Tobias Neumann-Haefelin

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi request reprint Diffusion- and perfusion-weighted MRI: influence of severe carotid artery stenosis on the DWI/PWI mismatch in acute stroke
    T Neumann-Haefelin
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Stroke 31:1311-7. 2000
  2. ncbi request reprint Serial MRI after transient focal cerebral ischemia in rats: dynamics of tissue injury, blood-brain barrier damage, and edema formation
    T Neumann-Haefelin
    Department of Radiology, Lucas MRS MRI Center, Stanford Stroke Center, Stanford University, CA, USA
    Stroke 31:1965-72; discussion 1972-3. 2000
  3. ncbi request reprint Diffusion- and perfusion-weighted MRI in a patient with a prolonged reversible ischaemic neurological deficit
    T Neumann-Haefelin
    Department of Neurology ZNN 95 1, Goethe Universitat, Frankfurt, Germany
    Neuroradiology 42:444-7. 2000
  4. ncbi request reprint Time is brain: is MRI the clock?
    Tobias Neumann-Haefelin
    Department of Neurology, Goethe University Frankfurt, Frankfurt, Germany
    Curr Opin Neurol 20:410-6. 2007
  5. ncbi request reprint Leukoaraiosis is a risk factor for symptomatic intracerebral hemorrhage after thrombolysis for acute stroke
    Tobias Neumann-Haefelin
    Klinik fur Neurologie, ZNN, Klinikum der Goethe Universität, Schleusenweg 2 16, 60528 Frankfurt, Germany
    Stroke 37:2463-6. 2006
  6. ncbi request reprint Effect of incomplete (spontaneous and postthrombolytic) recanalization after middle cerebral artery occlusion: a magnetic resonance imaging study
    T Neumann-Haefelin
    Department of Neurology, University Hospitals, Frankfurt, Germany
    Stroke 35:109-14. 2004
  7. ncbi request reprint Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance imaging
    Oliver C Singer
    Klinik fur Neurologie, Universitatsklinik, Johann Wolfgang von Goethe Universität, Frankfurt, Germany
    Ann Neurol 63:52-60. 2008
  8. doi request reprint Recanalization results after intracranial stenting of atherosclerotic stenoses
    Stella Blasel
    Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, 60528, Frankfurt, Germany
    Cardiovasc Intervent Radiol 33:914-20. 2010
  9. ncbi request reprint Evaluation of serum S100B as a surrogate marker for long-term outcome and infarct volume in acute middle cerebral artery infarction
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University Frankfurt am Main, Frankfurt am Main, Germany
    Arch Neurol 62:1130-4. 2005
  10. ncbi request reprint Serum S100B predicts a malignant course of infarction in patients with acute middle cerebral artery occlusion
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University Frankfurt am Main, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    Stroke 35:2160-4. 2004

Detail Information

Publications47

  1. ncbi request reprint Diffusion- and perfusion-weighted MRI: influence of severe carotid artery stenosis on the DWI/PWI mismatch in acute stroke
    T Neumann-Haefelin
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Stroke 31:1311-7. 2000
    ..In the present study, we compared DWI and PWI findings in acute stroke patients with and without severe extracranial internal carotid artery (ICA) disease...
  2. ncbi request reprint Serial MRI after transient focal cerebral ischemia in rats: dynamics of tissue injury, blood-brain barrier damage, and edema formation
    T Neumann-Haefelin
    Department of Radiology, Lucas MRS MRI Center, Stanford Stroke Center, Stanford University, CA, USA
    Stroke 31:1965-72; discussion 1972-3. 2000
    ....
  3. ncbi request reprint Diffusion- and perfusion-weighted MRI in a patient with a prolonged reversible ischaemic neurological deficit
    T Neumann-Haefelin
    Department of Neurology ZNN 95 1, Goethe Universitat, Frankfurt, Germany
    Neuroradiology 42:444-7. 2000
    ..These findings demonstrate the utility of PWI when be used in combination with DWI to investigate the pathophysiology of transient ischemic syndromes...
  4. ncbi request reprint Time is brain: is MRI the clock?
    Tobias Neumann-Haefelin
    Department of Neurology, Goethe University Frankfurt, Frankfurt, Germany
    Curr Opin Neurol 20:410-6. 2007
    ..MRI is increasingly used as the primary imaging modality in acute stroke, since it allows treatment based on individual pathophysiology rather than strict time windows...
  5. ncbi request reprint Leukoaraiosis is a risk factor for symptomatic intracerebral hemorrhage after thrombolysis for acute stroke
    Tobias Neumann-Haefelin
    Klinik fur Neurologie, ZNN, Klinikum der Goethe Universität, Schleusenweg 2 16, 60528 Frankfurt, Germany
    Stroke 37:2463-6. 2006
    ..The aim of the study was to evaluate whether leukoaraiosis (LA) is a risk factor for symptomatic intracerebral hemorrhage (sICH) in patients treated with thrombolysis for acute stroke...
  6. ncbi request reprint Effect of incomplete (spontaneous and postthrombolytic) recanalization after middle cerebral artery occlusion: a magnetic resonance imaging study
    T Neumann-Haefelin
    Department of Neurology, University Hospitals, Frankfurt, Germany
    Stroke 35:109-14. 2004
    ..The purpose of this study was to analyze the frequency and relevance of incomplete recanalization for tissue and clinical outcome...
  7. ncbi request reprint Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance imaging
    Oliver C Singer
    Klinik fur Neurologie, Universitatsklinik, Johann Wolfgang von Goethe Universität, Frankfurt, Germany
    Ann Neurol 63:52-60. 2008
    ..Here, we investigated the relation between pretreatment DWI lesion size and the risk for sICH after thrombolysis...
  8. doi request reprint Recanalization results after intracranial stenting of atherosclerotic stenoses
    Stella Blasel
    Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, 60528, Frankfurt, Germany
    Cardiovasc Intervent Radiol 33:914-20. 2010
    ..Suboptimal recanalization results were frequently detected and may be the source of neurological complications in individual cases...
  9. ncbi request reprint Evaluation of serum S100B as a surrogate marker for long-term outcome and infarct volume in acute middle cerebral artery infarction
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University Frankfurt am Main, Frankfurt am Main, Germany
    Arch Neurol 62:1130-4. 2005
    ..An easily accessible and valid surrogate marker for interventional stroke trials is needed...
  10. ncbi request reprint Serum S100B predicts a malignant course of infarction in patients with acute middle cerebral artery occlusion
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University Frankfurt am Main, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    Stroke 35:2160-4. 2004
    ..We investigated whether measurements of serum astroglial protein S100B can predict a malignant course of infarction in acute middle cerebral artery (MCA) occlusion...
  11. ncbi request reprint Effect of early and delayed recanalization on infarct pattern in proximal middle cerebral artery occlusion
    Marek Humpich
    Department of Neurology, J W Goethe University, Frankfurt am Main, Germany
    Cerebrovasc Dis 22:51-6. 2006
    ..To investigate the effect of early (<6 h) versus delayed (>6 h) recanalization on infarct pattern in acute middle cerebral artery (MCA) occlusion...
  12. ncbi request reprint MRI-based and CT-based thrombolytic therapy in acute stroke within and beyond established time windows: an analysis of 1210 patients
    Peter D Schellinger
    Department of Neurology, University of Erlangen, Schwabachanlage 6, D 91054 Erlangen, Germany
    Stroke 38:2640-5. 2007
    ..This window may be extended by using modern imaging-based selection algorithms. We assessed safety and efficacy of MRI-based thrombolysis within and beyond 3 hours compared with standard CT-based thrombolysis...
  13. ncbi request reprint Relation between relative cerebral blood flow, relative cerebral blood volume, and mean transit time in patients with acute ischemic stroke determined by perfusion-weighted MRI
    Oliver C Singer
    Department of Neurology, J W Goethe University, Frankfurt am Main, Germany
    J Cereb Blood Flow Metab 23:605-11. 2003
    ....
  14. ncbi request reprint A simple 3-item stroke scale: comparison with the National Institutes of Health Stroke Scale and prediction of middle cerebral artery occlusion
    Oliver C Singer
    Department of Neurology, J W Goethe University, Frankfurt Main, Germany
    Stroke 36:773-6. 2005
    ..The purpose of the study was to design a simple stroke scale that requires minimal training but reflects initial stroke severity and is predictive of middle cerebral artery (MCA) occlusion...
  15. ncbi request reprint Tissue plasminogen activator mediated blood-brain barrier damage in transient focal cerebral ischemia in rats: relevance of interactions between thrombotic material and thrombolytic agent
    Timo Kahles
    Department of Neurology, University Hospital, JW Goethe University Frankfurt, Schleusenweg 2 16, ZNN, 60528 Frankfurt Main, Germany
    Vascul Pharmacol 43:254-9. 2005
    ..The results of the present study indicate a major role for thrombus-thrombolytic interaction in focal cerebral ischemia with subsequent increased BBB permeability...
  16. doi request reprint Clinical outcome after mechanical recanalization as mono- or adjunctive therapy in acute stroke: importance of time to recanalization
    Jos S Becktepe
    Department of Neurology, Goethe University, Frankfurt, Germany
    Cerebrovasc Dis 32:211-8. 2011
    ..We report the clinical and imaging results of 34 consecutive patients, focusing on time aspects (i.e. vessel occlusion time and procedure duration)...
  17. doi request reprint Risk assessment of symptomatic intracerebral hemorrhage after thrombolysis using DWI-ASPECTS
    Oliver C Singer
    Department of Neurology, J W Goethe University Frankfurt am Main, Schleusenweg 2 16, D 60528 Frankfurt Main, Germany
    Stroke 40:2743-8. 2009
    ..Here, we investigated whether the Alberta Stroke Programme Early CT Score (ASPECTS) applied to DWI images (DWI-ASPECTS) predicts sICH risk accurately...
  18. ncbi request reprint Magnetic resonance imaging in basilar artery occlusion
    Richard du Mesnil de Rochemont
    Institute of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, 60528 Frankfurt, Germany
    Arch Neurol 59:398-402. 2002
    ..Acute basilar artery occlusion has particularly high mortality and morbidity...
  19. doi request reprint Age Dependency of Successful Recanalization in Anterior Circulation Stroke: The ENDOSTROKE Study
    Oliver C Singer
    Department of Neurology, Goethe University, Frankfurt, Germany
    Cerebrovasc Dis 36:437-45. 2013
    ..2013 S. Karger AG, Basel. ..
  20. pmc Yawning in acute anterior circulation stroke
    Oliver C Singer
    Department of Neurology, JW Goethe University Frankfurt am Main, Schleusenweg 2 16, D 60528 Frankfurt Main, Germany
    J Neurol Neurosurg Psychiatry 78:1253-4. 2007
    ..We hypothesise that excessive yawning is a consequence of lesions in cortical or subcortical areas, which physiologically control diencephalic yawning centres...
  21. ncbi request reprint Pretreatment with antiplatelet agents is not independently associated with unfavorable outcome in intracerebral hemorrhage
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    Stroke 37:2165-7. 2006
    ..This study investigated the effect of preexisting antiplatelet therapy on mortality and functional outcome in patients with intracerebral hemorrhage (ICH)...
  22. ncbi request reprint Sex disparity in the access of elderly patients to acute stroke care
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Stroke 38:2123-6. 2007
    ..We sought to determine whether sex disparities exist in acute stroke management, particularly with regard to early hospital admission and thrombolytic therapy...
  23. ncbi request reprint Practical limitations of acute stroke MRI due to patient-related problems
    Oliver C Singer
    Department of Neurology, J W Goethe University, Frankfurt am Main, Germany
    Neurology 62:1848-9. 2004
    ..In the subgroup of patients ineligible for MRI because of medical reasons (n = 11), intracerebral hemorrhage was frequent (n = 9; 73%)...
  24. ncbi request reprint Difference in recognition of right and left hemispheric stroke
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    Lancet 366:392-3. 2005
    ..Difficulties in recognition of symptoms due to right hemispheric stroke challenge efforts to optimise stroke management, particularly in the critical early hours of stroke...
  25. doi request reprint Future demographic trends decrease the proportion of ischemic stroke patients receiving thrombolytic therapy: a call to set-up therapeutic studies in the very old
    Christian Foerch
    Department of Neurology, Goethe University, Frankfurt am Main, Germany
    Stroke 40:1900-2. 2009
    ..The aim of the present analysis was to provide an estimate of the future number of ischemic stroke patients and the fraction thereof receiving tPA...
  26. pmc Risk of symptomatic intracerebral hemorrhage in patients treated with intra-arterial thrombolysis
    O C Singer
    Klinik fur Neurologie, Goethe Universitat, Frankfurt, Germany
    Cerebrovasc Dis 27:368-74. 2009
    ..In the present study, we investigated the rate of sICH in IA and combined IV + IA thrombolysis versus IV thrombolysis after adjusting for differences in clinical and MRI parameters...
  27. ncbi request reprint Early functional recovery and the fate of the diffusion/perfusion mismatch in patients with proximal middle cerebral artery occlusion
    Oliver C Singer
    Department of Neurology, J W Goethe University Frankfurt am Main, Germany
    Cerebrovasc Dis 17:13-20. 2004
    ..The relationship between early neurological recovery, time to recanalization and the salvage of hypoperfused, but not diffusion-restricted tissue was investigated...
  28. ncbi request reprint Brain stem infarction caused by proximal internal carotid artery stenosis in a patient with a persisting primitive trigeminal artery
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Cerebrovasc Dis 22:200-2. 2006
  29. ncbi request reprint Ipsilateral silent period: a marker of callosal conduction abnormality in early relapsing-remitting multiple sclerosis?
    Patrick Jung
    Department of Neurology, Johann Wolfgang Goethe University, Schleusenweg 2 16, D 60528 Frankfurt am Main, Germany
    J Neurol Sci 250:133-9. 2006
    ..Ziemann U. Differences of the ipsilateral silent period in small hand muscles. Muscle Nerve in press.], its diagnostic sensitivity in MS, about which conflicting results were reported in previous studies...
  30. ncbi request reprint Conjugate eye deviation in acute stroke: incidence, hemispheric asymmetry, and lesion pattern
    Oliver C Singer
    Department of Neurology, J W Goethe University Frankfurt am Main, Schleusenweg 2 16, D 60528 Frankfurt Main, Germany
    Stroke 37:2726-32. 2006
    ..The authors studied clinical features and lesion patterns associated with conjugate eye deviation (CED) in acute stroke...
  31. ncbi request reprint Multiple spin-echo spectroscopic imaging for rapid quantitative assessment of N-acetylaspartate and lactate in acute stroke
    Astrid Stengel
    Department of Neurology, J W Goethe University, Frankfurt am Main, Germany
    Magn Reson Med 52:228-38. 2004
    ..Considerable differences among the patients in terms of the Lac concentrations and the size of the SI-ADC mismatch were observed...
  32. doi request reprint Gender imbalances induced by age limits in stroke trials
    Christian Foerch
    Department of Neurology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Neuroepidemiology 35:226-30. 2010
    ..In this study, we model how applying upper age limits will lead to a gender disparity in stroke trials, favouring the inclusion of men rather than women...
  33. doi request reprint NADPH oxidase Nox1 contributes to ischemic injury in experimental stroke in mice
    Timo Kahles
    Department ofNeurology, University Hospital, Goethe University Frankfurt, Frankfurt Main, Germany
    Neurobiol Dis 40:185-92. 2010
    ..In conclusion, Nox1 is involved in the pathophysiology of cerebral ischemia. Our data however indicate that ROS-mediated direct cellular injury is unlikely to explain the protective effect achieved by genetic deletion of the enzyme...
  34. doi request reprint Pyrrolidine dithiocarbamate activates p38 MAPK and protects brain endothelial cells from apoptosis: a mechanism for the protective effect in stroke?
    Waltraud Pfeilschifter
    Klinik fur Neurologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Neurochem Res 35:1391-401. 2010
    ..The attenuation of apoptotic cell death in brain microvascular endothelial cells is dependent on p38 MAPK activity...
  35. doi request reprint T2' imaging within perfusion-restricted tissue in high-grade occlusive carotid disease
    Alexander Seiler
    Department of Neurology, Goethe University, Schleusenweg 2 16, D 60528 Frankfurt Main, Germany
    Stroke 43:1831-6. 2012
    ..We investigated quantitative T2' imaging in patients with high-grade stenoses of brain-supplying arteries and hypothesized that T2' values are lower in perfusion-restricted areas as compared with normally perfused tissue...
  36. doi request reprint MR volumetric changes after diagnostic CSF removal in normal pressure hydrocephalus
    Oliver C Singer
    Department of Neurology, Goethe University Frankfurt, Schleusenweg 2 16, 60528, Frankfurt Main, Germany
    J Neurol 259:2440-6. 2012
    ..In particular, we report evidence that CSF removal results in a change of the brain volume rather than only a change of the brain's shape...
  37. doi request reprint In-hospital complication rates after stent treatment of 388 symptomatic intracranial stenoses: results from the INTRASTENT multicentric registry
    Wiebke Kurre
    Department of Neuroradiology, University of Frankfurt, Schleusenweg 2 16, 60528 Frankfurt, Germany
    Stroke 41:494-8. 2010
    ..Data from the INTRASTENT multicentric registry should demonstrate in-hospital complications at the current stage of clinical development of the stent procedure...
  38. doi request reprint Coil embolization of cavernous sinus in patients with direct and dural arteriovenous fistula
    Andrea Bink
    Department of Neuroradiology, Goethe University, Schleusenweg 2 16, Haus 95, 60528, Frankfurt am Main, Germany
    Eur Radiol 19:1443-9. 2009
    ..Adequate anticoagulation is recommended to avoid thrombembolic complications. Long-term outcome has to be determined by further studies...
  39. ncbi request reprint Changes of cerebral blood flow, oxygenation, and oxidative metabolism during graded motor activation
    Andreas Kastrup
    Department of Radiology, Stanford University School of Medicine, Stanford, California 94305 5488, USA
    Neuroimage 15:74-82. 2002
    ..Comparable proportionality constants have been found in the visual cortex and primary sensory cortex, indicating similarities between the relationship of CBF and CMRO(2) in various cortical regions...
  40. doi request reprint Combining magnetic resonance imaging within six-hours of symptom onset with clinical follow-up at 24 h improves prediction of 'malignant' middle cerebral artery infarction
    Anna Kruetzelmann
    Department of Neurology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Int J Stroke 9:210-4. 2014
    ....
  41. doi request reprint Periprocedural aspects in mechanical recanalization for acute stroke: data from the ENDOSTROKE registry
    Oliver C Singer
    Department of Neurology, Goethe University, Schleusenweg 2 16, 60528, Frankfurt Main, Germany
    Neuroradiology 55:1143-51. 2013
    ..This analysis focuses on preprocedural imaging, patient handling and referral, as well as on different treatment modalities in mechanical recanalization...
  42. doi request reprint Adherence to hospital discharge medication in patients with ischemic stroke: a prospective, interventional 2-phase study
    Carina Hohmann
    Department of Neurology, Klinikum Fulda gAG, Fulda, Germany
    Stroke 44:522-4. 2013
    ..The aim of the study was to evaluate the adherence to hospital discharge medication in patients with ischemic stroke before and after implementing a systematic approach provided by a clinical pharmacist...
  43. doi request reprint Lifestyle risk factors for ischemic stroke and transient ischemic attack in young adults in the Stroke in Young Fabry Patients study
    Bettina von Sarnowski
    Department of Neurology, University Medicine, Ferdinand Sauerbruch Straße, D 17475 Greifswald, Germany
    Stroke 44:119-25. 2013
    ..Although many stroke patients are young or middle-aged, risk factor profiles in these age groups are poorly understood...
  44. ncbi request reprint Clinical and radiological correlates of reduced cerebral blood flow measured using magnetic resonance imaging
    Vincent N Thijs
    Department of Neurology, UZ Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Arch Neurol 59:233-8. 2002
    ..Reduced apparent diffusion coefficient (ADC) values of brain tissue are associated with reductions in regional CBF in animal stroke models...
  45. ncbi request reprint Diffusion-weighted imaging in acute stroke--a tool of uncertain value?
    Jens Fiehler
    Department of Neuroradiology, University Hospitals of Hamburg Eppendorf, Hamburg, Germany
    Cerebrovasc Dis 14:187-96. 2002
    ..MR stroke imaging delivers important information in acute stroke, particularly in defining the 'tissue at risk of infarction'...
  46. ncbi request reprint NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke
    Timo Kahles
    Institut für Kardiovaskuläre Physiologie, Fachbereich Medizin der J W Goethe Universität, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Stroke 38:3000-6. 2007
    ..We hypothesized that NADPH oxidases mediate blood-brain barrier (BBB) disruption and contribute to tissue damage in ischemia/reperfusion...
  47. ncbi request reprint Bleeding risk analysis in stroke imaging before thromboLysis (BRASIL): pooled analysis of T2*-weighted magnetic resonance imaging data from 570 patients
    Jens Fiehler
    Department of Neuroradiology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Stroke 38:2738-44. 2007
    ..Because of this concern, some centers withhold potentially beneficial thrombolytic therapy from these patients...