Ramona Steri

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. doi request reprint Truxillic acid derivatives act as peroxisome proliferator-activated receptor gamma activators
    Ramona Steri
    Goethe University Frankfurt, Institute of Pharmaceutical Chemistry ZAFES LiFF FIRST, Max von Laue Str 9, 60438 Frankfurt, Germany
    Bioorg Med Chem Lett 20:2920-3. 2010
  2. doi request reprint SAR studies of acidic dual γ-secretase/PPARγ modulators
    Martina Hieke
    Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max von Laue Str 9, D 60438 Frankfurt am Main, Germany
    Bioorg Med Chem 19:5372-82. 2011
  3. doi request reprint Investigation of imatinib and other approved drugs as starting points for antidiabetic drug discovery with FXR modulating activity
    Ramona Steri
    Institute of Pharmaceutical Chemistry, ZAFES LiFF Goethe University Frankfurt, Max von Laue Str 9, D 60438 Frankfurt Main, Germany
    Biochem Pharmacol 83:1674-81. 2012
  4. doi request reprint Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator
    Theresa M Thieme
    Institute of Pharmaceutical Chemistry, ZAFES LiFF FIRST, Goethe University Frankfurt, 60438 Frankfurt, Germany
    Bioorg Med Chem Lett 20:2469-73. 2010
  5. doi request reprint Discovery of a novel class of 2-mercaptohexanoic acid derivatives as highly active PPARalpha agonists
    Heiko Zettl
    Goethe University Frankfurt, Institute of Pharmaceutical Chemistry ZAFES LiFF, Max von Laue Str 9, D 60348 Frankfurt M, Germany
    Bioorg Med Chem Lett 19:4421-6. 2009

Collaborators

Detail Information

Publications5

  1. doi request reprint Truxillic acid derivatives act as peroxisome proliferator-activated receptor gamma activators
    Ramona Steri
    Goethe University Frankfurt, Institute of Pharmaceutical Chemistry ZAFES LiFF FIRST, Max von Laue Str 9, 60438 Frankfurt, Germany
    Bioorg Med Chem Lett 20:2920-3. 2010
    ..Herein we present the structure-activity relationships of 16 truxillic acid derivatives, investigated by a cell-based reporter gene assay guided by molecular docking analysis...
  2. doi request reprint SAR studies of acidic dual γ-secretase/PPARγ modulators
    Martina Hieke
    Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max von Laue Str 9, D 60438 Frankfurt am Main, Germany
    Bioorg Med Chem 19:5372-82. 2011
    ..Compound 17 showed an IC(50) Aβ42=2.4 μM and an EC(50) PPARγ=7.2 μM and could be a valuable tool to further evaluate the concept of dual γ-secretase/PPARγ modulators in animal models of Alzheimer's disease...
  3. doi request reprint Investigation of imatinib and other approved drugs as starting points for antidiabetic drug discovery with FXR modulating activity
    Ramona Steri
    Institute of Pharmaceutical Chemistry, ZAFES LiFF Goethe University Frankfurt, Max von Laue Str 9, D 60438 Frankfurt Main, Germany
    Biochem Pharmacol 83:1674-81. 2012
    ..We show FXR modulation by selected compounds in a full length FXR transactivation assay and modulation of a FXR target gene by imatinib...
  4. doi request reprint Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator
    Theresa M Thieme
    Institute of Pharmaceutical Chemistry, ZAFES LiFF FIRST, Goethe University Frankfurt, 60438 Frankfurt, Germany
    Bioorg Med Chem Lett 20:2469-73. 2010
    ..Herein we present modifications of pirinixic acid leading to subtype-selective PPARgamma agonists and furthermore the development of a selective PPARgamma modulator guided by molecular docking studies...
  5. doi request reprint Discovery of a novel class of 2-mercaptohexanoic acid derivatives as highly active PPARalpha agonists
    Heiko Zettl
    Goethe University Frankfurt, Institute of Pharmaceutical Chemistry ZAFES LiFF, Max von Laue Str 9, D 60348 Frankfurt M, Germany
    Bioorg Med Chem Lett 19:4421-6. 2009
    ..Compound 10 represents a low nano molar active PPARalpha activator with excellent selectivity towards PPARgamma...