Affiliation: Frankfurt am Main
Shiratori H, Feinweber C, Luckhardt S, Wallner N, Geisslinger G, Weigert A, et al
. An in vitro test system for compounds that modulate human inflammatory macrophage polarization. Eur J Pharmacol. 2018;833:328-338 pubmed publisher
Capelo R, Lehmann C, Ahmad K, Snodgrass R, Diehl O, Ringleb J, et al
. Cellular analysis of the histamine H4 receptor in human myeloid cells. Biochem Pharmacol. 2016;103:74-84 pubmed publisher
..Since availability of primary eosinophils is limited, we developed a cell model based on the differentiated eosinophilic cell line EOL-1, in which H4R pharmacology and physiology may be studied. ..
Sekar D, Govene L, del Rio M, Sirait Fischer E, Fink A, Brüne B, et al
. Downregulation of BTLA on NKT Cells Promotes Tumor Immune Control in a Mouse Model of Mammary Carcinoma. Int J Mol Sci. 2018;19: pubmed publisher
..Taken together, these data support a role of BTLA on type I NKT cells in limiting anti-tumor immunity. ..
Dillmann C, Ringel C, Ringleb J, Mora J, Olesch C, Fink A, et al
. S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-Î± Production by Human Plasmacytoid Dendritic Cells. J Immunol. 2016;196:1579-90 pubmed publisher
..In conclusion, S1PR4 agonists block human pDC activation and may therefore be a promising tool to restrict pathogenic IFN-Î± production. ..
Shiratori H, Feinweber C, Luckhardt S, Linke B, Resch E, Geisslinger G, et al
. THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro. Mol Immunol. 2017;88:58-68 pubmed publisher
..In conclusion, our data suggest that THP-1 may be useful for performing studies involving phagocytosis and M1 polarization, rather than M2 polarization. ..
Weichand B, Popp R, Dziumbla S, Mora J, Strack E, Elwakeel E, et al
. S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1Î². J Exp Med. 2017;214:2695-2713 pubmed publisher
..Conceptually, our study indicates an unappreciated role of the NLRP3 inflammasome in promoting metastasis via the lymphatics downstream of S1PR1 signaling in macrophages. ..