Ellen Niederberger

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. pmc Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain
    Hilmar Nils Kühlein
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt am Main, Frankfurt am Main, Germany
    PLoS ONE 6:e19270. 2011
  2. doi request reprint [Epigenetics and pain]
    E Niederberger
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt a M, Deutschland
    Anaesthesist 63:63-9. 2014
  3. ncbi request reprint The non-canonical IκB kinases IKKε and TBK1 as potential targets for the development of novel therapeutic drugs
    E Niederberger
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Curr Mol Med 13:1089-97. 2013
  4. ncbi request reprint The glutamate transporter GLAST is involved in spinal nociceptive processing
    Ellen Niederberger
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, Frankfurt am Main, Germany
    Biochem Biophys Res Commun 346:393-9. 2006
  5. ncbi request reprint Impaired acute and inflammatory nociception in mice lacking the p50 subunit of NF-kappaB
    Ellen Niederberger
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Eur J Pharmacol 559:55-60. 2007
  6. ncbi request reprint The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception
    Ellen Niederberger
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Biochem Biophys Res Commun 362:75-80. 2007
  7. doi request reprint Proteomics in neuropathic pain research
    Ellen Niederberger
    Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Frankfurt am Main, Germany
    Anesthesiology 108:314-23. 2008
  8. doi request reprint The IKK-NF-kappaB pathway: a source for novel molecular drug targets in pain therapy?
    Ellen Niederberger
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    FASEB J 22:3432-42. 2008
  9. doi request reprint Update on the pathobiology of neuropathic pain
    Ellen Niederberger
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Expert Rev Proteomics 5:799-818. 2008
  10. doi request reprint Analysis of NF-kappaB signaling pathways by proteomic approaches
    Ellen Niederberger
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Expert Rev Proteomics 7:189-203. 2010

Collaborators

Detail Information

Publications39

  1. pmc Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain
    Hilmar Nils Kühlein
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt am Main, Frankfurt am Main, Germany
    PLoS ONE 6:e19270. 2011
    ..Our results show the usefulness of proteomics as a screening tool to identify novel mechanisms of nerve injury evoked hypernociception and suggest that carboxypeptidase A inhibition might be useful to reduce cold allodynia...
  2. doi request reprint [Epigenetics and pain]
    E Niederberger
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt a M, Deutschland
    Anaesthesist 63:63-9. 2014
    ..As they are also involved in pain processing, a modulation of these mechanisms might represent a novel option for the therapy of pain patients. ..
  3. ncbi request reprint The non-canonical IκB kinases IKKε and TBK1 as potential targets for the development of novel therapeutic drugs
    E Niederberger
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Curr Mol Med 13:1089-97. 2013
    ..In this review, we summarize the roles of IKKε and TBK1 in different diseases and outline therapeutic options for modulation of these kinases. ..
  4. ncbi request reprint The glutamate transporter GLAST is involved in spinal nociceptive processing
    Ellen Niederberger
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, Frankfurt am Main, Germany
    Biochem Biophys Res Commun 346:393-9. 2006
    ..In conclusion, these data suggest that inhibition of GLAST expression in the spinal cord reduces excitatory synaptic activity and thereby spontaneous responses after nociceptive stimulation of the paw...
  5. ncbi request reprint Impaired acute and inflammatory nociception in mice lacking the p50 subunit of NF-kappaB
    Ellen Niederberger
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Eur J Pharmacol 559:55-60. 2007
    ..The participation to persistent pain might rely on activation of NF-kappaB by inflammatory stimuli while the contribution to acute pain responses might be related to constitutive NF-kappaB activity in neurons of the nociceptive system...
  6. ncbi request reprint The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception
    Ellen Niederberger
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Biochem Biophys Res Commun 362:75-80. 2007
    ..Thus, our data confirm that CREB is essential for spinal nociceptive processing. However, prevention of phosphorylation only at serine 142 is not sufficient to modulate the nociceptive response...
  7. doi request reprint Proteomics in neuropathic pain research
    Ellen Niederberger
    Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Frankfurt am Main, Germany
    Anesthesiology 108:314-23. 2008
    ..This might allow a better understanding of the pathophysiologic signaling pathways in this impairment, facilitate the discovery of specific biomarkers, and thus promote the development of novel pain therapies...
  8. doi request reprint The IKK-NF-kappaB pathway: a source for novel molecular drug targets in pain therapy?
    Ellen Niederberger
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    FASEB J 22:3432-42. 2008
    ..Therefore, a modulation of specific participants in the NF-kappaB signal transduction might exert a useful approach for the development of new painkillers...
  9. doi request reprint Update on the pathobiology of neuropathic pain
    Ellen Niederberger
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Expert Rev Proteomics 5:799-818. 2008
    ..The results of these studies and the potential clinical value of the proteomic data are summarized and discussed in this review...
  10. doi request reprint Analysis of NF-kappaB signaling pathways by proteomic approaches
    Ellen Niederberger
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Expert Rev Proteomics 7:189-203. 2010
    ..The results of these studies are summarized and discussed in this review...
  11. ncbi request reprint Different COX-independent effects of the COX-2 inhibitors etoricoxib and lumiracoxib
    Ellen Niederberger
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Biochem Biophys Res Commun 342:940-8. 2006
    ..In conclusion, we showed that etoricoxib and lumiracoxib have different COX-independent mechanisms which may be of clinical relevance...
  12. ncbi request reprint Opposite effects of rofecoxib on nuclear factor-kappaB and activating protein-1 activation
    Ellen Niederberger
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Frankfurt am Main, Germany
    J Pharmacol Exp Ther 304:1153-60. 2003
    ..The effects on AP-1 may possibly affect renal sodium transport because certain renal sodium channels are regulated through AP-1. Transcription factor regulation might therefore influence both wanted and unwanted effects of rofecoxib...
  13. ncbi request reprint Effects of the selective COX-2 inhibitors celecoxib and rofecoxib on human vascular cells
    Ellen Niederberger
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Biochem Pharmacol 68:341-50. 2004
    ....
  14. ncbi request reprint Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, 60590 Frankfurt, Germany
    J Neurosci 24:1637-45. 2004
    ..Our data indicate that IKK may prove an interesting novel drug target in the treatment of pathological pain and inflammation...
  15. ncbi request reprint Comparative proteomic analysis of the rat spinal cord in inflammatory and neuropathic pain models
    Susanne Kunz
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universität Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Neurosci Lett 381:289-93. 2005
    ..In conclusion, this study illustrates that employment of the proteomic 2D-PAGE approach allows for identification of novel regulated proteins that may be involved in the central sensitization and possibly manifestation of chronic pain...
  16. ncbi request reprint Increased CNS uptake and enhanced antinociception of morphine-6-glucuronide in rats after inhibition of P-glycoprotein
    Jorn Lotsch
    Pharmazentrum Frankfurt, Department of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt, Germany
    J Neurochem 83:241-8. 2002
    ..Antinociceptive effects of M6G were significantly enhanced by inhibition of P-gp. Inhibition of P-gp alters the transport of M6G across the blood-brain barrier, resulting in enhanced spinal cord uptake and enhanced antinociception...
  17. doi request reprint cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I
    Achim Schmidtko
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    J Neurosci 28:8568-76. 2008
    ..Together, our results provide evidence that NO-GC is crucially involved in the central sensitization of pain pathways during inflammatory and neuropathic pain...
  18. ncbi request reprint The calpain inhibitor MDL 28170 prevents inflammation-induced neurofilament light chain breakdown in the spinal cord and reduces thermal hyperalgesia
    Susanne Kunz
    Pharmazentrum Frankfurt, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Pain 110:409-18. 2004
    ..Our results indicate that inhibition of pathological calpain activity may present an interesting novel drug target in the treatment of pain and inflammation...
  19. ncbi request reprint Essential role of the synaptic vesicle protein synapsin II in formalin-induced hyperalgesia and glutamate release in the spinal cord
    Achim Schmidtko
    Pharmazentrum Frankfurt, Institut für Klinische Pharmakologie ZAFES, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Pain 115:171-81. 2005
    ..The distinctive role of synapsin II for pain signaling probably results from its specific localization and possibly from a specific control of glutamate release...
  20. doi request reprint Inhibitor kappa B kinase beta dependent cytokine upregulation in nociceptive neurons contributes to nociceptive hypersensitivity after sciatic nerve injury
    Maike Kanngiesser
    Pharmazentrum frankfurt ZAFES, Clinical Pharmacology, Goethe University, Frankfurt, Germany
    J Pain 13:485-97. 2012
    ..The results suggest that IKKβ-mediated NF-κB stimulation in injured primary sensory neurons promotes cytokine and chemokine production and contributes thereby to the development of chronic pain...
  21. doi request reprint Cofilin phosphorylation is involved in nitric oxide/cGMP-mediated nociception
    Lars Zulauf
    Pharmazentrum frankfurt ZAFES, Klinikum der Goethe Universität, Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Biochem Biophys Res Commun 390:1408-13. 2009
    ..Our results suggest that cofilin represents a downstream target of NO/cGMP/PKG signal transduction in neurons thus indicating that it is involved in NO-mediated nociception...
  22. doi request reprint Modulation of central nervous system-specific microRNA-124a alters the inflammatory response in the formalin test in mice
    Katharina L Kynast
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt, Frankfurt am Main, Germany
    Pain 154:368-76. 2013
    ..In conclusion, our results indicate that miRNA-124a is involved in inflammatory nociception by regulation of relevant target proteins and might therefore constitute a novel target for anti-inflammatory therapy...
  23. doi request reprint NADPH oxidase-4 maintains neuropathic pain after peripheral nerve injury
    Wiebke Kallenborn-Gerhardt
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    J Neurosci 32:10136-45. 2012
    ..Our results suggest that Nox4 essentially contributes to nociceptive processing in neuropathic pain states. Accordingly, inhibition of Nox4 may provide a novel therapeutic modality for the treatment of neuropathic pain...
  24. ncbi request reprint Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers
    Sabine Grosch
    Pharmazentrum Frankfurt, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    FASEB J 17:1316-8. 2003
    ....
  25. doi request reprint Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain
    Achim Schmidtko
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, 60590 Frankfurt am Main, Germany
    J Neurosci 28:1320-30. 2008
    ..These data suggest that CRP2 is a new downstream effector of cGKI-mediated spinal nociceptive processing and point to an inhibitory role of CRP2 in the generation of inflammatory pain...
  26. ncbi request reprint G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat, 60590 Frankfurt am Main, Germany
    Cancer Res 63:1846-52. 2003
    ..Our results suggest that morphine, alone or in combination with Nx, may reduce the growth of certain tumors, apparently in part through activation of p53...
  27. doi request reprint The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia
    Christine V Möser
    Pharmazentrum Frankfurt Das Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt, 60590 Frankfurt am Main, Germany
    J Immunol 187:2617-25. 2011
    ..Therefore, we concluded that IKKε modulates inflammatory nociceptive sensitivity by activation of NF-κB-dependent gene transcription and may be useful as a therapeutic target in the treatment of inflammatory pain...
  28. ncbi request reprint Induction of apoptosis by R-flurbiprofen in human colon carcinoma cells: involvement of p53
    Sabine Grosch
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, 60590 Frankfurt Main, Germany
    Biochem Pharmacol 69:831-9. 2005
    ....
  29. ncbi request reprint Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats
    Irmgard Tegeder
    Pharmazentrum Frankfurt, Klinikum der Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Neurosci Lett 332:146-50. 2002
    ..The antinociceptive effects of the PKG inhibitor suggest that a strong PKG activation may be responsible for 'high dose' 8-bromo-cGMP evoked hyperalgesia...
  30. doi request reprint The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-kinase signaling and formalin-specific receptors
    Ovidiu Coste
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Behav Brain Res 234:121-8. 2012
    ..Our results indicate that PAK 5 is involved in formalin-induced inflammatory nociception through regulation of MAPK-induced c-Fos-activation and formalin-specific TRP-channels...
  31. ncbi request reprint The effects of COX-2 selective and non-selective NSAIDs on the initiation and progression of atherosclerosis in ApoE-/- mice
    Julia Metzner
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    J Mol Med (Berl) 85:623-33. 2007
    ..However, because these results were only observed in ApoE(-/-) and not in wild-type animals, coxibs may increase the risk of thrombosis in patients with a predisposition for thrombotic complications...
  32. ncbi request reprint The influence of inhibition of probenecid sensitive transporters on the central nervous system (CNS) uptake and the antinociceptive activity of morphine-6-glucuronide in rats
    Jorn Lotsch
    Pharmazentrum Frankfurt, Department of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Neurosci Lett 329:145-8. 2002
    ....
  33. doi request reprint Activation of the AMP-activated protein kinase reduces inflammatory nociception
    Otto Quintus Russe
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt, Frankfurt am Main, Germany
    J Pain 14:1330-40. 2013
    ..In summary, our results indicate that activation of AMPKα2 might represent a novel therapeutic option for the treatment of inflammation-associated pain, providing analgesia with fewer unwanted side effects...
  34. doi request reprint Novel findings in pain processing pathways: implications for miRNAs as future therapeutic targets
    Katharina L Kynast
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Expert Rev Neurother 13:515-25. 2013
    ..In this review, the authors summarize the current knowledge and progress in miRNA research in pain and discuss their potential role as therapeutic antinociceptive targets...
  35. doi request reprint Altered gene expression in the prefrontal cortex of young rats induced by the ADHD drug atomoxetine
    Thomas Lempp
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe University Hospital Frankfurt, Deutschordenstrasse 50, 60528 Frankfurt am Main, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 40:221-8. 2013
    ..Especially the increased expression of SNAP-25 and GABA-A receptor subunits may indicate additional active therapeutic mechanisms for atomoxetine...
  36. doi request reprint PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis
    Susanne Schiffmann
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany Electronic address
    Biochem Pharmacol 87:625-35. 2014
    ..In conclusion, our data demonstrate that PGE2 synthesized by monocytes in the early preclinical phase promotes the development of EAE in an EP4 receptor dependent manner. ..
  37. doi request reprint Proteomics and NF-κB: an update
    Ellen Niederberger
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Expert Rev Proteomics 10:189-204. 2013
    ..The studies discussed here utilized innovative techniques and offer several new hypotheses on the role of NF-κB in physiological and pathophysiological processes, which open new avenues for research on NF-κB in the future...
  38. ncbi request reprint Erythropoietin and G-CSF receptors in human tumor cells: expression and aspects regarding functionality
    Gabriela Westphal
    Division of Radiobiology in Radiooncology, German Cancer Research Center DKFZ, Heidelberg
    Tumori 88:150-9. 2002
    ..We therefore investigated in human tumor cell lines the expression of these receptors in tumor cells as well as their response to Epo and G-CSF...
  39. ncbi request reprint Maillard reaction products modulating the growth of human tumor cells in vitro
    Doris Marko
    Department of Chemistry, Division of Food Chemistry and Environmental Toxicology, University of Kaiserslautern Erwin Schroedinger Strasse 52, 67663 Kaiserslautern, Germany
    Chem Res Toxicol 16:48-55. 2003
    ..The Maillard-type chromophores 2, 6, and 13 were found to interfere with the proliferation of gastric carcinoma cells, causing cell cycle arrest and apoptosis induction...