Abdelhaq Rami

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi request reprint Increased neuronal injury in clock gene Per-1 deficient-mice after cerebral ischemia
    Nina Wiebking
    Institute of Cellular and Molecular Anatomy Anatomie III, Dr Senckenbergische Anatomie, Clinics of the Johann Institute of Cellular and Molecular Anatomy Anatomie III, Dr Senckenbergische Anatomie, Clinics of the Johann, 60590 Frankfurt Main, Germany
    Curr Neurovasc Res 10:112-25. 2013
  2. doi request reprint Specific alterations of the HtrA2/HAX-1 ratio in the penumbra upon focal cerebral ischemia in mice
    A Rami
    Dr Senckenbergische Anatomy, Institut für Zelluläre und Molekulare Anatomie Anatomie III, Klinikum der Johann Wolfgang von Goethe Universität, Theodor Stern Kai 7, 60590 Franfurt, Germany
    Neurochem Res 37:548-56. 2012
  3. ncbi request reprint Apoptosis meets autophagy-like cell death in the ischemic penumbra: Two sides of the same coin?
    Abdelhaq Rami
    Institute of Cellular and Molecular Anatomy Anatomie III, Centre for Neurology and Neurosurgery, Johann Wolfgang Goethe University Clinics, Frankfurt Main, Germany
    Autophagy 4:422-6. 2008
  4. doi request reprint Review: autophagy in neurodegeneration: firefighter and/or incendiarist?
    A Rami
    Dr Senckenbergische Anatomie, Institute of Cellular and Molecular Anatomy Anatomie III, Wolfgang Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 35:449-61. 2009
  5. doi request reprint Translocation of the serine protease Omi/HtrA2 from mitochondria into the cytosol upon seizure-induced hippocampal injury in the neonatal rat brain
    A Rami
    Dr Senckenbergische Anatomie, Anatomie III, Universitatsklinikum, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Neurochem Res 35:2199-207. 2010
  6. ncbi request reprint Synergetic effects of caspase 3 and mu-calpain in XIAP-breakdown upon focal cerebral ischemia
    Abdelhaq Rami
    Institute of Cellular and Molecular Anatomy, Dr Senckenbergische Anatomie, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590, Frankfurt Main, Germany
    Neurochem Res 32:2072-9. 2007
  7. ncbi request reprint Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death
    A Rami
    Institute of Cellular and Molecular Anatomy Anatomie III, Klinikum der Johann Wolfgang von Goethe Universität, Theodor Stern Kai 7, 60590 Franfurt Main, Germany
    Neurobiol Dis 29:132-41. 2008
  8. ncbi request reprint Upregulation of Beclin 1 in the ischemic penumbra
    Abdelhaq Rami
    Institute of Cellular and Molecular Anatomy Anatomie III, Dr Senckenbergische Anatomie, Klinikum der Johann Wolfgang von Goethe Universität, Franfurt Main, Germany
    Autophagy 4:227-9. 2008
  9. ncbi request reprint beta2-Adrenergic receptor responsiveness of the calpain-calpastatin system and attenuation of neuronal death in rat hippocampus after transient global ischemia
    A Rami
    Anatomisches Institut III, Dr Senckenbergische Anatomie, Klinikum der JWG Universität, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Neurosci Res 47:373-82. 2003
  10. doi request reprint Alterations in the expression of the anti-apoptotic factor HAX-1 upon seizures-induced hippocampal injury in the neonatal rat brain
    A Rami
    Institut für Zelluläre und Molekulare Anatomie Anatomie III, Klinikum der Johann Wolfgang von Goethe Universität, Theodor Stern Kai 7, 60590 Franfurt Main, Germany
    Neurochem Res 37:116-25. 2012

Detail Information

Publications32

  1. ncbi request reprint Increased neuronal injury in clock gene Per-1 deficient-mice after cerebral ischemia
    Nina Wiebking
    Institute of Cellular and Molecular Anatomy Anatomie III, Dr Senckenbergische Anatomie, Clinics of the Johann Institute of Cellular and Molecular Anatomy Anatomie III, Dr Senckenbergische Anatomie, Clinics of the Johann, 60590 Frankfurt Main, Germany
    Curr Neurovasc Res 10:112-25. 2013
    ..These alterations may be causal for the observed innate vulnerability of Per1(-/-)-mice to cerebral ischemia...
  2. doi request reprint Specific alterations of the HtrA2/HAX-1 ratio in the penumbra upon focal cerebral ischemia in mice
    A Rami
    Dr Senckenbergische Anatomy, Institut für Zelluläre und Molekulare Anatomie Anatomie III, Klinikum der Johann Wolfgang von Goethe Universität, Theodor Stern Kai 7, 60590 Franfurt, Germany
    Neurochem Res 37:548-56. 2012
    ..Taken together, these results suggested that HAX-1 is probably involved in the pathophysiology of cell death induced by focal ischemia...
  3. ncbi request reprint Apoptosis meets autophagy-like cell death in the ischemic penumbra: Two sides of the same coin?
    Abdelhaq Rami
    Institute of Cellular and Molecular Anatomy Anatomie III, Centre for Neurology and Neurosurgery, Johann Wolfgang Goethe University Clinics, Frankfurt Main, Germany
    Autophagy 4:422-6. 2008
    ..A profound understanding of the biological effects and the mechanisms underlying ischemia-induced autophagy in neurons might be helpful in seeking effective new treatments for cerebral ischemia...
  4. doi request reprint Review: autophagy in neurodegeneration: firefighter and/or incendiarist?
    A Rami
    Dr Senckenbergische Anatomie, Institute of Cellular and Molecular Anatomy Anatomie III, Wolfgang Goethe University, Frankfurt Main, Germany
    Neuropathol Appl Neurobiol 35:449-61. 2009
    ..Here, we review the defining characteristics of autophagy with special attention to its role in neurodegenerative disorders, and recent efforts to delineate the pathway of autophagic protein degradation in neurone...
  5. doi request reprint Translocation of the serine protease Omi/HtrA2 from mitochondria into the cytosol upon seizure-induced hippocampal injury in the neonatal rat brain
    A Rami
    Dr Senckenbergische Anatomie, Anatomie III, Universitatsklinikum, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Neurochem Res 35:2199-207. 2010
    ....
  6. ncbi request reprint Synergetic effects of caspase 3 and mu-calpain in XIAP-breakdown upon focal cerebral ischemia
    Abdelhaq Rami
    Institute of Cellular and Molecular Anatomy, Dr Senckenbergische Anatomie, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590, Frankfurt Main, Germany
    Neurochem Res 32:2072-9. 2007
    ..Therefore, degradation of XIAP by mu-calpain in our system may decrease the activation threshold of caspase-3 normally held in check by the IAPs and/or lead to auto-activation of other caspases...
  7. ncbi request reprint Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death
    A Rami
    Institute of Cellular and Molecular Anatomy Anatomie III, Klinikum der Johann Wolfgang von Goethe Universität, Theodor Stern Kai 7, 60590 Franfurt Main, Germany
    Neurobiol Dis 29:132-41. 2008
    ..The upregulation of Beclin 1 and related changes of LC3 in the ischemic penumbra may represent enhanced autophagy either as a mechanism to recycle injured cells and reduce damage or a process leading to cell demise...
  8. ncbi request reprint Upregulation of Beclin 1 in the ischemic penumbra
    Abdelhaq Rami
    Institute of Cellular and Molecular Anatomy Anatomie III, Dr Senckenbergische Anatomie, Klinikum der Johann Wolfgang von Goethe Universität, Franfurt Main, Germany
    Autophagy 4:227-9. 2008
    ..The question that constantly arises, however, is whether autophagic activity in damaged cells is the cause of death or is actually an attempt to prevent it as a part of an endogenous neuroprotective response...
  9. ncbi request reprint beta2-Adrenergic receptor responsiveness of the calpain-calpastatin system and attenuation of neuronal death in rat hippocampus after transient global ischemia
    A Rami
    Anatomisches Institut III, Dr Senckenbergische Anatomie, Klinikum der JWG Universität, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Neurosci Res 47:373-82. 2003
    ..These results provide evidence that CLN is a potent neuroprotective substance, which through the enhancement of calpastatin synthesis attenuates the apoptotic machinery and modulates proteolysis...
  10. doi request reprint Alterations in the expression of the anti-apoptotic factor HAX-1 upon seizures-induced hippocampal injury in the neonatal rat brain
    A Rami
    Institut für Zelluläre und Molekulare Anatomie Anatomie III, Klinikum der Johann Wolfgang von Goethe Universität, Theodor Stern Kai 7, 60590 Franfurt Main, Germany
    Neurochem Res 37:116-25. 2012
    ..Taken together, these results suggested that HAX-1 is probably involved in the pathophysiology of cell death induced by epilepsy...
  11. ncbi request reprint Ischemic neuronal death in the rat hippocampus: the calpain-calpastatin-caspase hypothesis
    A Rami
    Institute of Anatomy III Dr Senckenbergische Anatomie, Faculty of Medicine, Clinic of the Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Neurobiol Dis 13:75-88. 2003
    ....
  12. ncbi request reprint Post-ischemic activation of caspase-3 in the rat hippocampus: evidence of an axonal and dendritic localisation
    A Rami
    Institute of Anatomy III, Dr Senckenbergische Anatomie, Faculty of Medicine, Clinic of the Johann Wolfgang Goethe University, Theodor Ster Kai 7, 60590 Frankfurt Main, Germany
    Neurochem Int 43:211-23. 2003
    ....
  13. ncbi request reprint Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia
    A Rami
    Anatomisches Institut III, Universitatsklinikum, Theodor Stern Kai 7, 60590, Frankfurt Main, Germany
    Neurochem Int 43:79-87. 2003
    ..This study presents the first evidence that PLSCR1, and probably remodelling of plasma membrane phospholipids (PL), plays a role in ischemic injury in the human hippocampus...
  14. ncbi request reprint Effective reduction of neuronal death by inhibiting gap junctional intercellular communication in a rodent model of global transient cerebral ischemia
    A Rami
    Anatomisches Institut III, Dr Senckenbergische Anatomie, Universitatsklinikum, Theodor Stern Kai 7, Frankfurt, 60590, FRG
    Exp Neurol 170:297-304. 2001
    ..This provides a novel perspective for analysis of the pathophysiology of cerebral ischemia...
  15. ncbi request reprint mu-Calpain activation, DNA fragmentation, and synergistic effects of caspase and calpain inhibitors in protecting hippocampal neurons from ischemic damage
    A Rami
    Anatomisches Institut III Dr Senckenbergische Anatomie, Universitatsklinikum, Theodor Stern Kai 7, 60590, Frankfurt, Germany
    Brain Res 866:299-312. 2000
    ..Moreover, the synergistic effect of caspase and calpain inhibitors in protecting neurons form ischemic damage suggests that there is a cross-talk between caspase and calpain during apoptosis...
  16. ncbi request reprint Muscarinic-receptor antagonist scopolamine rescues hippocampal neurons from death induced by glutamate
    A Rami
    Center of Morphology, Department of Anatomy III, University Clinic, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Brain Res 788:323-6. 1998
    ..These data show that interactions between the NMDA, muscarinic receptors and their corresponding neurotransmitter inputs to hippocampal neurons may play a crucial role in neurodegeneration...
  17. doi request reprint Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia
    Abdelhaq Rami
    Dr Senckenbergische Anatomie, Institute of Cellular and Molecular Anatomy Anatomie III, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Prog Neurobiol 85:273-96. 2008
    ....
  18. ncbi request reprint Differential effects of scopolamine on neuronal survival in ischemia and glutamate neurotoxicity: relationships to the excessive vulnerability of the dorsoseptal hippocampus
    A Rami
    Dr Senckenbergische Anatomie, , Frankfurt, Germany
    J Chem Neuroanat 13:201-8. 1997
    ..However, the mechanisms underlying the high vulnerability of dorsal hippocampus still remain enigmatic...
  19. pmc TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling
    Hans Georg König
    Experimental Neurosurgery, Center for Neurology and Neurosurgery, Johann Wolfgang Goethe University Clinics, D 60590 Frankfurt, Germany
    J Cell Biol 168:1077-86. 2005
    ..Our data suggest that TGF-beta1 simultaneously activates two distinct receptor pathways in neurons and that the ALK1 pathway mediates TGF-beta1-induced NF-kappaB survival signaling...
  20. ncbi request reprint Regulation of XIAP and Smac/DIABLO in the rat hippocampus following transient forebrain ischemia
    M D Siegelin
    Institute of Anatomy III, Dr Senckenbergische Anatomie, Clinic of the JWG University, Theodor Stern Kai 7, Frankfurt Main 60590, Germany
    Neurochem Int 46:41-51. 2005
    ..Smac/DIABLO expression was associated with alteration of the XIAP levels and the appearance of activated form of caspase-3 within the hippocampus during reperfusion in spatial and temporal manners...
  21. ncbi request reprint Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats
    J Althaus
    Institut für Molekulare und Zelluläre Anatomie, Universitatsklinikum, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Neurochem Int 48:687-95. 2006
    ..These findings open the possibility that the hypoxia-regulated pro-apoptotic protein BNIP3 enters the nucleus and could interact with other proteins involved in DNA structure, transcription or mRNA splicing after focal brain ischemia...
  22. ncbi request reprint Induction and redistribution of XAF1, a new antagonist of XIAP in the rat brain after transient focal ischemia
    M Siegelin
    Institut für Anatomie III, Universitatsklinikum, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Neurobiol Dis 20:509-18. 2005
    ..These finding indicate that Smac/DIABLO, XAF1, and XIAP are implicated in the pathophysiological mechanisms of reperfusion injury...
  23. ncbi request reprint Tissue plasminogen activator mediated blood-brain barrier damage in transient focal cerebral ischemia in rats: relevance of interactions between thrombotic material and thrombolytic agent
    Timo Kahles
    Department of Neurology, University Hospital, JW Goethe University Frankfurt, Schleusenweg 2 16, ZNN, 60528 Frankfurt Main, Germany
    Vascul Pharmacol 43:254-9. 2005
    ..The results of the present study indicate a major role for thrombus-thrombolytic interaction in focal cerebral ischemia with subsequent increased BBB permeability...
  24. doi request reprint Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia
    Waltraud Pfeilschifter
    Department of Neurology, University Hospital, Goethe University Frankfurt
    Biochem Biophys Res Commun 413:212-7. 2011
    ..This suggests that SphK2 activity is an important endogenous protective mechanism in cerebral ischemia and corroborates that the protective effect of FTY720 is mediated via phospho-FTY720...
  25. ncbi request reprint The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion
    J Althaus
    Institut für Zelluläre und Molekulare Anatomie Anatomie III, Johann Wolfgang von Goethe Universität, Theodor Stern Kai 7, 60590 Franfurt, Main, Germany
    Neurochem Int 50:172-80. 2007
    ..Blocking the proteolytic activity of Omi/HtrA2 with specific inhibitors, such as the ucf-101, could be a novel way to afford neuroprotection and minimize cellular damage in cerebral ischemia/reperfusion...
  26. pmc Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway
    Claus Reimertz
    Experimental Neurosurgery, Center for Biological Chemistry ZBC, HS 25 B, 4 OG, Johann Wolfgang Goethe University Clinics, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
    J Cell Biol 162:587-97. 2003
    ..Our data suggest that the transcriptional induction of Bbc3/PUMA may be sufficient and necessary for ER stress-induced apoptosis...
  27. doi request reprint Serum deprivation induced autophagy and predominantly an AIF-dependent apoptosis in hippocampal HT22 neurons
    S Steiger-Barraissoul
    Institute of Cellular and Molecular Anatomy, Clinics of the Wolfgang Goethe University, Frankfurt Main, Germany
    Apoptosis 14:1274-88. 2009
    ..The results of the current study suggest that SD induced predominantly caspase-independent apoptosis in hippocampal HT22 cells and that inhibition of autophagy is rather deleterious than protective...
  28. doi request reprint The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia
    Bozena Czech
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Biochem Biophys Res Commun 389:251-6. 2009
    ....
  29. doi request reprint Concomitant transitory up-regulation of X-linked inhibitor of apoptosis protein (XIAP) and the heterogeneous nuclear ribonucleoprotein C1-C2 in surviving cells during neuronal apoptosis
    A Spahn
    Institute of Cellular and Molecular Anatomy Anatomie III, Clinic of Johann Wolfgang von Goethe University, Theodor Stern Kai 7, 60590, Franfurt Main, Germany
    Neurochem Res 33:1859-68. 2008
    ..The up-regulation of hnRNP-C1/C2 may foster the synthesis of XIAP as a protective pathway by which neurons try to counteract the initial deleterious effects of apoptosis...
  30. ncbi request reprint Immunoreactivity for Bcl-2 and C-Jun/AP1 in hippocampal corpora amylacea after ischaemia in humans
    G Botez
    Institute of Anatomy III, Clinic of the JWG-University, Frankfurt, Germany
    Neuropathol Appl Neurobiol 27:474-80. 2001
    ....
  31. pmc Control of fetal growth and neonatal survival by the RasGAP-associated endoribonuclease G3BP
    Latifa Zekri
    Institut de génétique moléculaire de Montpellier UMR 5535, IFR 122, Centre National de Recherche Scientifique, 1919 Route de Mende, 34293 Montpellier, France
    Mol Cell Biol 25:8703-16. 2005
    ..The results demonstrate that G3BP is essential for proper embryonic growth and development by mediating the coordinate expression of multiple imprinted growth-regulatory transcripts...
  32. pmc Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    Daniel J Klionsky
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Autophagy 4:151-75. 2008
    ..In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response...