David Prvulovic

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi request reprint Functional activation imaging in aging and dementia
    David Prvulovic
    Laboratory for Neurophysiology and Neuroimaging, Department of Psychiatry, Johann Wolfgang Goethe Universitat, Heinrich Hoffmann Str 10, 60528 Frankfurt, Germany
    Psychiatry Res 140:97-113. 2005
  2. doi request reprint Association of microstructural white matter abnormalities with cognitive dysfunction in geriatric patients with major depression
    Gilberto Sousa Alves
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    Psychiatry Res 203:194-200. 2012
  3. pmc Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e48895. 2012
  4. pmc Using support vector machines with multiple indices of diffusion for automated classification of mild cognitive impairment
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e32441. 2012
  5. pmc Sexual dimorphism in healthy aging and mild cognitive impairment: a DTI study
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e37021. 2012
  6. doi request reprint Association between psychotic symptoms and cortical thickness reduction across the schizophrenia spectrum
    Viola Oertel-Knöchel
    Laboratory of Neuroscience, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Johann Wolfgang Goethe University, 60528 Frankfurt Main, Germany
    Cereb Cortex 23:61-70. 2013
  7. ncbi request reprint Verbal episodic memory deficits in remitted bipolar patients: a combined behavioural and fMRI study
    Viola Oertel-Knöchel
    Laboratory of Neurophysiology and Neuroimaging, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt Main, Germany
    J Affect Disord 150:430-40. 2013
  8. doi request reprint Perspectives for multimodal neurochemical and imaging biomarkers in Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    J Alzheimers Dis 33:S329-47. 2013
  9. pmc White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machines
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e36024. 2012
  10. doi request reprint Patterns of autobiographical memory in bipolar disorder examined by psychometric and functional neuroimaging methods
    Viola Oertel-Knöchel
    Laboratory of Neuroscience, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt Main, Germany
    J Nerv Ment Dis 200:296-304. 2012

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Functional activation imaging in aging and dementia
    David Prvulovic
    Laboratory for Neurophysiology and Neuroimaging, Department of Psychiatry, Johann Wolfgang Goethe Universitat, Heinrich Hoffmann Str 10, 60528 Frankfurt, Germany
    Psychiatry Res 140:97-113. 2005
    ....
  2. doi request reprint Association of microstructural white matter abnormalities with cognitive dysfunction in geriatric patients with major depression
    Gilberto Sousa Alves
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    Psychiatry Res 203:194-200. 2012
    ..Results provide additional evidence supporting the neuronal disconnection hypothesis in MDD and suggest that cognitive deficits are related to the loss of integrity in WM tracts associated with the disorder...
  3. pmc Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e48895. 2012
    ..Possession of the ApoE4 allele may lead to greater predilection for right hemisphere atrophy even in healthy young subjects in their twenties...
  4. pmc Using support vector machines with multiple indices of diffusion for automated classification of mild cognitive impairment
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e32441. 2012
    ..Such tools may be useful for large scale drug trials in Alzheimer's disease where the early identification of subjects with MCI is critical...
  5. pmc Sexual dimorphism in healthy aging and mild cognitive impairment: a DTI study
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e37021. 2012
    ..Overall, these data suggest that the same degree of cognitive impairment is associated with greater structural damage in men compared with women...
  6. doi request reprint Association between psychotic symptoms and cortical thickness reduction across the schizophrenia spectrum
    Viola Oertel-Knöchel
    Laboratory of Neuroscience, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Johann Wolfgang Goethe University, 60528 Frankfurt Main, Germany
    Cereb Cortex 23:61-70. 2013
    ..Our findings suggest that changes in specific cortical areas may predispose to specific symptoms, as exemplified by the association between temporal cortex thinning and hallucinations...
  7. ncbi request reprint Verbal episodic memory deficits in remitted bipolar patients: a combined behavioural and fMRI study
    Viola Oertel-Knöchel
    Laboratory of Neurophysiology and Neuroimaging, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt Main, Germany
    J Affect Disord 150:430-40. 2013
    ..Episodic memory deficits affect the majority of patients with bipolar disorder (BD)...
  8. doi request reprint Perspectives for multimodal neurochemical and imaging biomarkers in Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    J Alzheimers Dis 33:S329-47. 2013
    ..Critical testing of these predictions will help us to modify or even falsify the currently hold assumptions on the pathogenesis of AD based on in vivo evidence in humans...
  9. pmc White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machines
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    PLoS ONE 7:e36024. 2012
    ....
  10. doi request reprint Patterns of autobiographical memory in bipolar disorder examined by psychometric and functional neuroimaging methods
    Viola Oertel-Knöchel
    Laboratory of Neuroscience, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt Main, Germany
    J Nerv Ment Dis 200:296-304. 2012
    ..More frequent intrusions from a person's past, which had a neural correlate in the lack of deactivation in some default mode network areas in BD patients, may contribute to manic or depressive symptoms...
  11. ncbi request reprint Neuronal correlates of colour-graphemic synaesthesia: a fMRI study
    Julia M Sperling
    Department of Psychiatry, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Cortex 42:295-303. 2006
    ..These findings support the hypothesis that the grapheme-induced colour perception in synaesthesia is caused by an activation of the colour areas of the human visual cortex...
  12. ncbi request reprint Localizing P300 generators in visual target and distractor processing: a combined event-related potential and functional magnetic resonance imaging study
    Christoph Bledowski
    Department of Psychiatry, Johann Wolfgang Goethe University, 60590 Frankfurt, Germany
    J Neurosci 24:9353-60. 2004
    ..The results point to the involvement of distinct attentional subsystems in target and distractor processing...
  13. ncbi request reprint Functional connectivity as revealed by spatial independent component analysis of fMRI measurements during rest
    Vincent G van de Ven
    Laboratory for Neurophysiology and Neuroimaging, Department of Psychiatry, Johann Wolfgang Goethe University, Frankfurt, Germany
    Hum Brain Mapp 22:165-78. 2004
    ..These results are discussed in the context of the recent debate on the functional relevance of fluctuations of neural activity in the resting state...
  14. doi request reprint Visual perceptual organization deficits in Alzheimer's dementia
    Peter J Uhlhaas
    Department of Neurophysiology, Max Planck Institute for Brain Research, Department of Psychiatry, Frankfurt am Main, Germany
    Dement Geriatr Cogn Disord 25:465-75. 2008
    ..In the current study, we examined the hypothesis that perceptual organization is specifically impaired in AD compared to other dementias...
  15. doi request reprint Blood and plasma-based proteomic biomarker research in Alzheimer's disease
    Simone Lista
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University of Frankfurt, Frankfurt am Main, Germany
    Prog Neurobiol 101:1-17. 2013
    ..Currently, growing evidence suggests that blood protein signatures are helpful to increase the likelihood of successful diagnosis of AD. Accordingly, this area of research promises to yield exciting results in the next future...
  16. doi request reprint Functional magnetic resonance imaging as a dynamic candidate biomarker for Alzheimer's disease
    David Prvulovic
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University of Frankfurt, Frankfurt, Germany
    Prog Neurobiol 95:557-69. 2011
    ..Potential caveats of functional imaging are critically reviewed with focus on confound variables such as altered neurovascular coupling as well as parameters related to task- and study design...
  17. doi request reprint Cognitive and behavioural effects of physical exercise in psychiatric patients
    Christian Knöchel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Frankfurt Main, Heinrich Hoffmann Str 12, 60528 Frankfurt, Germany
    Prog Neurobiol 96:46-68. 2012
    ..Furthermore, exercise might have the potential to be a preventative treatment within the context of multi-modal therapeutic programs...
  18. doi request reprint Ethical considerations of biomarker use in neurodegenerative diseases--a case study of Alzheimer's disease
    David Prvulovic
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Frankfurt, Heinrich Hoffmann Str 10, 60528 Frankfurt, Germany
    Prog Neurobiol 95:517-9. 2011
    ....
  19. doi request reprint Recent developments of functional magnetic resonance imaging research for drug development in Alzheimer's disease
    Harald Hampel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt Main, Germany
    Prog Neurobiol 95:570-8. 2011
    ..The network based approach provides a new independent method from previous ones to translate preclinical knowledge into the clinical domain...
  20. doi request reprint Biomarkers for major depression and its delineation from neurodegenerative disorders
    Barbara Schneider
    Section for Neurophysiology and Neuroimaging, Laboratory of Neuroscience, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    Prog Neurobiol 95:703-17. 2011
    ..This model delineates common pathways and the intersection between AD and MDD. Applying these concepts to MDD gives hope that positive MDD biomarkers can be successfully identified in the near future...
  21. doi request reprint Biomarkers for Alzheimer's disease therapeutic trials
    Harald Hampel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Heinrich Hoffmann Str 10, 60528 Frankfurt, Germany
    Prog Neurobiol 95:579-93. 2011
    ....
  22. ncbi request reprint Attentional systems in target and distractor processing: a combined ERP and fMRI study
    Christoph Bledowski
    Department of Psychiatry, Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Neuroimage 22:530-40. 2004
    ..Our results thus demonstrate that distractor and target processing engage a common neuronal system for the detection of rare events, but also task-specific subsystems related to attention and memory processes...
  23. ncbi request reprint Automated segmentation of lateral ventricles from human and primate magnetic resonance images using cognition network technology
    Ralf Schönmeyer
    Brain Imaging Center, Johann Wolfgang Goethe University Frankfurt am Main, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    Magn Reson Imaging 24:1377-87. 2006
    ....
  24. ncbi request reprint Facial affect recognition training in autism: can we animate the fusiform gyrus?
    Sven Bolte
    Department of Child and Adolescent Psychiatry, J W Goethe University, Frankfurt, Germany
    Behav Neurosci 120:211-6. 2006
    ..Trained participants showed behavioral improvements, which were accompanied by higher BOLD fMRI signals in the superior parietal lobule and maintained activation in the right medial occipital gyrus...
  25. doi request reprint The future of Alzheimer's disease: the next 10 years
    Harald Hampel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    Prog Neurobiol 95:718-28. 2011
    ..These still unmet needs call for ever more concerted and focused efforts in research across the world to combat the erupting and as yet uncontrolled epidemic of AD...
  26. doi request reprint Discovery and development of integrative biological markers for schizophrenia
    Viola Oertel-Knöchel
    Laboratory of Neuroscience, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Heinrich Hoffmann Str 10, D 60590, Frankfurt, Germany
    Prog Neurobiol 95:686-702. 2011
    ..They should also advance our understanding of the subtle and intricate biological nature of schizophrenia...
  27. doi request reprint Using diffusion tensor imaging and mixed-effects models to investigate primary and secondary white matter degeneration in Alzheimer's disease and mild cognitive impairment
    Laurence O'Dwyer
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe University, Frankfurt, Germany
    J Alzheimers Dis 26:667-82. 2011
    ..A greater understanding of the pattern of WM changes in AD may prove useful for the early detection of AD...
  28. ncbi request reprint Tracking the mind's image in the brain II: transcranial magnetic stimulation reveals parietal asymmetry in visuospatial imagery
    Alexander T Sack
    Department of Psychiatry, Laboratory for Neurophysiology and Neuroimaging, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, DE 60590 Frankfurt, Germany
    Neuron 35:195-204. 2002
    ..This is compatible with current theories of spatial hemineglect and constitutes a constraint for models of distributed information processing in the parietal lobes...
  29. ncbi request reprint Pharmacokinetic and pharmacodynamic evaluation of donepezil for the treatment of Alzheimer's disease
    David Prvulovic
    Goethe University of Frankfurt, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Heinrich Hoffmann Straße 10, 60528 Frankfurt Main, Germany
    Expert Opin Drug Metab Toxicol 10:1039-50. 2014
    ..After numerous Phase III study failures of novel disease-modifying drugs for Alzheimer's disease, donepezil is likely going to stay a first-line therapeutic option in Alzheimer's disease in the upcoming years. ..
  30. ncbi request reprint Treatment options for tauopathies
    Tarik Karakaya
    Department of Psychiatry, J W Goethe University, Heinrich Hoffmann Str 10, 60528, Frankfurt, Germany
    Curr Treat Options Neurol 14:126-36. 2012
    ..Current research focuses on targeting tau protein pathology, including pathologic aggregation or phosphorylation; these approaches seem to be very promising...
  31. doi request reprint Novel biomarkers in major depression
    Barbara Schneider
    LVR Klinik Köln, Cologne, Germany
    Curr Opin Psychiatry 26:47-53. 2013
    ..This article reviews literature published over the period January 2011-June 2012 on biomarkers in major depression...
  32. doi request reprint Amyloid β (Aβ) and phospho-tau (p-tau) as diagnostic biomarkers in Alzheimer's disease
    David Prvulovic
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Frankfurt, Frankfurt, Germany
    Clin Chem Lab Med 49:367-74. 2011
    ..g., cerebrospinal fluid (CSF) analysis and PET imaging], and on their diagnostic and predictive value in preclinical and clinical stages of AD...
  33. ncbi request reprint The spatiotemporal pattern of auditory cortical responses during verbal hallucinations
    Vincent G van de Ven
    Department of Cognitive Neuroscience, Faculty of Psychology, University Maastricht, The Netherlands
    Neuroimage 27:644-55. 2005
    ..We suggest that detection of this activity may be facilitated by examining hallucination epochs of sufficient length, in combination with a data-driven approach...