Research Topics
| Albrecht LudwigSummaryAffiliation: Frankfurt am Main Country: Germany Publications
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Detail Information
Publications
Release of latent ClyA cytolysin from Escherichia coli mediated by a bacteriophage-associated putative holin (BlyA) from Borrelia burgdorferiAlbrecht Ludwig
Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe Universität Frankfurt am Main, Paul Ehrlich Str 40, D 60596 Frankfurt am Main, Germany
Int J Med Microbiol 298:473-81. 2008..These findings are compatible with the presumption that BlyA functions as a membrane-active holin...
Mutations affecting export and activity of cytolysin A from Escherichia coliAlbrecht Ludwig
Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe Universitat, Paul Ehrlich Str 40, D 60596 Frankfurt am Main, Germany
J Bacteriol 192:4001-11. 2010..The latter regions thus apparently promote membrane interaction without being directly required for pore formation in a lipid bilayer...- Molecular analysis of cytolysin A (ClyA) in pathogenic Escherichia coli strainsAlbrecht Ludwig
Institut fur Medizinische Mikrobiologie, Klinikum der Johann Wolfgang Goethe Universitat, 60596 Frankfurt am Main, Germany
J Bacteriol 186:5311-20. 2004..The presented data indicate that cytolysin A can play a role only for some of the pathogenic E. coli strains... 
ClyA cytolysin from Salmonella: distribution within the genus, regulation of expression by SlyA, and pore-forming characteristicsChristine von Rhein
Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
Int J Med Microbiol 299:21-35. 2009..Typhi and S. Paratyphi A strains produce substantial amounts of ClyA during human infection, these data suggest that ClyA may play a role in S. Typhi and S. Paratyphi A pathogenesis...- Compensatory adaptation to the loss of biological fitness associated with acquisition of fusidic acid resistance in Staphylococcus aureusSilke Besier
Institut fur Medizinische Mikrobiologie, Klinikum der Johann Wolfgang Goethe Universitat, Paul Ehrlich Strasse 40, 60596 Frankfurt am Main, Germany
Antimicrob Agents Chemother 49:1426-31. 2005..aureus can be reduced considerably by specific compensating mutations in this target protein. This compensatory adaptation most likely plays a significant role in the stabilization of resistant bacteria within a given population... - Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistancesSilke Besier
Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
Antimicrob Agents Chemother 52:1570-2. 2008.... - Occurrence and characteristics of the cytolysin A gene in Shigella strains and other members of the family EnterobacteriaceaeChristine von Rhein
Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe Universitat, Paul Ehrlich Strasse 40, Frankfurt am Main, Germany
FEMS Microbiol Lett 287:143-8. 2008..According to these data, ClyA may play a role only for a rather small subset of the enteric bacteria... - Molecular analysis of the thymidine-auxotrophic small colony variant phenotype of Staphylococcus aureusSilke Besier
Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Klinikum der Johann Wolfgang Goethe Universitat, Paul Ehrlich Strasse 40, D 60596 Frankfurt am Main, Germany
Int J Med Microbiol 297:217-25. 2007..In conclusion, these data confirm at the molecular level that impaired thymidylate synthase function is causative for the formation of the thymidine-auxotrophic SCV phenotype in S. aureus... - Biological cost of rifampin resistance from the perspective of Staphylococcus aureusThomas A Wichelhaus
Institut fur Medizinische Mikrobiologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
Antimicrob Agents Chemother 46:3381-5. 2002..The restriction to distinct mutations that confer rifampin resistance in vivo, as demonstrated here, appears to be determined by the Darwinian fitness of the organisms... - Serologic evidence for effective production of cytolysin A in Salmonella enterica serovars typhi and paratyphi A during human infectionChristine von Rhein
, , Paul-Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany
Infect Immun 74:6505-8. 2006..We show here that human infections by these pathogens cause a specific antibody response to ClyA, indicating effective toxin production during infection... - Molecular analysis of fusidic acid resistance in Staphylococcus aureusSilke Besier
, , Paul-Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany
Mol Microbiol 47:463-9. 2003..Thus, the data presented provide evidence for the crucial importance of individual amino acid exchanges within EF-G for the generation of fusidic acid resistance in S. aureus... - Differential regulation of multiple proteins of Escherichia coli and Salmonella enterica serovar Typhimurium by the transcriptional regulator SlyAAndrea Spory
Lehrstuhl fur Mikrobiologie, Theodor Boveri Institut für Biowissenschaften Biozentrum, Universitat Wurzburg, 97074 Wurzburg, Germany
J Bacteriol 184:3549-59. 2002..The data suggest that gene regulation by SlyA might be crucial for intracellular survival and/or replication of both EIEC and Salmonella serovar Typhimurium in phagocytic host cells...