S Zeuzem

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. doi request reprint Faldaprevir (BI 201335), deleobuvir (BI 207127) and ribavirin oral therapy for treatment-naive HCV genotype 1: SOUND-C1 final results
    Stefan Zeuzem
    JW Goethe University Hospital, Frankfurt am Main, Germany
    Antivir Ther 18:1015-9. 2013
  2. doi request reprint Simeprevir increases rate of sustained virologic response among treatment-experienced patients with HCV genotype-1 infection: a phase IIb trial
    Stefan Zeuzem
    JW Goethe University Hospital, Frankfurt, Germany Electronic address
    Gastroenterology 146:430-41.e6. 2014
  3. pmc Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study
    Bernd Kronenberger
    Medizinische Klinik 1, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    BMC Med 10:102. 2012
  4. doi request reprint Faldaprevir and deleobuvir for HCV genotype 1 infection
    Stefan Zeuzem
    Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, Germany
    N Engl J Med 369:630-9. 2013
  5. doi request reprint Optimized threshold for serum HCV RNA to predict treatment outcomes in hepatitis C patients receiving peginterferon alfa-2a/ribavirin
    S Zeuzem
    Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, Germany
    J Viral Hepat 19:766-74. 2012
  6. pmc Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers
    Johannes Vermehren
    Medizinische Klinik 1, Klinikum der J, W, Goethe Universitat, Frankfurt am Main, Germany
    BMC Gastroenterol 12:27. 2012
  7. pmc Long-term effects of treatment and response in patients with chronic hepatitis C on quality of life. An international, multicenter, randomized, controlled study
    Geert Bezemer
    Dpt, Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Gastroenterol 12:11. 2012
  8. doi request reprint The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin, or pegylated interferon plus ribavirin in hepatitis C
    Stefan Zeuzem
    University Hospital, JW Goethe University, Frankfurt, Germany
    Hepatology 55:749-58. 2012
  9. doi request reprint Telaprevir for the treatment of hepatitis C
    Nicole Forestier
    J W Goethe University Hospital, Department of Medicine, 1, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Expert Opin Pharmacother 13:593-606. 2012
  10. doi request reprint Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection
    Stefan Zeuzem
    J W Goethe University Hospital, Frankfurt, Germany
    Gastroenterology 141:2047-55; quiz e14. 2011

Collaborators

Detail Information

Publications146 found, 100 shown here

  1. doi request reprint Faldaprevir (BI 201335), deleobuvir (BI 207127) and ribavirin oral therapy for treatment-naive HCV genotype 1: SOUND-C1 final results
    Stefan Zeuzem
    JW Goethe University Hospital, Frankfurt am Main, Germany
    Antivir Ther 18:1015-9. 2013
    ..This article describes the final results of the Phase Ib SOUND-C1 study that evaluated the interferon-free oral combination of faldaprevir, deleobuvir and ribavirin in 32 treatment-naive patients infected with HCV genotype 1...
  2. doi request reprint Simeprevir increases rate of sustained virologic response among treatment-experienced patients with HCV genotype-1 infection: a phase IIb trial
    Stefan Zeuzem
    JW Goethe University Hospital, Frankfurt, Germany Electronic address
    Gastroenterology 146:430-41.e6. 2014
    ....
  3. pmc Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study
    Bernd Kronenberger
    Medizinische Klinik 1, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    BMC Med 10:102. 2012
    ..Systematic analysis of serum IL-22 in relation to morbidity and mortality of patients with advanced liver cirrhosis has not been performed so far...
  4. doi request reprint Faldaprevir and deleobuvir for HCV genotype 1 infection
    Stefan Zeuzem
    Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, Germany
    N Engl J Med 369:630-9. 2013
    ..Interferon-free regimens would be a major advance in the treatment of patients with chronic hepatitis C virus (HCV) infection...
  5. doi request reprint Optimized threshold for serum HCV RNA to predict treatment outcomes in hepatitis C patients receiving peginterferon alfa-2a/ribavirin
    S Zeuzem
    Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, Germany
    J Viral Hepat 19:766-74. 2012
    ..No threshold could be identified in HCV genotype 2 or 3 patients. A threshold HCV RNA level of 400,000 IU/mL is optimal for differentiating high and low probability of SVR in genotype 1-infected individuals with elevated ALT...
  6. pmc Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers
    Johannes Vermehren
    Medizinische Klinik 1, Klinikum der J, W, Goethe Universitat, Frankfurt am Main, Germany
    BMC Gastroenterol 12:27. 2012
    ..Our aim was to determine the prevalence of liver fibrosis and associated risk factors in HIV-infected individuals based on non-invasive fibrosis assessment using transient elastography (TE) and serum biomarkers (Fibrotest [FT])...
  7. pmc Long-term effects of treatment and response in patients with chronic hepatitis C on quality of life. An international, multicenter, randomized, controlled study
    Geert Bezemer
    Dpt, Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Gastroenterol 12:11. 2012
    ..HRQL improves after successful treatment. This trial explores the course of and factors associated with HRQL in patients given individualized or standard treatment based on early treatment response (Ditto-study)...
  8. doi request reprint The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin, or pegylated interferon plus ribavirin in hepatitis C
    Stefan Zeuzem
    University Hospital, JW Goethe University, Frankfurt, Germany
    Hepatology 55:749-58. 2012
    ..Transient elevations in serum bilirubin occurred in all treatment groups...
  9. doi request reprint Telaprevir for the treatment of hepatitis C
    Nicole Forestier
    J W Goethe University Hospital, Department of Medicine, 1, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Expert Opin Pharmacother 13:593-606. 2012
    ..With a better understanding of the HCV life-cycle, and of the structural features of HCV proteins, several promising direct antiviral drugs (DAAs) have entered clinical development...
  10. doi request reprint Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection
    Stefan Zeuzem
    J W Goethe University Hospital, Frankfurt, Germany
    Gastroenterology 141:2047-55; quiz e14. 2011
    ..We investigated the antiviral effect and safety of BI 201335 (an inhibitor of the NS3/4A protease) and BI 207127 (an inhibitor of the NS5B non-nucleoside polymerase) with ribavirin...
  11. pmc Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus
    Christoph Welsch
    Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, 66123 Saarbrucken, Germany
    Genome Biol 9:R16. 2008
    ..These mutations are located in the protein interior and far away from the ligand binding pocket...
  12. pmc HCV-related burden of disease in Europe: a systematic assessment of incidence, prevalence, morbidity, and mortality
    Nikolai Mühlberger
    Institute of Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, UMIT University of Health Sciences, Medical Informatics and Technology, Hall iT, Austria
    BMC Public Health 9:34. 2009
    ..We summarised burden of disease data presently available for Europe, compared the data to current expert estimates, and identified areas in which better data are needed...
  13. pmc Comparison of ELF, FibroTest and FibroScan for the non-invasive assessment of liver fibrosis
    Mireen Friedrich-Rust
    Department of Internal Medicine 1, JW Goethe University Hospital, Frankfurt, Germany
    BMC Gastroenterol 10:103. 2010
    ..While a systematic review has shown comparable results for both individual markers, there has been no direct comparison of both markers...
  14. ncbi request reprint A phase I/II study of recombinant human interleukin-12 in patients with chronic hepatitis C
    S Zeuzem
    Medizinische Klinik II, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Hepatology 29:1280-7. 1999
    ..In conclusion, antiviral activity of rHuIL-12 in patients with chronic hepatitis C does not appear advantageous in comparison with other currently available treatments...
  15. doi request reprint Pegylated-interferon plus ribavirin therapy in the treatment of CHC: individualization of treatment duration according to on-treatment virologic response
    Stefan Zeuzem
    Department of Medicine I, J W Goethe University Hospital, Frankfurt, Germany
    Curr Med Res Opin 26:1733-43. 2010
    ..However, recent studies have shown that on-treatment markers of virologic response can be used to tailor treatment duration according to each patient's response to therapy...
  16. doi request reprint Albinterferon alfa-2b dosed every two or four weeks in interferon-naïve patients with genotype 1 chronic hepatitis C
    Stefan Zeuzem
    JW Goethe University Hospital, Frankfurt, Germany
    Hepatology 48:407-17. 2008
    ..At week 12, mean treatment-associated missed workdays were significantly lower with alb-IFN 900 mug q2wk versus PEG-IFNalpha-2a (1.1 versus 4.3 days; P = 0.006)...
  17. ncbi request reprint Clinical implications of hepatitis C viral kinetics
    S Zeuzem
    Medizinische Klinik II, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt a M, Germany
    J Hepatol 31:61-4. 1999
    ....
  18. ncbi request reprint Peginterferon alfa-2a (40 kDa) monotherapy: a novel agent for chronic hepatitis C therapy
    S Zeuzem
    Medizinische Klinik II, Zentrum der Inneren Medizin, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt a M, Germany
    Expert Opin Investig Drugs 10:2201-13. 2001
    ..The advantages of PEG-IFN alfa-2a were also seen in patients with cirrhosis or hepatitis C virus (HCV) genotype 1...
  19. doi request reprint Albinterferon Alfa-2b was not inferior to pegylated interferon-α in a randomized trial of patients with chronic hepatitis C virus genotype 1
    Stefan Zeuzem
    JW Goethe University Hospital, Frankfurt, Germany
    Gastroenterology 139:1257-66. 2010
    ..We evaluated the efficacy/safety of albinterferon alfa-2b (albIFN), a novel, long-acting, genetic fusion polypeptide of albumin and IFNα-2b...
  20. ncbi request reprint [Pegylated interferon plus ribavirin in chronic hepatitis C. More than half of patients show a lasting response]
    S Zeuzem
    Medizinische Klinik II, Zentrum der Inneren Medizin, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt Main
    MMW Fortschr Med 144:30-4. 2002
    ..In the meantime, concrete treatment recommendations are available for every genetic type of HCV, for patients experiencing relapse, and for primary treatment failures...
  21. ncbi request reprint Randomized, double-blind, placebo-controlled trial of interferon alfa2a with and without amantadine as initial treatment for chronic hepatitis C
    S Zeuzem
    Medizinische Klinik II, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt a M, Germany
    Hepatology 32:835-41. 2000
    ..In conclusion, combination therapy IFN-alpha plus amantadine is as effective as IFN-alpha monotherapy in previously untreated patients with chronic hepatitis C...
  22. ncbi request reprint The kinetics of hepatitis C virus infection
    S Zeuzem
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Frankfurt a M, Germany
    Clin Liver Dis 5:917-30. 2001
    ..Nonresponding patients typically show constant viremia or even a rebound during this second phase...
  23. ncbi request reprint Peginterferon alfa-2a in patients with chronic hepatitis C
    S Zeuzem
    Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    N Engl J Med 343:1666-72. 2000
    ..We compared the clinical effects of a regimen of peginterferon alfa-2a with those of a regimen of interferon alfa-2a in the initial treatment of patients with chronic hepatitis C...
  24. pmc Expert opinion on the treatment of patients with chronic hepatitis C
    S Zeuzem
    Zentrum der Inneren Medizin, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    J Viral Hepat 16:75-90. 2009
    ....
  25. doi request reprint Interferon-based therapy for chronic hepatitis C: current and future perspectives
    Stefan Zeuzem
    Department of Medicine, JW Goethe University Hospital, Frankfurt, Germany
    Nat Clin Pract Gastroenterol Hepatol 5:610-22. 2008
    ..These compounds will be used, at least initially, in combination with peginterferon alpha plus ribavirin, extending the pivotal role of interferon-based therapy in the management of chronic hepatitis C...
  26. ncbi request reprint What is (cost) effective in patients with chronic hepatitis C virus infection?
    S Zeuzem
    Medizinische Klinik II, Zentrum der Inneren Medizin, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt aM, Germany
    Eur J Gastroenterol Hepatol 13:473-6. 2001
    ..g. by long-acting pegylated interferons), will have new impact on antiviral efficacy and cost effectiveness...
  27. ncbi request reprint Dynamic evolution of therapy for chronic hepatitis C: how will novel agents be incorporated into the standard of care?
    Stefan Zeuzem
    JW Goethe University Hospital, Frankfurt, Germany
    Antivir Ther 13:747-60. 2008
    ..The treatment paradigm for chronic hepatitis C continues to evolve and will eventually incorporate new drugs as they are approved...
  28. doi request reprint Telaprevir for retreatment of HCV infection
    Stefan Zeuzem
    Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, Germany
    N Engl J Med 364:2417-28. 2011
    ..Up to 60% of patients with hepatitis C virus (HCV) genotype 1 infection do not have a sustained virologic response to therapy with peginterferon alfa plus ribavirin...
  29. ncbi request reprint Gut-liver axis
    S Zeuzem
    Medizinische Klinik II, Zentrum der Inneren Medizin, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt a M, Germany
    Int J Colorectal Dis 15:59-82. 2000
    ..Furthermore, the liver is the primary organ for metastasis of intestinal cancer. Many viral, bacterial, fungal, and parasitic diseases affect the intestine as well as the liver and the biliary tract...
  30. ncbi request reprint Interleukin-12 in the treatment of chronic hepatitis B and C
    S Zeuzem
    Medizinische Klinik II, Zentrum der Inneren Medizin, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Antiviral Res 52:181-8. 2001
    ..5 microg/kg dose group. In conclusion, antiviral activity of rHuIL-12 in patients with chronic hepatitis B or C does not appear to be advantageous in comparison to other currently available treatments...
  31. doi request reprint Baseline characteristics and early on-treatment response predict the outcomes of 2 years of telbivudine treatment of chronic hepatitis B
    Stefan Zeuzem
    Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt a Main, Germany
    J Hepatol 51:11-20. 2009
    ..In the GLOBE trial, telbivudine treatment was identified as a significant, independent predictor of better outcomes at 2 years. We analyzed all telbivudine recipients in this trial to determine the predictors of optimal outcomes...
  32. doi request reprint Effect of ribavirin on the frequency of RNase L cleavage sites within the hepatitis C viral genome
    U Mihm
    Medizinische Klinik I, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt Main, Germany
    J Viral Hepat 17:217-21. 2010
    ..In conclusion, Ribavirin-induced mutagenesis did not increase RNase L cleavage sites (UU/UA dinucleotides) within the HCV NS3 or NS5B encoding regions...
  33. doi request reprint Serum microRNA-122 kinetics in patients with chronic hepatitis C virus infection during antiviral therapy
    V Köberle
    Department of Medicine I, University of Frankfurt M, Frankfurt, Germany
    J Viral Hepat 20:530-5. 2013
    ..We conclude that the serum level of miR-122 well reflects the success of interferon/ribavirin therapy in patients with chronic HCV infection...
  34. doi request reprint Dynamics of hepatitis B virus quasispecies heterogeneity and virologic response in patients receiving low-to-moderate genetic barrier nucleoside analogs
    J Peveling-Oberhag
    Department of Internal Medicine 1, J W Goethe University Hospital, Frankfurt, Germany
    J Viral Hepat 20:234-9. 2013
    ..Further studies are needed to confirm HBV quasispecies evolution as additional predictive marker for beneficial treatment outcome...
  35. ncbi request reprint Randomized, placebo-controlled, double-blind trial with interferon-alpha with and without amantadine sulphate in primary interferon-alpha nonresponders with chronic hepatitis C
    G Teuber
    Medizinische Klinik II, , Frankfurt, Germany
    J Viral Hepat 8:276-83. 2001
    ....
  36. ncbi request reprint Bethesda guidelines: relation to microsatellite instability and MLH1 promoter methylation in patients with colorectal cancer
    J Raedle
    Second Department of Internal Medicine, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Ann Intern Med 135:566-76. 2001
    ..The Bethesda guidelines were established to identify patients with colorectal cancer who should be tested for microsatellite instability...
  37. ncbi request reprint Viral kinetics in patients with chronic hepatitis C treated with standard or peginterferon alpha2a
    S Zeuzem
    Medizinische Klinik II, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Gastroenterology 120:1438-47. 2001
    ..The aim of the study was to compare viral kinetics in patients treated with standard or peginterferon alpha2a...
  38. doi request reprint Mutations selected in the hepatitis C virus NS3 protease domain during sequential treatment with boceprevir with and without pegylated interferon alfa-2b
    J Vermehren
    Medizinische Klinik 1, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    J Viral Hepat 19:120-7. 2012
    ..Sequential short-term dosing of boceprevir was not associated with accumulation of resistant variants but pre-existing variants may impair virologic response...
  39. doi request reprint Comparison of envelope 2 CD81 binding regions in PBMC-derived versus serum-derived hepatitis C virus isolates: higher conservation of CD81 region 2 in PBMC isolates
    M W Welker
    Klinikum der Johann Wolfgang Goethe Universitat, Medizinische Klinik 1, Frankfurt am Main, Germany
    J Viral Hepat 18:181-92. 2011
    ..026). CD81 expression on PBMC was not correlated with the number of mutations within the CD81 binding regions...
  40. doi request reprint Prospective study of bone mineral density and metabolism in patients with chronic hepatitis C during pegylated interferon alpha and ribavirin therapy
    W P Hofmann
    Department of Internal Medicine I, Johann Wolfgang Goethe University Hospital, Frankfurt, Germany
    J Viral Hepat 15:790-6. 2008
    ..Antiviral therapy leads to an on-treatment increase of BMD, which may last in those patients who achieve a sustained virological response...
  41. doi request reprint Modulation of replication efficacy of the hepatitis C virus replicon Con1 by site-directed mutagenesis of an NS4B aminoterminal basic leucine zipper
    M W Welker
    Klinikum der Johann Wolfgang Goethe Universitat, Medizinische Klinik, Theodor Stern Kai, Frankfurt am Main, Germany
    J Viral Hepat 19:775-83. 2012
    ..RNA replication efficacy can be modulated by site-directed mutagenesis at specific bZIP functional sites. New adaptive amino acid mutations were identified within the HCV NS4B protein...
  42. ncbi request reprint Efficacy and safety of sorafenib in advanced hepatocellular carcinoma under daily practice conditions
    M W Welker
    Medizinische Klinik1, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Chemother 22:205-11. 2010
    ..In conclusion, in daily practice sorafenib is safe and disease stabilization can be achieved in the majority of patients. However, intolerance to sorafenib can affect treatment adherence substantially...
  43. ncbi request reprint Quasispecies heterogeneity of the carboxy-terminal part of the E2 gene including the PePHD and sensitivity of hepatitis C virus 1b isolates to antiviral therapy
    C Sarrazin
    Medizinische Klinik II, , Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany
    Virology 289:150-63. 2001
    ....
  44. doi request reprint Thyroid function and changes in ultrasound morphology during antiviral therapy with pegylated interferon and ribavirin in patients with chronic hepatitis C
    M Friedrich-Rust
    Department of Internal Medicine, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany
    J Viral Hepat 16:168-77. 2009
    ....
  45. ncbi request reprint Interferon alfa down-regulates CD81 in patients with chronic hepatitis C
    B Kronenberger
    Medizinische Klinik II, , , Frankfurt am Main, Frankfurt am Main, Germany
    Hepatology 33:1518-26. 2001
    ..5 vs. 139.8 +/- 27.5 RFU; P =.057). In conclusion, IFN-alpha and ribavirin regulate CD81 expression in vitro and in vivo. CD81 expression correlates with HCV genotype and initial virologic response in patients with chronic hepatitis C...
  46. doi request reprint Real-time tissue elastography versus FibroScan for noninvasive assessment of liver fibrosis in chronic liver disease
    M Friedrich-Rust
    Department of Internal Medicine 1, J W Goethe University Hospital, Frankfurt, Germany
    Ultraschall Med 30:478-84. 2009
    ..The aim of the present study was to validate real-time elastography using the formulas calculated in previous studies and to compare the results to transient elastography and FibroTest for the noninvasive assessment of liver fibrosis...
  47. pmc Assessment, by transcription-mediated amplification, of virologic response in patients with chronic hepatitis C virus treated with peginterferon alpha-2a
    C Sarrazin
    Medizinische Klinik II, , 60590 Frankfurt am Main, Germany
    J Clin Microbiol 39:2850-5. 2001
    ....
  48. ncbi request reprint Randomized, controlled trial with IFN-alpha combined with ribavirin with and without amantadine sulphate in non-responders with chronic hepatitis C
    Gerlinde Teuber
    Medizinische Klinik II, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt M, Germany
    J Hepatol 39:606-13. 2003
    ..Efficacy and safety of interferon-alpha (IFN-alpha)/ribavirin retreatment with or without amantadine sulphate were evaluated in non-responders with chronic hepatitis C...
  49. doi request reprint Impact of ribavirin priming on viral kinetics and treatment response in chronic hepatitis C genotype 1 infection
    U Mihm
    Medizinische Klinik I, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt Main, Germany
    J Viral Hepat 21:42-52. 2014
    ..Ribavirin priming prior to PEG-IFN2a/ribavirin combination therapy did neither increase the first- or second-phase viral decline nor on-treatment response or SVR. ..
  50. doi request reprint New developments in HCV therapy
    B Kronenberger
    Department of Internal Medicine 1, Hospital of the Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Viral Hepat 19:48-51. 2012
    ..Several studies have been initiated that combine different novel therapies, with and without interferon α/ribavirin...
  51. ncbi request reprint Peri-hepatic lymphadenopathy in primary biliary cirrhosis reflects progression of the disease
    C F Dietrich
    Medizinische Klinik II, Johann Wolfgang Goethe Universitat, Germany
    Eur J Gastroenterol Hepatol 11:747-53. 1999
    ..We prospectively investigated the peri-hepatic lymph node volume in patients with primary biliary cirrhosis (PBC) and healthy controls to evaluate the correlation with histology, biochemical and immunological features...
  52. ncbi request reprint Characterization of the nuclear import of human MutLalpha
    A Brieger
    Medizinische Klinik I, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt a M, Germany
    Mol Carcinog 43:51-8. 2005
    ....
  53. doi request reprint Acoustic radiation force impulse imaging for non-invasive assessment of liver fibrosis in chronic hepatitis B
    M Friedrich-Rust
    Department of Internal Medicine 1, J W Goethe University Hospital, Frankfurt, Germany
    J Viral Hepat 20:240-7. 2013
    ..No significant difference was found between ARFI and transient elastography. ARFI imaging is a reliable ultrasound-based method for the assessment of advanced stages of liver fibrosis in chronic hepatitis B...
  54. doi request reprint Serum microRNA-122 levels in different groups of patients with chronic hepatitis B virus infection
    O Waidmann
    Medizinische Klinik 1, Schwerpunkt Gastroenterologie und Hepatologie, Klinikum der Goethe Universität, Frankfurt Main, Germany
    J Viral Hepat 19:e58-65. 2012
    ..Furthermore, serum miR-122 levels discriminated HBV carrier patients with high or low risk for disease progression and may, thus, be an additional marker for risk stratification...
  55. doi request reprint Review article: specifically targeted anti-viral therapy for hepatitis C - a new era in therapy
    C M Lange
    Department of Medicine, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Aliment Pharmacol Ther 32:14-28. 2010
    ..Novel, directly acting anti-viral agents, also named 'specifically targeted anti-viral therapy for hepatitis C' (STAT-C) compounds, are currently under development...
  56. ncbi request reprint Limited value of fluorine-18-fluorodeoxyglucose PET for the differential diagnosis of focal liver lesions in patients with chronic hepatitis C virus infection
    O Schroder
    Department of Nuclear Medicine, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Nuklearmedizin 37:279-85. 1998
    ..The differentiation of HCC from liver metastasis or benign disorders by imaging studies based upon morphological aspects may be difficult...
  57. ncbi request reprint Comparative sequence analysis of the core- and NS5-region of hepatitis C virus from tumor and adjacent non-tumor tissue
    B Ruster
    Medizinische Klinik II, Klinikum der Johann Wolfgang Goethe Universitat, D 60590 Frankfurt a M, Germany
    J Med Virol 63:128-34. 2001
    ..These observations might have important implications on the pathology of HCV, especially its potential tumorigenicity...
  58. doi request reprint Dysregulation of global microRNA expression in splenic marginal zone lymphoma and influence of chronic hepatitis C virus infection
    J Peveling-Oberhag
    Department of Internal Medicine 1, J W Goethe University Hospital, Frankfurt, Germany
    Leukemia 26:1654-62. 2012
    ..0016). In conclusion, there is a characteristic dysregulation of miRNA expression in SMZL with a possible implication in its molecular tumorigenesis...
  59. doi request reprint MUTYH hotspot mutations in unselected colonoscopy patients
    M Casper
    Department of Medicine II, Saarland University Medical Centre, Homburg, Germany
    Colorectal Dis 14:e238-44. 2012
    ..Y179C and p.G396D account for the majority of pathogenic variants of MUTYH in Caucasians. Our aim was to evaluate the prevalence of MUTYH mutations in a prospective cohort of unselected patients with different colorectal diseases...
  60. ncbi request reprint [44-year-old patient with fulminant liver failure]
    A Kerber
    Medizinische Klinik II, Zentrum der Inneren Medizin, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt
    Internist (Berl) 44:1301-7. 2003
    ..The case represents the yet oldest patient reported with an acute manifestation of Wilson's disease...
  61. ncbi request reprint Activation of a cryptic splice site of PTEN and loss of heterozygosity in benign skin lesions in Cowden disease
    J Trojan
    Second Department of Medicine, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Invest Dermatol 117:1650-3. 2001
    ..In conclusion, our data demonstrate that a PTEN splicing site mutation causes activation of a cryptic splice site, which results in aberrant transcripts...
  62. ncbi request reprint [Hypertransaminasaemia and impaired liver function in a patient with oligosymptomatic celiac disease]
    W P Hofmann
    Medizinische Klinik II, , Frankfurt/Main, Germany
    Z Gastroenterol 39:1027-32. 2001
    ..Serum aminotransferase levels normalized within 6 months. The clinical course demonstrates involvement of the liver in patients with celiac disease...
  63. ncbi request reprint 13C-methacetin breath test as liver function test in patients with chronic hepatitis C virus infection
    B Braden
    Medical Department II, University Hospital, Frankfurt Main, Germany
    Aliment Pharmacol Ther 21:179-85. 2005
    ..The 13C-methacetin breath test enables the quantitative evaluation of the cytochrome P450-dependent liver function...
  64. doi request reprint Clinical relevance of HCV antiviral drug resistance
    C Welsch
    J W Goethe University Hospital, Department of Internal Medicine I, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Curr Opin Virol 2:651-5. 2012
    ..Knowledge on molecular escape mechanisms of resistant variants, their time to wild-type reversal and potential persistence is of upmost importance to design treatment strategies for patients with previous DAA-treatment failure...
  65. doi request reprint Peroral cholangioscopy for diagnosis and therapy of biliary tract disease using an ultra-slim gastroscope
    J G Albert
    Department of Medicine I, Johann Wolfgang Goethe University Hospital, Frankfurt, Germany
    Endoscopy 43:1004-9. 2011
    ..This technique should only be performed using CO2 insufflation...
  66. doi request reprint Performance of Acoustic Radiation Force Impulse imaging for the staging of liver fibrosis: a pooled meta-analysis
    M Friedrich-Rust
    Department of Internal Medicine 1, JW Goethe University Hospital, Frankfurt, Germany
    J Viral Hepat 19:e212-9. 2012
    ..91 for the diagnosis of severe fibrosis (F ≥ 3), and 0.93 for the diagnosis of cirrhosis. ARFI can be performed with good diagnostic accuracy for the noninvasive staging of liver fibrosis...
  67. ncbi request reprint TH1/TH2 serum cytokine profiles and soluble TNF-receptor response in patients with chronic hepatitis C during recombinant human interleukin-12 (rHuIL-12) treatment
    G Teuber
    Medizinische Klinik II, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Z Gastroenterol 40:487-95. 2002
    ..This may offer an explanation for the unsatisfactory clinical efficiency of the substance...
  68. doi request reprint [Prevention and therapy of reactivation of hepatitis B in immunosuppressed patients]
    M von Wagner
    Medizinische Klinik I, Johann Wolfgang Goethe Universitat Frankfurt, Frankfurt a M, Germany
    Dtsch Med Wochenschr 134:255-8. 2009
    ..In case of bone marrow transplantation prophylaxis with nucleos(t)idanalogue has to be initiated before onset of treatment if anti-HBc is detectable, independent from HBsAg result...
  69. ncbi request reprint Hepatitis C viral kinetic models
    E Herrmann
    Department of Medicine, Saarland University Hospital, Germany
    Cell Death Differ 10:S7-8. 2003
  70. doi request reprint [Prediction of perioperative mortality in patients with advanced liver disease and abdominal surgery by the use of different scoring systems and tests]
    W P Hofmann
    Medizinische Klinik 1, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main
    Z Gastroenterol 46:1283-9. 2008
    ..Besides other dynamic tests, the indocyanine green (ICG) clearance and the monoethylglycinxylid (MEGX) clearance tests have been satisfactorily evaluated...
  71. ncbi request reprint [Clinical aspects of liver cirrhoses and its complications and diagnostic problems]
    M Huber
    Medizinische Klinik II, Zentrum der Inneren Medizin, , Theodor-Stern-Kai 7, 60590 Frankfurt
    Radiologe 41:840-51. 2001
    ..Therapeutic management should mainly focus on the treatment of the underlying chronic liver disease in a precirrhotic stage. In the case of cirrhosis, prevention and treatment of complications are clinically most important...
  72. ncbi request reprint A de novo deletion of chromosome 5q causing familial adenomatous polyposis, dysmorphic features, and mild mental retardation
    J Raedle
    2nd Department of Internal Medicine and Institute of Human Genetics, University of Frankfurt/Main, Frankfurt am Main, Germany
    Am J Gastroenterol 96:3016-20. 2001
    ..If the deletion encompasses the APC gene, these patients are at high risk of developing FAP and associated complications...
  73. ncbi request reprint Pertussis toxin inhibits cholecystokinin- and epidermal growth factor-induced mitogen-activated protein kinase activation by disinhibition of the cAMP signaling pathway and inhibition of c-Raf-1
    A Piiper
    Department of Internal Medicine, Johann Wolfgang Goethe University, Frankfurt, Germany
    Mol Pharmacol 58:608-13. 2000
    ....
  74. ncbi request reprint Subcellular distribution and function of Rab3A-D in pancreatic acinar AR42J cells
    A Piiper
    Department of Medicine II, University of Frankfurt Main, Frankfurt, 60590, Germany
    Biochem Biophys Res Commun 287:746-51. 2001
    ..In conclusion, our data indicate that the different Rab3 proteins show distinct subcellular distribution, suggesting different impact on exocrine secretory response in dexamethasone-differentiated AR42J cells...
  75. ncbi request reprint [Diagnostic imaging in liver cirrhosis]
    R M Hammerstingl
    Institut für Diagnostische und Interventionelle Radiologie, Johann Wolfgang Goethe Universitat, ZRAD Haus 23 A, Theodor Stern Kai 7, 60590 Frankfurt am Main
    Radiologe 41:852-67. 2001
    ..This technique is the optimal protocol for diagnostic imaging in patients suffering from liver cirrhosis and the method of choice to reach the final diagnosis...
  76. ncbi request reprint Frequency of the Amsterdam criteria in a regional German cohort of patients with colorectal cancer
    J Raedle
    Medizinische Klinik II, Klinikum der J W Goethe Universitat, Frankfurt Main, Germany
    Z Gastroenterol 40:561-8. 2002
    ..However, the final diagnosis of HNPCC can only be established by detection of pathogenic germline mutations within the DNA mismatch repair genes...
  77. ncbi request reprint [Transarterial chemoembolization (TACE) in hepatocellular carcinoma: technique, indication and results]
    T J Vogl
    Institut für Diagnostische und Interventionelle Radiologie, J W Goethe Universitat, Frankfurt
    Rofo 179:1113-26. 2007
    ..The symptomatic therapy option of TACE is used to counteract pain directly caused by HCC and acute/subacute bleeding in the HCC. The local tumor response reaches up to 88% and the bleeding control is from 83 to 100%...
  78. ncbi request reprint Nodular regenerative hyperplasia of the liver: a rare differential diagnosis of cholestasis with response to ursodeoxycholic acid
    D Faust
    2nd Department of Internal Medicine and Gastroenterology, Johann Wolfgang Goethe University, Frankfurt, Germany
    Z Gastroenterol 41:255-8. 2003
    ..Based on this case, it may be concluded that treatment with ursodeoxycholic acid might be beneficial in patients with NRHL and progression to liver insufficiency...
  79. doi request reprint Real-time elastography and contrast-enhanced ultrasound for the assessment of thyroid nodules
    M Friedrich-Rust
    Department of Internal Medicine 1, JW Goethe University Hospital, Frankfurt, Germany
    Exp Clin Endocrinol Diabetes 118:602-9. 2010
    ..The aim of the present study was to evaluate real-time elastography (RTE) and contrast-enhanced ultrasound with Sonovue (CEUS) for the differentiation of benign and malignant thyroid nodules...
  80. ncbi request reprint Severity of HCV-induced liver damage alters glucose homeostasis in noncirrhotic patients with chronic HCV infection
    T Konrad
    Department of Internal Medicine and ndash I, Research Group for Clinical Physiology and Transplantation Physiology, J W Goethe University, Frankfurt a M, Germany
    Digestion 62:52-9. 2000
    ....
  81. ncbi request reprint [Transient elastography (FibroScan) for the non-invasive assessment of liver fibrosis: current status and perspectives]
    M Friedrich-Rust
    Medizinische Klinik I, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main
    Z Gastroenterol 45:387-94. 2007
    ..In addition, several studies have shown, that the FibroScan can be applied to estimate the risk of complications associated with liver cirrhosis...
  82. ncbi request reprint Involvement of the platelet-derived growth factor receptor in angiotensin II-induced activation of extracellular regulated kinases 1 and 2 in human mesangial cells
    U F Mondorf
    Department of Medicine, Division of Nephrology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    FEBS Lett 472:129-32. 2000
    ..In conclusion, our data show that Ang II-induced activation of mitogenic signalling cascade in human mesangial cells involves ligand-independent activation of the PDGFR, but not of the coexpressed EGFR...
  83. pmc Transient mismatch repair gene transfection for functional analysis of genetic hMLH1 and hMSH2 variants
    A Brieger
    Medizinische Klinik II, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Gut 51:677-84. 2002
    ..Germline mutations in the mismatch repair (MMR) genes hMLH1 and hMSH2 can cause hereditary non-polyposis colorectal cancer (HNPCC). However, the functional in vitro analysis of hMLH1 and hMSH2 mutations remains difficult...
  84. doi request reprint Female patients suffering from inflammatory bowel diseases are treated less frequently with immunosuppressive medication and have a higher disease activity: a subgroup analysis of a large multi-centre, prospective, internet-based study
    I Blumenstein
    First Department of Internal Medicine, Division of Gastroenterology, Goethe University Hospital, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    J Crohns Colitis 5:203-10. 2011
    ..The aim of the present study was to evaluate gender-related differences in the treatment of a distinct IBD patient population treated in the Rhein-Main region, Germany...
  85. doi request reprint [Magnetic resonance cholangiopancreatography (MRCP) from a radiological and gastroenterological perspective]
    T J Vogl
    Institut für Diagnostische und Interventionelle Radiologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main
    Dtsch Med Wochenschr 134:1011-4. 2009
    ..MRCP is integrated in the preinterventional concept for performing invasive endoscopic retrograde cholangiopancreatography (ERCP) and for follow-up post intervention and for diagnosing complications...
  86. pmc Thymostimulin versus placebo for palliative treatment of locally advanced or metastasised hepatocellular carcinoma: a phase III clinical trial
    Matthias M Dollinger
    Department of Medicine I, Martin Luther University Halle Wittenberg, Germany
    BMC Cancer 10:457. 2010
    ..The aim of this study was to assess the efficacy of thymostimulin in a phase III trial...
  87. ncbi request reprint Expression and release of IL-18 binding protein in response to IFN-gamma
    J Paulukat
    Pharmazentrum Frankfurt and Second Department of Medicine, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Immunol 167:7038-43. 2001
    ..Down-regulation of IL-18BPa by sodium butyrate suggests that reinforcement of local IL-18 activity may contribute to actions of this short-chain fatty acid in the colonic microenvironment...
  88. ncbi request reprint Patterns of viral decline during PEG-interferon alpha-2b therapy in HBeAg-positive chronic hepatitis B: relation to treatment response
    Martijn J ter Borg
    Department of Gastroenterology and Hepatology, Erasmus Medical Center Rotterdam, The Netherlands
    Hepatology 44:721-7. 2006
    ..Since there was a considerable response, even in patients with a late or posttreatment decline pattern, prediction of response based on viral decline during the first months of therapy was difficult...
  89. ncbi request reprint Triple therapy with amantadine in treatment-naive patients with chronic hepatitis C: a placebo-controlled trial
    Thomas Berg
    Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
    Hepatology 37:1359-67. 2003
    ....
  90. ncbi request reprint Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system
    Joerg Trojan
    Second Department of Medicine, Johann Wolfgang Goethe University, Frankfurt a M, Germany
    Gastroenterology 122:211-9. 2002
    ..To date, functional analysis of missense mutations has been performed primarily in Saccharomyces cerevisiae. The aim of this study was to examine the biochemical properties of hMLH1 protein variants in a human expression system...
  91. ncbi request reprint Mycophenolate mofetil in combination with recombinant interferon alfa-2a in interferon-nonresponder patients with chronic hepatitis C
    Markus Cornberg
    Department of Gastroenterology, Hepatology, and Endocrinology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Hepatol 37:843-7. 2002
    ..The present study is a pilot study evaluating the efficacy and safety of combination therapy with interferon alfa-2a and MMF in interferon alfa nonresponder patients...
  92. ncbi request reprint Twelve weeks of follow-up is sufficient for the determination of sustained virologic response in patients treated with interferon alpha for chronic hepatitis C
    Stefan Zeuzem
    Klinik fur Innere Medizin II, Universitatskliniken des Saarlandes, 66421 Homburg Saar, Germany
    J Hepatol 39:106-11. 2003
    ..Sensitive molecular tests may permit earlier determination of sustained virologic response following the completion of therapy in end-of-treatment responders...
  93. ncbi request reprint Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C
    Thierry Poynard
    Service d Hepato Gastroenterologie, Groupe Hospitalier Pitie Salpetriere, Universite Paris VI, Paris, France
    Hepatology 38:75-85. 2003
    ..In conclusion, sustained disappearance of the virus is associated with reduction of steatosis in genotype 3 as well as a correction of baseline low serum cholesterol...
  94. ncbi request reprint Relationship between early HCV kinetics and T-cell reactivity in chronic hepatitis C genotype 1 during peginterferon and ribavirin therapy
    Kwok H Tang
    Institute of Hepatology, University College London, 69 75 Chenies Mews, London WC1E 6HX, UK
    J Hepatol 43:776-82. 2005
    ..To gain understanding of inter-individual differences of treatment response in hepatitis C virus genotype 1 (HCV-G1) patients, we investigated simultaneously the early HCV kinetics and virus-specific T-cell reactivity...
  95. ncbi request reprint Effect of ribavirin on hepatitis C viral kinetics in patients treated with pegylated interferon
    Eva Herrmann
    Medizinische Klinik und Poliklinik, Innere Medizin II, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Hepatology 37:1351-8. 2003
    ..This finding suggests that combination treatment leads to a better restoration of the patient's immune response...
  96. ncbi request reprint HCV-specific T-cell response in relation to viral kinetics and treatment outcome (DITTO-HCV project)
    Massimo Pilli
    Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Gastroenterology 133:1132-43. 2007
    ....
  97. ncbi request reprint Prognostic factors and early predictability of sustained viral response with peginterferon alfa-2a (40KD)
    Samuel S Lee
    Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    J Hepatol 37:500-6. 2002
    ..We evaluated the prognostic value of baseline factors and early viral RNA among patients treated with peginterferon alfa-2a (40KD)...
  98. ncbi request reprint Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells
    Albrecht Piiper
    Department of Internal Medicine and Institute for Biochemistry II, Johann Wolfgang Goethe University, D 60590 Frankfurt, Germany
    J Biol Chem 277:43623-30. 2002
    ....
  99. ncbi request reprint Peginterferon alpha-2a (40kD) [Pegasys] improves HR-QOL outcomes compared with unmodified interferon alpha-2a [Roferon-A]: in patients with chronic hepatitis C
    Jens Rasenack
    Klinikum der Albert Ludwigs Universität, Freiburg, Germany
    Pharmacoeconomics 21:341-9. 2003
    ..Treatment with peginterferon alpha-2a (40kD) provides an improved sustained response over unmodified interferon alpha-2a...
  100. ncbi request reprint Prediction of treatment outcome in patients with chronic hepatitis C: significance of baseline parameters and viral dynamics during therapy
    Thomas Berg
    Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
    Hepatology 37:600-9. 2003
    ..This algorithm recognizes 53.7% of nonresponders previously identified at week 24 of treatment...
  101. ncbi request reprint Protein kinase A mediates cAMP-induced tyrosine phosphorylation of the epidermal growth factor receptor
    Albrecht Piiper
    Department of Internal Medicine, University of Saarland, D 66421, Homburg Saar, Germany
    Biochem Biophys Res Commun 301:848-54. 2003
    ..While PKA may directly phosphorylate the EGFR on serine residues, PKA-induced tyrosine phosphorylation of the EGFR occurs by an indirect mechanism...