T Wichelhaus

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. pmc Treatment with the immunomodulator FTY720 does not promote spontaneous bacterial infections after experimental stroke in mice
    Waltraud Pfeilschifter
    Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Germany
    Exp Transl Stroke Med 3:2. 2011
  2. pmc Rapid detection of epidemic strains of methicillin-resistant Staphylococcus aureus
    T A Wichelhaus
    Institute of Medical Microbiology, University Hospital of Frankfurt am Main, Frankfurt am Main, Germany
    J Clin Microbiol 37:690-3. 1999
  3. pmc Biological cost of rifampin resistance from the perspective of Staphylococcus aureus
    Thomas A Wichelhaus
    Institut fur Medizinische Mikrobiologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Antimicrob Agents Chemother 46:3381-5. 2002
  4. ncbi request reprint Elution characteristics of vancomycin, teicoplanin, gentamicin and clindamycin from calcium sulphate beads
    T A Wichelhaus
    Institute of Medical Microbiology, University Hospital, Paul Ehrlich Strasse 40, 60596 Frankfurt am Main, Germany
    J Antimicrob Chemother 48:117-9. 2001
  5. ncbi request reprint Differential effect of rpoB mutations on antibacterial activities of rifampicin and KRM-1648 against Staphylococcus aureus
    T Wichelhaus
    Institute of Medical Microbiology, University Hospital, Paul Ehrlich Strasse 40, 60596 Frankfurt am Main, Germany
    J Antimicrob Chemother 47:153-6. 2001
  6. pmc The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates
    Silke Besier
    Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt am Main, Paul Ehrlich Strasse 40, 60596 Frankfurt am Main, Germany
    Antimicrob Agents Chemother 52:2183-9. 2008
  7. pmc Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances
    Silke Besier
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Antimicrob Agents Chemother 52:1570-2. 2008
  8. pmc Influence of dTMP on the phenotypic appearance and intracellular persistence of Staphylococcus aureus
    Johannes Zander
    Institute of Medical Microbiology and Infection Control, Hospital of Johann Wolfgang Goethe University, Paul Ehrlich Str 40, 60596 Frankfurt Main, Germany
    Infect Immun 76:1333-9. 2008
  9. ncbi request reprint Molecular analysis of the thymidine-auxotrophic small colony variant phenotype of Staphylococcus aureus
    Silke Besier
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe Universitat, Paul Ehrlich Strasse 40, D 60596 Frankfurt am Main, Germany
    Int J Med Microbiol 297:217-25. 2007
  10. pmc Prevalence and clinical significance of Staphylococcus aureus small-colony variants in cystic fibrosis lung disease
    Silke Besier
    Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt am Main, Germany
    J Clin Microbiol 45:168-72. 2007

Collaborators

Detail Information

Publications17

  1. pmc Treatment with the immunomodulator FTY720 does not promote spontaneous bacterial infections after experimental stroke in mice
    Waltraud Pfeilschifter
    Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Germany
    Exp Transl Stroke Med 3:2. 2011
    ..abstract:..
  2. pmc Rapid detection of epidemic strains of methicillin-resistant Staphylococcus aureus
    T A Wichelhaus
    Institute of Medical Microbiology, University Hospital of Frankfurt am Main, Frankfurt am Main, Germany
    J Clin Microbiol 37:690-3. 1999
    ..This is the first study demonstrating the Slidex Staph-Kit's capability for identifying epidemic clumping factor-negative S. aureus strains as methicillin resistant even prior to antimicrobial susceptibility testing...
  3. pmc Biological cost of rifampin resistance from the perspective of Staphylococcus aureus
    Thomas A Wichelhaus
    Institut fur Medizinische Mikrobiologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Antimicrob Agents Chemother 46:3381-5. 2002
    ..The restriction to distinct mutations that confer rifampin resistance in vivo, as demonstrated here, appears to be determined by the Darwinian fitness of the organisms...
  4. ncbi request reprint Elution characteristics of vancomycin, teicoplanin, gentamicin and clindamycin from calcium sulphate beads
    T A Wichelhaus
    Institute of Medical Microbiology, University Hospital, Paul Ehrlich Strasse 40, 60596 Frankfurt am Main, Germany
    J Antimicrob Chemother 48:117-9. 2001
    ..Local carrier-associated antibiotic treatment with CaSO(4) beads may prove to be effective in the management of chronic bone infections...
  5. ncbi request reprint Differential effect of rpoB mutations on antibacterial activities of rifampicin and KRM-1648 against Staphylococcus aureus
    T Wichelhaus
    Institute of Medical Microbiology, University Hospital, Paul Ehrlich Strasse 40, 60596 Frankfurt am Main, Germany
    J Antimicrob Chemother 47:153-6. 2001
    ..Mutations at some sites were associated with high-level resistance to both rifamycins, while certain mutations were associated with the activity of KRM-1648 being < or = 100-fold better than that of rifampicin...
  6. pmc The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates
    Silke Besier
    Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt am Main, Paul Ehrlich Strasse 40, 60596 Frankfurt am Main, Germany
    Antimicrob Agents Chemother 52:2183-9. 2008
    ..In conclusion, these data provide direct evidence that TD-SCVs are hypermutators. This hypermutability apparently favors the acquisition of antibiotic resistance and facilitates bacterial adaptation during long-term persistence...
  7. pmc Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances
    Silke Besier
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Antimicrob Agents Chemother 52:1570-2. 2008
    ....
  8. pmc Influence of dTMP on the phenotypic appearance and intracellular persistence of Staphylococcus aureus
    Johannes Zander
    Institute of Medical Microbiology and Infection Control, Hospital of Johann Wolfgang Goethe University, Paul Ehrlich Str 40, 60596 Frankfurt Main, Germany
    Infect Immun 76:1333-9. 2008
    ..In conclusion, these results show that the dTMP concentration plays a key role in both the phenotypic appearance and the intracellular persistence of S. aureus...
  9. ncbi request reprint Molecular analysis of the thymidine-auxotrophic small colony variant phenotype of Staphylococcus aureus
    Silke Besier
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe Universitat, Paul Ehrlich Strasse 40, D 60596 Frankfurt am Main, Germany
    Int J Med Microbiol 297:217-25. 2007
    ..In conclusion, these data confirm at the molecular level that impaired thymidylate synthase function is causative for the formation of the thymidine-auxotrophic SCV phenotype in S. aureus...
  10. pmc Prevalence and clinical significance of Staphylococcus aureus small-colony variants in cystic fibrosis lung disease
    Silke Besier
    Institute of Medical Microbiology and Infection Control, University Hospital of Frankfurt am Main, Germany
    J Clin Microbiol 45:168-72. 2007
    ..Nonetheless, the independent risk factors determined here point to the impact of S. aureus SCVs on chronic and persistent infections in advanced CF lung disease...
  11. ncbi request reprint [Staphylococcal infections of the skin and mucous membranes. Guideline of the German Dermatologic Society, Study Group of Dermatologic Infectiology]
    Helmut Schöfer
    Universitäts Hautklinik ZDV, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main
    J Dtsch Dermatol Ges 3:726-34. 2005
  12. pmc Compensatory adaptation to the loss of biological fitness associated with acquisition of fusidic acid resistance in Staphylococcus aureus
    Silke Besier
    Institut fur Medizinische Mikrobiologie, Klinikum der Johann Wolfgang Goethe Universitat, Paul Ehrlich Strasse 40, 60596 Frankfurt am Main, Germany
    Antimicrob Agents Chemother 49:1426-31. 2005
    ..aureus can be reduced considerably by specific compensating mutations in this target protein. This compensatory adaptation most likely plays a significant role in the stabilization of resistant bacteria within a given population...
  13. ncbi request reprint Prevalence of mupirocin resistance in clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis: results of the Antimicrobial Resistance Surveillance Study of the Paul-Ehrlich-Society for Chemotherapy, 2001
    Michael Kresken
    Antiinfectives Intelligence GmbH, Immenburgstrasse 20, 53121 Bonn, Germany
    Int J Antimicrob Agents 23:577-81. 2004
    ..Mupirocin resistance was almost exclusively observed in oxacillin-resistant isolates of S. aureus (MRSA) and S. epidermidis (MRSE). High-level mupirocin resistance was detected in 3.1 and 4.5% of MRSA and MRSE, respectively...
  14. pmc Comparison of in vitro activities of ketolides, macrolides, and an azalide against the spirochete Borrelia burgdorferi
    Klaus Peter Hunfeld
    Institute of Medical Microbiology, University Hospital of Frankfurt, D 60596 Frankfurt Main, Germany
    Antimicrob Agents Chemother 48:344-7. 2004
    ..0019 micro g/ml) and telithromycin (MIC(90), 0.0078 micro g/ml). Electron-microscope analysis and time-kill studies also supported enhanced effectiveness of both ketolides...
  15. ncbi request reprint In vitro activity of eight oral cephalosporins against Borrelia burgdorferi
    Klaus Peter Hunfeld
    Institute of Medical Microbiology, University Hospital of Frankfurt, Paul Ehrlich Street 40, D 60596 Frankfurt Main, Germany
    Int J Antimicrob Agents 21:313-8. 2003
    ..Our study demonstrates the superior in vitro effectiveness of ceftriaxone with good to excellent activity with the oral agents cefuroxime-axetil, cefixime and cefdinir against B. burgdorferi under strictly standardised test conditions...
  16. ncbi request reprint Molecular analysis of fusidic acid resistance in Staphylococcus aureus
    Silke Besier
    Institut fur Medizinische Mikrobiologie, Klinikum der J W Goethe Universitat, Paul Ehrlich Str 40, 60596 Frankfurt am Main, Germany
    Mol Microbiol 47:463-9. 2003
    ..Thus, the data presented provide evidence for the crucial importance of individual amino acid exchanges within EF-G for the generation of fusidic acid resistance in S. aureus...
  17. ncbi request reprint Nanocrystalline hydroxyapatite and calcium sulphate as biodegradable composite carrier material for local delivery of antibiotics in bone infections
    Michael A Rauschmann
    Department of Orthopaedic Surgery, University Hospital, Johann Wolfgang Goethe University, Marienburgstrasse 2, 60528 Frankfurt am Main, Germany
    Biomaterials 26:2677-84. 2005
    ..Calcium sulphate showed cytotoxic effects in two out of four tests. PerOssal exhibits excellent properties regarding resorption, biocompatibility, and antibiotic release...