U Mahlknecht

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. ncbi Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene
    Susanne Voelter-Mahlknecht
    Department of Hematology Oncology, University of Heidelberg Medical Center, D 69120 Heidelberg, Germany
    Int J Oncol 28:899-908. 2006
  2. ncbi Assignment of the human histone deacetylase 4 gene (HDAC4) to chromosome 2q37.2 by in situ hybridization
    U Mahlknecht
    University of Frankfurt, Department of Hematology Oncology, Theodor Stern Kai 7, DF 60590 Frankfurt am Main, Germany
    Cytogenet Cell Genet 93:137-8. 2001
  3. ncbi Chromosomal organization and localization of the human histone deacetylase 9 gene (HDAC9)
    Ulrich Mahlknecht
    University of Frankfurt Medical Center, Department of Hematology Oncology, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Biochem Biophys Res Commun 293:182-91. 2002
  4. ncbi [Epigenetic regulators as novel therapeutic targets in hematology/oncology]
    U Mahlknecht
    Klinikum der J W Goethe Universität Frankfurt am Main, Medizinische Klinik III, Abteilung für Hämatologie Onkologie, Frankfurt am Main
    Dtsch Med Wochenschr 128:2423-6. 2003
  5. ncbi Assignment of the human histone deacetylase 6 gene (HDAC6) to X chromosome p11.23 by in situ hybridization
    U Mahlknecht
    University of Frankfurt, Department of Hematology Oncology, Theodor Stern Kai 7, DF 60590 Frankfurt am Main, Germany
    Cytogenet Cell Genet 93:135-6. 2001
  6. ncbi Far-Western based protein-protein interaction screening of high-density protein filter arrays
    U Mahlknecht
    Department of Hematology Oncology, University of Frankfurt Medical Center, Theodor Stern Kai 7, D 60590, Frankfurt, Germany
    J Biotechnol 88:89-94. 2001
  7. pmc Histone acetylation modifiers in the pathogenesis of malignant disease
    U Mahlknecht
    Department of Hematology Oncology, University of Frankfurt Medical Center, Germany
    Mol Med 6:623-44. 2000
  8. ncbi Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5)
    U Mahlknecht
    Department of Hematology Oncology, University of Frankfurt Medical Center, Frankfurt, Germany
    Biochim Biophys Acta 1493:342-8. 2000
  9. ncbi High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region
    U Mahlknecht
    Laboratory of Medical Biochemistry, The Picower Institute for Medical Research, Manhasset NY, USA
    Cytogenet Cell Genet 86:237-9. 1999
  10. ncbi Cloning and characterization of the murine histone deacetylase (HDAC3)
    U Mahlknecht
    Picower Institute for Medical Research, 350 Community Drive, Manhasset, New York, 11030, USA
    Biochem Biophys Res Commun 263:482-90. 1999

Collaborators

Detail Information

Publications28

  1. ncbi Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene
    Susanne Voelter-Mahlknecht
    Department of Hematology Oncology, University of Heidelberg Medical Center, D 69120 Heidelberg, Germany
    Int J Oncol 28:899-908. 2006
    ..Functional characteristics of SIRT7 are essentially unknown at present and remain to be further elucidated...
  2. ncbi Assignment of the human histone deacetylase 4 gene (HDAC4) to chromosome 2q37.2 by in situ hybridization
    U Mahlknecht
    University of Frankfurt, Department of Hematology Oncology, Theodor Stern Kai 7, DF 60590 Frankfurt am Main, Germany
    Cytogenet Cell Genet 93:137-8. 2001
  3. ncbi Chromosomal organization and localization of the human histone deacetylase 9 gene (HDAC9)
    Ulrich Mahlknecht
    University of Frankfurt Medical Center, Department of Hematology Oncology, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Biochem Biophys Res Commun 293:182-91. 2002
    ..3 kDa and an isoelectric point of 6.41. Fluorescence in situ hybridization analysis localized the human HDAC9 gene to chromosome 7p21, a region which has been associated particularly with the pathogenesis of gynecological tumors...
  4. ncbi [Epigenetic regulators as novel therapeutic targets in hematology/oncology]
    U Mahlknecht
    Klinikum der J W Goethe Universität Frankfurt am Main, Medizinische Klinik III, Abteilung für Hämatologie Onkologie, Frankfurt am Main
    Dtsch Med Wochenschr 128:2423-6. 2003
  5. ncbi Assignment of the human histone deacetylase 6 gene (HDAC6) to X chromosome p11.23 by in situ hybridization
    U Mahlknecht
    University of Frankfurt, Department of Hematology Oncology, Theodor Stern Kai 7, DF 60590 Frankfurt am Main, Germany
    Cytogenet Cell Genet 93:135-6. 2001
  6. ncbi Far-Western based protein-protein interaction screening of high-density protein filter arrays
    U Mahlknecht
    Department of Hematology Oncology, University of Frankfurt Medical Center, Theodor Stern Kai 7, D 60590, Frankfurt, Germany
    J Biotechnol 88:89-94. 2001
    ..Taken together, we describe an approach that allows the easy and reproducible identification of protein ligands on the basis of a whole-genome expression analysis...
  7. pmc Histone acetylation modifiers in the pathogenesis of malignant disease
    U Mahlknecht
    Department of Hematology Oncology, University of Frankfurt Medical Center, Germany
    Mol Med 6:623-44. 2000
    ....
  8. ncbi Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5)
    U Mahlknecht
    Department of Hematology Oncology, University of Frankfurt Medical Center, Frankfurt, Germany
    Biochim Biophys Acta 1493:342-8. 2000
    ..84. Fluorescence in situ hybridization analysis localized the human HDAC5 gene to chromosome 17q21, a region which is characterized by frequent gains and losses of chromosomal material in several types of cancer...
  9. ncbi High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region
    U Mahlknecht
    Laboratory of Medical Biochemistry, The Picower Institute for Medical Research, Manhasset NY, USA
    Cytogenet Cell Genet 86:237-9. 1999
    ..Since HDAC3 carries strong potential to be a tumor suppressor gene, we report herein its exact position between the CD14 and GRIA1 genes within the 5q31.1 subband...
  10. ncbi Cloning and characterization of the murine histone deacetylase (HDAC3)
    U Mahlknecht
    Picower Institute for Medical Research, 350 Community Drive, Manhasset, New York, 11030, USA
    Biochem Biophys Res Commun 263:482-90. 1999
    ..We report herein the identification and characterization of HDAC3, a yeast RPD3 ortholog in the mouse. Studies on murine HDAC3 may yield important insights on the understanding of myeloproliferative disease in humans...
  11. ncbi Assignment of the histone deacetylase gene (Hdac3) to mouse chromosome 18B3 by in situ hybridization
    U Mahlknecht
    The Picower Institute for Medical Research, Manhasset, NY, USA
    Cytogenet Cell Genet 84:192-3. 1999
  12. ncbi Cloning and chromosomal characterization of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 gene (PFKFB3, iPFK2)
    Ulrich Mahlknecht
    Department of Hematology Oncology, University of Frankfurt Medical Center, D 60590 Frankfurt, Germany
    Int J Oncol 23:883-91. 2003
    ..PFKFB3 has been shown to be abundantly expressed in human tumors and its expression linked to long-standing observations concerning the apparent coupling of enhanced glycolysis and cell proliferation...
  13. ncbi Genomic organization and chromosomal localization of the human histone deacetylase 3 gene
    U Mahlknecht
    The Picower Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Genomics 56:197-202. 1999
    ..2 region, were used as probes showed that the HDAC3 gene lies in region 5q31.3, immediately distal to EGR1 with respect to the centromere...
  14. ncbi Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization
    U Mahlknecht
    Department of Hematology Oncology, University of Heidelberg Medical Center, Heidelberg, Germany
    Cytogenet Genome Res 112:208-12. 2006
    ..Human SIRT5 is most predominantly expressed in heart muscle cells and in lymphoblasts. Fluorescence in situ hybridization analysis localized the human SIRT5 gene to chromosome 6p23...
  15. ncbi Cloning and structural characterization of the human histone deacetylase 6 gene
    Susanne Voelter-Mahlknecht
    Department of Hematology Oncology, University of Frankfurt Medical Center, D 60590 Frankfurt, Germany
    Int J Mol Med 12:87-93. 2003
    ..22-23, a region which is characterized by frequent gains and losses of chromosomal material in several types of cancer and neurological disorders...
  16. ncbi Chromosomal organization and fluorescence in situ hybridization of the human Sirtuin 6 gene
    Ulrich Mahlknecht
    Department of Hematology Oncology, University of Heidelberg Medical Center, D 69120 Heidelberg, Germany
    Int J Oncol 28:447-56. 2006
    ..The functional characteristics of SIRT6 are essentially unknown at present and remain to be elucidated...
  17. ncbi Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression
    Ulrich Mahlknecht
    Department of Hematology Oncology, University of Frankfurt Medical Center, Frankfurt am Main, Germany
    J Immunol 173:3979-90. 2004
    ....
  18. ncbi The histone deacetylase inhibitor suberoylanilide hydroxamic acid down-regulates expression levels of Bcr-abl, c-Myc and HDAC3 in chronic myeloid leukemia cell lines
    Yaoxian Xu
    Department of Hematology Oncology, University of Heidelberg Medical Center, Heidelberg, Germany
    Int J Mol Med 15:169-72. 2005
    ..In conclusion, our results imply a molecular mechanism for SAHA-induced apoptosis in BV-173 cells, which involves decreased protein expression levels of Bcr-Abl, c-Myc and HDAC3...
  19. ncbi FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2)
    Susanne Voelter-Mahlknecht
    Department of Hematology Oncology, University of Heidelberg Medical Center, D 69120 Heidelberg, Germany
    Int J Oncol 27:1187-96. 2005
    ....
  20. ncbi Role of histone deacetylase inhibitors in the treatment of cancer (Review)
    Shaoping Mei
    Department of Hematology Oncology, University of Heidelberg Medical Center, Hospitalstrasse 3, 69115 Heidelberg, Germany
    Int J Oncol 25:1509-19. 2004
    ..A combination of HDAC inhibitors with differentiation-inducing agents and cytotoxic drugs is an innovative therapeutic strategy that carries the potential for significant improvements in the treatment of cancer...
  21. pmc Valproic acid sensitizes chronic lymphocytic leukemia cells to apoptosis and restores the balance between pro- and antiapoptotic proteins
    Imke Bokelmann
    Department of Hematology Oncology, University of Heidelberg Medical Center, Im Neuenheimer Feld 410, Heidelberg, Germany
    Mol Med 14:20-7. 2008
    ..With the results presented in this study, we have identified the HDAC inhibitor VPA as restoring the apoptotic pathways in CLL cells and thus their ability to undergo apoptosis...
  22. ncbi Chromosomal organization and localization of the novel class IV human histone deacetylase 11 gene
    Susanne Voelter-Mahlknecht
    University of Mainz, Department of Occupational, Social and Environmental Medicine, Obere Zahlbacher Str 67, D 55131 Mainz, Germany
    Int J Mol Med 16:589-98. 2005
    ..88. Fluorescence in situ hybridization analysis localized the human HDAC11 gene to chromosome 3p25, a region characterized by frequent gains and losses of chromosomal material in a number of various types of cancer...
  23. ncbi Cloning, chromosomal characterization and mapping of the NAD-dependent histone deacetylases gene sirtuin 1
    Susanne Voelter-Mahlknecht
    Department of Occupational, Social and Environmental Medicine, University of Mainz, D 55131 Mainz, Germany
    Int J Mol Med 17:59-67. 2006
    ..7 kDa and an isoelectric point of 4.55. Fluorescence in situ hybridization analysis localized the human Sirt1 gene to chromosome 10q21.3...
  24. doi Histone deacetylase inhibitor treatment downregulates VLA-4 adhesion in hematopoietic stem cells and acute myeloid leukemia blast cells
    Ulrich Mahlknecht
    Saarland University Medical Center Department of Immunotherapy and Gene Therapy, Kirrberger Strasse, Bldg 4 3, D 66424 Homburg Saar, Germany
    Haematologica 93:443-6. 2008
    ....
  25. ncbi Aging and anti-aging: unexpected side effects of everyday medication through sirtuin1 modulation
    Nicole Engel
    Department of Hematology Oncology, University of Heidelberg Medical Center, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Int J Mol Med 21:223-32. 2008
    ..These findings have an important impact on the long-term use of a number of frequently used clinical agents in the treatment of chronic disease with respect to aging and carcinogenesis...
  26. ncbi NF-kappaB-dependent control of HIV-1 transcription by the second coding exon of Tat in T cells
    Ulrich Mahlknecht
    Franche Comte School of Medicine, Hopital Saint Jacques, 2 Place Saint Jacques, F 25030 Besancon Cedex, France
    J Leukoc Biol 83:718-27. 2008
    ....
  27. ncbi Darwinism and pharmacogenomics: from 'one treatment fits all' to 'selection of the richest'?
    Susanne Voelter-Mahlknecht
    Trends Mol Med 10:208-9. 2004
  28. doi SIRTUIN 1: regulating the regulator
    Barbara Zschoernig
    Saarland University Medical Center, Department of Internal Medicine, Division of Immunotherapy and Gene Therapy, José Carreras Center for Immunotherapy and Gene Therapy, Kirrberger Strasse, Building 40, D 66421 Homburg Saar, Germany
    Biochem Biophys Res Commun 376:251-5. 2008
    ..In this review we outline recent research advances on the regulation of SIRT1 which may provide the basis for the development of therapeutic inhibitors with improved specificity...