intracortical facilitation (SICF)
    Sinikka H Peurala
    Motor Cortex Group, Department of Neurology, Goethe University of Frankfurt, Schleusenweg 2 16, D 60528 Frankfurt am Main, Germany
    Clin Neurophysiol 119:2291-7. 2008
    ..However, facilitatory processes may contaminate SICI under certain conditions. Here, we specifically address the contribution of short-interval intracortical facilitation (SICF)...
  33. ncbi request reprint Methylphenidate facilitates and disinhibits the motor cortex in intact humans
    Tihomir V Ilic
    Clinic of Neurology, J W Goethe University Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Neuroreport 14:773-6. 2003
    ..MEP threshold, cortical silent period and measures of spinal and neuromuscular excitability remained unaffected. Findings support the idea that MPH promotes accelerated motor recovery after lesion through facilitation and disinhibition...
  34. ncbi request reprint New graphical method to measure silent periods evoked by transcranial magnetic stimulation
    M A Garvey
    Pediatric Movement Disorders Unit, Pediatrics and Developmental Neuropsychiatry Branch, NIMH, National Institutes of Health, 10 Center Drive, 4N208, MSC 1255, Bethesda, MD 20892 1255, USA
    Clin Neurophysiol 112:1451-60. 2001
    ..We describe a graphical method to measure silent periods with greater precision. The statistical process underlying this new method is simple and particularly suited to signal detection in serially dependent data...
  35. ncbi request reprint Cortical correlates of neuromotor development in healthy children
    M A Garvey
    Pediatric Movement Disorders Unit, Human Motor Control Section, Motor Neurology Branch, NINDS, National Institutes of Health, 10 Center Drive, 5N226, MSC 1428, Bethesda, MD 20982 1428, USA
    Clin Neurophysiol 114:1662-70. 2003
    ..To examine the relationship between acquisition of fine motor skills in childhood and development of the motor cortex...
  36. pmc Short-interval paired-pulse inhibition and facilitation of human motor cortex: the dimension of stimulus intensity
    Tihomir V Ilic
    Clinic of Neurology, Johann Wolfgang Goethe University of Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    J Physiol 545:153-67. 2002
    ..In contrast, SICF originates through non-synaptic facilitation at the initial axon segment of interneurones along a high-threshold excitatory pathway...
  37. ncbi request reprint Crossed reduction of human motor cortex excitability by 1-Hz transcranial magnetic stimulation
    E M Wassermann
    Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1428, USA
    Neurosci Lett 250:141-4. 1998
    ..This demonstrates that rTMS can condition cortical excitability at a distance of one or more synapses and suggest that decreased excitability to TMS is a correlate of decreased blood flow and metabolism...
  38. ncbi request reprint Differences of the ipsilateral silent period in small hand muscles
    Patrick Jung
    Motor Cortex Laboratory, Department of Neurology, Johann Wolfgang Goethe University, Schleusenweg 2 16, Frankfurt am Main, Germany
    Muscle Nerve 34:431-6. 2006
    ..Therefore, for specific assessment of callosal conduction, the iSP should be measured in the APB rather than FDI...
  39. ncbi request reprint Modification of motor cortical excitability by an acetylcholinesterase inhibitor
    Alexei Korchounov
    Motor Cortex Laboratory, Department of Neurology, Johann Wolfgang Goethe University of Frankfurt, Schleusenweg 2 16, 60528, Frankfurt am Main, Germany
    Exp Brain Res 164:399-405. 2005
    ..The findings predict that acetylcholine has the potential to promote plasticity and learning in human motor cortex...
  40. ncbi request reprint Homeostatic plasticity in human motor cortex demonstrated by two consecutive sessions of paired associative stimulation
    J Florian M Müller
    Motor Cortex Laboratory, Department of Neurology, Johann Wolfgang Goethe University, D 60528 Frankfurt am Main, Germany
    Eur J Neurosci 25:3461-8. 2007
    ..Because the two PAS sessions activate identical neuronal circuits, we conclude that 'homosynaptic-like' homeostatic mechanisms in accord with the BCM rule contribute to regulating plasticity in human M1...
  41. ncbi request reprint Vasogenic edema in Bickerstaff's brainstem encephalitis: a serial MRI study
    S Weidauer
    Institute of Neuroradiology, University of Frankfurt, Frankfurt, Germany
    Neurology 61:836-8. 2003
    ..High apparent diffusion coefficient values imply a vasogenic rather than cytotoxic edema as the cause of the hyperintense signal changes on T2-weighted images...
  42. pmc Anthropometric approximation of body weight in unresponsive stroke patients
    M W Lorenz
    Johann Wolfgang Goethe University, Department for Neurology, Schleusenweg 2 16, D 60528 Frankfurt Main, Germany
    J Neurol Neurosurg Psychiatry 78:1331-6. 2007
    ..Instead, weight is estimated visually by the attending physician, but this is known to be inaccurate...
  43. ncbi request reprint Acute neuropathy with multiple conduction blocks after TNFalpha monoclonal antibody therapy
    Oliver C Singer
    Department of Neurology, J W Goethe University Frankfurt am Main, Schleusenweg 2 16, D 60528 Frankfurt Main, Germany
    Neurology 63:1754. 2004
  44. ncbi request reprint Improving hand function in chronic stroke
    Wolf Muellbacher
    Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Dr, Bldg 10, Room 5N226, Bethesda, MD 20892, USA
    Arch Neurol 59:1278-82. 2002
    ..Deafferentation of a body part in a healthy brain enhances cortical representations of adjacent body parts, and this effect is markedly increased by voluntary activity of the adjacent part...
  45. doi request reprint Interindividual variability and age-dependency of motor cortical plasticity induced by paired associative stimulation
    J Florian M Müller-Dahlhaus
    Motor Cortex Group, Department of Neurology, Johann Wolfgang Goethe University, Schleusenweg 2 16, 60528, Frankfurt am Main, Germany
    Exp Brain Res 187:467-75. 2008
    ..In conclusion, measures of motor cortical excitability (RMT, MEP(1 mV)) and age determine direction and magnitude of PAS effects in individual subjects...
  46. doi request reprint Intraoperative motor evoked potential alteration in intracranial tumor surgery and its relation to signal alteration in postoperative magnetic resonance imaging
    Andrea Szelenyi
    Department of Neurosurgery, Johann Wolfgang Goethe University, Frankfurt, Germany
    Neurosurgery 67:302-13. 2010
    ....
  47. ncbi request reprint The ipsilateral silent period in boys with attention-deficit/hyperactivity disorder
    Marjorie A Garvey
    Pediatric Movement Disorders Unit, Human Motor Control Section, MNB, NINDS, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Neurophysiol 116:1889-96. 2005
    ..Characterize maturation of transcallosal inhibition (ipsilateral silent period [iSP]) in attention deficit/hyperactivity disorder (ADHD) using transcranial magnetic stimulation (TMS)...
  48. ncbi request reprint Short latency afferent inhibition and facilitation in patients with writer's cramp
    Kirn R Kessler
    Motor Cortex Laboratory, Department of Neurology, J W Goethe University, Frankfurt Main, Germany
    Mov Disord 20:238-42. 2005
    ..These findings suggest that somatosensory short-latency inhibitory input into the primary motor cortex is normal in WC, whereas a later excitatory input, which very likely reflects the long-latency reflex II, is exaggerated...
  49. ncbi request reprint Modification of practice-dependent plasticity in human motor cortex by neuromodulators
    Frank Meintzschel
    Motor Cortex Laboratory, Department of Neurology, J W Goethe University Frankfurt, Schleusenweg 2 16, D 60528 Frankfurt am Main, Germany
    Cereb Cortex 16:1106-15. 2006
    ..Enhancement of plasticity occurred through different strategies that either favoured extrinsic (NE, ACh) or intrinsic (DA) modulating influence on the motor cortical output network...
  50. pmc Interactions between short-interval intracortical inhibition and short-latency afferent inhibition in human motor cortex
    Henrik Alle
    Department of Neurology, Goethe University, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    J Physiol 587:5163-76. 2009
    ..Furthermore, dominance of S1 over P is compatible with the notion that the SICI interneurons target the corticospinal neurons closer to their axon initial segment than the SAI interneurons...
  51. ncbi request reprint Ipsilateral silent period: a marker of callosal conduction abnormality in early relapsing-remitting multiple sclerosis?
    Patrick Jung
    Department of Neurology, Johann Wolfgang Goethe University, Schleusenweg 2 16, D 60528 Frankfurt am Main, Germany
    J Neurol Sci 250:133-9. 2006
    ..Ziemann U. Differences of the ipsilateral silent period in small hand muscles. Muscle Nerve in press.], its diagnostic sensitivity in MS, about which conflicting results were reported in previous studies...
  52. doi request reprint A practical guide to diagnostic transcranial magnetic stimulation: report of an IFCN committee
    S Groppa
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    Clin Neurophysiol 123:858-82. 2012
    ..Additional sections cover safety issues, the triple stimulation technique, and neuropediatric aspects of TMS...
  53. doi request reprint Multimodal evoked potentials measure and predict disability progression in early relapsing-remitting multiple sclerosis
    P Jung
    Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Mult Scler 14:553-6. 2008
    ..39, p < 0.02). The data suggest that serial mEPS measure and moderately predict clinically relevant disease activity in the therapeutically most relevant early stage of RRMS...
  54. ncbi request reprint Mechanisms underlying human motor system plasticity
    B Boroojerdi
    Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5N 234, 10 Center Drive, MSC 1428, Bethesda, Maryland 20892-1428, USA
    Muscle Nerve 24:602-13. 2001
    ..In this review, we describe paradigms used to study mechanisms of plasticity in the intact human motor system, the functional relevance of such plasticity, and possible ways to modulate it...
  55. ncbi request reprint TMS-assisted neurophysiological profiling of the dopamine receptor agonist cabergoline in human motor cortex
    A Korchounov
    Motor Cortex Laboratory, Department of Neurology, Johann Wolfgang Goethe University of Frankfurt, Frankfurt am Main, Germany
    J Neural Transm 114:223-9. 2007
    ..This shift in the balance from excitation to inhibition may assist, by improving the 'signal-to-noise ratio' in motor cortex, in the positive modulating effect of cabergoline on practice-dependent plasticity...
  56. doi request reprint Interhemispheric motor inhibition: its role in controlling electromyographic mirror activity
    Annemarie Hübers
    Motor Cortex Group, Department of Neurology, Goethe University, D 60528 Frankfurt am Main, Germany
    Eur J Neurosci 28:364-71. 2008
    ..These results provide strong and consistent evidence that transcallosal inhibitory interhemispheric interaction provides a significant route by which unwanted MA during intended unimanual motor tasks can be controlled...
  57. ncbi request reprint Rapid modulation of GABA in sensorimotor cortex induced by acute deafferentation
    Lucien M Levy
    Neuroimaging Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, 5D20, Bethesda, MD 20892, USA
    Ann Neurol 52:755-61. 2002
    ..Reduction of brain GABA can play a pivotal role in regulating the extent of rapid cortical reorganization after lesions or changes in sensory input...
  58. pmc Transitions between dynamical states of differing stability in the human brain
    Andreas Meyer-Lindenberg
    Clinical Brain Disorders Branch, National Institute of Mental Health, and Human Cortical Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:10948-53. 2002
    ....
  59. ncbi request reprint Early consolidation in human primary motor cortex
    Wolf Muellbacher
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg 10, Rm 5N226, 10 Center Drive MSC 1428, Bethesda, Maryland 20892 1428, USA
    Nature 415:640-4. 2002
    ..These findings indicate that the human M1 is specifically engaged during the early stage of motor consolidation...
  60. doi request reprint Homeostatic and nonhomeostatic modulation of learning in human motor cortex
    Patrick Jung
    Department of Neurology, Goethe University Frankfurt, 60528 Frankfurt am Main, Germany
    J Neurosci 29:5597-604. 2009
    ..The present findings demonstrate that motor learning in humans can be modulated by noninvasive brain stimulation and suggest the possibility of enhancing motor relearning in defined neurological patients...
  61. ncbi request reprint The human motor corpus callosum
    Mathias Wahl
    Department of Neurology, Goethe University, Frankfurt am Main, Germany
    Rev Neurosci 19:451-66. 2008
    ..This review surveys current knowledge about the human motor CC, with a focus on recent studies which assessed the motor CC by multimodal advanced neurophysiological and neuroimaging techniques...
  62. ncbi request reprint Human motor corpus callosum: topography, somatotopy, and link between microstructure and function
    Mathias Wahl
    Department of Neurology, Johann Wolfgang Goethe University of Frankfurt, D 60528 Frankfurt am Main, Germany
    J Neurosci 27:12132-8. 2007
    ....
  63. pmc Inhibitory circuits and the nature of their interactions in the human motor cortex a pharmacological TMS study
    J Florian
    Motor Cortex Group, Department of Neurology, Johann Wolfgang Goethe University, Schleusenweg 2 16, D 60528 Frankfurt am Main, Germany
    J Physiol 586:495-514. 2008
    ..It will be argued that the negative interactions between SIHI and SICI, LICI and SIHI, and LICI and SICI are most likely due to presynaptic GABA B R-mediated autoinhibition...
  64. ncbi request reprint The role of GABA(B) receptors in intracortical inhibition in the human motor cortex
    Michelle N McDonnell
    Research Centre for Human Movement Control, The University of Adelaide, Adelaide, Australia
    Exp Brain Res 173:86-93. 2006
    ..The increase in LICI is likely to be a result of increased GABA(B) receptor mediated inhibitory post-synaptic potentials, while the reduction in SICI may relate to the activation of pre-synaptic GABA(B) receptors reducing GABA release...
  65. ncbi request reprint Exploring motor cortical plasticity using transcranial magnetic stimulation in humans
    Tihomir V Ilic
    Clinic of Neurology, Military Medical Academy, Belgrade, Serbia and Montenegro
    Ann N Y Acad Sci 1048:175-84. 2005
    ..Purposeful modulation of motor cortical plastic changes by manipulative TMS protocols may offer useful rehabilitative strategies in patients with chronic motor deficits...
  66. pmc Dissociated effects of diazepam and lorazepam on short-latency afferent inhibition
    Vincenzo Di Lazzaro
    Istituto di Neurologia, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
    J Physiol 569:315-23. 2005
    ..This dissociation suggests, for the first time, that TMS measures of cortical inhibition provide the opportunity to segregate differences of benzodiazepine action in human central nervous system circuits...
  67. ncbi request reprint Improving disability in stroke with RTMS
    Ulf Ziemann
    Lancet Neurol 4:454-5. 2005
  68. ncbi request reprint Separate ipsilateral and contralateral corticospinal projections in congenital mirror movements: Neurophysiological evidence and significance for motor rehabilitation
    Massimo Cincotta
    Unit of Neurology, Santa Maria Nuova Hospital, Florence, Italy
    Mov Disord 18:1294-300. 2003
    ..A marked reduction of MM was observed after training, suggesting that unwanted mirror activity in the ipsilateral pathway can be suppressed by learning...
  69. ncbi request reprint Functional connectivity between secondary and primary motor areas underlying hand-foot coordination
    Winston D Byblow
    Movement Neuroscience Laboratory, University of Auckland, Auckland, New Zealand
    J Neurophysiol 98:414-22. 2007
    ..These results may have implications for targeted neurorehabilitation after stroke...
  70. doi request reprint Homeostatic metaplasticity in the human somatosensory cortex
    Barbara Bliem
    Ruhr University Bochum, Germany
    J Cogn Neurosci 20:1517-28. 2008
    ..These interactions demonstrate that homeostatic metaplasticity operates in the human somatosensory cortex, controlling both cortical excitability and somatosensory skill...
  71. ncbi request reprint The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee
    Robert Chen
    Division of Neurology, Toronto Western Research Institute, University of Toronto, 7MC411, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ont, Canada M5T 2S8
    Clin Neurophysiol 119:504-32. 2008
    ..TMS measures have potential clinical utility in cerebellar disease, dementia, facial nerve disorders, movement disorders, stroke, epilepsy, migraine and chronic pain...
  72. ncbi request reprint Involvement of the human dorsal premotor cortex in unimanual motor control: an interference approach using transcranial magnetic stimulation
    Massimo Cincotta
    U O di Neurologia, Azienda Sanitaria di Firenze, Ospedale S Maria Nuova, Piazza S Maria Nuova, 1, 50122 Firenze, Italy
    Neurosci Lett 367:189-93. 2004
    ..Findings suggest that activity in the dPMC contributes to the suppression of mirror movements during intended unilateral movements...
  73. ncbi request reprint Cortical inhibition and excitation in abstinent cocaine-dependent patients: a transcranial magnetic stimulation study
    Karthik Sundaresan
    Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, USA
    Neuroreport 18:289-92. 2007
    ..Although the increase in long-interval intracortical facilitation suggests exaggerated cortical glutamatergic excitability, the increase in resting motor threshold may signify a protective mechanism against seizures and psychosis...
  74. ncbi request reprint Suppression of LTP-like plasticity in human motor cortex by the GABAB receptor agonist baclofen
    Michelle N McDonnell
    Research Centre for Human Movement Control, The University of Adelaide, Adelaide, Australia
    Exp Brain Res 180:181-6. 2007
    ..This suggests that increased GABAB mediated inhibitory postsynaptic potentials drive this effect, and that baclofen may have a negative impact on LTP-dependent behavioural processes such as motor learning...
  75. doi request reprint Deafferentation of neighbouring motor cortex areas does not further enhance saturated practice-dependent plasticity in healthy adults
    Michael Walther
    Department of Neuropediatrics and Muscle Disorders, University Children s Hospital, Freiburg, Germany
    Clin Neurophysiol 119:886-91. 2008
    ..To assess effects of deafferentation of the arm representation of primary motor cortex (M1) on practice-dependent plasticity in healthy adults...
  76. ncbi request reprint Myoclonus-dystonia syndrome: epsilon-sarcoglycan mutations and phenotype
    Friedrich Asmus
    Neurologische Klinik Grosshadern, Ludwig Maximilians Universitat, Munich, Germany
    Ann Neurol 52:489-92. 2002
    ..Six novel and one previously known heterozygous SGCE mutations were identified. SGCE deficiency seems to be the common pathogenetic mechanism in myoclonus-dystonia syndrome...
  77. ncbi request reprint TMS for ALS: why and why not
    Ulf Ziemann
    Clin Neurophysiol 115:1237-8. 2004
  78. pmc GABAA receptor subtype specific enhancement of inhibition in human motor cortex
    Vincenzo Di Lazzaro
    Istituto di Neurologia, Universita Cattolica, L go A Gemelli 8, 00168 Rome, Italy
    J Physiol 575:721-6. 2006
    ....
  79. ncbi request reprint Surface electromyography shows increased mirroring in Parkinson's disease patients without overt mirror movements
    Massimo Cincotta
    Unit of Neurology, Santa Maria Nuova Hospital, Florence, Italy
    Mov Disord 21:1461-5. 2006
    ..Our findings suggest that dysfunction of unimanual motor control is a general feature of PD. It is likely that this deficient movement lateralization contributes to an impairment of nonsymmetrical bimanual movements in PD...