Jorg Trojan

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. doi request reprint Tivantinib in hepatocellular carcinoma
    Jorg Trojan
    Klinikum der Johann Wolfgang Goethe Universitat, Medizinische Klinik 1, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Expert Opin Investig Drugs 22:141-7. 2013
  2. ncbi request reprint Treatment of HCV infection with interferon alpha-2b and ribavirin in a patient with X-linked lymphoproliferative syndrome
    Nicola Strnad-Trojan
    Department of Paediatrics, Johann Wolfgang Goethe University Medical Centre, Frankfurt am Main, Germany
    Eur J Pediatr 165:348-50. 2006
  3. ncbi request reprint An infected esophageal duplication cyst in a patient with non-Hodgkin's lymphoma mimicking persistent disease
    J Trojan
    Division of Gastroenterology, Department of Internal Medicine, Johann Wolfgang Goethe University Medical Centre, Frankfurt, Germany
    Dis Esophagus 18:287-9. 2005
  4. ncbi request reprint In vitro chemosensitivity to gemcitabine, oxaliplatin and zoledronic acid predicts treatment response in metastatic gastric cancer
    Jorg Trojan
    Division of Gastroenterology, Department of Internal Medicine, Johann Wolfgang Goethe University Medical Center, Frankfurt, Germany
    Anticancer Drugs 16:87-91. 2005
  5. ncbi request reprint BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability
    Joerg Trojan
    2nd Department of Medicine and Senckenberg Center of Pathology, Johann Wolfgang Goethe University Medical Center, Theodor Stern Kai 7, 60590 Frankfurt a M, Germany
    Int J Colorectal Dis 19:538-44. 2004
  6. doi request reprint Serum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma
    Verena Köberle
    Department of Medicine I, Division of Gastroenterology and Hepatology, Johann Wolfgang Goethe University Hospital Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Eur J Cancer 49:3442-9. 2013
  7. pmc Transient mismatch repair gene transfection for functional analysis of genetic hMLH1 and hMSH2 variants
    A Brieger
    Medizinische Klinik II, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Gut 51:677-84. 2002
  8. doi request reprint Expression defect size among unclassified MLH1 variants determines pathogenicity in Lynch syndrome diagnosis
    Inga Hinrichsen
    Medizinische Klinik 1, Biomedical Research Laboratory, Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Clin Cancer Res 19:2432-41. 2013
  9. pmc SEMS vs cSEMS in duodenal and small bowel obstruction: high risk of migration in the covered stent group
    Oliver Waidmann
    Oliver Waidmann, Jörg Trojan, Mireen Friedrich Rust, Christoph Sarrazin, Stefan Zeuzem, Jörg Gerhard Albert, Medizinische Klinik 1, Schwerpunkt Gastroenterologie und Hepatologie, Klinikum der Johann Wolfgang Goethe Universitat, D 60590 Frankfurt Main, Germany
    World J Gastroenterol 19:6199-206. 2013
  10. doi request reprint Long-term follow-up of endoscopic therapy for stenosis of the biliobiliary anastomosis associated with orthotopic liver transplantation
    Jörg G Albert
    Department of Medicine I, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Liver Transpl 19:586-93. 2013

Collaborators

Detail Information

Publications29

  1. doi request reprint Tivantinib in hepatocellular carcinoma
    Jorg Trojan
    Klinikum der Johann Wolfgang Goethe Universitat, Medizinische Klinik 1, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Expert Opin Investig Drugs 22:141-7. 2013
    ..Tivantinib (ARQ 197) is a selective, oral MET receptor tyrosine kinase inhibitor with broad-spectrum antitumor activity as single agent and in combination in preclinical studies including several MET overexpressing cell lines...
  2. ncbi request reprint Treatment of HCV infection with interferon alpha-2b and ribavirin in a patient with X-linked lymphoproliferative syndrome
    Nicola Strnad-Trojan
    Department of Paediatrics, Johann Wolfgang Goethe University Medical Centre, Frankfurt am Main, Germany
    Eur J Pediatr 165:348-50. 2006
    ..After combination treatment with interferon alpha-2b and ribavirin, clearance of HCV-RNA was achieved, and noteworthily, EBV DNA also became undetectable...
  3. ncbi request reprint An infected esophageal duplication cyst in a patient with non-Hodgkin's lymphoma mimicking persistent disease
    J Trojan
    Division of Gastroenterology, Department of Internal Medicine, Johann Wolfgang Goethe University Medical Centre, Frankfurt, Germany
    Dis Esophagus 18:287-9. 2005
    ..Thus, this report further demonstrated the impact of EUS and EUS-FNA for management of posterior mediastinal cystic lesions in selected cases...
  4. ncbi request reprint In vitro chemosensitivity to gemcitabine, oxaliplatin and zoledronic acid predicts treatment response in metastatic gastric cancer
    Jorg Trojan
    Division of Gastroenterology, Department of Internal Medicine, Johann Wolfgang Goethe University Medical Center, Frankfurt, Germany
    Anticancer Drugs 16:87-91. 2005
    ..An initially existing disseminated intravascular coagulopathy quickly resolved and after 6 months of treatment on ongoing complete response was induced, thus confirming the results of in vitro chemosensitivity testing...
  5. ncbi request reprint BAX and caspase-5 frameshift mutations and spontaneous apoptosis in colorectal cancer with microsatellite instability
    Joerg Trojan
    2nd Department of Medicine and Senckenberg Center of Pathology, Johann Wolfgang Goethe University Medical Center, Theodor Stern Kai 7, 60590 Frankfurt a M, Germany
    Int J Colorectal Dis 19:538-44. 2004
    ..The aim of this study was to further characterize the role of BAX and cas-5 inactivation for spontaneous apoptosis...
  6. doi request reprint Serum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma
    Verena Köberle
    Department of Medicine I, Division of Gastroenterology and Hepatology, Johann Wolfgang Goethe University Hospital Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Eur J Cancer 49:3442-9. 2013
    ..Extracellular microRNAs (miRNAs) circulating in the blood are a new class of highly promising disease markers...
  7. pmc Transient mismatch repair gene transfection for functional analysis of genetic hMLH1 and hMSH2 variants
    A Brieger
    Medizinische Klinik II, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Gut 51:677-84. 2002
    ..Germline mutations in the mismatch repair (MMR) genes hMLH1 and hMSH2 can cause hereditary non-polyposis colorectal cancer (HNPCC). However, the functional in vitro analysis of hMLH1 and hMSH2 mutations remains difficult...
  8. doi request reprint Expression defect size among unclassified MLH1 variants determines pathogenicity in Lynch syndrome diagnosis
    Inga Hinrichsen
    Medizinische Klinik 1, Biomedical Research Laboratory, Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Clin Cancer Res 19:2432-41. 2013
    ..The functionality of these variants can be tested in the laboratory, but the results cannot be used for clinical diagnosis. We therefore aimed to establish a laboratory test that can be applied clinically...
  9. pmc SEMS vs cSEMS in duodenal and small bowel obstruction: high risk of migration in the covered stent group
    Oliver Waidmann
    Oliver Waidmann, Jörg Trojan, Mireen Friedrich Rust, Christoph Sarrazin, Stefan Zeuzem, Jörg Gerhard Albert, Medizinische Klinik 1, Schwerpunkt Gastroenterologie und Hepatologie, Klinikum der Johann Wolfgang Goethe Universitat, D 60590 Frankfurt Main, Germany
    World J Gastroenterol 19:6199-206. 2013
    ..To compare clinical success and complications of uncovered self-expanding metal stents (SEMS) vs covered SEMS (cSEMS) in obstruction of the small bowel...
  10. doi request reprint Long-term follow-up of endoscopic therapy for stenosis of the biliobiliary anastomosis associated with orthotopic liver transplantation
    Jörg G Albert
    Department of Medicine I, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Liver Transpl 19:586-93. 2013
    ..ABSs might occur late (>36 months) after OLT, and lifelong follow-up is essential for identifying OLT patients with ABSs...
  11. doi request reprint MUTYH gene expression and alternative splicing in controls and polyposis patients
    Guido Plotz
    Biomedical Research Laboratory, Medizinische Klinik 1, Klinik der Johann Wolfgang Goethe Universität, Theodor Stern Kai 7, Frankfurt, Germany
    Hum Mutat 33:1067-74. 2012
    ..Since this alteration decreases protein production of the gene, an increased cancer risk for compound heterozygous carriers is possible...
  12. doi request reprint Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1
    Angela Brieger
    Medical Clinic I, Biomedical Research Laboratory, Goethe University, Frankfurt, Germany
    Proteomics 10:3343-55. 2010
    ..Our data suggest novel roles of MLH1 in cellular organization and colorectal cancerogenesis...
  13. ncbi request reprint Limited value of fluorine-18-fluorodeoxyglucose PET for the differential diagnosis of focal liver lesions in patients with chronic hepatitis C virus infection
    O Schroder
    Department of Nuclear Medicine, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Nuklearmedizin 37:279-85. 1998
    ..The differentiation of HCC from liver metastasis or benign disorders by imaging studies based upon morphological aspects may be difficult...
  14. ncbi request reprint Frequency of colorectal polyps in patients with sporadic adenomas or adenocarcinomas of the papilla of vater--an age-matched, controlled study
    A R J Schneider
    Medical Department I, University Hospital, Frankfurt Main, Germany
    Z Gastroenterol 43:1123-7. 2005
    ..Patients with familial adenomatous polyposis bear a particularly increased risk for periampullary tumors. Data on whether the prevalence of colorectal tumors is increased in patients with sporadic ampullary neoplasms are scarce...
  15. ncbi request reprint Frequency of the Amsterdam criteria in a regional German cohort of patients with colorectal cancer
    J Raedle
    Medizinische Klinik II, Klinikum der J W Goethe Universitat, Frankfurt Main, Germany
    Z Gastroenterol 40:561-8. 2002
    ..However, the final diagnosis of HNPCC can only be established by detection of pathogenic germline mutations within the DNA mismatch repair genes...
  16. ncbi request reprint Bethesda guidelines: relation to microsatellite instability and MLH1 promoter methylation in patients with colorectal cancer
    J Raedle
    Second Department of Internal Medicine, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Ann Intern Med 135:566-76. 2001
    ..The Bethesda guidelines were established to identify patients with colorectal cancer who should be tested for microsatellite instability...
  17. doi request reprint Prevalence of colorectal cancer and its precursor lesions in symptomatic and asymptomatic patients undergoing total colonoscopy: results of a large prospective, multicenter, controlled endoscopy study
    Irina Blumenstein
    First Department of Internal Medicine, Division of Gastroenterology, Johann Wolfgang Goethe University Hospital, Frankfurt Main, Germany
    Eur J Gastroenterol Hepatol 25:556-61. 2013
    ..Colorectal cancer (CRC) is the second most common cancer in Germany. Screening colonoscopies have been offered in Germany since 2002. However, validation of screening programs for CRC relies on estimates up to date...
  18. doi request reprint Diagnostic and prognostic significance of cell death and macrophage activation markers in patients with hepatocellular carcinoma
    Oliver Waidmann
    Medizinische Klinik 1, Schwerpunkt Gastroenterologie und Hepatologie, Klinikum der Goethe Universität, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany Electronic address
    J Hepatol 59:769-79. 2013
    ..However, their diagnostic and prognostic potential in patients with hepatocellular carcinoma (HCC) has not yet been investigated...
  19. doi request reprint Nucleos(t)ide analogue treatment reduces apoptotic activity in patients with chronic hepatitis B
    Harald Farnik
    Medizinische Klinik 1, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, Haus 11, 60590 Frankfurt, Germany
    J Clin Virol 52:204-9. 2011
    ..Reduction of necroinflammatory activity is a major goal of antiviral therapy of patients with chronic hepatitis B. Serum ALT does not detect all forms of cell death...
  20. doi request reprint Transarterial chemoembolization of unresectable systemic chemotherapy-refractory liver metastases from colorectal cancer: Long-term results over a 10-year period
    Tatjana Gruber-Rouh
    Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University Frankfurt, Frankfurt, Germany
    Int J Cancer 134:1225-31. 2014
    ..TN stage, extrahepatic metastases, number of lesions, tumor location within the liver and choice of chemotherapy protocol of TACE are none significant factors for patient's survival. ..
  21. pmc Overexpression of the far upstream element binding protein 1 in hepatocellular carcinoma is required for tumor growth
    Uta Rabenhorst
    Chemotherapeutisches Forschungsinstitut Georg Speyer Haus, Frankfurt, Germany
    Hepatology 50:1121-9. 2009
    ....
  22. doi request reprint Transarterial chemoembolization in the treatment of patients with unresectable cholangiocarcinoma: Results and prognostic factors governing treatment success
    Thomas J Vogl
    Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University Frankfurt Theodor Stern Kai 7, Frankfurt am Main, Germany
    Int J Cancer 131:733-40. 2012
    ..In conclusion, TACE is a palliative and safe treatment option for patients with unresectable CCC. Child Pugh class B, tumor hypovascularity and initially progressive disease were poor prognostic factors for patient survival...
  23. pmc Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma
    Verena Bihrer
    Department of Medicine I, University of Frankfurt M, Frankfurt, Germany
    PLoS ONE 6:e26971. 2011
    ..Here we correlated serum miR-21 levels with clinical parameters in patients with different stages of chronic hepatitis C virus infection (CHC) and CHC-associated HCC...
  24. pmc hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA
    Guido Plotz
    Second Department of Medicine, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Nucleic Acids Res 30:711-8. 2002
    ..Purified hMutLalpha showed an intrinsic affinity for DNA, with a preference for single-stranded over double-stranded DNA...
  25. doi request reprint Neoadjuvant short- or long-term radio(chemo)therapy for rectal cancer: how and who should be treated?
    Claus Rodel
    Department of Radiotherapy and Oncology, University of Frankfurt, Frankfurt, Germany
    Dig Dis 30:102-8. 2012
    ..Clearly, future developments will aim at identifying and selecting patients for ideal treatment alternatives...
  26. ncbi request reprint Efficacy and safety of sorafenib in advanced hepatocellular carcinoma under daily practice conditions
    M W Welker
    Medizinische Klinik1, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    J Chemother 22:205-11. 2010
    ..In conclusion, in daily practice sorafenib is safe and disease stabilization can be achieved in the majority of patients. However, intolerance to sorafenib can affect treatment adherence substantially...
  27. ncbi request reprint A de novo deletion of chromosome 5q causing familial adenomatous polyposis, dysmorphic features, and mild mental retardation
    J Raedle
    2nd Department of Internal Medicine and Institute of Human Genetics, University of Frankfurt/Main, Frankfurt am Main, Germany
    Am J Gastroenterol 96:3016-20. 2001
    ..If the deletion encompasses the APC gene, these patients are at high risk of developing FAP and associated complications...
  28. ncbi request reprint Role of ultrasonography in the detection of small adrenal masses
    J Trojan
    Medizinische Klinik II, Klinikum der Johann Wolfgang Goethe, Universitat, Frankfurt, Germany
    Ultraschall Med 23:96-100. 2002
    ..In this prospective study we evaluated whether adrenal gland masses of less or equal than 20 mm in diameter could be detected by modern abdominal ultrasonography (US)...
  29. ncbi request reprint A new immunological test strip device for the rapid, qualitative detection of faecal occult blood
    J Trojan
    Medizinische Klinik II, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Z Gastroenterol 40:921-4. 2002
    ....