Jorg Kreuter

Summary

Affiliation: Frankfurt am Main
Country: Germany

Publications

  1. pmc Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers
    Stefanie Wohlfart
    Institute of Pharmaceutical Technology, Goethe University, Frankfurt, Germany
    PLoS ONE 6:e19121. 2011
  2. doi Drug delivery to the brain using surfactant-coated poly(lactide-co-glycolide) nanoparticles: influence of the formulation parameters
    Svetlana Gelperina
    Nanosystem LTD, Moscow, Russia
    Eur J Pharm Biopharm 74:157-63. 2010
  3. doi Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles
    Kamila B Kurakhmaeva
    Zakusov Institute of Pharmacology RAMS, Moscow, Russia
    J Drug Target 17:564-74. 2009
  4. ncbi Significant entry of tubocurarine into the brain of rats by adsorption to polysorbate 80-coated polybutylcyanoacrylate nanoparticles: an in situ brain perfusion study
    R N Alyautdin
    Department of Pharmacology, Sechenov Medical Academy, Moscow, Russia
    J Microencapsul 15:67-74. 1998
  5. ncbi Influence of the formulation on the tolerance profile of nanoparticle-bound doxorubicin in healthy rats: focus on cardio- and testicular toxicity
    E Pereverzeva
    Gauze Institute of Novel Antibiotics, Academy of Medical Sciences, Moscow, Russia
    Int J Pharm 337:346-56. 2007
  6. doi Mechanism of polymeric nanoparticle-based drug transport across the blood-brain barrier (BBB)
    Jorg Kreuter
    Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany
    J Microencapsul 30:49-54. 2013
  7. ncbi Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain
    Jorg Kreuter
    Institut fur Pharmazeutische Technologie, Biozentrum, Johann Wolfgang Goethe Universitat Frankfurt, Germany
    J Control Release 118:54-8. 2007
  8. ncbi Use of nanoparticles for cerebral cancer
    Jorg Kreuter
    Institute for Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Tumori 94:271-7. 2008
  9. ncbi Nanoparticles--a historical perspective
    Jorg Kreuter
    Institut fur Pharmazeutische Technologie, Biozentrum, J W Goethe Universitat, D 60439 Frankfurt, Germany
    Int J Pharm 331:1-10. 2007
  10. ncbi Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier
    Jorg Kreuter
    Institut fur Pharmazeutische Technologie, Biozentrum, J W Goethe Universitat, Frankfurt, Germany
    J Drug Target 10:317-25. 2002

Collaborators

Detail Information

Publications70

  1. pmc Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers
    Stefanie Wohlfart
    Institute of Pharmaceutical Technology, Goethe University, Frankfurt, Germany
    PLoS ONE 6:e19121. 2011
    ..In the present study the anti-tumour efficacy of the surfactant-coated doxorubicin-loaded PLGA nanoparticles against rat glioblastoma 101/8 was investigated using histological and immunohistochemical methods...
  2. doi Drug delivery to the brain using surfactant-coated poly(lactide-co-glycolide) nanoparticles: influence of the formulation parameters
    Svetlana Gelperina
    Nanosystem LTD, Moscow, Russia
    Eur J Pharm Biopharm 74:157-63. 2010
    ..The results of the study also demonstrated that the efficacy of brain delivery by nanoparticles not only is influenced by the coating surfactants but also by other formulation parameters such as core polymer, drug, and stabilizer...
  3. doi Brain targeting of nerve growth factor using poly(butyl cyanoacrylate) nanoparticles
    Kamila B Kurakhmaeva
    Zakusov Institute of Pharmacology RAMS, Moscow, Russia
    J Drug Target 17:564-74. 2009
    ..This approach may improve the NGF-based therapy of age-related neurodegenerative diseases...
  4. ncbi Significant entry of tubocurarine into the brain of rats by adsorption to polysorbate 80-coated polybutylcyanoacrylate nanoparticles: an in situ brain perfusion study
    R N Alyautdin
    Department of Pharmacology, Sechenov Medical Academy, Moscow, Russia
    J Microencapsul 15:67-74. 1998
    ..Thus only the loading of tubocurarine onto the polysorbate 80-coated nanoparticles appears to enable the transport of this quaternary ammonium compound through the blood-brain barrier...
  5. ncbi Influence of the formulation on the tolerance profile of nanoparticle-bound doxorubicin in healthy rats: focus on cardio- and testicular toxicity
    E Pereverzeva
    Gauze Institute of Novel Antibiotics, Academy of Medical Sciences, Moscow, Russia
    Int J Pharm 337:346-56. 2007
    ..Specifically, these formulations display a considerably reduced cardio- and testicular toxicity, as compared to a free drug...
  6. doi Mechanism of polymeric nanoparticle-based drug transport across the blood-brain barrier (BBB)
    Jorg Kreuter
    Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany
    J Microencapsul 30:49-54. 2013
    ..From these results it can be concluded that the nanoparticles act as "Trojan Horses" taking advantage of physiological receptor-mediated transport processes across the BBB...
  7. ncbi Covalent attachment of apolipoprotein A-I and apolipoprotein B-100 to albumin nanoparticles enables drug transport into the brain
    Jorg Kreuter
    Institut fur Pharmazeutische Technologie, Biozentrum, Johann Wolfgang Goethe Universitat Frankfurt, Germany
    J Control Release 118:54-8. 2007
    ..This result demonstrates that more than one mechanism is involved in the interaction of nanoparticles with the brain endothelial cells and the resulting delivery of drugs to the central nervous system...
  8. ncbi Use of nanoparticles for cerebral cancer
    Jorg Kreuter
    Institute for Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Tumori 94:271-7. 2008
    ....
  9. ncbi Nanoparticles--a historical perspective
    Jorg Kreuter
    Institut fur Pharmazeutische Technologie, Biozentrum, J W Goethe Universitat, D 60439 Frankfurt, Germany
    Int J Pharm 331:1-10. 2007
    ....
  10. ncbi Apolipoprotein-mediated transport of nanoparticle-bound drugs across the blood-brain barrier
    Jorg Kreuter
    Institut fur Pharmazeutische Technologie, Biozentrum, J W Goethe Universitat, Frankfurt, Germany
    J Drug Target 10:317-25. 2002
    ..Bound drugs then may be further transported into the brain by diffusion following release within the endothelial cells or, alternatively, by transcytosis...
  11. ncbi Nanoparticulate systems for brain delivery of drugs
    J Kreuter
    Institut fur Pharmazeutische Technologie, Biozentrum, J W Goethe Universitat, D 60439 Frankfurt, Germany
    Adv Drug Deliv Rev 47:65-81. 2001
    ..Other processes such as tight junction modulation or P-glycoprotein (Pgp) inhibition also may occur. Moreover, these mechanisms may run in parallel or may be cooperative thus enabling a drug delivery to the brain...
  12. doi Treatment of glioblastoma with poly(isohexyl cyanoacrylate) nanoparticles
    Stefanie Wohlfart
    Institute of Pharmaceutical Technology, Goethe University, Max von Laue Straße 9, D 60438 Frankfurt Main, Germany
    Int J Pharm 415:244-51. 2011
    ..The results suggest that poly(isohexyl cyanoacrylate) nanoparticles hold great promise for the non-invasive therapy of human glioblastomas...
  13. ncbi Cytotoxicity of doxorubicin bound to poly(butyl cyanoacrylate) nanoparticles in rat glioma cell lines using different assays
    Berta Sanchez De Juan
    Institute of Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Drug Target 14:614-22. 2006
    ..It was shown that the presence of polysorbate 80 (Tween 80) in the nanoparticle formulation significantly enhanced the cytotoxicity, whereas poloxamer 188 (Pluronic F68) and poloxamine 908 (Tetronic 908) had a negligible influence...
  14. ncbi Influence of surfactants, polymer and doxorubicin loading on the anti-tumour effect of poly(butyl cyanoacrylate) nanoparticles in a rat glioma model
    Alessandra Ambruosi
    Institute of Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    J Microencapsul 23:582-92. 2006
    ....
  15. ncbi Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles
    Jorg Kreuter
    Institut fur Pharmazeutische Technologie, Biozentrum, J W Goethe Universitat, Frankfurt, Germany
    Pharm Res 20:409-16. 2003
    ..The purpose of this study is to explore more fully the mechanism by which PBCA nanoparticles can deliver drugs to the brain...
  16. ncbi Biodistribution of polysorbate 80-coated doxorubicin-loaded [14C]-poly(butyl cyanoacrylate) nanoparticles after intravenous administration to glioblastoma-bearing rats
    Alessandra Ambruosi
    Institute of Pharmaceutical Technology, Johann Wolfgang Goethe University, Marie Curie Strasse 9, 60439, Frankfurt am Main, Germany
    J Drug Target 14:97-105. 2006
    ..The uptake of the NP by the organs of the reticuloendothelial system (RES) was reduced after PS 80-coating, but the addition of DOX increased again the concentration of NP in the RES...
  17. doi Interaction of folate-conjugated human serum albumin (HSA) nanoparticles with tumour cells
    Karsten Ulbrich
    Institute of Pharmaceutical Technology, Biocenter of Johann Wolfgang Goethe University, D 60438 Frankfurt am Main, Germany
    Int J Pharm 406:128-34. 2011
    ..These data suggest that covalent linkage of folic acid can specifically increase cancer cell HSA NP uptake...
  18. ncbi Body distribution of polysorbate-80 and doxorubicin-loaded [14C]poly(butyl cyanoacrylate) nanoparticles after i.v. administration in rats
    Alessandra Ambruosi
    Institut fur Pharmazeutische Technologie, Johann Wolfgang Goethe Universitat, Marie Curie Strabe 9, D 60439, Frankfurt am Main, Germany
    J Drug Target 13:535-42. 2005
    ..After longer time periods after injection the differences between the three preparations decreased...
  19. ncbi Highly specific HER2-mediated cellular uptake of antibody-modified nanoparticles in tumour cells
    Heidrun Wartlick
    Institute for Pharmaceutical Technology, Biocenter of Johann Wolfgang Goethe University, Marie Curie Strasse 9, D 60439 Frankfurt, Germany
    J Drug Target 12:461-71. 2004
    ..To our knowledge, this is the first study that demonstrates the effective and specific targeting of protein-based nanoparticles as drug delivery systems...
  20. doi HI 6 human serum albumin nanoparticles--development and transport over an in vitro blood-brain barrier model
    Miriam Dadparvar
    Institute of Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Toxicol Lett 206:60-6. 2011
    ..These findings show that nanoparticles made of HSA may enable a sufficient antidote OP-poisoning therapy with HI 6 derivatives even within the central nervous system (CNS)...
  21. ncbi Use of isothermal heat conduction microcalorimetry, X-ray diffraction, and optical microscopy for characterisation of crystals grown in steroid combination-containing transdermal drug delivery systems
    Silvia Latsch
    Institut fur Pharmazeutische Technologie, Frankfurt am Main, Germany
    Eur J Pharm Biopharm 57:397-410. 2004
    ..This treatment enabled a slight reduction of the crystallisation in the TDDSs. Microcalorimetry enabled the classification of various additives according to their influence on the crystallisation process...
  22. doi Kinetics of transport of doxorubicin bound to nanoparticles across the blood-brain barrier
    Stefanie Wohlfart
    Goethe University, Institute of Pharmaceutical Technology, Frankfurt am Main, Germany
    J Control Release 154:103-7. 2011
    ..These observations demonstrate the great potential of surface-coated PBCA nanoparticles for the delivery of drugs to the central nervous system...
  23. doi Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB)
    Karsten Ulbrich
    Institute for Pharmaceutical Technology, Goethe University, Frankfurt, Germany
    Eur J Pharm Biopharm 71:251-6. 2009
    ..Control loperamide-loaded HSA nanoparticles with IgG2a antibodies yielded only marginal effects...
  24. doi Adsorption of plasma proteins on uncoated PLGA nanoparticles
    Karim Sempf
    Institute of Pharmaceutical Technology, Goethe University, Frankfurt, Germany
    Eur J Pharm Biopharm 85:53-60. 2013
    ..These proteins also are constituents of HDL. ..
  25. ncbi Microparticles derived from marine sponge collagen (SCMPs): preparation, characterization and suitability for dermal delivery of all-trans retinol
    Dieter Swatschek
    KliniPharm, Frankfurt Main, Germany
    Eur J Pharm Biopharm 54:125-33. 2002
    ..The SCMPs had no influence on the chemical stability of retinol in the hydrogel. The dermal penetration of retinol into the skin increased significantly by approximately two-fold...
  26. doi Human serum albumin nanoparticles modified with apolipoprotein A-I cross the blood-brain barrier and enter the rodent brain
    Anja Zensi
    Goethe University, Institute of Pharmaceutical Technology, Frankfurt am Main, Germany
    J Drug Target 18:842-8. 2010
    ....
  27. doi Adsorption of obidoxime onto human serum albumin nanoparticles: drug loading, particle size and drug release
    Jürgen Kufleitner
    Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany
    J Microencapsul 27:506-13. 2010
    ..The in vitro release of obidoxime from HSA nanoparticles showed a rapid release of the drug from the nanoparticles within 3 h...
  28. doi Enteric coating derived from marine sponge collagen
    Martina Nicklas
    KliniPharm GmbH, Frankfurt, Germany
    Drug Dev Ind Pharm 35:1384-8. 2009
    ..Aim: The objective of this study was to develop a novel gastroresistant delayed-release tablet coating based on the marine sponge Chondrosia reniformis Nardo and to investigate the technical feasibility of the coating process...
  29. doi Specific targeting of HER2 overexpressing breast cancer cells with doxorubicin-loaded trastuzumab-modified human serum albumin nanoparticles
    Marion G Anhorn
    Institute of Pharmaceutical Technology, Biocenter of Johann Wolfgang Goethe University, 60438 Frankfurt Main, Germany
    Bioconjug Chem 19:2321-31. 2008
    ..To our knowledge, this is the first study demonstrating a specific trastuzumab-based targeting of HER2 overexpressing breast cancer cells with doxorubicin-loaded nanoparticles...
  30. ncbi Determination of the physical state of norethindrone acetate containing transdermal drug delivery systems by isothermal microcalorimetry, X-ray diffraction, and optical microscopy
    Silvia Latsch
    Institut fur Pharmazeutische Technologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Eur J Pharm Biopharm 57:383-95. 2004
    ..8+/-2.6 kJ/mol. The most specific method to observe the crystal formation is polarisation light microscopy. However, the microscopic analysis requires much longer storage times than microcalorimetry to detect crystallisation...
  31. doi Targeting the insulin receptor: nanoparticles for drug delivery across the blood-brain barrier (BBB)
    Karsten Ulbrich
    Institute for Pharmaceutical Technology, Goethe University, Frankfurt, Germany
    J Drug Target 19:125-32. 2011
    ..The loperamide transport across the BBB using the NP with covalently attached insulin could be totally inhibited by the pretreatment with the antibody 29B4...
  32. ncbi Preparation and characterisation of antibody modified gelatin nanoparticles as drug carrier system for uptake in lymphocytes
    Sabine Balthasar
    Institut fur Pharmazeutische Technologie, Biozentrum Niederursel, Johann Wolfgang Goethe Universitat, Marie Curie Strasse 9, Frankfurt am Main D 60439, Germany
    Biomaterials 26:2723-32. 2005
    ..Therefore, a well-defined nanoparticle system with drug targeting ligand modification was established that holds promise for further effective preclinical testing...
  33. ncbi Influence of the surface properties on nanoparticle-mediated transport of drugs to the brain
    Jorg Kreuter
    Institut fur Pharmazeutische Technologie, Johann Wolfgang Goethe Universitat, Frankfurt, Marie Curie Strasse 9, D 60439 Frankfurt Main, Germany
    J Nanosci Nanotechnol 4:484-8. 2004
    ..quot; The drug, then, may be released either within these cells followed by passive diffusion into the brain or be transported into the brain by transcytosis...
  34. ncbi Tumour cell delivery of antisense oligonuclceotides by human serum albumin nanoparticles
    Heidrun Wartlick
    Institute for Pharmaceutical Technology, Biocenter of Johann Wolfgang Goethe University, Marie Curie Strasse 9, D 60439 Frankfurt, Germany
    J Control Release 96:483-95. 2004
    ....
  35. ncbi Encapsulation of water-insoluble drugs in poly(butyl cyanoacrylate) nanoparticles
    Telli Hekmatara
    Institute of Pharmaceutical Technology, J W Goethe University, Max von Laue Str 9, D 60438 Frankfurt, Germany
    J Nanosci Nanotechnol 9:5091-8. 2009
    ..Thus produced poly(butyl cyanoacrylate) nanoparticles enabled delivery of loperamide across the blood-brain barrier, which was evidenced by the drug analgesic effect evaluated by the tail-flick test...
  36. ncbi Physicochemical characterisation of cationic polybutylcyanoacrylate-nanoparticles by fluorescence correlation spectroscopy
    Jörg Weyermann
    Institute for Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Eur J Pharm Biopharm 58:25-35. 2004
    ..The FCS measurements of the ON adsorption in situ was found to be much higher with approximately 95 microg ON per 100 g NP...
  37. ncbi Ethylcellulose: a new type of emulsion stabilizer
    Eva Melzer
    Institut fur Pharmazeutische Technologie, Technische Universität Carolo Wilhelmina zu Braunschweig, Braunschweig, Germany
    Eur J Pharm Biopharm 56:23-7. 2003
    ..Thus, ethylcellulose was demonstrated to represent a new type of particulate polymeric emulsifier...
  38. ncbi Crystallisation of estradiol containing TDDS determined by isothermal microcalorimetry, X-ray diffraction, and optical microscopy
    Silvia Latsch
    Institut fur Pharmazeutische Technologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Eur J Pharm Biopharm 56:43-52. 2003
    ..Much lower amounts of crystal were detected by this method than with the significantly less sensitive XRPD method. Microscopy was equally sensitive to but much more time-consuming than microcalorimetry...
  39. ncbi Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles
    Sebastian C J Steiniger
    Institute of Pharmaceutical Technology, University of Frankfurt, Marie Curie Strasse 9, D 60439 Frankfurt Main, Germany
    Int J Cancer 109:759-67. 2004
    ..Additionally, binding to nanoparticles may reduce the systemic toxicity of doxorubicin. This study showed that therapy with doxorubicin bound to nanoparticles offers a therapeutic potential for the treatment of human glioblastoma...
  40. doi Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones
    Anja Zensi
    Goethe University, Institute of Pharmaceutical Technology, Max von Laue Str 9 Biozentrum, D 60438 Frankfurt am Main, Germany
    J Control Release 137:78-86. 2009
    ..These findings indicate that nanoparticles with covalently bound apolipoprotein E are taken up into the cerebral endothelium by an endocytic mechanism followed by transcytosis into brain parenchyma...
  41. ncbi Cationic lipid-protamine-DNA (LPD) complexes for delivery of antisense c-myc oligonucleotides
    Monika Junghans
    Institute for Pharmaceutical Technology, Biocenter, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Eur J Pharm Biopharm 60:287-94. 2005
    ..The C-MYC level was reduced after treatment of these antisense ODN carrier complexes. Furthermore, no changes in target mRNA concentration of the treated cells was found by reverse transcription and competitive multiplex-PCR...
  42. ncbi In vitro antiviral activity of aphidicolin and its derivates. Synergistic effects of aphidicolin with other antiviral drugs
    Martin Michaelis
    Institut fur Medizinische Virologie, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt Main, Germany
    Arzneimittelforschung 52:393-9. 2002
    ..Aphidicolin and its two antiviral active derivatives might represent useful additional tools for antiviral therapy of HSV and HCMV infections, especially in combination with clinically used drugs...
  43. ncbi Human serum albumin-polyethylenimine nanoparticles for gene delivery
    Stephanie Rhaese
    Institute for Pharmaceutical Technology, Biocenter of Johann Wolfgang Goethe University, Marie Curie Strasse 9, D 60439 Frankfurt, Germany
    J Control Release 92:199-208. 2003
    ..8 and 8.4. Furthermore, they displayed a low cytotoxicity when tested in cell culture. Our results show that HSA-PEI-DNA nanoparticles are a versatile carrier for DNA that may be suitable for i.v. administration...
  44. ncbi Molecular weights of poly(butyl cyanoacrylate) nanoparticles determined by mass spectrometry and size exclusion chromatography
    Alexander Bootz
    Institut fur Pharmazeutische Technologie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Eur J Pharm Biopharm 60:391-9. 2005
    ..The most uniform nanoparticles, with the highest polymerisation yield, narrowest particle size, and mass distribution were produced at pH 1...
  45. ncbi Marine sponge collagen: isolation, characterization and effects on the skin parameters surface-pH, moisture and sebum
    Dieter Swatschek
    Institute of Pharmaceutical Technology, Johann Wolfgang Goethe 1 1 University, Biocenter, Marie Curie Strasse 9, 60439 Frankfurt am Main, Germany
    Eur J Pharm Biopharm 53:107-13. 2002
    ..None of the preparations had a noticeable influence on the physiological skin surface pH. Skin hydration increased only slightly. However, all tested formulations showed a significant increase of lipids measured by sebumetry...
  46. doi Incorporation of obidoxime into human serum albumin nanoparticles: optimisation of preparation parameters for the development of a stable formulation
    Jürgen Kufleitner
    Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany
    J Microencapsul 27:594-601. 2010
    ..The in vitro release study showed a sustained release profile, indicating the suitability of the developed formulation for the transport of oximes across the BBB...
  47. doi Transport of drugs across the blood-brain barrier by nanoparticles
    Stefanie Wohlfart
    Goethe University, Institute of Pharmaceutical Technology, Frankfurt am Main, Germany
    J Control Release 161:264-73. 2012
    ..These data, together with the possibility to employ nanoparticles for delivery of proteins and other macromolecules across the BBB, suggest that this technology holds great promise for non-invasive therapy of the CNS diseases...
  48. ncbi Preparation, characterisation and maintenance of drug efficacy of doxorubicin-loaded human serum albumin (HSA) nanoparticles
    S Dreis
    Institute of Pharmaceutical Technology, Biocenter Niederursel, Johann Wolfgang Goethe University, Max von Laue Strasse 9, D 60438 Frankfurt Main, Germany
    Int J Pharm 341:207-14. 2007
    ..Based on these result a standard protocol for the preparation of doxorubicin-loaded HSA nanoparticles for further antitumoural studies was established...
  49. doi Preparation and characterization of marine sponge collagen nanoparticles and employment for the transdermal delivery of 17beta-estradiol-hemihydrate
    Martina Nicklas
    KliniPharm GmbH, Frankfurt am Main, Germany
    Drug Dev Ind Pharm 35:1035-42. 2009
    ..Transdermal administration of estradiol offers advantages over oral estrogens for hormone replacement therapy regarding side effects by bypassing the hepatic presystemic metabolism...
  50. ncbi Preparation of avidin-labeled protein nanoparticles as carriers for biotinylated peptide nucleic acid
    K Langer
    Institut fur Pharmazeutische Technologie, Johann Wolfgang Goethe Universitat, Frankfurt aM, Main, Germany
    Eur J Pharm Biopharm 49:303-7. 2000
    ..Since the formation of the interaction between biotin and avidin is very rapid and stable a highly effective drug carrier system for biotinylated compounds such as PNAs was achieved...
  51. ncbi Pharmacology of intracellular cytosine-arabinoside-5'-triphosphate in malignant cells of pediatric patients with initial or relapsed leukemia and in normal lymphocytes
    U Koehl
    Pediatric Hematology and Oncology, Laboratory for Stem Cell Transplantation and Immunotherapy, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60596 Frankfurt a M, Germany
    Cancer Chemother Pharmacol 60:467-77. 2007
    ..The purpose of the present study was to investigate the relation between sensitivity and pharmacokinetic parameters Cmax, t1/2 and AUC of ara-CTP. The obtained results were compared to previous studies...
  52. ncbi Antiviral and immunomodulatory activity of the metal chelator ethylenediaminedisuccinic acid against cytomegalovirus in vitro and in vivo
    J U Vogel
    Institut fur Medizinische Virologie, Klinikum der Johann Wolfgang Goethe Universitat, Paul Ehrlich Str 40, D 60596 a M, Frankfurt, Germany
    Antiviral Res 55:179-88. 2002
    ..Since immunopathological factors may play a significant role in HCMV disease it will be of interest to further study whether EDDS is effective in terms of modulation of inflammatory responses to HCMV infections...
  53. ncbi Neuroprotective activity of a nanoparticulate formulation of the glycineB site antagonist MRZ 2/576 in transient focal ischaemia in rats
    Monika Sopala
    Preclinical Research and Development, Merz Co, Frankfurt Main, Germany
    Arzneimittelforschung 52:168-74. 2002
    ..The results suggest that nanoparticles hold promise as an effective strategy e.g. for substances with physico-chemical characteristics that otherwise would preclude them from pre-clinical development and/or clinical application...
  54. doi Survivin-miRNA-loaded nanoparticles as auxiliary tools for radiation therapy: preparation, characterisation, drug release, cytotoxicity and therapeutic effect on colorectal cancer cells
    Sebastian Gaca
    Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany
    J Microencapsul 29:685-94. 2012
    ..These nanoparticles comprise a promising option to enhance the response of carcinoma cells to therapy with ionising irradiation...
  55. ncbi Influence of the preparation methods on the drug release behaviour of loperamide-loaded nanoparticles
    M Ueda
    , , Frankfurt Main, Germany
    J Microencapsul 15:361-72. 1998
    ..In conclusion, a rapid loperamide release from nanoparticles can be achieved by use of PLA or PLGA with low molecular weights and in the adsorption method by the addition of SFAEs...
  56. ncbi Gelatin nanoparticles by two step desolvation--a new preparation method, surface modifications and cell uptake
    C J Coester
    Institute for Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    J Microencapsul 17:187-93. 2000
    ..In addition, two fluorescent dyes (Texasred and fluoresceinamine) were coupled to the nanoparticles for cell uptake studies. The fluorescent nanoparticles showed a high uptake into monocytes/macrophages...
  57. ncbi Comparison of scanning electron microscopy, dynamic light scattering and analytical ultracentrifugation for the sizing of poly(butyl cyanoacrylate) nanoparticles
    Alexander Bootz
    Institut fur Pharmazeutische Technologie, Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Eur J Pharm Biopharm 57:369-75. 2004
    ..Molar particle mass distributions centered around 2.3x10(9) g/mol. The advantages and disadvantages of the three sizing techniques are discussed...
  58. pmc Anticancer effects of the nitric oxide-modified saquinavir derivative saquinavir-NO against multidrug-resistant cancer cells
    Florian Rothweiler
    Institut fur Medizinische Virologie, Klinikum der J W Goethe Universitat, Frankfurt am Main, Germany
    Neoplasia 12:1023-30. 2010
    ..These data support the further investigation of saq-NO as an anticancer drug, especially in multidrug-resistant tumors...
  59. ncbi Contrast enhancement of the brain by folate-conjugated gadolinium-diethylenetriaminepentaacetic acid-human serum albumin nanoparticles by magnetic resonance imaging
    Huedayi Korkusuz
    Department of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University Hospital, Frankfurt, Germany
    Mol Imaging 11:272-9. 2012
    ..0069); Gd-HSA-NP and Gd-HSA-NP-FA did not show CE in skeletal muscle and gallbladder; Gd-HSA-NP, but not Gd-HSA-NP-FA, showed CE in the cardiac muscle. Gd-HSA-NP-FA has potential as an MRI contrast agent in the brain...
  60. ncbi Collagen microparticles: preparation and properties
    B Rössler
    Institute of Pharmaceutical Technology, J W Goethe University, Frankfurt Main, Germany
    J Microencapsul 12:49-57. 1995
    ..g. retinol, tretinoin, or tetracaine and lidocaine in free base form. Another feature of the biodegradable CMPs is their thermal stability, thus their sterilization can be readily achieved...
  61. ncbi Efficient systemic therapy of rat glioblastoma by nanoparticle-bound doxorubicin is due to antiangiogenic effects
    T Hekmatara
    Institute of Pharmaceutical Technology, J W Goethe University, Frankfurt Main, Germany
    Clin Neuropathol 28:153-64. 2009
    ..A drastic effect of Dox-np on vascularization indicated an antiangiogenic mode of action...
  62. ncbi Physicochemical characterization of protamine-phosphorothioate nanoparticles
    D Lochmann
    Institute for Pharmaceutical Technology, Johann Wolfgang Goethe University, Marie Curie Strasse 9, 60439 Frankfurt am Main, Germany
    J Microencapsul 21:625-41. 2004
    ..However, the colloidal solution in water could be stabilized by polyethylenglycol 20000 (PEG), which also led to an increase of stability in cell medium...
  63. ncbi Covalent linkage of apolipoprotein e to albumin nanoparticles strongly enhances drug transport into the brain
    K Michaelis
    Institute for Pharmaceutical Technology, Biocenter of Johann Wolfgang Goethe University, Marie Curie Strasse 9, D 60439 Frankfurt, Germany
    J Pharmacol Exp Ther 317:1246-53. 2006
    ....
  64. ncbi Phagocytosis and degradation of human serum albumin microspheres and nanoparticles in human macrophages
    V Schafer
    Institut für Pharmazeutische Technologie d J W Goethe Universität, Frankfurt, Germany
    J Microencapsul 11:261-9. 1994
    ..The metabolism started some hours after particle uptake. After 3 days the process was almost terminated. After 7 days of cultivation only small numbers of intact microspheres were found in the cytoplasm...
  65. ncbi Degradation of microvascular brain endothelial cell beta-catenin after co-culture with activated neutrophils from patients undergoing cardiac surgery with prolonged cardiopulmonary bypass
    Alina Maria Schuller
    Klinik fur Thorax, Herz und thorakale Gefässchirurgie, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Biochem Biophys Res Commun 329:616-23. 2005
    ..In conclusion, prolonged CPB time entails neutrophil-mediated decrease in MVEC beta-catenin expression, and thus may be an important trigger for BBB disruption...
  66. ncbi Optimization of the preparation of loperamide-loaded poly (L-lactide) nanoparticles by high pressure emulsification-solvent evaporation
    M Ueda
    , , Frankfurt am Main, Germany
    J Microencapsul 14:593-605. 1997
    ..Different drug release profiles from nanoparticles can be achieved by addition of sorbitan fatty acid esters, or the employment of different solvents as the organic phase...
  67. ncbi Studies on the transport pathway of PBCA nanoparticles in ocular tissues
    A Zimmer
    , , Frankfurt a M, Germany
    J Microencapsul 8:497-504. 1991
    ..Only a transcellular pathway was observed. A possible penetration through tight junctions was not noticed; moreover, penetration was observed only into the first two cell layers and no full tissue penetration occurred...
  68. ncbi Effect of ultrasonication on the stability of oligonucleotides adsorbed on nanoparticles and liposomes
    H P Zobel
    , , Frankfurt am Main, Germany
    J Microencapsul 16:501-9. 1999
    ..More than 80% of the oligonucleotides entangled in the surface matrix of these nanoparticles remained intact...
  69. ncbi Influence of polybutylcyanoacrylate nanoparticles and liposomes on the efficacy and toxicity of the anticancer drug mitoxantrone in murine tumour models
    P Beck
    , Frankfurt, Germany
    J Microencapsul 10:101-14. 1993
    ..Neither nanoparticles nor liposomes were able to reduce the toxic side-effects caused by mitoxantrone, namely leucocytopenia. A slight additional influence of the coating surfactant was observed with only one preparation...
  70. ncbi Phosphodiester and phosphorothioate oligonucleotide condensation and preparation of antisense nanoparticles
    M Junghans
    , , Biozentrum, Marie-Curie-Strasse 9, 60439, Frankfurt am Main, Germany
    Biochim Biophys Acta 1544:177-88. 2001
    ..In contrast, spermine and spermidine, which are also known condensation agents, did not aggregate with oligonucleotides into nanoparticles under the same conditions...