Irmgard Tegeder

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. pmc Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo
    Vijayan Gangadharan
    Pharmacology Institute, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Mol Pain 5:68. 2009
  2. ncbi request reprint G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    Cancer Res 63:1846-52. 2003
  3. ncbi request reprint Peripheral opioid analgesia in experimental human pain models
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Brain 126:1092-102. 2003
  4. doi request reprint SNO-ing at the nociceptive synapse?
    Irmgard Tegeder
    Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt, Theodor Stern Kai 7, Haus 74 60590 Frankfurt am Main, Germany
    Pharmacol Rev 63:366-89. 2011
  5. ncbi request reprint Cisplatin tumor concentrations after intra-arterial cisplatin infusion or embolization in patients with oral cancer
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Klinik und Poliklinik für Kiefer und Plastische Gesichtschirugie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Clin Pharmacol Ther 73:417-26. 2003
  6. doi request reprint Current evidence for a modulation of low back pain by human genetic variants
    Irmgard Tegeder
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universität Frankfurt am Main, Frankfurt am Main, Germany
    J Cell Mol Med 13:1605-19. 2009
  7. ncbi request reprint Release of algesic substances in human experimental muscle pain
    L Tegeder
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Inflamm Res 51:393-402. 2002
  8. ncbi request reprint Tissue distribution of imipenem in critically ill patients
    Irmgard Tegeder
    Frankfurt Pharmacy Center, Johann Wolfgang Goethe University Clinic, Krankenhaus Nordwest, Theodor Stern Kai 7, 605290 Frankfurt am Main, Germany
    Clin Pharmacol Ther 71:325-33. 2002
  9. ncbi request reprint Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences?
    Irmgard Tegeder
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    Naunyn Schmiedebergs Arch Pharmacol 373:1-17. 2006
  10. doi request reprint Inhibitor kappa B kinase beta dependent cytokine upregulation in nociceptive neurons contributes to nociceptive hypersensitivity after sciatic nerve injury
    Maike Kanngiesser
    Pharmazentrum frankfurt ZAFES, Clinical Pharmacology, Goethe University, Frankfurt, Germany
    J Pain 13:485-97. 2012

Detail Information

Publications60

  1. pmc Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo
    Vijayan Gangadharan
    Pharmacology Institute, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Mol Pain 5:68. 2009
    ..Although there is evidence for a key function of GABA(B) receptors in the modulation of pain, the relative contribution of peripherally- versus centrally-expressed GABA(B) receptors is unclear...
  2. ncbi request reprint G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    Cancer Res 63:1846-52. 2003
    ..Our results suggest that morphine, alone or in combination with Nx, may reduce the growth of certain tumors, apparently in part through activation of p53...
  3. ncbi request reprint Peripheral opioid analgesia in experimental human pain models
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Brain 126:1092-102. 2003
    ..Since this occurs at concentrations that do not cause central opioid effects, M6G might be useful as a peripheral opioid analgesic...
  4. doi request reprint SNO-ing at the nociceptive synapse?
    Irmgard Tegeder
    Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt, Theodor Stern Kai 7, Haus 74 60590 Frankfurt am Main, Germany
    Pharmacol Rev 63:366-89. 2011
    ..In addition, S-Nitrosylation may alter the production of nitric oxide itself...
  5. ncbi request reprint Cisplatin tumor concentrations after intra-arterial cisplatin infusion or embolization in patients with oral cancer
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Klinik und Poliklinik für Kiefer und Plastische Gesichtschirugie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Clin Pharmacol Ther 73:417-26. 2003
    ..Recently, crystalline cisplatin embolization has been described as a novel treatment variant with increased tumor response rates...
  6. doi request reprint Current evidence for a modulation of low back pain by human genetic variants
    Irmgard Tegeder
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universität Frankfurt am Main, Frankfurt am Main, Germany
    J Cell Mol Med 13:1605-19. 2009
    ....
  7. ncbi request reprint Release of algesic substances in human experimental muscle pain
    L Tegeder
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Inflamm Res 51:393-402. 2002
    ....
  8. ncbi request reprint Tissue distribution of imipenem in critically ill patients
    Irmgard Tegeder
    Frankfurt Pharmacy Center, Johann Wolfgang Goethe University Clinic, Krankenhaus Nordwest, Theodor Stern Kai 7, 605290 Frankfurt am Main, Germany
    Clin Pharmacol Ther 71:325-33. 2002
    ..Most patients were >60 years old and had renal failure; most patients also had impaired liver, heart, or lung function...
  9. ncbi request reprint Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences?
    Irmgard Tegeder
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    Naunyn Schmiedebergs Arch Pharmacol 373:1-17. 2006
    ....
  10. doi request reprint Inhibitor kappa B kinase beta dependent cytokine upregulation in nociceptive neurons contributes to nociceptive hypersensitivity after sciatic nerve injury
    Maike Kanngiesser
    Pharmazentrum frankfurt ZAFES, Clinical Pharmacology, Goethe University, Frankfurt, Germany
    J Pain 13:485-97. 2012
    ..The results suggest that IKKβ-mediated NF-κB stimulation in injured primary sensory neurons promotes cytokine and chemokine production and contributes thereby to the development of chronic pain...
  11. doi request reprint CNGA3: a target of spinal nitric oxide/cGMP signaling and modulator of inflammatory pain hypersensitivity
    Sandra Heine
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    J Neurosci 31:11184-92. 2011
    ..Our results provide evidence that CNGA3 contributes in an inhibitory manner to the central sensitization of pain pathways during inflammatory pain as a target of NO/cGMP signaling...
  12. ncbi request reprint Increased CNS uptake and enhanced antinociception of morphine-6-glucuronide in rats after inhibition of P-glycoprotein
    Jorn Lotsch
    Pharmazentrum Frankfurt, Department of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt, Germany
    J Neurochem 83:241-8. 2002
    ..Antinociceptive effects of M6G were significantly enhanced by inhibition of P-gp. Inhibition of P-gp alters the transport of M6G across the blood-brain barrier, resulting in enhanced spinal cord uptake and enhanced antinociception...
  13. ncbi request reprint cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I
    Achim Schmidtko
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    J Neurosci 28:8568-76. 2008
    ..Together, our results provide evidence that NO-GC is crucially involved in the central sensitization of pain pathways during inflammatory and neuropathic pain...
  14. pmc R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids
    Philipp Bishay
    Pharmazentrum frankfurt ZAFES, Clinical Pharmacology, Goethe University, Frankfurt, Germany
    PLoS ONE 5:e10628. 2010
    ..R-flurbiprofen, one of the enantiomers of flurbiprofen racemate, is inactive with respect to cyclooxygenase inhibition, but shows analgesic properties without relevant toxicity. Its mode of action is still unclear...
  15. ncbi request reprint Essential role of the synaptic vesicle protein synapsin II in formalin-induced hyperalgesia and glutamate release in the spinal cord
    Achim Schmidtko
    Pharmazentrum Frankfurt, Institut für Klinische Pharmakologie ZAFES, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Pain 115:171-81. 2005
    ..The distinctive role of synapsin II for pain signaling probably results from its specific localization and possibly from a specific control of glutamate release...
  16. pmc Inter-strain differences of serotonergic inhibitory pain control in inbred mice
    Nina Wijnvoord
    Pharmazentrum Frankfurt, ZAFES, Clinical Pharmacology, Goethe University, Frankfurt, Germany
    Mol Pain 6:70. 2010
    ..The clinical efficacy of antidepressants suggests that serotonin may be particularly relevant for neuropathic pain conditions. Serotonergic signaling is regulated by synthesis, metabolisms, reuptake and receptors...
  17. ncbi request reprint Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity
    Vanessa Bockhart
    Pharmazentrum Frankfurt, Zentrum fur Arzneimittelforschung, Entwicklung und Sicherheit, Department of Clinical Pharmacology, Goethe University, 60590 Frankfurt, Germany
    J Neurosci 29:12919-29. 2009
    ..6 at NR. The results suggest that IKKbeta functions as a negative modulator of sensory neuron excitability, mediated at least in part by modulation of TRP channel sensitivity...
  18. ncbi request reprint Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, 60590 Frankfurt, Germany
    J Neurosci 24:1637-45. 2004
    ..Our data indicate that IKK may prove an interesting novel drug target in the treatment of pathological pain and inflammation...
  19. pmc Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    Proc Natl Acad Sci U S A 101:3253-7. 2004
    ..The paucity of substance P in laminae I-III may contribute to the reduction of nociception in PKG-I(-/-) mice and suggests a role of PKG-I in substance P synthesis...
  20. doi request reprint Analgesic efficacy of tramadol, pregabalin and ibuprofen in menthol-evoked cold hyperalgesia
    Kosta Altis
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universität Frankfurt am Main, Frankfurt am Main, Germany
    Pain 147:116-21. 2009
    ....
  21. doi request reprint Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype
    Irmgard Tegeder
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    Eur J Pain 12:1069-77. 2008
    ..The present study aimed at (i) testing this hypothesis and (ii) independently reproducing the pain-decreasing effects of a particular GCH1 haplotype having been previously associated with pain protection...
  22. doi request reprint Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages
    Geethanjali Pickert
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Goethe Universitat, Frankfurt, Germany
    Int J Cancer 132:591-604. 2013
    ..The data suggest that GCH1 inhibition reduces tumor growth by (i) direct killing of tumor cells, (ii) by inhibiting angiogenesis, and (iii) by enhancing the antitumoral immune response...
  23. doi request reprint Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn
    Achim Schmidtko
    Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Pain 139:632-43. 2008
    ....
  24. ncbi request reprint Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain
    Maria Burian
    Pharmazentrum Frankfurt, Klinikum der Johann Wofgang Goethe Universität Frankfurt, Frankfurt Main, Germany
    Clin Pharmacol Ther 74:113-20. 2003
    ..The aim of this study was to assess peripheral and central antihyperalgesic effects of diclofenac in a human experimental pain model...
  25. doi request reprint Anandamide deficiency and heightened neuropathic pain in aged mice
    Philipp Bishay
    Pharmazentrum Frankfurt, Institute of Clinical Pharmacology, Goethe University Frankfurt am Main, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Neuropharmacology 71:204-15. 2013
    ..This may overwhelm the capacity of R-flurbiprofen to restore anandamide homeostasis and may contribute to the heightened risk for neuropathic pain at old age...
  26. doi request reprint Inhibition of GTP cyclohydrolase reduces cancer pain in mice and enhances analgesic effects of morphine
    Geethanjali Pickert
    Pharmazentrum Frankfurt, ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt, Theodor Stern Kai 7, Hs 74, 60590 Frankfurt, Germany
    J Mol Med (Berl) 90:1473-86. 2012
    ....
  27. doi request reprint Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain
    Achim Schmidtko
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, 60590 Frankfurt am Main, Germany
    J Neurosci 28:1320-30. 2008
    ..These data suggest that CRP2 is a new downstream effector of cGKI-mediated spinal nociceptive processing and point to an inhibitory role of CRP2 in the generation of inflammatory pain...
  28. ncbi request reprint Comparative proteomic analysis of the rat spinal cord in inflammatory and neuropathic pain models
    Susanne Kunz
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universität Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Neurosci Lett 381:289-93. 2005
    ..In conclusion, this study illustrates that employment of the proteomic 2D-PAGE approach allows for identification of novel regulated proteins that may be involved in the central sensitization and possibly manifestation of chronic pain...
  29. ncbi request reprint Inhibition of cyclic guanosine 5'-monophosphate-dependent protein kinase I (PKG-I) in lumbar spinal cord reduces formalin-induced hyperalgesia and PKG upregulation
    Achim Schmidtko
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, Frankfurt am Main, 60590, Germany
    Nitric Oxide 8:89-94. 2003
    ..Our data suggest that PKG-I activation is involved in the synaptic transmission of nociceptive stimuli in the spinal cord and that PKG-I inhibitors might be interesting novel drugs for pain treatment...
  30. ncbi request reprint The calpain inhibitor MDL 28170 prevents inflammation-induced neurofilament light chain breakdown in the spinal cord and reduces thermal hyperalgesia
    Susanne Kunz
    Pharmazentrum Frankfurt, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Pain 110:409-18. 2004
    ..Our results indicate that inhibition of pathological calpain activity may present an interesting novel drug target in the treatment of pain and inflammation...
  31. ncbi request reprint Determination of 8-methoxypsoralen in human plasma, and microdialysates using liquid chromatography-tandem mass spectrometry
    Lutz Bräutigam
    Pharmazentrum Frankfurt, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 798:223-9. 2003
    ..2-->174.0. The assays were validated over the concentration ranges of 0.5-50 ng/ml for plasma samples and 0.25-50 ng/ml for microdialysates, respectively...
  32. ncbi request reprint The influence of inhibition of probenecid sensitive transporters on the central nervous system (CNS) uptake and the antinociceptive activity of morphine-6-glucuronide in rats
    Jorn Lotsch
    Pharmazentrum Frankfurt, Department of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Neurosci Lett 329:145-8. 2002
    ....
  33. pmc Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain
    Hilmar Nils Kühlein
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt am Main, Frankfurt am Main, Germany
    PLoS ONE 6:e19270. 2011
    ..Our results show the usefulness of proteomics as a screening tool to identify novel mechanisms of nerve injury evoked hypernociception and suggest that carboxypeptidase A inhibition might be useful to reduce cold allodynia...
  34. ncbi request reprint Protein associated with Myc (PAM) is involved in spinal nociceptive processing
    Corina Ehnert
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    J Neurochem 88:948-57. 2004
    ..Taken together our findings demonstrate that PAM is involved in spinal nociceptive processing...
  35. doi request reprint Dichotomy of CCL21 and CXCR3 in nerve injury-evoked and autoimmunity-evoked hyperalgesia
    Katja Schmitz
    Pharmazentrum Frankfurt, Institute of Clinical Pharmacology, Goethe University Hospital, Frankfurt, Germany
    Brain Behav Immun 32:186-200. 2013
    ....
  36. ncbi request reprint The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception
    Ellen Niederberger
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Biochem Biophys Res Commun 362:75-80. 2007
    ..Thus, our data confirm that CREB is essential for spinal nociceptive processing. However, prevention of phosphorylation only at serine 142 is not sufficient to modulate the nociceptive response...
  37. ncbi request reprint Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice
    Laura Popp
    Pharmazentrum Frankfurt, ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, Haus 74, Rm 437, 60590 Frankfurt am Main, Germany
    Eur J Pain 13:691-703. 2009
    ....
  38. doi request reprint The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia
    Christine V Möser
    Pharmazentrum Frankfurt Das Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt, 60590 Frankfurt am Main, Germany
    J Immunol 187:2617-25. 2011
    ..Therefore, we concluded that IKKε modulates inflammatory nociceptive sensitivity by activation of NF-κB-dependent gene transcription and may be useful as a therapeutic target in the treatment of inflammatory pain...
  39. pmc Spatial distribution of 8-methoxypsoralen penetration into human skin after systemic or topical administration
    Marcella Grundmann-Kollmann
    Department of Dermatology, Klinikum der Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Br J Clin Pharmacol 54:535-9. 2002
    ..Recommendations for the time of UVA irradiation are mainly based on the time course of minimal phototoxic doses. However, the time course and depth of skin penetration of psoralens is not well characterized...
  40. doi request reprint Progranulin contributes to endogenous mechanisms of pain defense after nerve injury in mice
    Hee Young Lim
    Pharmazentrum Frankfurt, ZAFES, Clinical Pharmacology, Goethe University, Frankfurt, Germany
    J Cell Mol Med 16:708-21. 2012
    ..A deficiency in this mechanism may increase the risk for injury-associated chronic pain...
  41. ncbi request reprint Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers
    Sabine Grosch
    Pharmazentrum Frankfurt, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    FASEB J 17:1316-8. 2003
    ....
  42. doi request reprint No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing
    Achim Schmidtko
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Trends Neurosci 32:339-46. 2009
    ..Here, we summarize the most recent advances in the understanding of NO- and cGMP-dependent signaling pathways in the spinal cord and further unravel the role of NO and cGMP in pain processing...
  43. doi request reprint Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk
    Alexandra Doehring
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Mutat Res 659:195-201. 2008
    ....
  44. doi request reprint Exogenous delta⁹-tetrahydrocannabinol influences circulating endogenous cannabinoids in humans
    Carmen Walter
    Institute of Clinical Pharmacology, Goethe University, Frankfurt am Main, Germany
    J Clin Psychopharmacol 33:699-705. 2013
    ....
  45. ncbi request reprint Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Neurosci Lett 332:146-50. 2002
    ..The antinociceptive effects of the PKG inhibitor suggest that a strong PKG activation may be responsible for 'high dose' 8-bromo-cGMP evoked hyperalgesia...
  46. ncbi request reprint Opposite effects of rofecoxib on nuclear factor-kappaB and activating protein-1 activation
    Ellen Niederberger
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Frankfurt am Main, Germany
    J Pharmacol Exp Ther 304:1153-60. 2003
    ..The effects on AP-1 may possibly affect renal sodium transport because certain renal sodium channels are regulated through AP-1. Transcription factor regulation might therefore influence both wanted and unwanted effects of rofecoxib...
  47. ncbi request reprint Time course of 8-methoxypsoralen concentrations in skin and plasma after topical (bath and cream) and oral administration of 8-methoxypsoralen
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Clin Pharmacol Ther 71:153-61. 2002
    ..To achieve optimal therapeutic effects, ultraviolet A irradiation should be performed at the time of maximum photosensitivity, that is, at the time of maximum 8-methoxypsoralen tissue concentrations...
  48. doi request reprint Protein S-nitrosylation and denitrosylation in the mouse spinal cord upon injury of the sciatic nerve
    Reynir Scheving
    Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt, 60590 Frankfurt am Main, Germany
    J Proteomics 75:3987-4004. 2012
    ..The data show that nitric oxide mediated S-nitrosylation contributes to the nerve injury-evoked pathology in nociceptive signaling pathways...
  49. doi request reprint Genetic modulation of the pharmacological treatment of pain
    Jorn Lotsch
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Pharmacol Ther 124:168-84. 2009
    ....
  50. ncbi request reprint Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms
    Jorn Lotsch
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Clin Chem 53:1010-5. 2007
    ..A haplotype in the GTP cyclohydrolase 1 (dopa-responsive dystonia) gene (GCH1) is associated with decreased persistent pain. The aim of the present study was to develop a screening method for the pain-protective haplotype...
  51. pmc Validation of a new fluorogenic real-time PCR assay for detection of CYP2C9 allelic variants and CYP2C9 allelic distribution in a German population
    Maria Burian
    Pharmazentrum Frankfurt, Institut fur Klinische Pharmakologie, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Br J Clin Pharmacol 54:518-21. 2002
    ..The aim was to develop a fast detection method for the polymorphic alleles related to impaired CYP2C9-mediated metabolism...
  52. ncbi request reprint Drug interactions with patient-controlled analgesia
    Jorn Lotsch
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Clin Pharmacokinet 41:31-57. 2002
    ....
  53. ncbi request reprint Opioids as modulators of cell death and survival--unraveling mechanisms and revealing new indications
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Germany
    Pharmacol Rev 56:351-69. 2004
    ..The present review tries to unravel controversial findings and provides a hypothesis that may help to integrate diverse results...
  54. pmc Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
    Nitin Agarwal
    Institute for Pharmacology, University of Heidelberg, Im Neuenheimer Feld, Heidelberg, 69120 Germany
    Nat Neurosci 10:870-9. 2007
    ....
  55. pmc Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats
    Joachim Scholz
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Room 4309, Charlestown, MA 02129, USA
    Pain 138:130-42. 2008
    ..We confirm that microglial activation is crucial for the development of pain after nerve injury, and demonstrates that suppression of this cellular immune response is a promising approach for preventing neuropathic pain...
  56. ncbi request reprint GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
    Irmgard Tegeder
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Room 4309, Charlestown, Massachusetts 02129, USA
    Nat Med 12:1269-77. 2006
    ..BH4 is therefore an intrinsic regulator of pain sensitivity and chronicity, and the GTP cyclohydrolase haplotype is a marker for these traits...
  57. pmc GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function
    Charalambos Antoniades
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    J Am Coll Cardiol 52:158-65. 2008
    ....
  58. ncbi request reprint Pathophysiology and treatment of pain in joint disease
    Hans Georg Schaible
    Institut fur Physiologie, Universitat Jena, Teichgraben 8, D 07740 Jena, Germany
    Adv Drug Deliv Rev 58:323-42. 2006
    ..Therapeutic targets are also found among the axonal channels that set membrane potential and modulate discharge frequency such as voltage sensitive sodium channels and various potassium channels...
  59. doi request reprint Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats
    Charles Mills
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Eur J Neurosci 27:937-46. 2008
    ..Furthermore, although Ro5-4864 is only a very weak promoter of survival in adult neurons, it significantly enhances regeneration and functional recovery in adults...