Research Topics

Genomes and Genes


Andreas Weigert


Affiliation: Frankfurt am Main
Country: Germany


  1. Shiratori H, Feinweber C, Luckhardt S, Wallner N, Geisslinger G, Weigert A, et al. An in vitro test system for compounds that modulate human inflammatory macrophage polarization. Eur J Pharmacol. 2018;833:328-338 pubmed publisher
  2. Capelo R, Lehmann C, Ahmad K, Snodgrass R, Diehl O, Ringleb J, et al. Cellular analysis of the histamine H4 receptor in human myeloid cells. Biochem Pharmacol. 2016;103:74-84 pubmed publisher
    ..Since availability of primary eosinophils is limited, we developed a cell model based on the differentiated eosinophilic cell line EOL-1, in which H4R pharmacology and physiology may be studied. ..
  3. Sekar D, Govene L, del Rio M, Sirait Fischer E, Fink A, Brüne B, et al. Downregulation of BTLA on NKT Cells Promotes Tumor Immune Control in a Mouse Model of Mammary Carcinoma. Int J Mol Sci. 2018;19: pubmed publisher
    ..Taken together, these data support a role of BTLA on type I NKT cells in limiting anti-tumor immunity. ..
  4. Dillmann C, Ringel C, Ringleb J, Mora J, Olesch C, Fink A, et al. S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells. J Immunol. 2016;196:1579-90 pubmed publisher
    ..In conclusion, S1PR4 agonists block human pDC activation and may therefore be a promising tool to restrict pathogenic IFN-α production. ..
  5. Shiratori H, Feinweber C, Luckhardt S, Linke B, Resch E, Geisslinger G, et al. THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro. Mol Immunol. 2017;88:58-68 pubmed publisher
    ..In conclusion, our data suggest that THP-1 may be useful for performing studies involving phagocytosis and M1 polarization, rather than M2 polarization. ..
  6. Weichand B, Popp R, Dziumbla S, Mora J, Strack E, Elwakeel E, et al. S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β. J Exp Med. 2017;214:2695-2713 pubmed publisher
    ..Conceptually, our study indicates an unappreciated role of the NLRP3 inflammasome in promoting metastasis via the lymphatics downstream of S1PR1 signaling in macrophages. ..