P Kraiczy


Affiliation: Frankfurt am Main
Country: Germany


  1. Bigelmayr S, Koenigs A, Kraiczy P. Inter- and intraspecies-specific adhesion of Lyme borreliae to human keratinocytes. Ticks Tick Borne Dis. 2019;10:207-212 pubmed publisher
    ..Taken together, these data provide evidence that distinct borrelial genospecies differ in their ability to bind to human keratinocytes and, in addition, support a role of ErpC as a potential adhesin of spirochetes. ..
  2. Kraiczy P, Hunfeld K, Breitner Ruddock S, Wurzner R, Acker G, Brade V. Comparison of two laboratory methods for the determination of serum resistance in Borrelia burgdorferi isolates. Immunobiology. 2000;201:406-19 pubmed
    ..The IFA, however, is regarded as superior to the GIA owing to the obvious ease of performance and its rapid capability for the classification of even very slow growing isolates. ..
  3. Kraiczy P, Skerka C, Brade V, Zipfel P. Further characterization of complement regulator-acquiring surface proteins of Borrelia burgdorferi. Infect Immun. 2001;69:7800-9 pubmed
    ..The characterization of the individual CRASPs on the molecular level is expected to identify new virulence factors and potential vaccine candidates. ..
  4. Kraiczy P, Wurzner R. Complement escape of human pathogenic bacteria by acquisition of complement regulators. Mol Immunol. 2006;43:31-44 pubmed
    ..Further studies on the utilization of host complement regulatory proteins will likely have a marked impact on a more efficient and specific clinical treatment. ..
  5. Kraiczy P, Rossmann E, Brade V, Simon M, Skerka C, Zipfel P, et al. Binding of human complement regulators FHL-1 and factor H to CRASP-1 orthologs of Borrelia burgdorferi. Wien Klin Wochenschr. 2006;118:669-76 pubmed
    ..burgdorferi s.s. and thus may be helpful in the development of novel therapeutic strategies against Lyme borreliosis. ..
  6. Kraiczy P, Hanssen Hübner C, Kitiratschky V, Brenner C, Besier S, Brade V, et al. Mutational analyses of the BbCRASP-1 protein of Borrelia burgdorferi identify residues relevant for the architecture and binding of host complement regulators FHL-1 and factor H. Int J Med Microbiol. 2009;299:255-68 pubmed publisher
    ..The elucidation of BbCRASP-1 structure - function may allow development of novel therapeutic strategies against Lyme disease. ..
  7. Röttgerding F, Wagemakers A, Koetsveld J, Fingerle V, Kirschfink M, Hovius J, et al. Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties. Sci Rep. 2017;7:303 pubmed publisher
    ..In conclusion, our data revealed a dual strategy of B. miyamotoi to efficiently evade complement via CbiA, which possesses complement binding and inhibitory activities. ..
  8. Kraiczy P, Hunfeld K, Peters S, Wurzner R, Ackert G, Wilske B, et al. Borreliacidal activity of early Lyme disease sera against complement-resistant Borrelia afzelii FEM1 wild-type and an OspC-lacking FEM1 variant. J Med Microbiol. 2000;49:917-28 pubmed
    ..These results provide direct evidence that anti-OspC antibodies, once developed during the immune response, are of critical importance for efficient killing of borreliae in the early phase of infection. ..
  9. Kraiczy P, Skerka C, Kirschfink M, Zipfel P, Brade V. Mechanism of complement resistance of pathogenic Borrelia burgdorferi isolates. Int Immunopharmacol. 2001;1:393-401 pubmed
    ..Thus, complement-resistant Borreliae bind human complement regulators and control complement activation on their surface and prevent the formation of toxic activation products. ..

More Information


  1. Kraiczy P, Skerka C, Kirschfink M, Zipfel P, Brade V. Immune evasion of Borrelia burgdorferi: insufficient killing of the pathogens by complement and antibody. Int J Med Microbiol. 2002;291 Suppl 33:141-6 pubmed
    ..These antigens may include the recently detected CRASPs. ..
  2. Kraiczy P, Hellwage J, Skerka C, Becker H, Kirschfink M, Simon M, et al. Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins. J Biol Chem. 2004;279:2421-9 pubmed
    ..is the key molecule of the complement resistance of spirochetes, and (iii). is distinct from the Erp protein family. Thus, BbCRASP-1 most likely contributes to persistence of B. burgdorferi and to pathogenesis of Lyme disease. ..
  3. Kraiczy P, Hartmann K, Hellwage J, Skerka C, Kirschfink M, Brade V, et al. Immunological characterization of the complement regulator factor H-binding CRASP and Erp proteins of Borrelia burgdorferi. Int J Med Microbiol. 2004;293 Suppl 37:152-7 pubmed
    ..Together, these data indicate that most of the factor H-binding CRASPs are members of the Erp protein family, which represents a polymorphic class of proteins with similar or identical immunological reactivities. ..
  4. Kraiczy P, Stevenson B. Complement regulator-acquiring surface proteins of Borrelia burgdorferi: Structure, function and regulation of gene expression. Ticks Tick Borne Dis. 2013;4:26-34 pubmed publisher
    ..In this review, we focus on the current knowledge on structure, function, and gene regulation of these B. burgdorferi infection-associated proteins...
  5. Kraiczy P. Identification and Characterization of Borrelia burgdorferi Complement-Binding Proteins. Methods Mol Biol. 2018;1690:95-103 pubmed publisher
  6. Kraiczy P, Skerka C, Zipfel P, Brade V. Complement regulator-acquiring surface proteins of Borrelia burgdorferi: a new protein family involved in complement resistance. Wien Klin Wochenschr. 2002;114:568-73 pubmed
    ..The continued characterization of CRASPs at the molecular level is expected to identify new virulence factors and potential vaccine candidates. ..
  7. Kraiczy P. Travelling between Two Worlds: Complement as a Gatekeeper for an Expanded Host Range of Lyme Disease Spirochetes. Vet Sci. 2016;3: pubmed publisher