D Mebs

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi request reprint Direct cDNA cloning of novel conopeptide precursors of the O-superfamily
    Silke Kauferstein
    Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
    Peptides 26:361-7. 2005
  2. ncbi request reprint Studies on the cardenolide sequestration in African milkweed butterflies (Danaidae)
    Dietrich Mebs
    Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
    Toxicon 45:581-4. 2005
  3. ncbi request reprint Ichthyotoxicity caused by marine cone snail venoms?
    Dietrich Mebs
    Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 69596 Frankfurt am Main, Germany
    Toxicon 46:355-6. 2005
  4. ncbi request reprint Modulation of voltage-gated Na+ and K+ channels by pumiliotoxin 251D: a "joint venture" alkaloid from arthropods and amphibians
    Thomas Vandendriessche
    Laboratory of Toxicology, University of Leuven, Leuven, Belgium
    Toxicon 51:334-44. 2008
  5. doi request reprint Poor alkaloid sequestration by arrow poison frogs of the genus Phyllobates from Costa Rica
    Dietrich Mebs
    Institute of Legal Medicine, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany Electronic address
    Toxicon 80:73-7. 2014
  6. doi request reprint History of the International Society on Toxinology--a personal view
    Dietrich Mebs
    Institute of Legal Medicine, University of Frankfurt, Kennedyallee 104, 60596 Frankfurt, Germany
    Toxicon 69:21-8. 2013
  7. doi request reprint Tetrodotoxin does not protect red-spotted newts, Notophthalmus viridescens, from intestinal parasites
    Dietrich Mebs
    Institute of Legal Medicine, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
    Toxicon 60:66-9. 2012
  8. ncbi request reprint Studies on the poisonous skin secretion of individual red bellied toads, Melanophryniscus montevidensis (Anura, Bufonidae), from Uruguay
    Dietrich Mebs
    Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
    Toxicon 46:641-50. 2005
  9. ncbi request reprint Studies on biological and enzymatic activities of salivary glands from the European hedgehog (Erinaceus europaeus)
    D Mebs
    Zentrum der Rechtsmedizin, University of Frankfurt, Germany
    Toxicon 37:1635-8. 1999
  10. ncbi request reprint [Snakes, scorpions and other poisonous creatures: prophylaxis and emergency medicine]
    D Mebs
    Zentrum der Rechtsmedizin Klinikum der Johann Wolfgang Goethe Universität Frankfurt a Main
    MMW Fortschr Med 148:31-4. 2006

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Direct cDNA cloning of novel conopeptide precursors of the O-superfamily
    Silke Kauferstein
    Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
    Peptides 26:361-7. 2005
    ..These findings demonstrate that beside a common genetic pattern divergent evolution of toxins occurred in a highly mutating peptide family...
  2. ncbi request reprint Studies on the cardenolide sequestration in African milkweed butterflies (Danaidae)
    Dietrich Mebs
    Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
    Toxicon 45:581-4. 2005
    ....
  3. ncbi request reprint Ichthyotoxicity caused by marine cone snail venoms?
    Dietrich Mebs
    Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 69596 Frankfurt am Main, Germany
    Toxicon 46:355-6. 2005
    ..No sedative or hypnotic symptoms were observed. The experiments confirm that Conus venoms exert a quick and prompt activity only by parenteral injection into the prey as it is performed by the snail...
  4. ncbi request reprint Modulation of voltage-gated Na+ and K+ channels by pumiliotoxin 251D: a "joint venture" alkaloid from arthropods and amphibians
    Thomas Vandendriessche
    Laboratory of Toxicology, University of Leuven, Leuven, Belgium
    Toxicon 51:334-44. 2008
    ..hK(v)1.3 was the most sensitive channel, with an IC(50) value 10.8+/-0.5 microM. To the best of our knowledge this is the first report of a PTX affecting VGPCs...
  5. doi request reprint Poor alkaloid sequestration by arrow poison frogs of the genus Phyllobates from Costa Rica
    Dietrich Mebs
    Institute of Legal Medicine, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany Electronic address
    Toxicon 80:73-7. 2014
    ....
  6. doi request reprint History of the International Society on Toxinology--a personal view
    Dietrich Mebs
    Institute of Legal Medicine, University of Frankfurt, Kennedyallee 104, 60596 Frankfurt, Germany
    Toxicon 69:21-8. 2013
    ..IST sponsors the Redi Award to recognize distinguished work in the field of toxinology. Toxicon is the official journal of the Society...
  7. doi request reprint Tetrodotoxin does not protect red-spotted newts, Notophthalmus viridescens, from intestinal parasites
    Dietrich Mebs
    Institute of Legal Medicine, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
    Toxicon 60:66-9. 2012
    ....
  8. ncbi request reprint Studies on the poisonous skin secretion of individual red bellied toads, Melanophryniscus montevidensis (Anura, Bufonidae), from Uruguay
    Dietrich Mebs
    Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
    Toxicon 46:641-50. 2005
    ..The analysis of extracts from 125 arthropod samples (Arachnida and Insecta, including termites, ants and beetles), which may represent a potential food source, revealed no alkaloids of the PTX group...
  9. ncbi request reprint Studies on biological and enzymatic activities of salivary glands from the European hedgehog (Erinaceus europaeus)
    D Mebs
    Zentrum der Rechtsmedizin, University of Frankfurt, Germany
    Toxicon 37:1635-8. 1999
    ..These experiments suggest that toxic saliva in mammals is restricted to certain insectivores (shrews and solenodons) only...
  10. ncbi request reprint [Snakes, scorpions and other poisonous creatures: prophylaxis and emergency medicine]
    D Mebs
    Zentrum der Rechtsmedizin Klinikum der Johann Wolfgang Goethe Universität Frankfurt a Main
    MMW Fortschr Med 148:31-4. 2006
    ..While the sting of a scorpion or a spider bite often do not lead to severe complications in adults, a brush with a poisonous snake may be much more serious...
  11. ncbi request reprint Lack of bufadienolides in the skin secretion of red bellied toads, Melanophryniscus spp. (Anura, Bufonidae), from Uruguay
    Dietrich Mebs
    Institute of Forensic Toxicology, Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
    Comp Biochem Physiol C Toxicol Pharmacol 144:398-402. 2007
    ..bufo tadpoles bufotoxin and two alkylamines. Melanophryniscus toads appear not to be able to compensate the high variability of toxic skin alkaloids by producing defensive bufadienolides...
  12. ncbi request reprint Further studies on pumiliotoxin 251D and hydroquinone content of the skin secretion of Melanophryniscus species (Anura, Bufonidae) from Uruguay
    Dietrich Mebs
    Institute of Forensic Toxicology, Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
    Toxicon 50:166-9. 2007
    ..The extracts of the eggs and tadpoles were entirely free of alkaloids as well as hydroquinone, pointing to a dietary origin of these compounds...
  13. doi request reprint Chemical biology of the mutualistic relationships of sea anemones with fish and crustaceans
    Dietrich Mebs
    Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
    Toxicon 54:1071-4. 2009
    ..Whether the natural or acquired mucus layers contain components that inhibit nematocyst discharge or simply lack compounds stimulating the stinging cell's exocytosis is still unknown...
  14. ncbi request reprint Cantharidin and demethylcantharidin (palasonin) content of blister beetles (Coleoptera: Meloidae) from southern Africa
    Dietrich Mebs
    Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
    Toxicon 53:466-8. 2009
    ....
  15. doi request reprint Tissue distribution of tetrodotoxin in the red-spotted newt Notophthalmus viridescens
    Dietrich Mebs
    Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
    Toxicon 55:1353-7. 2010
    ....
  16. ncbi request reprint Variability of alkaloids in the skin secretion of the European fire salamander (Salamandra salamadra terrestris)
    Dietrich Mebs
    Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
    Toxicon 45:603-6. 2005
    ..Alkaloid synthesis appears to take place also in liver, testes and ovaries, whereas the larvae of the salamanders are entirely free of alkaloids...
  17. ncbi request reprint Biochemical and biological activities of the venom of a new species of pitviper from Vietnam, Triceratolepidophis sieversorum
    Dietrich Mebs
    Zentrum de Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596, Frankfurt, Germany
    Toxicon 41:139-43. 2003
    ..Other enzymatic activities (phospholipase A(2), kallikrein) were moderate. The approximate i.p. LD(50) (mice) of the venom is about 5-6 mg/kg...
  18. ncbi request reprint Notes on the traditional use of plants to treat snake bite in northern Papua New Guinea
    D Mebs
    Zentrum der Rechtsmedizin, University of Frankfurt, Germany
    Toxicon 38:299-302. 2000
    ..g. alkaloids, steroids, saponins or flavonoids have been detected by thin-layer chromatography in alcoholic extracts of the plants involved rendering this type of snake bite treatment questionable...
  19. ncbi request reprint A novel conotoxin inhibiting vertebrate voltage-sensitive potassium channels
    Silke Kauferstein
    Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt am Main, Germany
    Toxicon 42:43-52. 2003
    ..1 and Kv1.3 but not Kv1.2. The chemically synthesized product exhibited the same physiological activity and identical molecular mass (3933.7 Da) as the native toxin...
  20. ncbi request reprint Identification of alpha-bungarotoxin (A31) as the major postsynaptic neurotoxin, and complete nucleotide identity of a genomic DNA of Bungarus candidus from Java with exons of the Bungarus multicinctus alpha-bungarotoxin (A31) gene
    Ulrich Kuch
    Zentrum der Rechtsmedizan, Klinikum der Johann Wolfgang Goethe Universitat, Kennedyallee 104, 60596 Frankfurt am Main, Germany
    Toxicon 42:381-90. 2003
    ..alpha-Bungarotoxin appears to be widely present and conserved in Southeast and East Asian black-and-white kraits across populations and taxa...
  21. ncbi request reprint Phylogeography of Australia's king brown snake (Pseudechis australis) reveals Pliocene divergence and Pleistocene dispersal of a top predator
    Ulrich Kuch
    Zentrum der Rechtsmedizin, Klinikum der Johann Wolfgang Goethe Universitat, Kennedyallee 104, 60596 Frankfurt am Main, Germany
    Naturwissenschaften 92:121-7. 2005
    ..Thus, our data support the recognition of at least five species from within P. australis (auct.) under various criteria. We discuss biogeographical, ecological and medical implications of our findings...
  22. ncbi request reprint Novel conopeptides of the I-superfamily occur in several clades of cone snails
    Silke Kauferstein
    Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt am Main, Germany
    Toxicon 44:539-48. 2004
    ..Moreover, I-superfamily conopeptides were detected both in vermivorous and piscivorous species of Conus, thus demonstrating the widespread presence of such toxins in this speciose genus beyond evolutionary and ecological groups...
  23. ncbi request reprint Biochemical and biological activities of the venom of the Chinese pitviper Zhaoermia mangshanensis, with the complete amino acid sequence and phylogenetic analysis of a novel Arg49 phospholipase A2 myotoxin
    Dietrich Mebs
    Zentrum der Rechtsmedizin, Klinikum der Johann Wolfgang Goethe Universitat, Kennedyallee 104, D 60596 Frankfurt am Main, Germany
    Toxicon 47:797-811. 2006
    ....
  24. doi request reprint New conopeptides of the D-superfamily selectively inhibiting neuronal nicotinic acetylcholine receptors
    S Kauferstein
    Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, D 60596 Frankfurt, Germany
    Toxicon 54:295-301. 2009
    ..Due to their high affinity, these new ligands may provide a tool to decipher the localisation and function of the various neuronal nAChRs...
  25. doi request reprint Detection of hemolytic bacteria from Palythoa caribaeorum (Cnidaria, Zoantharia) using a novel palytoxin-screening assay
    Petra Seemann
    Zentrum der Rechtsmedizin, University of Frankfurt, Kennedyallee 104, 60596 Frankfurt, Germany
    Antonie Van Leeuwenhoek 96:405-11. 2009
    ..The results indicate the presence of Na+/K+-ATPase toxins and possibly PTX in hemolytic bacteria from P. caribaeorum...
  26. ncbi request reprint Snake fangs from the Lower Miocene of Germany: evolutionary stability of perfect weapons
    Ulrich Kuch
    Zentrum der Rechtsmedizin, Klinikum der Johann Wolfgang Goethe Universitat, Kennedyallee 104, 60596 Frankfurt am Main, Germany
    Naturwissenschaften 93:84-7. 2006
    ....
  27. doi request reprint Crystal structure of a novel myotoxic Arg49 phospholipase A2 homolog (zhaoermiatoxin) from Zhaoermia mangshanensis snake venom: insights into Arg49 coordination and the role of Lys122 in the polarization of the C-terminus
    Mario T Murakami
    Center for Structural and Molecular Biology, Department of Physics, IBILCE UNESP, R Cristovao Colombo 2265, Sao Jose do Rio Preto, São Paulo CEP 15054 000, Brazil
    Toxicon 51:723-35. 2008
    ....
  28. pmc Crystallization and preliminary X-ray diffraction analysis of a novel Arg49 phospholipase A2 homologue from Zhaoermia mangshanensis venom
    Mario T Murakami
    Department of Physics, UNESP State University of São Paulo, São José do Rio Preto 15054 000, Brazil
    Acta Crystallogr Sect F Struct Biol Cryst Commun 63:605-7. 2007
    ..05 A using synchrotron radiation and the diffraction pattern was indexed in the hexagonal space group P6(4), with unit-cell parameters a = 72.9, b = 72.9, c = 93.9 A...
  29. ncbi request reprint Complete amino acid sequence and phylogenetic analysis of a long-chain neurotoxin from the venom of the African banded water cobra, Boulengerina annulata
    Yuko Ogawa
    Institute of Medicinal Chemistry, Hoshi University, Ebara 2 4 41, Shinagawa ku, Tokyo 142 8501, Japan
    Toxicon 43:855-8. 2004
    ..These results are discussed in the light of phylogenetic hypotheses on the relationships of African cobras...
  30. ncbi request reprint Isolation, toxicity and amino terminal sequences of three major neurotoxins in the venom of Malayan krait (Bungarus candidus) from Thailand
    Orawan Khow
    Queen Saovabha Memorial Institute, The Thai Red Cross Society, 1871 Rama IV Rd, Bangkok 10330, Thailand
    J Biochem 134:799-804. 2003
    ..The amino terminal sequences of the two chains of each of the toxins determined by Edman degradation exhibited considerable similarity with those of the A-chains and B-chains of beta-BTxs in the venom of Bungarus multicinctus...
  31. ncbi request reprint Tetrodotoxin and its analogue 6-epitetrodotoxin in newts (Triturus spp.; Urodela, Salamandridae) from southern Germany
    Mari Yotsu-Yamashita
    Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai 981 8555, Japan
    Toxicon 50:306-9. 2007
    ..Both toxins were detected in only 15 specimens of the four species. The toxins levels varied considerably among individuals (TTX: 0.11-9.0microg/g; 6-epiTTX: 0.05-17.0microg/g). 6-epiTTX was found to be the major component...
  32. ncbi request reprint Distribution of tetrodotoxin in the body of the blue-ringed octopus (Hapalochlaena maculosa)
    Mari Yotsu-Yamashita
    Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai 981 8555, Japan
    Toxicon 49:410-2. 2007
    ..TTX was found to be present in all body parts, e.g. in high concentrations in the arms followed by the abdomen and cephalothorax. The toxin is not associated exclusively with the posterior salivary gland...
  33. doi request reprint A case of palytoxin poisoning due to contact with zoanthid corals through a skin injury
    Katrin Hoffmann
    Department of General Surgery, Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany
    Toxicon 51:1535-7. 2008
    ..Symptomatic treatment consisted of infusion of physiological fluids. The patient recovered within 3 days. Analysis of the zoanthid coral involved revealed extremely high concentrations of palytoxin (between 2 and 3 mg/g)...
  34. ncbi request reprint Persistent paresis of the facialis muscle after European adder (Vipera berus) bite on the forehead
    Wolfgang Weinelt
    Bundeswehrkrankenhaus Berlin, Scharnhorststr 13, D 10115 Berlin, Germany
    Toxicon 40:1627-9. 2002
    ..These resolved over several days but there was a persistent unilateral facial frontalis muscle paresis and ptosis most likely due to the location of the bite in the left fronto-temporal area...
  35. ncbi request reprint [In Africa snake venom antivenins in short supply. Fatal risk for foreign tourists?]
    Dietrich Mebs
    Zentrum der Rechtsmedizin Kennedyallee 104, D 60596 Frankfurt
    MMW Fortschr Med 144:57. 2002
  36. ncbi request reprint An aqueous extract of the marine sponge Ectyoplasia ferox stimulates L-type Ca2+-current by direct interaction with the Cav1.2 subunit
    Torsten Christ
    Department of Pharmacology and Toxicology, Dresden University of Technology, Fetscherstrasse 74, 01309 Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 370:474-83. 2004
    ..These findings suggest that the effect of C47 is restricted to the Ca(2+) channel...
  37. ncbi request reprint 'Venomics' or : The venomous systems genome project
    André Ménez
    Toxicon 47:255-9. 2006