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Genomes and Genes | C SchultzSummaryAffiliation: Frankfurt am Main Country: Germany Publications
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Publications
Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neuronsChristian Schultz
Institute for Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
Mol Cell Neurosci 33:68-80. 2006..These data provide the first evidence for a compartmentalized clustering of NF-kappaB pathway components in the AIS and implicate this neuronal compartment in the activation of NF-kappaB...
Vulnerability of cortical neurons to Alzheimer's and Parkinson's diseasesHeiko Braak
Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt am Main, Germany
J Alzheimers Dis 9:35-44. 2006..The severity of the neocortical lesions decreases in inverse proportion to the trajectories of increasing cortical differentiation and hierarchical refinement...
A sex difference in neurodegeneration of the human hypothalamusC Schultz
Department of Morphology, J W Goethe University, Frankfurt Main, Germany
Neurosci Lett 212:103-6. 1996..The sex-dependent neurofibrillary degeneration is suggested as an explanation for an impairment in neuroendocrine function previously reported in elderly men...
Expression of stress proteins alpha B-crystallin, ubiquitin, and hsp27 in pallido-nigral spheroids of aged rhesus monkeysC Schultz
Department of Anatomy, Johann Wolfgang Goethe University, 60590, Frankfurt Main, Germany
Neurobiol Aging 22:677-82. 2001....
Age-related progression of tau pathology in brains of baboonsC Schultz
Department of Anatomy, Johann Wolfgang Goethe University, 60590, Frankfurt Main, Germany
Neurobiol Aging 21:905-12. 2000..In conclusion, the present findings underline the value of the baboon as a potential nonhuman primate model for age-related tau pathology afflicting the human brain...
Cytoskeletal alterations in the human tuberal hypothalamus related to argyrophilic grain diseaseC Schultz
Department of Anatomy, Johann Wolfgang Goethe University, Frankfurt Main, Germany
Acta Neuropathol 96:596-602. 1998..The present findings support the concept that AGD is a distinct neurodegenerative entity afflicting not only cortical but also subcortical predilection sites of the human brain...
High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobeChristian Schultz
Institute for Clinical Neuroanatomy, Johann Wolfgang Goethe University, 60590 Frankfurt Main, Germany
Neurobiol Aging 25:397-405. 2004..In summary, this study suggests that TSA is a distinct form of glial tau pathology that occurs with a high frequency in elderly individuals...
Neurofibrillary pathology in the human paraventricular and supraoptic nucleiC Schultz
Department of Morphology, Johann Wolfgang Goethe University, Frankfurt Main, Germany
Acta Neuropathol 94:99-102. 1997..The alterations in the paraventricular and supraoptic nuclei were consistently accompanied by neurofibrillary changes in the mediobasal hypothalamus...
Cytoskeletal alterations in the aged human neurohypophysisC Schultz
Department of Morphology, J W Goethe University, Frankfurt Main, Germany
Neurosci Lett 237:93-6. 1997..In conclusion, the aged human neurohypophysis is revealed as a potential focus of abnormal cytoskeletal changes which may impair the neuroendocrine function of the hypothalamo-neurohypophyseal system...
The autonomic higher order processing nuclei of the lower brain stem are among the early targets of the Alzheimer's disease-related cytoskeletal pathologyU Rüb
Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt Main, Germany
Acta Neuropathol 101:555-64. 2001..This relationship remains to be established, but it could provide insights into the illusive correlation between the AD-related cytoskeletal pathology and the function of affected neurons...
Spinocerebellar ataxias types 2 and 3: degeneration of the pre-cerebellar nuclei isolates the three phylogenetically defined regions of the cerebellumU Rüb
Institute of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
J Neural Transm 112:1523-45. 2005....
Degeneration of the central vestibular system in spinocerebellar ataxia type 3 (SCA3) patients and its possible clinical significanceU Rüb
Institute for Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai, Frankfurt Main, Germany
Neuropathol Appl Neurobiol 30:402-14. 2004..The reported lesions can help to explain the truncal and postural instability as well as the impaired optokinetic nystagmus, vestibulo-ocular reaction, and horizontal gaze-holding present in SCA3 cases...
Damage to the reticulotegmental nucleus of the pons in spinocerebellar ataxia type 1, 2, and 3U Rüb
Institute for Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
Neurology 63:1258-63. 2004....
Extended pathoanatomical studies point to a consistent affection of the thalamus in spinocerebellar ataxia type 2U Rüb
Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
Neuropathol Appl Neurobiol 31:127-40. 2005....
The evolution of Alzheimer's disease-related cytoskeletal pathology in the human raphe nucleiU Rüb
Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt Main, Germany
Neuropathol Appl Neurobiol 26:553-67. 2000....
Early involvement of the tegmentopontine reticular nucleus during the evolution of Alzheimer's disease-related cytoskeletal pathologyU Rüb
Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
Brain Res 908:107-12. 2001....
Argyrophilic grain disease is associated with apolipoprotein E epsilon 2 alleleE Ghebremedhin
Department of Anatomy, J W Goethe University, Frankfurt Main, Germany
Acta Neuropathol 96:222-4. 1998..0002). The association between AGD and epsilon2 allele of ApoE suggests that AGD can be distinguished from other neurodegenerative disorders not only neuropathologically, but also genetically...
Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of MeynertI Sassin
Department of Anatomy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Acta Neuropathol 100:259-69. 2000..The considerable morphological diversity of cytoskeletal alterations is typical of stages III and IV. These results indicate that individual neurons of the bnM enter the sequence of cytoskeletal deterioration at different times...
Sex-dependent cytoskeletal changes of the human hypothalamus develop independently of Alzheimer's diseaseC Schultz
Department of Anatomy, Johann Wolfgang Goethe University, Frankfurt Main, Germany
Exp Neurol 160:186-93. 1999..Instead, the sex-dependent hypothalamic pathology probably corresponds to a distinct neurodegenerative entity preferentially affecting elderly males...
Degeneration of ingestion-related brainstem nuclei in spinocerebellar ataxia type 2, 3, 6 and 7U Rüb
Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
Neuropathol Appl Neurobiol 32:635-49. 2006....
Anatomically based guidelines for systematic investigation of the central somatosensory system and their application to a spinocerebellar ataxia type 2 (SCA2) patientU Rüb
Institute for Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
Neuropathol Appl Neurobiol 29:418-33. 2003..In proposing these new guidelines, we hope to enable others to study the hitherto unknown morphological counterparts of somatosensory dysfunctions in additional CAG-repeat disease patients...
Gender and age modify the association between APOE and AD-related neuropathologyE Ghebremedhin
Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt, Germany
Neurology 56:1696-701. 2001..To assess the impact of apolipoprotein E (APOE) polymorphism on AD-related neurofibrillary tangle (NFT) formation and senile plaques (SP)...
Involvement of the cranial nerves and their nuclei in spinocerebellar ataxia type 2 (SCA2)K Gierga
Institute of Clinical Neuroanatomy, J.W. Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt/Main, Germany
Acta Neuropathol (Berl) 109:617-31. 2005....
Degeneration of the external cuneate nucleus in spinocerebellar ataxia type 3 (Machado-Joseph disease)U Rüb
Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
Brain Res 953:126-34. 2002....
Progressive supranuclear palsy: neuronal and glial cytoskeletal pathology in the higher order processing autonomic nuclei of the lower brainstemU Rüb
Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Frankfurt, Main, Germany
Neuropathol Appl Neurobiol 28:12-22. 2002..In view of their functional role, the neuronal pathology in the nuclei studied offers a possible explanation for the autonomic dysfunctions that eventually develop in the course of PSP...
The premotor region essential for rapid vertical eye movements shows early involvement in Alzheimer's disease-related cytoskeletal pathologyU Rüb
Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590, Frankfurt Main, Germany
Vision Res 41:2149-56. 2001..In the event that the cytoskeletal pathology impairs the function of the premotor neurons of the riMLF, one would predict a progressive slowing of vertical saccades corresponding to the advancing cortical NFT/NT-stages...
Nerve cells expressing heat-shock proteins in Parkinson's diseaseH Braak
Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
Acta Neuropathol 102:449-54. 2001..Nevertheless, most of the telencephalic alphaB-crystallin-immunopositive neurons refrain from developing Lewy bodies and Lewy neurites and, vice versa, most of the nerve cells containing Lewy bodies do not accumulate alphaB-crystallin...
The nucleus raphe interpositus in spinocerebellar ataxia type 3 (Machado-Joseph disease)U Rüb
Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
J Chem Neuroanat 25:115-27. 2003....
Amyloid beta-protein (Abeta)-containing astrocytes are located preferentially near N-terminal-truncated Abeta deposits in the human entorhinal cortexD R Thal
Department of Anatomy, J W Goethe University, Frankfurt, Germany
Acta Neuropathol 100:608-17. 2000....
Spinocerebellar ataxia type 7 (SCA7): first report of a systematic neuropathological study of the brain of a patient with a very short expanded CAG-repeatU Rüb
Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
Brain Pathol 15:287-95. 2005..Finally, our immunocytochemical analysis confirms previous studies which described the presence of NI in obviously degenerated brain and retinal regions as well as in apparently well-preserved brain regions and retina of SCA7 patients...
Vulnerability of select neuronal types to Alzheimer's diseaseH Braak
Department of Clinical Neuroanatomy, J W Goethe University, D 60590 Frankfurt Main, Germany
Ann N Y Acad Sci 924:53-61. 2000....
Spinocerebellar ataxia type 3 (Machado-Joseph disease): severe destruction of the lateral reticular nucleusU Rüb
Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
Brain 125:2115-24. 2002..In view of its afferent and efferent connections, destruction of the LRT probably contributes to gait ataxia in individuals suffering from SCA3...
Thalamic involvement in a spinocerebellar ataxia type 2 (SCA2) and a spinocerebellar ataxia type 3 (SCA3) patient, and its clinical relevanceU Rüb
Institute for Clinical Neuroanatomy, Department of Neurology, Johann Wolfgang Goethe University, Frankfurt Main, Germany
Brain 126:2257-72. 2003....
Accumulation of phosphorylated I kappaB alpha and activated IKK in nodes of RanvierC Politi
Institute of Clinical Neuroanatomy, J W Goethe University, Frankfurt, Germany
Neuropathol Appl Neurobiol 34:357-65. 2008..As the AIS shares fundamental features with nodes of Ranvier (NR), we examined whether pI kappaB alpha and activated IKK are also enriched in NR...
Parkinson's disease: the thalamic components of the limbic loop are severely impaired by alpha-synuclein immunopositive inclusion body pathologyU Rüb
Department of Clinical Neuroanatomy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590, Frankfurt Main, Germany
Neurobiol Aging 23:245-54. 2002..Damage to the thalamic components of the limbic loop nuclei may contribute not only to the cognitive, emotional, and autonomic symptoms of PD but to the somatomotor and oculomotor dysfunctions as well...
Genetic association of argyrophilic grain disease with polymorphisms in alpha-2 macroglobulin and low-density lipoprotein receptor-related protein genesE Ghebremedhin
Department of Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
Neuropathol Appl Neurobiol 28:308-13. 2002..9% vs. 13.2%, P=0.93). This association, however, is only apparent in the presence of the LRP CC genotype. In conclusion, the present study shows that AGD is associated with the LRP, A2M and ApoE genes...
UV light-induced autofluorescence of full-length Abeta-protein deposits in the human brainD R Thal
Department of Anatomy, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Clin Neuropathol 21:35-40. 2002....
159C>T CD14 genotype--functional effects on innate immune responses in term neonatesChristoph Hartel
Department of Pediatrics, University at Lubeck, Lubeck, Germany
Hum Immunol 69:338-43. 2008..Further studies are needed to delineate whether the 159C>T CD14 genotype is a risk factor for severity of neonatal infection in the clinical setting and a potential target for prevention strategies...
Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent mannerDietmar Rudolf Thal
Department of Neuropathology, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
Acta Neuropathol 110:459-71. 2005..Moreover, apoE-positive newly formed plaques were seen more frequently in APOE epsilon4/4 cases than in non-APOE epsilon4/4 individuals, thereby underlining the potentially crucial role of apoE for the development of Abeta deposits...
Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer's disease and argyrophilic grain diseaseChris Conrad
Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
J Neurochem 89:179-88. 2004..More detailed studies confirm the H2 haplotype to be the ancestral tau gene. This situation is reminiscent of the evolution of the apolipoprotein (ApoE) gene, another locus that is potentially important for the risk of development of AD...
Homozygosity for the K variant of BCHE gene increases the risk for development of neurofibrillary pathology but not amyloid deposits at young agesEstifanos Ghebremedhin
Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
Acta Neuropathol 114:359-63. 2007..These findings suggest that homozygosity, but not heterozygosity, for BCHE-K is a potential risk factor for the development of NFT pathology in young individuals implicating BCHE-K in the pathogenesis of early AD...
Loss of the cisternal organelle in the axon initial segment of cortical neurons in synaptopodin-deficient miceCarlos Bas Orth
Institute of Clinical Neuroanatomy, J W Goethe University, D 60590 Frankfurt Main, Germany
J Comp Neurol 504:441-9. 2007..Taken together, our data demonstrate that synaptopodin is an essential component of the cisternal organelle of axons and of the dendritic spine apparatus, two organelles that are structurally and molecularly related...
Consistent affection of the central somatosensory system in spinocerebellar ataxia type 2 and type 3 and its significance for clinical symptoms and rehabilitative therapyUdo Rüb
Department of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
Brain Res Rev 53:235-49. 2007....
Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brainsEstifanos Ghebremedhin
Department of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Neurosci Lett 320:25-8. 2002..036 for NFTs, and P=0.045 for A beta-deposits) at ages > or = 70 years but not 50-69 years. Furthermore, no interaction was apparent between BCHE-K and ApoE...
Genetic association studies in VLBW infants exemplifying susceptibility to sepsis--recent findings and implications for future researchChristoph Hartel
Department of Pediatrics, University of Lübeck Children s Hospital, Ratzeburger Allee 160, 23538 Lubeck, Germany
Acta Paediatr 96:158-65. 2007..g. habits and comorbidities...
Current approaches for risk stratification of infectious complications in pediatric oncologyChristoph Hartel
Department of Pediatric Hematology, Oncology and Immunology, University of Lubeck, Childrens Hospital, Germany
Pediatr Blood Cancer 49:767-73. 2007..Given the data available from a significant number of small studies, a large prospective non-inferiority trial is essential to assess low-risk clinical factors and additional laboratory or genetic markers for their predictive value...
Corynebacterial protein kinase G controls 2-oxoglutarate dehydrogenase activity via the phosphorylation status of the OdhI proteinAxel Niebisch
Institut für Biotechnologie 1, Forschungszentrum Julich, D 52425 Julich, Germany
J Biol Chem 281:12300-7. 2006..glutamicum. Moreover, because this signaling cascade is likely to operate also in mycobacteria, our results suggest that the attenuated pathogenicity of mycobacteria lacking PknG might be caused by a disturbed tricarboxylic acid cycle...
Glutamate production by Corynebacterium glutamicum: dependence on the oxoglutarate dehydrogenase inhibitor protein OdhI and protein kinase PknGChristian Schultz
Institut für Biotechnologie 1, Forschungszentrum Julich, 52425, Julich, Germany
Appl Microbiol Biotechnol 76:691-700. 2007..Under strong biotin limitation and in the presence of ethambutol, the DeltapknG mutant showed significantly increased glutamate production, offering a new way to improve production strains...
Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transportSara K Custer
Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington 98195, USA
Nat Neurosci 9:1302-11. 2006..Our studies indicate that impairment of glutamate transport secondary to glial dysfunction contributes to SCA7 neurodegeneration, and suggest a similar role for glial dysfunction in other polyglutamine diseases and SCAs...
Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary culturesNora John
Department for Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology Magdeburg, Germany
Mol Cell Neurosci 31:774-84. 2006..Furthermore, axon initial segments are strongly covered by a dense brevican coat. Altogether, we show that mature primary cultures can form PNN, and that basic features of these extracellular matrix structures may be studied in vitro...
Pallido-nigral spheroids in nonhuman primates: accumulation of heat shock proteins in astroglial processesDirk Willwohl
Department of Anatomy, Johann-Wolfgang Goethe University, Theodor-Stern Kai-7, 60590 Frankfurt am Main, Germany
Acta Neuropathol (Berl) 103:276-80. 2002..Further investigations of these structures may provide information pertinent to our understanding of astroglial heat shock protein inclusions developing in degenerative human brain diseases...
Anaplastic ependymoma with pleuropulmonary relapseTobias Strunk
Department of Pediatrics, , , Germany
Med Pediatr Oncol 41:467-8. 2003
Subacute leukencephalopathy after low-dose intrathecal methotrexate in an adolescent heterozygous for the MTHFR C677T polymorphismTobias Strunk
Department of Pediatrics, University of Luebeck Medical School, Germany
Med Pediatr Oncol 40:48-50. 2003
Intranuclear aggregation of nonexpanded ataxin-3 in marinesco bodies of the nonhuman primate substantia nigraMattias Kettner
Department of Anatomy, J. W. Goethe University, Frankfurt/Main, Germany
Exp Neurol 176:117-21. 2002..In conclusion MB in nonhuman primates permit experimental examination of mechanisms involved in transnuclear localization, intranuclear aggregation, and ubiquitination of nonexpanded polyglutamine proteins...
HPA-1 carrier status and thrombocytopenia in preterm infants with a birth weight below 1500 gramsWolfgang Gopel
Department of Pediatrics, University of Lubeck, Germany
J Perinat Med 30:176-8. 2002....
