S W Toennes

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi request reprint A fatal human intoxication with the herbicide allyl alcohol (2-propen-1-ol)
    Stefan W Toennes
    Institute of Forensic Toxicology, University of Frankfurt, Frankfurt Main, Germany
    J Anal Toxicol 26:55-7. 2002
  2. ncbi request reprint Pharmacokinetic properties of delta9-tetrahydrocannabinol in serum and oral fluid
    Gerold F Kauert
    Institute of Forensic Toxicology, University of Frankfurt, Frankfurt, Main, Germany
    J Anal Toxicol 31:288-93. 2007
  3. doi request reprint [Severe encephalopathy after taking a "phytopharmacon" from Vietnam]
    S W Toennes
    Institut fur Rechtsmedizin, Klinikum der Universität Frankfurt Main
    Dtsch Med Wochenschr 138:783-5. 2013
  4. doi request reprint Influence of ethanol on the pharmacokinetic properties of Δ9-tetrahydrocannabinol in oral fluid
    Stefan W Toennes
    Institute of Legal Medicine, University of Frankfurt Main, Germany
    J Anal Toxicol 37:152-8. 2013
  5. ncbi request reprint Determination of naltrexone and 6-beta-naltrexol in human plasma following implantation of naltrexone pellets using gas chromatography-mass spectrometry
    Stefan W Toennes
    Center of Legal Medicine, Institute of Forensic Toxicology, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    J Pharm Biomed Anal 35:169-76. 2004
  6. ncbi request reprint Screening for drugs of abuse in oral fluid--correlation of analysis results with serum in forensic cases
    Stefan W Toennes
    Institute of Forensic Toxicology, Center of Legal Medicine, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    J Anal Toxicol 29:22-7. 2005
  7. ncbi request reprint Driving under the influence of drugs -- evaluation of analytical data of drugs in oral fluid, serum and urine, and correlation with impairment symptoms
    Stefan W Toennes
    Institute of Forensic Toxicology, Center of Legal Medicine, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    Forensic Sci Int 152:149-55. 2005
  8. ncbi request reprint Comparison of cannabinoid pharmacokinetic properties in occasional and heavy users smoking a marijuana or placebo joint
    Stefan W Toennes
    Institute of Forensic Toxicology, Institute for Legal Medicine, Goethe University of Frankfurt, Germany
    J Anal Toxicol 32:470-7. 2008
  9. ncbi request reprint Pharmacokinetic properties of delta9-tetrahydrocannabinol in oral fluid of occasional and chronic users
    Stefan W Toennes
    Institute of Forensic Toxicology, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    J Anal Toxicol 34:216-21. 2010
  10. doi request reprint Application of LC-TOF MS to analysis of hemoglobin acetaldehyde adducts in alcohol detoxification patients
    Stefan W Toennes
    Institute of Legal Medicine, University of Frankfurt, Kennedyallee 104, 60596, Frankfurt Main, Germany
    Anal Bioanal Chem 398:769-77. 2010

Collaborators

Detail Information

Publications27

  1. ncbi request reprint A fatal human intoxication with the herbicide allyl alcohol (2-propen-1-ol)
    Stefan W Toennes
    Institute of Forensic Toxicology, University of Frankfurt, Frankfurt Main, Germany
    J Anal Toxicol 26:55-7. 2002
    ..The concentration of acrolein in blood was 7.2 mg/L. Death was attributed to acrolein-induced acute cardiotoxicity, similar to that previously documented in animal experiments...
  2. ncbi request reprint Pharmacokinetic properties of delta9-tetrahydrocannabinol in serum and oral fluid
    Gerold F Kauert
    Institute of Forensic Toxicology, University of Frankfurt, Frankfurt, Main, Germany
    J Anal Toxicol 31:288-93. 2007
    ..The oral compartment and its kinetics for drugs, particularly THC, are not yet satisfactorily understood...
  3. doi request reprint [Severe encephalopathy after taking a "phytopharmacon" from Vietnam]
    S W Toennes
    Institut fur Rechtsmedizin, Klinikum der Universität Frankfurt Main
    Dtsch Med Wochenschr 138:783-5. 2013
    ..A 59-year-old woman went into coma after she had taken a phytopharmacon from Vietnamese generally used as an antidiabetic drug to treat her skin disease...
  4. doi request reprint Influence of ethanol on the pharmacokinetic properties of Δ9-tetrahydrocannabinol in oral fluid
    Stefan W Toennes
    Institute of Legal Medicine, University of Frankfurt Main, Germany
    J Anal Toxicol 37:152-8. 2013
    ..8%, specificity 96.0%, accuracy 84.3%) could be explained by a higher number of true negatives, differences between OF and serum and differences between occasional and chronic users...
  5. ncbi request reprint Determination of naltrexone and 6-beta-naltrexol in human plasma following implantation of naltrexone pellets using gas chromatography-mass spectrometry
    Stefan W Toennes
    Center of Legal Medicine, Institute of Forensic Toxicology, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    J Pharm Biomed Anal 35:169-76. 2004
    ..7-13.7 and 0.9-17.0 ng/ml, respectively. The simple analytical procedure described provided good sensitivity for the assay of naltrexone and naltrexol in plasma after naltrexone pellet implantation...
  6. ncbi request reprint Screening for drugs of abuse in oral fluid--correlation of analysis results with serum in forensic cases
    Stefan W Toennes
    Institute of Forensic Toxicology, Center of Legal Medicine, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    J Anal Toxicol 29:22-7. 2005
    ..Oral fluid testing is therefore suitable for the efficient confirmation of drug use of drivers suspected of being under the influence of drugs...
  7. ncbi request reprint Driving under the influence of drugs -- evaluation of analytical data of drugs in oral fluid, serum and urine, and correlation with impairment symptoms
    Stefan W Toennes
    Institute of Forensic Toxicology, Center of Legal Medicine, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    Forensic Sci Int 152:149-55. 2005
    ..7%). The data demonstrate that oral fluid is superior to urine in correlating with serum analytical data and impairment symptoms of drivers under the influence of drugs of abuse...
  8. ncbi request reprint Comparison of cannabinoid pharmacokinetic properties in occasional and heavy users smoking a marijuana or placebo joint
    Stefan W Toennes
    Institute of Forensic Toxicology, Institute for Legal Medicine, Goethe University of Frankfurt, Germany
    J Anal Toxicol 32:470-7. 2008
    ..From the results, it must be cautioned that cannabinoid blood concentrations from heavy users in a late elimination phase may be difficult to distinguish from concentrations measured in occasional users after acute cannabis use...
  9. ncbi request reprint Pharmacokinetic properties of delta9-tetrahydrocannabinol in oral fluid of occasional and chronic users
    Stefan W Toennes
    Institute of Forensic Toxicology, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    J Anal Toxicol 34:216-21. 2010
    ..5) with no difference between chronic and occasional users. The large inter- and intraindividual variability observed precludes a reliable estimation of THC serum concentrations from oral fluid data using this collection device...
  10. doi request reprint Application of LC-TOF MS to analysis of hemoglobin acetaldehyde adducts in alcohol detoxification patients
    Stefan W Toennes
    Institute of Legal Medicine, University of Frankfurt, Kennedyallee 104, 60596, Frankfurt Main, Germany
    Anal Bioanal Chem 398:769-77. 2010
    ....
  11. doi request reprint Influence of ethanol on cannabinoid pharmacokinetic parameters in chronic users
    Stefan W Toennes
    Institute of Legal Medicine, Forensic Toxicology Department, Johann Wolfgang Goethe University, Kennedyallee 104, 60596 Frankfurt am Main, Germany
    Anal Bioanal Chem 400:145-52. 2011
    ..Though not significant in the present study, this might be relevant in the interpretation of cannabinoid concentrations in blood...
  12. ncbi request reprint Driving under the influence of khat--alkaloid concentrations and observations in forensic cases
    Stefan W Toennes
    Institute of Forensic Toxicology, Center of Legal Medicine, University of Frankfurt, Kennedyallee 104, Frankfurt Main D 60596, Germany
    Forensic Sci Int 140:85-90. 2004
    ..From these results it can be concluded that chewing khat may severely impair driving ability, but may also be without noticeable effects...
  13. ncbi request reprint Artifact production in the assay of anhydroecgonine methyl ester in serum using gas chromatography-mass spectrometry
    Stefan W Toennes
    Department of Forensic Toxicology, Center of Legal Medicine, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 792:345-51. 2003
    ..1 microg/l. In 16 serum samples and five postmortem blood samples, cocaine and AEME were detected, but after application of the correction method only ten were truly positive for AEME...
  14. pmc Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves
    Stefan W Toennes
    Institute of Forensic Toxicology, Centre of Legal Medicine, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    Br J Clin Pharmacol 56:125-30. 2003
    ..The stimulating herbal drug khat is habitually used in East Africa and the Arabian peninsula but is also imported into other countries. The aim was to study the pharmacokinetics of its alkaloids cathinone, cathine and norephedrine...
  15. ncbi request reprint Importance of vacutainer selection in forensic toxicological analysis of drugs of abuse
    S W Toennes
    Institute of Forensic Toxicology, University of Frankfurt, Frankfurt Main, Germany
    J Anal Toxicol 25:339-43. 2001
    ..Unexpectedly, the concentrations of benzoylecgonine in unpreserved serum were almost half as high as in the fluoride-containing samples...
  16. ncbi request reprint Excretion and detection of cathinone, cathine, and phenylpropanolamine in urine after kath chewing
    Stefan W Toennes
    Institute of Forensic Toxicology, Center of Legal Medicine, University of Frankfurt Main, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    Clin Chem 48:1715-9. 2002
    ..Therefore, a study with kath was carried out to compare the efficiencies of different analytical techniques used to detect drug use...
  17. ncbi request reprint Gas chromatographic-mass spectrometric detection of anhydroecgonine methyl ester (methylecgonidine) in human serum as evidence of recent smoking of crack
    S W Toennes
    Zentrum der Rechtsmedizin, University of Frankfurt, Frankfurt Main, Germany
    J Chromatogr B Biomed Sci Appl 735:127-32. 1999
    ..The concentrations found were in a range of 3 to 34 ng/ml, a correlation with the storage time of the samples or with benzoylecgonine concentrations could not be found...
  18. ncbi request reprint Studies on metabolic pathways of cocaine and its metabolites using microsome preparations from rat organs
    Stefan W Toennes
    Institute of Forensic Toxicology, Center of Legal Medicine, University of Frankfurt Main, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    Chem Res Toxicol 16:375-81. 2003
    ..This might be relevant in the development of lung toxicity observed in smokers of cocaine ("crack")...
  19. ncbi request reprint Studies on hydrolytic and oxidative metabolic pathways of anhydroecgonine methyl ester (methylecgonidine) using microsomal preparations from rat organs
    Anabel S Fandino
    Institute of Forensic Toxicology, Center of Legal Medicine, J W Goethe University, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    Chem Res Toxicol 15:1543-8. 2002
    ..Further metabolism of AE or ANEME was not observed. No N-hydroxy-anhydronorecgonine derivatives were found which could represent precursors of cytotoxic metabolites as known to be formed from cocaine...
  20. ncbi request reprint Incidence of axonal injury in human brain tissue
    C Niess
    Zentrum der Rechtsmedizin, Johann Wolfgang Goethe Universitat, Kennedyallee 104, 60596 Frankfurt Main, Germany
    Acta Neuropathol 104:79-84. 2002
    ..A correlation between axonal damage and age-related processes could not be shown...
  21. ncbi request reprint Studies on in vitro degradation of anhydroecgonine methyl ester (methylecgonidine) in human plasma
    Anabel S Fandino
    Institute of Forensic Toxicology, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    J Anal Toxicol 26:567-70. 2002
    ..The data suggest that AEME is degraded via two mechanisms: chemical hydrolysis at basic pH and enzymatic hydrolysis by butyrylcholine esterase. Therefore, proper storage conditions must be provided for the assay of AEME in plasma...
  22. ncbi request reprint Influence of ethanol on the pharmacokinetics of methylphenidate's metabolites ritalinic acid and ethylphenidate
    Michaela Koehm
    Institute of Forensic Toxicology, University of Frankfurt, Frankfurt Main, Germany
    Arzneimittelforschung 60:238-44. 2010
    ..Unexpectedly one subject exhibited a methylphenidate hydrolysis defect yielding very high methylphenidate and low ritalinic acid concentrations in all study conditions...
  23. ncbi request reprint Identification of anhydroecgonine methyl ester N-oxide, a new metabolite of anhydroecgonine methyl ester, using electrospray mass spectrometry
    Anabel S Fandino
    Institute of Forensic Toxicology, J W Goethe University, Kennedyallee 104, 60596 Frankfurt Main, Germany
    J Mass Spectrom 37:525-32. 2002
    ..This study demonstrated that AEMENO is produced by rat hepatic microsomal metabolism in vitro and is present in body fluids from crack users...
  24. doi request reprint Caffeine enhances endothelial repair by an AMPK-dependent mechanism
    Ioakim Spyridopoulos
    Department of Internal Medicine III, University of Frankfurt, Germany
    Arterioscler Thromb Vasc Biol 28:1967-74. 2008
    ..Migratory capacity of endothelial progenitor cells (EPCs) and mature endothelial cells (ECs) is a key prerequisite for endothelial repair after denuding injury or endothelial damage...
  25. ncbi request reprint Assay of Delta9-tetrahydrocannabinol (THC) in oral fluid-evaluation of the OraSure oral specimen collection device
    Gerold F Kauert
    Institute of Forensic Toxicology, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt Main, Germany
    J Anal Toxicol 30:274-7. 2006
    ..1%. From these results it can be concluded that the OraSure OSCD is useful to collect oral fluid for reliable quantitative THC assay applying a modified elution procedure and gravimetric determination of the amount of oral fluid...
  26. doi request reprint Criminal poisoning of commuters in Bangladesh: prospective and retrospective study
    M Mahbub Alam Majumder
    Department of Medicine, Dhaka Medical College and Hospital, Dhaka 1000, Bangladesh
    Forensic Sci Int 180:10-6. 2008
    ..They also highlight the need for more research in the neglected field of acute poisoning in Bangladesh, and for criminal investigations of the use of benzodiazepine drugs in this country...
  27. doi request reprint Determination of clopidogrel main metabolite in plasma: a useful tool for monitoring therapy?
    Helen Mani
    Department of Internal Medicine, Division of Vascular Medicine, University Hospital Frankfurt Main, Germany
    Ther Drug Monit 30:84-9. 2008
    ..Nevertheless, in the majority of clopidogrel-treated patients, the variability of platelet response is not caused by noncompliance...