K Willenbrock

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. pmc Analysis of T-cell subpopulations in T-cell non-Hodgkin's lymphoma of angioimmunoblastic lymphadenopathy with dysproteinemia type by single target gene amplification of T cell receptor- beta gene rearrangements
    K Willenbrock
    Senckenberg Institute of Pathology, University of Frankfurt, Frankfurt am Main, Germany
    Am J Pathol 158:1851-7. 2001
  2. ncbi request reprint Frequent occurrence of B-cell lymphomas in angioimmunoblastic T-cell lymphoma and proliferation of Epstein-Barr virus-infected cells in early cases
    Klaus Willenbrock
    Senckenbergisches Institut für Pathologie, Klinikum der Johann Wolfgang Goethe Universität Frankfurt am Main, Frankfurt am Main, Germany
    Br J Haematol 138:733-9. 2007
  3. ncbi request reprint Common features and differences in the transcriptome of large cell anaplastic lymphoma and classical Hodgkin's lymphoma
    Klaus Willenbrock
    Senckenbergisches Institut für Pathologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Haematologica 91:596-604. 2006
  4. ncbi request reprint Nodular lymphoid lesion of the liver with simultaneous focal nodular hyperplasia and hemangioma: discrimination from primary hepatic MALT-type non-Hodgkin's lymphoma
    Klaus Willenbrock
    Senckenbergisches Institut für Pathologie, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Virchows Arch 448:223-7. 2006
  5. ncbi request reprint In angioimmunoblastic T-cell lymphoma, neoplastic T cells may be a minor cell population. A molecular single-cell and immunohistochemical study
    Klaus Willenbrock
    Senckenbergisches Institut für Pathologie, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Virchows Arch 446:15-20. 2005
  6. ncbi request reprint T-cell variant of classical Hodgkin's lymphoma with nodal and cutaneous manifestations demonstrated by single-cell polymerase chain reaction
    Klaus Willenbrock
    Senckenberg Institute of Pathology, University of Frankfurt, Frankfurt am Main, Germany
    Lab Invest 82:1103-9. 2002
  7. pmc Survival and clonal expansion of mutating "forbidden" (immunoglobulin receptor-deficient) epstein-barr virus-infected b cells in angioimmunoblastic t cell lymphoma
    A Bräuninger
    Department of Pathology, University of Frankfurt, 60590 Frankfurt, Germany
    J Exp Med 194:927-40. 2001
  8. doi request reprint Gene expression profiling of isolated tumour cells from anaplastic large cell lymphomas: insights into its cellular origin, pathogenesis and relation to Hodgkin lymphoma
    S Eckerle
    Senckenberg Institute for Pathology, University of Frankfurt, Medical School, Frankfurt Main, Germany
    Leukemia 23:2129-38. 2009
  9. ncbi request reprint High expression of several tyrosine kinases and activation of the PI3K/AKT pathway in mediastinal large B cell lymphoma reveals further similarities to Hodgkin lymphoma
    C Renne
    Senckenberg Institute for Pathology, University of Frankfurt, Frankfurt, Germany
    Leukemia 21:780-7. 2007
  10. ncbi request reprint [Villous adenoma of the renal pelvis and ureter]
    H Frickmann
    Urologische Klinik, St Elisabethen Krankenhaus, Frankfurt M
    Urologe A 45:1435-7. 2006

Collaborators

Detail Information

Publications17

  1. pmc Analysis of T-cell subpopulations in T-cell non-Hodgkin's lymphoma of angioimmunoblastic lymphadenopathy with dysproteinemia type by single target gene amplification of T cell receptor- beta gene rearrangements
    K Willenbrock
    Senckenberg Institute of Pathology, University of Frankfurt, Frankfurt am Main, Germany
    Am J Pathol 158:1851-7. 2001
    ..T-cell clones in 4 of 10 cases were found to express similar TCRbeta chains, indicating a potential role of (super) antigen triggering in at least some cases of AILD...
  2. ncbi request reprint Frequent occurrence of B-cell lymphomas in angioimmunoblastic T-cell lymphoma and proliferation of Epstein-Barr virus-infected cells in early cases
    Klaus Willenbrock
    Senckenbergisches Institut für Pathologie, Klinikum der Johann Wolfgang Goethe Universität Frankfurt am Main, Frankfurt am Main, Germany
    Br J Haematol 138:733-9. 2007
    ..This might be relevant in the development of secondary lymphomas...
  3. ncbi request reprint Common features and differences in the transcriptome of large cell anaplastic lymphoma and classical Hodgkin's lymphoma
    Klaus Willenbrock
    Senckenbergisches Institut für Pathologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Haematologica 91:596-604. 2006
    ..However, both lymphomas share a similar cytological and immunohistochemical tumor cell phenotype with little resemblance to their cells of origin...
  4. ncbi request reprint Nodular lymphoid lesion of the liver with simultaneous focal nodular hyperplasia and hemangioma: discrimination from primary hepatic MALT-type non-Hodgkin's lymphoma
    Klaus Willenbrock
    Senckenbergisches Institut für Pathologie, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Virchows Arch 448:223-7. 2006
    ..The simultaneous occurrence of NLL with focal nodular hyperplasia and hemangioma in the liver has not been described before...
  5. ncbi request reprint In angioimmunoblastic T-cell lymphoma, neoplastic T cells may be a minor cell population. A molecular single-cell and immunohistochemical study
    Klaus Willenbrock
    Senckenbergisches Institut für Pathologie, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Virchows Arch 446:15-20. 2005
    ..In two of five cases investigated, only a minority of the T-cells compartment belonged to the tumour clone. Neoplastic T cells were found throughout the tissue, including areas dominated by B cells...
  6. ncbi request reprint T-cell variant of classical Hodgkin's lymphoma with nodal and cutaneous manifestations demonstrated by single-cell polymerase chain reaction
    Klaus Willenbrock
    Senckenberg Institute of Pathology, University of Frankfurt, Frankfurt am Main, Germany
    Lab Invest 82:1103-9. 2002
    ....
  7. pmc Survival and clonal expansion of mutating "forbidden" (immunoglobulin receptor-deficient) epstein-barr virus-infected b cells in angioimmunoblastic t cell lymphoma
    A Bräuninger
    Department of Pathology, University of Frankfurt, 60590 Frankfurt, Germany
    J Exp Med 194:927-40. 2001
    ..It is likely the interplay between the microenvironment in AILD lymph nodes and the viral transformation that leads to the survival and clonal expansion of Ig-less B cells...
  8. doi request reprint Gene expression profiling of isolated tumour cells from anaplastic large cell lymphomas: insights into its cellular origin, pathogenesis and relation to Hodgkin lymphoma
    S Eckerle
    Senckenberg Institute for Pathology, University of Frankfurt, Medical School, Frankfurt Main, Germany
    Leukemia 23:2129-38. 2009
    ..ALK(+) ALCL are characterized by expression of genes regulated by pathways constitutively activated by ALK. This study provides multiple novel insights into the molecular biology and pathogenesis of ALCL...
  9. ncbi request reprint High expression of several tyrosine kinases and activation of the PI3K/AKT pathway in mediastinal large B cell lymphoma reveals further similarities to Hodgkin lymphoma
    C Renne
    Senckenberg Institute for Pathology, University of Frankfurt, Frankfurt, Germany
    Leukemia 21:780-7. 2007
    ..In conclusion, aberrant TK activities are a further shared pathogenic mechanism of MBL and HL and may be interesting targets for therapeutic intervention...
  10. ncbi request reprint [Villous adenoma of the renal pelvis and ureter]
    H Frickmann
    Urologische Klinik, St Elisabethen Krankenhaus, Frankfurt M
    Urologe A 45:1435-7. 2006
    ..They can be associated with other neoplasias, especially with carcinomas. We describe the case of an 85-year-old female patient suffering from a villous adenoma of the renal pelvis and ureter...
  11. doi request reprint Expression of activation-induced cytidine deaminase in malignant lymphomas infiltrating the bone marrow
    Knut Engels
    Senckenbergisches Institut für Pathologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Appl Immunohistochem Mol Morphol 16:521-9. 2008
    ..These results suggest that the expression pattern of AID in lymphoma infiltrates in the bone marrow reflects that of extramedullary lymphoma infiltrates...
  12. ncbi request reprint Somatic hypermutation of SOCS1 in lymphocyte-predominant Hodgkin lymphoma is accompanied by high JAK2 expression and activation of STAT6
    Anja Mottok
    Senckenberg Institute of Pathology, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Blood 110:3387-90. 2007
    ..In lymphocyte-predominant Hodgkin lymphoma SOCS1 function may thus be frequently impaired by mutations, and this may contribute to high JAK2 expression and activation of the JAK2/STAT6 pathway...
  13. ncbi request reprint Human splenic marginal zone B cells lack expression of activation-induced cytidine deaminase
    Klaus Willenbrock
    Senckenberg Institute of Pathology, University of Frankfurt, Frankfurt a M, Germany
    Eur J Immunol 35:3002-7. 2005
    ..Moreover, the lack of AID-positive MZ B cells questions the recent speculation that B cell chronic lymphocytic leukemias with mutated V genes are derived from mutating MZ B cells...
  14. ncbi request reprint [WHO classification of Hodgkin's lymphoma and its molecular pathological relevance]
    M L Hansmann
    Senckenbergisches Institut für Pathologie, Universitätsklinik Frankfurt am Main, Theodor Stern Kai 7, 60590 Frankfurt am Main
    Pathologe 23:207-18. 2002
    ..These results suggest that future classifications of HL will not only take into account the morphological and phenotypical profile, but also mechanisms of transformation yet to be discovered...
  15. ncbi request reprint The aberrant coexpression of several receptor tyrosine kinases is largely restricted to EBV-negative cases of classical Hodgkin's lymphoma
    Christoph Renne
    Senckenberg Institute for Pathology, University of Frankfurt, Frankfurt, Germany
    Int J Cancer 120:2504-9. 2007
    ..For cases with aberrant coexpression of several RTKs inclusion of RTK inhibitors in therapy regimens may be a novel option...
  16. ncbi request reprint Autocrine- and paracrine-activated receptor tyrosine kinases in classic Hodgkin lymphoma
    Christoph Renne
    Department of Pathology, University of Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Blood 105:4051-9. 2005
    ..These findings show the unprecedented coexpression of multiple RTKs in a tumor and indicate that aberrant RTK signaling is an important factor in HL pathogenesis and that it may be a novel therapeutic target...
  17. ncbi request reprint [Global gene expression analysis and novel signalling pathways in Hodgkin lymphoma]
    Andreas Bräuninger
    Senckenbergisches Institut für Pathologie, Klinikum der J W Goethe Universitat, Frankfurt
    Verh Dtsch Ges Pathol 90:136-41. 2006
    ....