Research Topics
| D MebsSummaryAffiliation: Frankfurt am Main Country: Germany Publications
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Detail Information
Publications
Direct cDNA cloning of novel conopeptide precursors of the O-superfamilySilke Kauferstein
Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
Peptides 26:361-7. 2005..These findings demonstrate that beside a common genetic pattern divergent evolution of toxins occurred in a highly mutating peptide family...- Modulation of voltage-gated Na+ and K+ channels by pumiliotoxin 251D: a "joint venture" alkaloid from arthropods and amphibiansThomas Vandendriessche
Laboratory of Toxicology, University of Leuven, Leuven, Belgium
Toxicon 51:334-44. 2008..hK(v)1.3 was the most sensitive channel, with an IC(50) value 10.8+/-0.5 microM. To the best of our knowledge this is the first report of a PTX affecting VGPCs... - Studies on the cardenolide sequestration in African milkweed butterflies (Danaidae)Dietrich Mebs
Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
Toxicon 45:581-4. 2005.... - Tetrodotoxin does not protect red-spotted newts, Notophthalmus viridescens, from intestinal parasitesDietrich Mebs
Institute of Legal Medicine, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
Toxicon 60:66-9. 2012.... - Variability of alkaloids in the skin secretion of the European fire salamander (Salamandra salamadra terrestris)Dietrich Mebs
Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
Toxicon 45:603-6. 2005..Alkaloid synthesis appears to take place also in liver, testes and ovaries, whereas the larvae of the salamanders are entirely free of alkaloids... - Ichthyotoxicity caused by marine cone snail venoms?Dietrich Mebs
Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 69596 Frankfurt am Main, Germany
Toxicon 46:355-6. 2005..No sedative or hypnotic symptoms were observed. The experiments confirm that Conus venoms exert a quick and prompt activity only by parenteral injection into the prey as it is performed by the snail... - Studies on the poisonous skin secretion of individual red bellied toads, Melanophryniscus montevidensis (Anura, Bufonidae), from UruguayDietrich Mebs
Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
Toxicon 46:641-50. 2005..The analysis of extracts from 125 arthropod samples (Arachnida and Insecta, including termites, ants and beetles), which may represent a potential food source, revealed no alkaloids of the PTX group... - Studies on biological and enzymatic activities of salivary glands from the European hedgehog (Erinaceus europaeus)D Mebs
Zentrum der Rechtsmedizin, University of Frankfurt, Germany
Toxicon 37:1635-8. 1999..These experiments suggest that toxic saliva in mammals is restricted to certain insectivores (shrews and solenodons) only... - [Snakes, scorpions and other poisonous creatures: prophylaxis and emergency medicine]D Mebs
Zentrum der Rechtsmedizin Klinikum der Johann Wolfgang Goethe Universität Frankfurt a Main
MMW Fortschr Med 148:31-4. 2006..While the sting of a scorpion or a spider bite often do not lead to severe complications in adults, a brush with a poisonous snake may be much more serious... - Lack of bufadienolides in the skin secretion of red bellied toads, Melanophryniscus spp. (Anura, Bufonidae), from UruguayDietrich Mebs
Institute of Forensic Toxicology, Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
Comp Biochem Physiol C Toxicol Pharmacol 144:398-402. 2007..bufo tadpoles bufotoxin and two alkylamines. Melanophryniscus toads appear not to be able to compensate the high variability of toxic skin alkaloids by producing defensive bufadienolides... - Further studies on pumiliotoxin 251D and hydroquinone content of the skin secretion of Melanophryniscus species (Anura, Bufonidae) from UruguayDietrich Mebs
Institute of Forensic Toxicology, Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
Toxicon 50:166-9. 2007..The extracts of the eggs and tadpoles were entirely free of alkaloids as well as hydroquinone, pointing to a dietary origin of these compounds... - Chemical biology of the mutualistic relationships of sea anemones with fish and crustaceansDietrich Mebs
Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
Toxicon 54:1071-4. 2009..Whether the natural or acquired mucus layers contain components that inhibit nematocyst discharge or simply lack compounds stimulating the stinging cell's exocytosis is still unknown... - Cantharidin and demethylcantharidin (palasonin) content of blister beetles (Coleoptera: Meloidae) from southern AfricaDietrich Mebs
Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
Toxicon 53:466-8. 2009.... - Tissue distribution of tetrodotoxin in the red-spotted newt Notophthalmus viridescensDietrich Mebs
Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
Toxicon 55:1353-7. 2010.... - Biochemical and biological activities of the venom of a new species of pitviper from Vietnam, Triceratolepidophis sieversorumDietrich Mebs
Zentrum de Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596, Frankfurt, Germany
Toxicon 41:139-43. 2003..Other enzymatic activities (phospholipase A(2), kallikrein) were moderate. The approximate i.p. LD(50) (mice) of the venom is about 5-6 mg/kg... - Notes on the traditional use of plants to treat snake bite in northern Papua New GuineaD Mebs
Zentrum der Rechtsmedizin, University of Frankfurt, Germany
Toxicon 38:299-302. 2000..g. alkaloids, steroids, saponins or flavonoids have been detected by thin-layer chromatography in alcoholic extracts of the plants involved rendering this type of snake bite treatment questionable... - Phylogeography of Australia's king brown snake (Pseudechis australis) reveals Pliocene divergence and Pleistocene dispersal of a top predatorUlrich Kuch
Zentrum der Rechtsmedizin, Klinikum der Johann Wolfgang Goethe Universitat, Kennedyallee 104, 60596 Frankfurt am Main, Germany
Naturwissenschaften 92:121-7. 2005..Thus, our data support the recognition of at least five species from within P. australis (auct.) under various criteria. We discuss biogeographical, ecological and medical implications of our findings... - A novel conotoxin inhibiting vertebrate voltage-sensitive potassium channelsSilke Kauferstein
Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt am Main, Germany
Toxicon 42:43-52. 2003..1 and Kv1.3 but not Kv1.2. The chemically synthesized product exhibited the same physiological activity and identical molecular mass (3933.7 Da) as the native toxin... - Identification of alpha-bungarotoxin (A31) as the major postsynaptic neurotoxin, and complete nucleotide identity of a genomic DNA of Bungarus candidus from Java with exons of the Bungarus multicinctus alpha-bungarotoxin (A31) geneUlrich Kuch
Zentrum der Rechtsmedizan, Klinikum der Johann Wolfgang Goethe Universitat, Kennedyallee 104, 60596 Frankfurt am Main, Germany
Toxicon 42:381-90. 2003..alpha-Bungarotoxin appears to be widely present and conserved in Southeast and East Asian black-and-white kraits across populations and taxa... - Novel conopeptides of the I-superfamily occur in several clades of cone snailsSilke Kauferstein
Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt am Main, Germany
Toxicon 44:539-48. 2004..Moreover, I-superfamily conopeptides were detected both in vermivorous and piscivorous species of Conus, thus demonstrating the widespread presence of such toxins in this speciose genus beyond evolutionary and ecological groups... - Biochemical and biological activities of the venom of the Chinese pitviper Zhaoermia mangshanensis, with the complete amino acid sequence and phylogenetic analysis of a novel Arg49 phospholipase A2 myotoxinDietrich Mebs
Zentrum der Rechtsmedizin, , Kennedyallee 104, D-60596 Frankfurt am Main, Germany
Toxicon 47:797-811. 2006.... - New conopeptides of the D-superfamily selectively inhibiting neuronal nicotinic acetylcholine receptorsS Kauferstein
Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
Toxicon 54:295-301. 2009..Due to their high affinity, these new ligands may provide a tool to decipher the localisation and function of the various neuronal nAChRs... - Detection of hemolytic bacteria from Palythoa caribaeorum (Cnidaria, Zoantharia) using a novel palytoxin-screening assayPetra Seemann
Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, 60596 Frankfurt, Germany
Antonie Van Leeuwenhoek 96:405-11. 2009..The results indicate the presence of Na+/K+-ATPase toxins and possibly PTX in hemolytic bacteria from P. caribaeorum... - Snake fangs from the Lower Miocene of Germany: evolutionary stability of perfect weaponsUlrich Kuch
Zentrum der Rechtsmedizin, , Kennedyallee 104, 60596 Frankfurt am Main, Germany
Naturwissenschaften 93:84-7. 2006.... - Crystal structure of a novel myotoxic Arg49 phospholipase A2 homolog (zhaoermiatoxin) from Zhaoermia mangshanensis snake venom: insights into Arg49 coordination and the role of Lys122 in the polarization of the C-terminusMario T Murakami
Center for Structural and Molecular Biology, Department of Physics, IBILCE UNESP, R Cristovao Colombo 2265, Sao Jose do Rio Preto, São Paulo CEP 15054 000, Brazil
Toxicon 51:723-35. 2008.... - Crystallization and preliminary X-ray diffraction analysis of a novel Arg49 phospholipase A2 homologue from Zhaoermia mangshanensis venomMario T Murakami
Department of Physics, UNESP State University of São Paulo, São José do Rio Preto 15054 000, Brazil
Acta Crystallogr Sect F Struct Biol Cryst Commun 63:605-7. 2007..05 A using synchrotron radiation and the diffraction pattern was indexed in the hexagonal space group P6(4), with unit-cell parameters a = 72.9, b = 72.9, c = 93.9 A... - Complete amino acid sequence and phylogenetic analysis of a long-chain neurotoxin from the venom of the African banded water cobra, Boulengerina annulataYuko Ogawa
Institute of Medicinal Chemistry, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan
Toxicon 43:855-8. 2004..These results are discussed in the light of phylogenetic hypotheses on the relationships of African cobras... - Isolation, toxicity and amino terminal sequences of three major neurotoxins in the venom of Malayan krait (Bungarus candidus) from ThailandOrawan Khow
Queen Saovabha Memorial Institute, The Thai Red Cross Society, 1871 Rama IV Rd, Bangkok 10330, Thailand
J Biochem (Tokyo) 134:799-804. 2003..The amino terminal sequences of the two chains of each of the toxins determined by Edman degradation exhibited considerable similarity with those of the A-chains and B-chains of beta-BTxs in the venom of Bungarus multicinctus... - Tetrodotoxin and its analogue 6-epitetrodotoxin in newts (Triturus spp.; Urodela, Salamandridae) from southern GermanyMari Yotsu Yamashita
Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai 981 8555, Japan
Toxicon 50:306-9. 2007..Both toxins were detected in only 15 specimens of the four species. The toxins levels varied considerably among individuals (TTX: 0.11-9.0microg/g; 6-epiTTX: 0.05-17.0microg/g). 6-epiTTX was found to be the major component... - A case of palytoxin poisoning due to contact with zoanthid corals through a skin injuryKatrin Hoffmann
Department of General Surgery, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany
Toxicon 51:1535-7. 2008..Symptomatic treatment consisted of infusion of physiological fluids. The patient recovered within 3 days. Analysis of the zoanthid coral involved revealed extremely high concentrations of palytoxin (between 2 and 3 mg/g)... - Persistent paresis of the facialis muscle after European adder (Vipera berus) bite on the foreheadWolfgang Weinelt
Bundeswehrkrankenhaus Berlin, Scharnhorststr 13, D 10115 Berlin, Germany
Toxicon 40:1627-9. 2002..These resolved over several days but there was a persistent unilateral facial frontalis muscle paresis and ptosis most likely due to the location of the bite in the left fronto-temporal area... - Distribution of tetrodotoxin in the body of the blue-ringed octopus (Hapalochlaena maculosa)Mari Yotsu Yamashita
Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai 981 8555, Japan
Toxicon 49:410-2. 2007..TTX was found to be present in all body parts, e.g. in high concentrations in the arms followed by the abdomen and cephalothorax. The toxin is not associated exclusively with the posterior salivary gland... - [In Africa snake venom antivenins in short supply. Fatal risk for foreign tourists?]Dietrich Mebs
Zentrum der Rechtsmedizin Kennedyallee 104, D-60596 Frankfurt
MMW Fortschr Med 144:57. 2002 - An aqueous extract of the marine sponge Ectyoplasia ferox stimulates L-type Ca2+-current by direct interaction with the Cav1.2 subunitTorsten Christ
Department of Pharmacology and Toxicology, Dresden University of Technology, Fetscherstrasse 74, 01309 Dresden, Germany
Naunyn Schmiedebergs Arch Pharmacol 370:474-83. 2004..These findings suggest that the effect of C47 is restricted to the Ca(2+) channel...