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Genomes and Genes | Achim RodySummaryAffiliation: Frankfurt am Main Country: Germany Publications
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Publications
Androgen receptor expression in ductal carcinoma in situ of the breast: not a helpful marker for classification such as estrogen receptor alpha and progesterone receptorAchim Rody
Department of Obstetrics and Gynecology, University Hospital of Frankfurt, Frankfurt, Germany
Appl Immunohistochem Mol Morphol 13:25-9. 2005..The immunohistochemical assessment of AR status, therefore, may not help in providing a more objective way of classifying DCIS...
[Molecular diagnostic and targeted therapy--"Barking dogs are going to bite": presentations from the 42nd Annual Meeting of the American Society of Clinical Oncology, Atlanta 2006]A Rody
Klinik fur Gynakologie und Geburtshilfe, J W Goethe Universitat, Frankfurt am Main
Zentralbl Gynakol 128:233-41. 2006..In this year again there have been registered an increasing number of interesting contributions from Germany, which also received international attention...
Gene expression profiles of breast cancer obtained from core cut biopsies before neoadjuvant docetaxel, adriamycin, and cyclophoshamide chemotherapy correlate with routine prognostic markers and could be used to identify predictive signaturesA Rody
Department of Obstetrics and Gynecology, J W Goethe University, Frankfurt, Germany
Zentralbl Gynakol 128:76-81. 2006..Furthermore we evaluated the predictive significance of prognostic gene signatures as described by Sorlie, van't Veer and Ahr for response to neoadjuvant chemotherapy...
Gene expression profiling of breast cancer patients treated with docetaxel, doxorubicin, and cyclophosphamide within the GEPARTRIO trial: HER-2, but not topoisomerase II alpha and microtubule-associated protein tau, is highly predictive of tumor responseA Rody
Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Breast 16:86-93. 2007..017) as well as overall response (P=0.037) and clinical complete response (cCR, P=0.050). In contrast, for both TOPO IIalpha and MAPT no correlation with pCR was observed in our sample group...
[Diagnosis and therapy of breast cancer--meeting highlights ASCO 2005]A Rody
, , Frankfurt/Main
Zentralbl Gynakol 127:389-94. 2005
T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancersAchim Rody
Department of Obstetrics and Gynecology, JW Goethe University, Theodor Stern Kai 7, Frankfurt, Germany
Breast Cancer Res 11:R15. 2009..However, specific lymphocytes might also promote tumor progression by shifting the cytokine milieu in the tumor...
Use of goserelin in the treatment of breast cancerAchim Rody
Department of Obstetrics and Gynecology, JW Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
Expert Rev Anticancer Ther 5:591-604. 2005..Treatment decisions depend upon adjuvant endocrine pretreatment. Clinical data regarding ovarian protection by synchronous use of gonadotropin-releasing hormone in young breast cancer patients receiving chemotherapy are incoherent...
"Stem cell like" breast cancers-a model for the identification of new prognostic/predictive markers in endocrine responsive breast cancer exemplified by Plexin B1A Rody
Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
Eur J Obstet Gynecol Reprod Biol 139:11-5. 2008..032; ER positive: p=0.022). In conclusion those strategies of gene expression analysis in a context of biological meaningful classifications could be helpful to reveal new prognostic/predictive markers...
Gene expression of topoisomerase II alpha (TOP2A) by microarray analysis is highly prognostic in estrogen receptor (ER) positive breast cancerA Rody
Department of Obstetrics and Gynecology, JW Goethe University, Frankfurt, Germany
Breast Cancer Res Treat 113:457-66. 2009..There is growing evidence that TOP2A protein expression is a strong prognostic and TOP2A gene amplification might be a predictive marker (particularly for the use of anthracyclines)...
[Forensic aspects of female breast reconstructive surgery]K Ulsenheimer
Maximiliansplatz 12,
Zentralbl Gynakol 127:66-70. 2005
[San Antonio Breast Cancer Symposium -- highlights 2004]A Rody
Klinik fur Gynakologie und Geburtshilfe, J W Goethe Universitat, Frankfurt, Germany
Zentralbl Gynakol 127:59-65. 2005..The morbidity of this method is low compared with conventional axillary dissection in multicenter studies. Local tumor control is an important parameter which offers a significant survival benefit in all age cohorts...
The erbB2+ cluster of the intrinsic gene set predicts tumor response of breast cancer patients receiving neoadjuvant chemotherapy with docetaxel, doxorubicin and cyclophosphamide within the GEPARTRIO trialA Rody
Department of Obstetrics and Gynecology, J W Goethe University, Frankfurt, Germany
Breast 16:235-40. 2007..6%), basal-like (30.0%) and luminal (13.6%) cluster (P=0.215). Our data suggest that the molecular tumor subtypes based on the "intrinsic gene set" can be used to predict tumor response according to NAC...
Differentially expressed genes of reprogrammed human pluripotent stem cells in breast cancerA Rody
Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
Eur J Cancer 44:1789-92. 2008..This analysis reveals two breast cancer subgroups with stem cell-like features, differing in ER-status and proliferation as well as in their clinical course of disease...
Estrogen receptor alpha and beta, progesterone receptor, pS2 and HER-2/neu expression delineate different subgroups in ductal carcinoma in situ of the breastAchim Rody
Department of Obstetrics and Gynecology, University of Hospital of Muenster, Germany
Oncol Rep 12:695-9. 2004..012). In contrast, 50.0% of her-2/neu negative DCIS expressed ER-beta receptor (p=0.052). We propose that there are subpopulations of DCIS which can be described by distinct endocrine-associated expression patterns...
Data-driven derivation of cutoffs from a pool of 3,030 Affymetrix arrays to stratify distinct clinical types of breast cancerThomas Karn
Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590, Frankfurt, Germany
Breast Cancer Res Treat 120:567-79. 2010..In contrast, markers displaying a continuous distribution like proliferation markers as Ki67 rather describe the composition of the mixture of cells in the tumor...
Gene expression profiling of luminal B breast cancers reveals NHERF1 as a new marker of endocrine resistanceThomas Karn
Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Breast Cancer Res Treat 130:409-20. 2011..However, based on previous findings of NHERF1 functioning in PI3K signalling from basic research, these tumors might be appropriate candidates for a targeted therapy of the PI3K/Akt pathway...
Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancerEugen Ruckhäberle
Department of Gynecology, J W Goethe University, Frankfurt, Germany
J Cancer Res Clin Oncol 135:81-90. 2009....
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancerEugen Ruckhäberle
Department of Gynecology, J W Goethe University, 60590, Frankfurt, Germany
Breast Cancer Res Treat 112:41-52. 2008..Targeting of the sphingolipid rheostat may thus open new treatment options...
Loss of Plexin B1 is highly prognostic in low proliferating ER positive breast cancers--results of a large scale microarray analysisAchim Rody
Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
Eur J Cancer 45:405-13. 2009..In conclusion, this study confirms our previous observations suggesting Plexin B1 as a new prognostic marker in ER positive breast cancers...
A clinically relevant gene signature in triple negative and basal-like breast cancerAchim Rody
Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, Frankfurt, 60590, Germany
Breast Cancer Res 13:R97. 2011..Triple negative breast cancers (TNBC) are clinically heterogeneous and prognostic markers and biology-based therapies are needed to better treat this disease...
Differential expression of claudins in human endometrium and endometriosisRegine Gaetje
Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
Gynecol Endocrinol 24:442-9. 2008..The downregulation of various members of the claudin family may contribute to endometrial cell detachment and increase the number of cells invading pelvic organs...
Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signaturesThomas Karn
Department of Obstetrics and Gynecology, J W Goethe University, Frankfurt, Germany
PLoS ONE 6:e28403. 2011..The identification of prognostic signatures from TNBC cohorts was limited in the past due to small sample sizes...
Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosisRegine Gaetje
Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
Gynecol Endocrinol 23:567-73. 2007..Various members of the MMPs also seem to play an important role in the invasion process of endometriosis; however, so far only a limited number of studies have focused on membrane-associated MMPs...
Expression of endothelin-1, endothelin-A, and endothelin-B receptor in human breast cancer and correlation with long-term follow-upPia Wülfing
Department of Obstetrics and Gynecology, Gerhard Domagk Institute of Pathology, Westfalische Wilhelms University, 48129 Munster, Germany
Clin Cancer Res 9:4125-31. 2003..In this study, we evaluated the expression of ET-1 and ET receptors in breast carcinomas and determined its clinical and prognostic significance...
Melanoma antigen family A identified by the bimodality index defines a subset of triple negative breast cancers as candidates for immune response augmentationThomas Karn
Department of Obstetrics and Gynecology, JW Goethe University, Frankfurt, Germany
Eur J Cancer 48:12-23. 2012..Oestrogen (ER) and human epidermal growth factor receptor 2 (HER2) receptors are strongly bimodally expressed genes in breast cancer...
Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancerEugen Ruckhäberle
Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
J Cancer Res Clin Oncol 135:1005-13. 2009..Sphingolipids are bioactive lipids implicated in apoptosis, cell survival and proliferation. We analyzed the prognostic value of enzymes from sphingolipid metabolism in breast cancer...
SATB1 gene expression and breast cancer prognosisLars C Hanker
Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
Breast 20:309-13. 2011....
Poor outcome in estrogen receptor-positive breast cancers predicted by loss of plexin B1Achim Rody
Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
Clin Cancer Res 13:1115-22. 2007..One of those genes is plexin B1, a cell-surface receptor for the semaphorin Sema4D (CD 100). However, the biological role of plexin B1 in breast cancer is largely unknown...
Characterization of WNT7A expression in human endometrium and endometriotic lesionsRegine Gaetje
Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
Fertil Steril 88:1534-40. 2007..To characterize the expression of WNT7A in human eutopic and ectopic endometrium...
Extended breast cancer treatment with an aromatase inhibitor (Letrozole) after tamoxifen: why, who and how long?Manfred Kaufmann
Department of Obstetrics and Gynaecology, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
Eur J Obstet Gynecol Reprod Biol 126:146-54. 2006....
Long-term risk of breast cancer recurrence: the need for extended adjuvant therapyManfred Kaufmann
Klinik fur Gynakologie und Geburtshilfe, J W Goethe Universität Frankfurt am Main, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
J Cancer Res Clin Oncol 131:487-94. 2005..That trial, MA.17, evaluated letrozole as extended adjuvant treatment following standard adjuvant tamoxifen in postmenopausal women with predominantly estrogen receptor--and/or progesterone receptor--positive early breast cancer...
Utero-tubal sperm transport and its impairment in endometriosis and adenomyosisStefan Kissler
Department Obstetrics and Gynecology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
Ann N Y Acad Sci 1101:38-48. 2007..Hence, dysperistalsis is significantly associated with reduced spontaneous pregnancy rates. We therefore recommend MRI and HSSG in every sterility workup...
Analysis of cyclooxygenase-2 expression in human breast cancer: high throughput tissue microarray analysisPia Wülfing
Department of Obstetrics and Gynecology, University of Munster, Albert Schweitzer Strasse 33, 48129, Munster, Germany
J Cancer Res Clin Oncol 129:375-82. 2003..The objective of this study was to evaluate breast carcinomas for the expression of cyclooxygenase-2 (Cox-2) using a tissue microarray (TMA) and to determine its clinical and prognostic relevance...
Prognostic impact of fascin-1 (FSCN1) in epithelial ovarian cancerLars C Hanker
Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Anticancer Res 33:371-7. 2013..Fascin-1 (FSCN1) plays an important role in cancer development and is associated with invasion and metastasis. Therefore, we explored the expression and localization of FSCN1 in epithelial ovarian cancer (EOC)...
Preoperative (neoadjuvant) systemic treatment of breast cancerManfred Kaufmann
Department of Obstetrics and Gynaecology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Breast 14:576-81. 2005..PST will lead to individualised (tailored) treatment in patients with primary breast cancer...
Prognostic impact of thymidine phosphorylase expression in breast cancer--comparison of microarray and immunohistochemical dataE Ruckhäberle
Department of Obstetrics and Gynecology, Goethe University, Frankfurt M, Germany
Eur J Cancer 46:549-57. 2010..In conclusion, the tumour infiltrating immune cells seem to be a major source of TP expression and predict a favourable prognosis in ER-negative breast cancer. Our data point to a role of TP in host immune response...
Uterine contractility and directed sperm transport assessed by hysterosalpingoscintigraphy (HSSG) and intrauterine pressure (IUP) measurementStefan Kissler
Division of Gynecologic Endocrinology and Reproductive Medicine, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Acta Obstet Gynecol Scand 83:369-74. 2004..This study is the first to be designed to investigate utero-tubal transport function by HSSG and uterine contractility by intrauterine pressure measurement (IUP) consecutively on the same day in the periovulatory phase...
Endometriosis may be generated by mimicking the ontogenetic development of the female genital tractRegine Gaetje
Department of Obstetrics and Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
Fertil Steril 87:651-6. 2007..To compare the expression of genes playing a decisive role during the embryonic development of the female genital tract (WNT4, WNT5A, WNT7A, PAX8) in the peritoneum of patients with endometriosis and control patients...
Evaluation of the stereotactic 8G vacuum-assisted breast biopsy in the histologic evaluation of suspicious mammography findings (BI-RADS IV)Thomas Diebold
Institute for Diagnostic and Interventional Radiology, J W G University Frankfurt Main, Germany
Invest Radiol 40:465-71. 2005..The purpose of this study was to evaluate the potential of the new 8G stereotactic vacuum-assisted breast biopsy (ST-driver, Mammotome; Ethicon Endosurgery) in the histologic evaluation of BI-RADS IV microcalcifications...
[Identification of preeclampsia by cDNA-gene expression profiling in human placentas and serum -- a pilot study]A Ahr
Gynäkologische Praxis am Ziegelturm, Am Ziegelturm 4, 63571 Gelnhausen
Zentralbl Gynakol 128:138-42. 2006..With a new approach, the cDNA-Array analysis, human placentas and blood from preeclamptic and healthy pregnant women were examined for differentially expressed genes to find typical genes expression profiles...
[Cervical cancer screening of HIV-positive women: is a prolongation of the screening interval meaningful?]A Ahr
Gynäkologische Praxis am Ziegelturm, Gelnhausen
Zentralbl Gynakol 128:242-5. 2006..Cervical cancer screening guidelines stated recently that the screening interval of healthy women can be extended up to 3 years. Can those recommendations be applied for high risk populations?..
[Risk factors for recurrence of vulvar intraepithelial neoplasia III (VIN III)]A Ahr
Gynäkologische Praxis am Ziegelturm, Gelnhausen
Zentralbl Gynakol 128:347-51. 2006..The therapy of VIN is the in toto resection. Still some patients develop VIN recurrence. The aim of this retrospective study is the identification of risk factors for VIN recurrence...
[Integrin expression in eutopic and ectopic endometrium]R Gaetje
Klinik fur Gynakologie und Geburtshilfe, Johann Wolfgang Goethe Universitat, Frankfurt
Zentralbl Gynakol 128:135-7. 2006..g., in the peritoneal fluid -- on the ectopic endometrium...
Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancerE Ruckhäberle
Departments of Obstetrics and Gynecology, J W Goethe University, Frankfurt, Germany
Climacteric 12:502-13. 2009..We investigated the relevance of ceramide- and sphingosine-generating enzymes in breast cancer (acid ceramidase 1 (ASAH1), ceramide synthases 4 (LASS4) and 6 (LASS6)) by means of gene expression analysis...
Effect of humidified and heated CO2 during gynecologic laparoscopic surgery on analgesic requirements and postoperative painStefan Kissler
Division of Gynecologic Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, Johann Wolfgang Goethe-University, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany
J Am Assoc Gynecol Laparosc 11:473-7. 2004..CONCLUSION: The use of humidified, heated gas did not reduce postoperative pain or intraoperative analgesic requirements and is thus not preferable to standard dry, cold gas in gynecologic laparoscopic surgery...
[Sentinel lymph node biopsy in breast cancer]A Rody
, , Frankfurt/Main
Chirurg 75:767-73. 2004..Since many issues are controversial such as the prognostic value of micrometastases and extramammary nodes as well as the use of SNB after primary chemotherapy and in ductal carcinoma in situ, further clinical studies are necessary...
Laparoscopic and laparotomic approaches for endometrial cancer treatment: a comprehensive reviewIngolf Juhasz-Böss
Department of Obstetrics and Gynecology, University of Saarland, Homburg, Saar, Germany
Arch Gynecol Obstet 286:167-72. 2012..Endoscopic surgery is gaining more popularity among surgeons as a safe and feasible option for treatment of endometrial carcinoma, providing the possibility of adequate lymph node excision...
Prescribing preferences and personal experience of female gynaecologists in Germany and Austria regarding use of extended-cycle oral contraceptivesInka Wiegratz
Centre of Obstetrics and Gynaecology, Department of Gynaecological Endocrinology and Reproductive Medicine, University Hospital of Frankfurt, Theodor Stern Kai 7, Frankfurt am Main, Germany
Eur J Contracept Reprod Health Care 15:405-12. 2010..To investigate prescribing preferences and personal experience of female gynaecologists with extended-cycle use of combined oral contraceptives (COCs) in Germany and Austria...
Methylation of estrogen receptor beta promoter correlates with loss of ER-beta expression in mammary carcinoma and is an early indication marker in premalignant lesionsA Rody
Department of Gynecology, Johann Wolfgang Goethe University, Frankfurt, Germany
Endocr Relat Cancer 12:903-16. 2005..Interestingly, by comparing the promoter sequences of ER-beta with other genes known to be epigenetically inactivated in breast cancers, we identified a sequence motif possibly involved in promoter methylation...
Clinical relevance of the putative stem cell marker p63 in breast cancerL Hanker
Department of Obstetrics and Gynecology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Breast Cancer Res Treat 122:765-75. 2010..5). P63 is a positive prognostic factor in endocrine-treated ER positive breast cancer and might influence responsiveness to endocrine treatment. Thus, p63 could be helpful as a predictive factor for endocrine therapy...
Uterotubal transport disorder in adenomyosis and endometriosis--a cause for infertilityS Kissler
Division of Gynaecologic Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynaecology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
BJOG 113:902-8. 2006....
[Systemic therapy of operable carcinoma of the breast]M Kaufmann
, Frankfurt
Zentralbl Gynakol 127:207-12. 2005
Clinical use of GnRH analoguesL A Kiesel
Department of Obstetrics and Gynaecology, University of Muenster, Germany
Clin Endocrinol (Oxf) 56:677-87. 2002
Diminished pregnancy rates in endometriosis due to impaired uterotubal transport assessed by hysterosalpingoscintigraphyS Kissler
Division of Gynaecologic Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynaecology, Johann Wolfgang Goethe University, Frankfurt Main, Germany
BJOG 112:1391-6. 2005..To investigate uterotubal transport by means of hysterosalpingoscintigraphy (HSSG) in women with and without endometriosis...
Duration of dysmenorrhoea and extent of adenomyosis visualised by magnetic resonance imagingS Kissler
Division of Gynaecologic Endocrinology and Reproductive Medicine, Johann Wolfgang Goethe University, Frankfurt Main, Germany
Eur J Obstet Gynecol Reprod Biol 137:204-9. 2008..This study was conducted to analyse the extent of adenomyosis using magnetic resonance imaging (MRI) and relate it to the duration of dysmenorrhoea...
Quantitative measurement of telomerase activity and localization of its catalytic subunit (hTERT) in chronic inflammation of capsule formation around various model implants and in sarcomas in a rat modelO Bettendorf
Institute of Pathology, University of Munster, Domagkstrasse 17, D 48149 Munster, Germany
J Biomed Mater Res A 85:646-50. 2008..So the quantitative measurement of telomerase activity should not be applied in general as a marker for malignancy in capsule tissue...
